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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Respiratory Mucosa (3):
Recent article
Respiratory Mucosa
Journal of Trauma (70)1 2011
Caveolin-1 siRNA increases the pulmonary microvascular and alveolar epithelial permeability in rats.
Abstract
We used small interfering RNA (siRNA) to knock down caveolin-1 expression in rat lungs and to confirm the important role of caveolin-1 in regulating pulmonary edema.
After pulmonary injection of siRNA against caveolin-1 messenger RNA incorporated in liposomes with three concentrations of 0.4, 0.8, a...
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PMID: 20693910
PDF is available here.
PDF is available here.
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Journal of Trauma (69)4 2010
Abstract
We investigated the local and systemic kinetics of TNF-α, IL-1β, and IL-6 after injury in mice. We also hypothesized that injection of exogenous TNF-α, IL-1β, and IL-6 would replicate the airway IgA response to injury.
: Experiment 1: male Institute of Cancer Research mice were randomized to uni...
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PMID: 20173656
PDF is available here.
PDF is available here.
Nanotechnology (21)35 2010
Characterization of endocytosis and exocytosis of cationic nanoparticles in airway epithelium cells.
Abstract
We found that clathrin pathway is implied in their endocytosis. Cholesterol depletion increased NP uptake by 300% and this phenomenon was explained by the fact that cholesterol depletion totally blocked NP exocytosis. These results suggest that these cationic NPs interact with anionic sites, are qui...
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PMID: 20689164
PDF is available here.
PDF is available here.
Abstract
We reported that functional NMDA receptors were expressed in alveolar type II cells in the lungs. Over-activation of these receptors led to down-regulation of pulmonary surfactants synthesis. We further demonstrated that decreased cellular choline-phosphate cytidylyltransferase alpha expression indu...
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PMID: 20406200
PDF is available here.
PDF is available here.
Abstract
We aim to gain detailed insight into the molecular pathogenesis of respiratory virus infections by studying the protein expression profiles of infected lung epithelial cells. A549 cells were exposed to a set of respiratory viruses [RSV, hMPV, PIV and Measles virus (MV)] using both live and UV-inacti...
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PMID: 20470912
PDF is available here.
PDF is available here.
Abstract
We treated lungs from adult rats using a procedure that removes cellular components but leaves behind a scaffold of extracellular matrix that retains the hierarchical branching structures of airways and vasculature. We then used a bioreactor to culture pulmonary epithelium and vascular endothelium o...
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PMID: 20576850
PDF is available here.
PDF is available here.
Cancer Letters (295)1 2010
Abstract
Current anti-cancer research is focused on cell surface receptors targeting, mainly epidermal growth factor receptor and vascular endothelial growth factor receptor, against which a few targeted agents are now available in clinical practice. Recent improvements of our understanding on the intracellu...
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PMID: 20381956
PDF is available here.
PDF is available here.
Abstract
Lung gene therapy is being developed to treat acute and chronic airway diseases, and many viral and non-viral gene transfer vectors have been evaluated in the airway epithelium lining the nose and lung. Stem cells have not been clearly defined in the airways and, currently, it is only possible to ta...
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PMID: 20677089
PDF is available here.
PDF is available here.
Respirology (15)6 2010
Abstract
This is the first detailed description of fragmentation and cellularity of the Rbm in smokers, which were most marked in subjects with COPD. The data are consistent with active EMT in these subjects....
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PMID: 20630030
PDF is available here.
PDF is available here.
Abstract
Epithelial overexpression of Smad2 can specifically alter airway hyperreactivity and remodeling in response to an aeroallergen. Moreover, we have identified novel roles for IL-25 and activin A in driving airway hyperreactivity and remodeling....
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PMID: 20339149
PDF is available here.
PDF is available here.
Abstract
dsRNA dose-dependently increased IL-8 expression in BECs with no significant difference between the groups. However, BECs from subjects with asthma expressed less IFNbeta and more TSLP mRNA and protein in response to dsRNA than BECs from those without asthma (median (IQR) 57 (38-82) pg/ml vs 106 (57...
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PMID: 20627922
PDF is available here.
PDF is available here.
Abstract
This study was designed to characterize and compare the effects of jet propellant-8 (JP-8) fuel and synthetic-8 (S-8) on cell viability and nitric oxide synthesis in cultured alveolar type II epithelial cells of rats. Exposure times varied from 0.25, 0.5, 1, and 6 hours at the following concentratio...
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PMID: 20504826
PDF is available here.
PDF is available here.
Journal of Virology (84)13 2010
Abstract
We introduced all previously described amino acid substitutions and combinations thereof into a single genetic background, influenza virus A/Indonesia/5/05 HA, and tested the receptor specificity of these 27 mutant viruses. The attachment pattern to ferret and human tissues of the upper and lower re...
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PMID: 20392847
PDF is available here.
PDF is available here.
Abstract
We investigated the identity and the pH-dependent function of the apical H(+) channel in the airway epithelium. In pH stat recordings of confluent JME airway epithelia in Ussing chambers, Zn-sensitive acid secretion was activated at a mucosal threshold pH of approximately 7, above which it increased...
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PMID: 20548053
PDF is available here.
PDF is available here.
Mucosal Immunology (3)4 2010
Abstract
The absolute requirement of the pulmonary immune system is to limit the inflammatory consequences of inhaled infectious agents while maintaining tolerance to harmless aeroallergens. This tolerance is maintained by a complex network of cells and molecules interacting with lung stromal...
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PMID: 20505664
PDF is available here.
PDF is available here.
Abstract
We constructed a successive ozone-stressed rat model and showed that AHR caused by ozone stress presented as increased lung resistance (R(L)) to inhaled histamine but not baseline R(L). Meanwhile, structural disruption and decreased expression of integrin beta4 on airway epithelia were observed. Fur...
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PMID: 20510671
PDF is available here.
PDF is available here.
Abstract
We established an in vitro system to examine epigenomic effects of cigarette smoke in respiratory epithelia. Normal human small airway epithelial cells and cdk-4/hTERT-immortalized human bronchial epithelial cells (HBEC) were cultured in normal media with or without cigarette smoke condensate (CSC)...
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PMID: 20440268
PDF is available here.
PDF is available here.
Journal of Immunology (184)12 2010
Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice.
Abstract
We tested leptin-deficient ob/ob mice (C57BL/6), leptin receptor-deficient db/db mice (C57BKS), and littermates in a model of cigarette smoke (CS)-induced pulmonary inflammation. Wild-type (WT) C57BL/6 mice were exposed for 4 or 24 wk to control air or CS. Pulmonary leptin expression was analyzed by...
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PMID: 20488786
PDF is available here.
PDF is available here.
Abstract
Light and electron microscopy revealed a differentiated epithelium with ciliated cells, nonciliated mucous cells, and basal-like cells. Recombinant equine tumor necrosis factor-alpha was the major mediator in the cytokine panel that significantly increased MUC5AC mRNA by a factor of 5 in a dose- and...
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PMID: 20513186
PDF is available here.
PDF is available here.
Abstract
Our short-term exposure study of high level induction of genotoxic response of CuO NPs will need to be further investigated to determine whether long-term exposure consequences may exist for CuO NPs application.
Copyright (c) 2010 Elsevier Inc. All rights reserved....
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PMID: 20447378
PDF is available here.
PDF is available here.
Inflammation (33)3 2010
Abstract
We investigated the cellular and molecular effects of ozone exposure in Cynomolgus monkeys. Thirty-six Cynomolgus monkeys were exposed to single or repeat ozone challenge. Pulmonary inflammation was assessed using bronchoalveolar lavage fluid (BAL) and histology. Gene expression profiling in lung an...
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PMID: 19941046
PDF is available here.
PDF is available here.
Abstract
The omental wrap provided vascular growth within and around the constructs as they were integrated along the outer surface area of the scaffold. After removal of the stents, the engineered conduit revealed a structure similar to the esophagus. Histologic investigations demonstrated esophageal epithe...
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PMID: 20438914
PDF is available here.
PDF is available here.
Laryngo-Rhino-Otologie (89 Suppl 1) 2010
Abstract
In this review, anatomy and physiology of the respiratory mucosa of nose and paranasal sinuses are summarized under the aspect of its clinical significance. Basics of endonasal cleaning including mucociliary clearance and nasal reflexes, as well as defence mechanisms are explained. Physiological wou...
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PMID: 20352568
PDF is available here.
PDF is available here.
Inflammation Research (59)5 2010
Abstract
The presence of maternal asthma during pregnancy was associated with increased monocyte and neutrophil numbers, increased BEAS-2B cell production of IL-8 and sICAM-1 (P < 0.05) and increased chemotactic capacity relative to pregnant women without asthma. CONCLUSION: The results of this study suggest...
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PMID: 19876718
PDF is available here.
PDF is available here.
Abstract
The direct suppression of PAI-1 in the lung by the intrapulmonary administration of PAI-1-siRNA attenuated the development and progression of pulmonary fibrosis. The inhibition of EMT may be, at least in part, involved in this effect....
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PMID: 20388759
PDF is available here.
PDF is available here.
Abstract
We explored the role of inflammation in lung tumor development in mice with knockout of the tumor suppressor Gprc5a. Examination of normal lung tissue and tumors from 51 Gprc5a(+/+) (adenoma incidence, 9.8%; adenocarcinoma, 0%) and 38 Gprc5a(-/-) mice (adenoma, 63%; adenocarcinoma, 21%) revealed mac...
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PMID: 20354164
PDF is available here.
PDF is available here.
Abstract
The expressions of human EF-1 beta p31 at different stages of 16HBE cells transformed by CdCl2 was elevated (P < 0.01 or P < 0.05). Compared with their corresponding non-transformed cells, the overexpression level of EF-1 delta p31 was averagely increased 2.9 folds in Cd-pretransformed cells, 4.3 fo...
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PMID: 20514991
PDF is available here.
PDF is available here.
Abstract
Minimal inhibitory concentration (MIC) of MUC5AC expression of each polyphenol was found as follows: [6]-gingerol, 1 microM; EGCG, 20 microM; quercetin, 40 microM; and curcumin, 10 microM. No polyphenol influenced cell proliferation at this MIC. CBF was not affected by [6]-gingerol, quercetin, or EG...
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PMID: 20338103
PDF is available here.
PDF is available here.
Abstract
Cilia were not measured quantitatively but were equally present on the treated and untreated mucosa. There was no histological evidence of inflammation, epithelial injury, or significant morphological changes. CONCLUSION: The application of a manuka honey solution to rabbit nasal respiratory mucosa...
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PMID: 20338104
PDF is available here.
PDF is available here.
Abstract
Our data show that tryptase does not alter paracellular permeability in human airway cells over minutes or hours, and that tryptase does not alter the structure of the cell junction. CONCLUSION: Tryptase alone does not alter paracellular permeability in human airway cells. Tryptase may be altering t...
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PMID: 20338110
PDF is available here.
PDF is available here.
Journal of Asthma (47)2 2010
Abstract
Asthma is an epithelial disorder in which T helper 2 (Th2)-type inflammation has a prominent role. Recent studies indicated that a cytokine, thymic stromal lymphopoietin (TSLP), is essential for the development of antigen-induced asthma. The authors used ovalbumin (OVA) sensitization and challenge t...
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PMID: 20170316
PDF is available here.
PDF is available here.
Abstract
Glutaraldehyde can cause acute mucosal injury to supraglottic and glottic structures, and diligent procedures must be maintained for flushing the channels and monitoring glutaraldehyde retention in the channels. Great care should be taken to avoid damage to the lining of working channels from instru...
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PMID: 20392027
PDF is available here.
PDF is available here.
Abstract
A complex interplay of genetic predisposition and environmental influences results in the clinical picture of allergic asthma. This article addresses recently identified genetic markers and environmental factors that contribute to disease development in asthma. Focus is placed on aspects of the inna...
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PMID: 20406590
PDF is available here.
PDF is available here.
Abstract
Defective chloride transport in epithelial cells increases mucus viscosity and leads to recurrent infections with high oxidative stress in patients with CF (cystic fibrosis). NAC (N-acetylcysteine) is a well known mucolytic and antioxidant drug, and an indirect precursor of glutathione. Since GSNO (...
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PMID: 19947928
PDF is available here.
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: Mucoadhesive drug delivery vehicles attract much attention owing to benefits such as extended residence time of the drug at the site of application, a relatively rapid uptake of a drug into the systemic circulation, and enhanced bioavailability of therapeutic agents. Mucoadh...
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PMID: 20095946
PDF is available here.
PDF is available here.
Abstract
We review current knowledge on the regulation of Na,K-ATPase activity during lung injury, focusing on the role of Na,K-ATPase ubiquitination during hypoxia. A better understanding of these signaling pathways can be of relevance for the design of novel treatments to ameliorate the deleterious effects...
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PMID: 20160150
PDF is available here.
PDF is available here.
Abstract
Increases in smooth muscle mass have been shown to be an early finding in childhood asthma, related to clinical severity and predictive of greater airflow obstruction. Both hyperplasia and hypertrophy contribute to the increase in smooth muscle mass. A phenotypic shift in the epithelium of asthmatic...
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PMID: 19858714
PDF is available here.
PDF is available here.
Abstract
In this review, a case is made that asthma has its primary origin in the airways that involves defective behaviour of the epithelium in relation to environmental exposures. These include defects in barrier function and an impaired innate immunity to provide the substrate upon which allergic sensitiz...
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PMID: 19915457
PDF is available here.
PDF is available here.
Infection and Immunity (78)2 2010
Abstract
We explored the influence of morphine treatment on the interleukin-23 (IL-23)/IL-17 axis and related innate immunity. Impairment of early IL-23/IL-17 production caused by morphine treatment was associated with delayed neutrophil migration and decreased pneumococcal clearance. Furthermore, morphine t...
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PMID: 19995896
PDF is available here.
PDF is available here.
Abstract
We describe a new endoscopic technique for closure of recurrent tracheoesophageal fistula in which fibrin glue is injected into the submucosa of the lateral walls of the fistula until the lumen is occluded. This technique eliminates the possibility of the fibrin glue plug becoming dislodged and aspi...
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PMID: 20128111
PDF is available here.
PDF is available here.
Abstract
Environmental particulates impact first on airway epithelium, whereas circulating infiltrating cells are recruited through the underlying endothelium. An effective cellular immune response requires coordination between endothelium and epithelium. The authors have developed a bilayer culture model co...
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PMID: 20128677
PDF is available here.
PDF is available here.
Abstract
We have previously shown the upregulation and downregulation of RP genes in tumors of colorectal and nasopharyngeal carcinomas (NPCs), respectively. Herein, we show that a subset of RP genes for the large ribosomal subunit is differentially expressed among cell lines derived from the human nasophary...
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PMID: 19927161
PDF is available here.
PDF is available here.
Innate Immunity (16)1 2010
Abstract
We hypothesize that integrin expression can be altered by stimulation of lung epithelial cells with an opportunistic bacterial pathogen Pseudomonas aeruginosa. Using the A549 adenocarcinoma cell line that expressed a low level of several integrin subunits we have demonstrated that P. aeruginosa infe...
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PMID: 19710103
PDF is available here.
PDF is available here.
The effects of omalizumab on IgE-induced cytokine synthesis by asthmatic airway smooth muscle cells.
Abstract
Omalizumab reduced IgE-stimulated synthesis and secretion of proinflammatory cytokines by human ASMCs. These findings imply a beneficial action of omalizumab in asthma therapy. This effect is not restricted to inflammatory cells; it also includes tissue-forming cells....
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PMID: 20306819
PDF is available here.
PDF is available here.
Oncology Reports (23)2 2010
Abstract
Arsenic is well documented as a chemotherapeutic agent capable of inducing cell death; however, it is also considered as a human carcinogen. Although it has recently been shown that arsenite exposure can potentiate genotoxicity, little is known about its global effects exerted in cells at the proteo...
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PMID: 20043101
PDF is available here.
PDF is available here.
Oncology Reports (23)2 2010
Abstract
We also observed the presence of endothelin receptors in SCLC, although the ET(A)R levels and the ratio ET(A)R/ET(B)R were lower than in normal tissue and in other carcinomas. In conclusion, both ET(A)R and ET(B)R are present in lung carcinomas but at different levels, according to the histological...
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PMID: 20043107
PDF is available here.
PDF is available here.
Abstract
Breast cancer resistance protein (BCRP), a 72 kDa protein belongs to the subfamily G of the human ATP-binding cassette transporter superfamily. Overexpression of BCRP was found to play a major role in the development of resistance against various chemotherapeutic agents. BCRP plays an important role...
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PMID: 19782742
PDF is available here.
PDF is available here.
Abstract
We determined that the minor pulmonary surfactant phospholipid, palmitoyl-oleoyl-phosphatidylglycerol (POPG), could markedly attenuate inflammatory responses induced by lipopolysaccharide through direct interactions with the Toll-like receptor 4 (TLR4) interacting proteins CD14 and MD-2. CD14 and TL...
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PMID: 20080799
PDF is available here.
PDF is available here.
Abstract
Rhinovirus (RV) infections trigger asthma exacerbations. Genome-wide expression analysis of RV1A-infected primary bronchial epithelial cells from normal and asthmatic donors was performed to determine whether asthma is associated with a unique pattern of RV-induced gene expression. Virus replication...
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PMID: 19710636
PDF is available here.
PDF is available here.
Abstract
One hundred and eighteen subjects living at various distances from the carrier rocket fall places underwent cytomorphological studies of the upper airways (rhinocytogram) and buccal epithelium. The findings indicate that the dwellers of the settlements of Ulytausky District have chronic hypertrophic...
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PMID: 20496490
PDF is available here.
PDF is available here.
Abstract
Arkhiv Patologii (72)1 2010
Abstract
The lungs of 184 dead neonates and babies who were from birth on artificial ventilation with rough parameters and hyperoxygenation were found to have peculiar pathohistological changes that were used to work out an illustrated algorithm for the morphological diagnosis of neonatal bronchopulmonary dy...
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PMID: 20369582
PDF is available here.
PDF is available here.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR (55)7-8 2010
Abstract
The Ingavirin antiviral properties with respect to the parainfluenza virus, as an actual human respiratory tract pathogen, were investigated by two methods, i.e. immunoenzymatic analysis and microtetrazolium test. The results showed that along with the immediate antiviral activity Ingavirin had nons...
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PMID: 21140558
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of TNF-alpha on the expressions of MMP-12 in airway epithelial cells, one of the sources of MMP-12 in the airway, and its underlying mechanism. MMP-12 mRNA and protein expressions induced by TNF-alpha in the absence or presence of BMS-345541 (a selective IkappaB kinase inh...
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PMID: 20051654
PDF is available here.
PDF is available here.
Respiratory Research (11) 2010
Abstract
We propose an alternative path to apoptosis for cell elimination. We argue that transepithelial migration of airway wall leukocytes, followed by mucociliary clearance, efficiently and non-injuriously eliminates pro-inflammatory cells from diseased airway tissues. First, it seems clear that numerous...
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PMID: 20540713
PDF is available here.
PDF is available here.
Swiss medical weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology (140) 2010
Abstract
We have used this tool to establish and evaluate a three dimensional model of the human epithelial airway wall....
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PMID: 20458650
PDF is available here.
PDF is available here.
Swiss medical weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology (140) 2010
Abstract
A misled or overreacting immune response is assumed to be the major cause of the most prevalent chronic inflammatory lung diseases, asthma and chronic obstructive pulmonary disease (COPD). The contribution of tissue forming cells, especially of airway smooth muscle cells, to the pathologies of both...
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PMID: 20458646
PDF is available here.
PDF is available here.
Abstract
We developed a method for delivering RU486, the conditional activator of Cre recombinase progesterone receptor (CrePR) fusion proteins to the lung and then examined the activity of three keratin-driven CrePR constructs in the conducting airways. We also developed a technique for survival bronchioalv...
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PMID: 20140084
PDF is available here.
PDF is available here.
Respiratory Research (11)1 2010
Abstract
Taken together, human pulmonary cells produce hBD-3 upon L. pneumophila infection via a TLR-JNK-AP-1-dependent pathway which may contribute to an efficient innate immune defense....
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PMID: 20615218
PDF is available here.
PDF is available here.