Abstract
To evaluate oxygen flow through several transtracheal devices in native and right angle kinked states.
Eight catheter-over-needle, and two oxygen conveyance devices (Enk Flow Modulator 10 L/min flow and Manujet III Jet device 15, 30, 50 psi) were examined. Oxygen flow...
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PMID: 21863680
PDF is available here.
Abstract
In stimulation of preganglionic and postganglionic nervous fibres of the trachea and stimulation of preganglionic nervous fibres of the bronchi, serotonin strengthened reduction of a smooth muscle to 114 %. Methysergide (1.0 mkg) reduced responses to serotonin to 74-77 % on the trach...
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PMID: 21961311
PDF is available here.
Abstract
In this paper, an automatic and unsupervised snore detection algorithm is proposed. The respiratory sound signals of 30 patients with different levels of airway obstruction were recorded by two microphones: one placed over the trachea (the tracheal microphone), and the other was a freestanding microp...
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PMID: 20679022
PDF is available here.
Hao H Cao,
Qin Q Lan,
Qian Q Shi,
Xiaohui X Zhou,
Gang G Liu,
Jian J Liu,
Guangliang G Tang,
Chenli C Qiu,
Chao C Qiu,
Jianqing J Xu,
Huimin H Fan and
Zhongmin Z Liu
Abstract
We have investigated the role of IL-23/IL-17 pathway in acute and chronic airway allograft rejection. We used a rat OB model in orthotopic tracheal transplantation, and investigated the effects of anti-IL-23 blockade antibody on acute and chronic airway allograft rejection. Anti-IL-23 antibody impai...
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PMID: 21094688
PDF is available here.
Abstract
We investigated whether ceramide concentrations are also altered in the trachea and the intestine of cystic fibrosis mice and whether an accumulation of ceramide in these organs has functional consequences that are typical of cystic fibrosis. Our findings demonstrate a marked accumulation of ceramid...
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PMID: 21078296
PDF is available here.
Abstract
We report a 60-year-old man who presented 12 years after a McKeown esophagectomy with a fistula between the tracheal carina and the gastric conduit. In view of his severe sepsis and profound malnutrition, he underwent placement of a silicon Y-stent with a successful three-stage surgical repair consi...
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PMID: 21095291
PDF is available here.
Abstract
Our data suggest that bioabsorbable materials can be used as a reliable, temporary, tracheal replacement conduit.
Copyright © 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved....
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PMID: 21095312
PDF is available here.
Abstract
We evaluated differences in airway versus systemic inflammatory responses to primary versus secondary organic particle components, particle size fractions, and the potential of particles to induce cellular production of reactive oxygen species.
A total of 60 elderly subjects contributed up to 12 wee...
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PMID: 20811287
PDF is available here.
Abstract
Our results confirm that the upper respiratory tract acts as an important reservoir of P aeruginosa colonization and infection in the mechanically ventilated patients and emphasize the importance of exogenous acquisition of P aeruginosa. A combination of early identification and eradication of airwa...
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PMID: 20627453
PDF is available here.
Abstract
We used this technique in five patients. There were no complications such as bleeding, desaturation, and displacement of the tube; and there were no postoperative complications such as severe contamination or infection of the tracheostomy site from the nearby cervical wound, difficulty in securing t...
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PMID: 21140694
PDF is available here.
Sabine Jurado,
Ian Smyth,
Bryce van Denderen,
Nora Tenis,
Andrew Hammet,
Kimberly Hewitt,
Jane-Lee Ng,
Carolyn J McNees,
Sergei V Kozlov,
Hayato Oka,
Masahiko Kobayashi,
Lindus A Conlan,
Timothy J Cole,
Ken-Ichi Yamamoto,
Yoshihito Taniguchi,
Shunichi Takeda,
Martin F Lavin and
Jörg Heierhorst
Abstract
We show that absence of ASCIZ leads to p53-independent late-embryonic lethality in mice. Asciz-deficient primary fibroblasts exhibit increased sensitivity to DNA base damaging agents MMS and H2O2, but Asciz deletion knock-down does not affect ATM levels and activation in mouse, chicken, or human cel...
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PMID: 20975950
PDF is available here.
Abstract
We hypothesized that esophageal displacement would be significantly more common in older versus younger children. The purposes of this study were to determine the alignment of the trachea to the esophagus at the level of the cricoid cartilage on cervical spine or neck computed tomographic (CT) scans...
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PMID: 20881908
PDF is available here.
Abstract
Measuring subglottic airway diameter with ultrasonography facilitates the selection of appropriately sized ETTs in pediatric patients. This selection method better predicted optimal outer ETT diameter than standard age- and height-based formulas....
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PMID: 20808208
PDF is available here.
Abstract
We cultured iPS cells in a 3-dimensional (3-D) scaffold in chondrocyte differentiation medium (bioengineered scaffold model), and the results were compared with those in a 3-D scaffold without iPS cells (control scaffold model). The 3-D scaffolds were implanted into tracheal defects in 8 nude rats....
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PMID: 21049856
PDF is available here.
Abstract
Surgical resection and reconstruction of the trachea can be performed both for benign and malignant diseases. The main indications for surgery include inflammatory (generally post-intubation), congenital or post-traumatic stenoses, degenerative lesions, benign or malignant neoplasms. Success can be...
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PMID: 21214040
PDF is available here.
Abstract
Our findings show that EOET has myorelaxant effects on rat airways, but potentiates ACh-induced contractions. Monoterpenes alpha- and beta-pinene are involved in its potentiating actions, but are not responsible for its myorelaxant effects. A putative inhibition of the acetylcholinesterase enzyme is...
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PMID: 20302920
PDF is available here.
Abstract
We physiologically characterized CSH and pharmacological action of tungstate, using a nymphalid butterfly Junonia orithya. We first showed that the precise patterns of modification were dependent on the time-point of the cold-shock treatment after pupation, and confirmed that the modification proper...
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PMID: 20206631
PDF is available here.
Abstract
We assessed the safety and efficacy of balloon dilation as treatment for recurrent stenosis after pediatric laryngotracheoplasty.
We studied a retrospective case series at an academic tertiary care children's hospital. We included all patients under the age of 18 years with subglottic or tracheal st...
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PMID: 21033030
PDF is available here.
Abstract
Mucociliary clearance (MC), designed by evolution to eliminate inhaled and possibly noxious material from the airways, considerably limits the benefit of inhalation therapy. Although the principles of MC seem to be understood, there are still many open questions on mucociliary particle clearance. In...
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PMID: 20500091
PDF is available here.
Abstract
Our study aimed to characterize the effects of Croton sonderianus essential oil samples, collected at 1:00 pm (EO-13) and 9:00 pm (EO-21), on rat tracheal smooth muscle. The two samples were submitted to gas chromatography (GC) and mass spectrometry (MS) analysis to identify their components. Rat tr...
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PMID: 20171859
PDF is available here.
Abstract
Children with URI had a lower overall perioperative complication rate if they received a lidocaine gel (35%) rather than placebo (94%) (P < 0.01). Also, the incidence of postoperative coughing was less (12% vs 53%; P = 0.03). In non-URI patients, lidocaine did not significantly reduce the rate of ai...
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PMID: 20524104
PDF is available here.
Abstract
Magnetite iron nanoparticles have been widely used as contrast agents and in thermal therapy for cancer. However, their adverse effects on human health have not been fully investigated. In this study, iron oxide nanoparticles were prepared using inorganic iron chloride (size: 5.3+/-3.6 nm in phospha...
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PMID: 20540983
PDF is available here.
Abstract
We review the possible means of surgical treatment of TEF, of which we most frequently used segmental tracheal resection with end-to-end anastomosis and a non-overlying suture of the esophageal defect without muscle flap interposition (16 patients), transsection of the fistula with muscular flap int...
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PMID: 21121142
PDF is available here.
Abstract
We analyze the potential causes of tracheal restenosis in patients who underwent segmental tracheal resection for benign tracheal stenosis between 1995-2009 and propose an algorithm for prevention and treatment of such complication.
Between 1995-2009, of 249 patients with benign tracheal stenosis 16...
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PMID: 21121143
PDF is available here.
Abstract
Production of the QS-dependent virulence factor rhamnolipids by colonising P aeruginosa isolates is associated with development of VAP....
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PMID: 20685744
PDF is available here.
Abstract
Among 114 intubated patients, mean altitude increase was 2,260 feet (95% confidence interval [CI] 2,040 to 2,481 feet; median 2,085 feet; interquartile range [IQR] 1,477.5 to 2,900 feet). Mean flight time was 14.8 minutes (95% CI 13.1 to 16.4 minutes; median 13.5 minutes; IQR 10 to 16.1 minutes). In...
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PMID: 20188442
PDF is available here.
Abstract
We examined the virulence of an R(low) Delta MGA0674 mutant (P1H9) in vivo and observed reduced recovery and attenuated virulence in the tracheas of experimentally infected chickens. The virulence of two additional R(low) Delta MGA0674 mutants, 2162 and 2204, was assessed in a second in vivo virulen...
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PMID: 20515935
PDF is available here.
Abstract
Three tracheostomies conducted using Fantoni's translaryngeal technique (TLT) are described in patients with particular anatomical conditions of the trachea and neck. The first case is of a patient with tracheal stenosis, which is known to be problematic with regard to gaining adequate endoscopic co...
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PMID: 20661208
PDF is available here.
Abstract
These results suggest that surveillance with NQ-ETA is better than the Q-ETA in predicting the development and causative pathogen of VAP in patients who have already been receiving antibiotic therapy....
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PMID: 20661200
PDF is available here.
Abstract
There are multiple drivers of leukocyte recruitment in lung allografts that contribute to lymphocytic bronchitis (LB) and bronchiolitis obliterans (BO). The innate mechanisms driving (or inhibiting) leukocyte trafficking to allografts remain incompletely understood. This study tested the hypothesis...
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PMID: 20548026
PDF is available here.
Abstract
Enzymatic removal of the sialic acid moiety of HPIV receptors inhibits infection with all tested HPIV strains, both in vitro and in cotton rats. Enzyme-mediated removal of sialic acid receptors represents a novel antiviral strategy for HPIV. The results of this study raise the possibility of a broad...
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PMID: 20533871
PDF is available here.
Abstract
On June 2008, the first human tissue-engineered trachea replacement was performed using decellularized (de-antigenised) cadaveric donor trachea, seeded with recipient epithelial cells on the internal surface of the graft and mesenchymal stem-cell-derived chondrocytes on the external. During the foll...
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PMID: 20378162
PDF is available here.
Abstract
The objective of this study was to compare the pulmonary inflammatory response of premature infants with respiratory distress following instillation of one of two commonly available surfactant preparations.
This was a prospective, randomized investigation of preterm infants who were less than 30 wee...
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PMID: 20586001
PDF is available here.
Abstract
Our patients were predominantly males (95.4%) of Chinese descent with a mean age of 62.1 years. The types of voice prostheses used were ProvoxTM (n = 15), Voicemasters (n = 6), and Blom-Singer (n = 1). Prosthesis- related complications occurred in 77.3%. Notable complications were leakage (82.5%), p...
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PMID: 20697675
PDF is available here.
Abstract
We have generated a transgenic mouse line in which two conserved exons of the mouse intermediate dynein chain gene, Dnaic1, are flanked by loxP sites (Dnaic1(flox/flox)). Dnaic1 is the murine homolog of human DNAI1, which is mutated in approximately 10% of human PCD cases. These mice have been cross...
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PMID: 19675306
PDF is available here.
Arnaud Goolaerts,
Jérémie Roux,
Michael T Ganter,
Vadim Shlyonsky,
Ahmed Chraibi,
Renauld Stéphane,
Frédérique Mies,
Michael A Matthay,
Robert Naeije,
Sarah Sariban-Sohraby,
Marybeth Howard and
Jean-Francois Pittet
Abstract
We investigated the effect of 5-HT on ion and fluid transport across the alveolar epithelium. 5-HT caused a dose-dependent inhibition of the amiloride-sensitive current across primary rat and human alveolar epithelial type II cell monolayers, but did not affect Na(+)/K(+) ATPase function. Furthermor...
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PMID: 19717814
PDF is available here.
Abstract
These results provide parametric data for comparison with fluid secretion from glands in ferrets lacking CFTR....
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PMID: 20435689
PDF is available here.
Abstract
We investigated the identity and the pH-dependent function of the apical H(+) channel in the airway epithelium. In pH stat recordings of confluent JME airway epithelia in Ussing chambers, Zn-sensitive acid secretion was activated at a mucosal threshold pH of approximately 7, above which it increased...
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PMID: 20548053
PDF is available here.
Abstract
We investigated the alteration of Th17 and regulatory T cells (Treg) distribution in an animal model of bronchiolitis obliterans following ectopic tracheal transplantation model.
Tracheal grafts from B6 mice transplanted into subcutaneous sites of C3H mice. Allografts were histologic...
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PMID: 20393404
PDF is available here.
Abstract
We report here that the beating asymmetry is crucial for ciliary function and requires tubulin glutamylation, a unique posttranslational modification that is highly abundant in cilia. WT murine tracheal cilia have an axoneme-intrinsic structural curvature that points in the direction of effective st...
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PMID: 20498047
PDF is available here.
Abstract
Light and electron microscopy revealed a differentiated epithelium with ciliated cells, nonciliated mucous cells, and basal-like cells. Recombinant equine tumor necrosis factor-alpha was the major mediator in the cytokine panel that significantly increased MUC5AC mRNA by a factor of 5 in a dose- and...
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PMID: 20513186
PDF is available here.
Abstract
We identified here a new facet of vrille (vri) function and show that it is required for tracheal development. We show that, in the embryo, VRI is expressed in a complex and dynamic pattern and is found in amnioserosa, subdomains of the developing gut and in trachea cells. We also show that, as expe...
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PMID: 20507356
PDF is available here.
Abstract
We observed may vary widely, reflecting the aetiologic heterogeneity of this group of conditions. Therefore, possible additional defects must be accurately investigated in all newborns with OA....
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PMID: 21089741
PDF is available here.