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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Respiratory Hypersensitivity (5):
Recent article
Respiratory Hypersensitivity
Abstract
There is growing concern that exposure to air pollutants during pregnancy affects health outcomes in the offspring due to alterations in the development of immune and other homeostatic processes. To assess the risks of maternal inhalation exposure to ozone (O(3)), timed pregnant BALB...
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PMID: 21534884
PDF is available here.
PDF is available here.
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Abstract
We focus on preclinical models to describe the recent developments and major breakthroughs for treating allergic airway diseases with gene therapy....
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PMID: 21243453
PDF is available here.
PDF is available here.
Abstract
We found that IL-1, but not IL-33, played a substantial role in induction of T cell-mediated type IV hypersensitivity such as contact and delayed-type hypersensitivity and autoimmune diseases such as experimental autoimmune encephalomyelitis. Most notably, however, IL-33 was important for innate-typ...
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PMID: 20937871
PDF is available here.
PDF is available here.
Abstract
We undertook this study to investigate the effect of ozone exposure on airway response to ovalbumin in sensitized guinea pigs and its modulation by dietary supplementation with antioxidant vitamins C and E.
After in vivo measurements of specific airways conductance (SGaw) and airway hyperresponsiven...
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PMID: 20693596
PDF is available here.
PDF is available here.
Abstract
We conclude that coir work induced nasobronchial allergy and pulmonary function abnormalities. In absence of CT scan and bronchial challenge testing it may be inappropriate to label coir work as occupational hazard. However the present study may be used as thought provoking study to initiate further...
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PMID: 21121206
PDF is available here.
PDF is available here.
Abstract
We have developed a coculture system which in parallel indicates the sensitizing and irritative potential of xenobiotics. The assay is named loose-fit coculture-based sensitization assay (LCSA) and may be performed within 5 days. The system is composed of human monocytes that differentiate to a kind...
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PMID: 20219181
PDF is available here.
PDF is available here.
Inflammation Research (59)6 2010
Abstract
The allergen challenge model resulted in increased eosinophil number in BALF and damage to elastin fiber. Upregulation of MMP-12 was also found in the airways of challenged mice. The increased eosinophil number in the BALF after antigen challenge was inhibited by S-1. CONCLUSION: These findings sugg...
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PMID: 20066556
PDF is available here.
PDF is available here.
Abstract
Pharmaceutical Research (27)5 2010
Abstract
Results indicate that dextran 10 has promise as a novel excipient for dry powder inhalation drug delivery, in a preclinical setting, over a wide range of drug loadings....
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PMID: 20232119
PDF is available here.
PDF is available here.
Abstract
Effective hazard screening will require the development of high-throughput or in vitro assays for the identification of potential sensitizers. The goal of this preliminary study was to identify potential biomarkers that differentiate the response to allergens vs non-allergens following an acute expo...
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PMID: 20045013
PDF is available here.
PDF is available here.
Abstract
The airway mucosal surfaces are constantly exposed to inhaled particles that can be potentially toxic, infectious or allergenic and should elicit inflammatory changes. The proximal and distal air spaces, however, are normally infection and inflammation free due to a specialized interplay between cel...
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PMID: 20447075
PDF is available here.
PDF is available here.
Abstract
There are conceptual and historical links between homeopathic medicine and modern allergy desensitization treatment. Conventional allergy desensitization and homeopathic treatment both utilize small doses of substances that might cause symptoms in order to prevent or treat a hypersensitive state. Ho...
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PMID: 20359268
PDF is available here.
PDF is available here.
Ugeskrift for laeger (172)12 2010
Abstract
Abstract
We concluded that ICR could be a useful tool for primary care physicians to rule in or out the clinical relevance of single ICR allergens....
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PMID: 20236576
PDF is available here.
PDF is available here.
Toxicology (268)3 2010
Abstract
A wide range of substances have been recognized as sensitizing, either to the skin and/or to the respiratory tract. Many of these are useful materials, so to ensure that they can be used safely it is necessary to characterize the hazards and establish appropriate exposure limits. Under new EU legisl...
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PMID: 20026217
PDF is available here.
PDF is available here.
Journal of Asthma (47)1 2010
Abstract
We recruited 102 physician-diagnosed young asthmatic subjects from outpatient clinics with change in FEV(1) > or = 12% with inhaled salbutamol and collected data on asthma severity, concurrent allergic rhinitis (AR) and atopic dermatitis (AD), and medication used (bronchodilator and corticosteroid)....
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PMID: 20100023
PDF is available here.
PDF is available here.
Mammalian Genome (21)1-2 2010
Abstract
We analyzed recombinant congenic strains (RCS) of mice generated from these hyper- and hyporesponsive parental strains to identify genetic loci underlying the trait of airway responsiveness in response to methacholine as assessed by whole-body plethysmography. Our screen identified 16 chromosomal re...
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PMID: 20012967
PDF is available here.
PDF is available here.
Abstract
We hypothesized that the lung uses the mechanism of LPS tolerance to maintain the balance between hypoinflammatory and hyperinflammatory states. We developed a model of chronic pulmonary LPS tolerance induced by pulmonary exposure to 1 microg LPS for 4 consecutive days. Mice were challenged with 10...
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PMID: 19487981
PDF is available here.
PDF is available here.
Abstract
We used ovalbumin (OVA)-inhaled female C57BL/6 mice to evaluate the roles of silver nanoparticles and the related molecular mechanisms in allergic airway disease. In this study with an OVA-induced murine model of allergic airway disease, we found that the increased inflammatory cells, airway hyperre...
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PMID: 20957173
PDF is available here.
PDF is available here.
Swiss medical weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology (140) 2010
Abstract
A misled or overreacting immune response is assumed to be the major cause of the most prevalent chronic inflammatory lung diseases, asthma and chronic obstructive pulmonary disease (COPD). The contribution of tissue forming cells, especially of airway smooth muscle cells, to the pathologies of both...
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PMID: 20458646
PDF is available here.
PDF is available here.
Abstract
We review the role of beta2-AR agonist intrinsic efficacy in asthma treatment focusing on recent literature.
In acute asthma, a full agonist (high intrinsic efficacy) offers a clinical advantage over a partial agonist (low intrinsic efficacy) but with the potential of inducing dose-dependent adverse...
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PMID: 19887938
PDF is available here.
PDF is available here.
Abstract
Eosinophilic inflammation was clearly reduced by TLR2/6 agonism. This effect was also seen without simultaneous administration of IFN-gamma. However, lymphocyte counts were not affected among the different treatment groups. More precise determination of the lymphocyte-mediated immune reaction showed...
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PMID: 20016195
PDF is available here.
PDF is available here.
Abstract
The incidence of allergic respiratory diseases and bronchial asthma appears to be increasing worldwide, and people living in urban areas more frequently experience these conditions than those living in rural areas. One of the several causes of the rise in morbidity associated with allergic respirato...
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PMID: 20461963
PDF is available here.
PDF is available here.
Abstract
The independent factors associated with non-adherence may vary between different settings and countries. There is a need for developing individual case holding programmes to improve clinical outcomes in patients receiving specific allergen immunotherapy....
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PMID: 20578401
PDF is available here.
PDF is available here.
Abstract
We identified many differentially expressed genes by IL-4 stimulation by microarray analysis. NFIL3 (nuclear factor, interleukin 3 regulated) is the most strongly induced transcription factor by IL-4 stimulation in a STAT6-dependent manner. To analyze the role of NFIL3 in the immune system, we have...
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PMID: 20697558
PDF is available here.
PDF is available here.
Medical Laboratory Observer (41)12 2009
Abstract
Arerugi = [Allergy] (58)12 2009
Abstract
Abstract
The results of this study do not provide strong support for a primary intervention focused on general modification of the home environment during pregnancy for high-risk children. It does not address the effects of more aggressive approaches or of interventions targeting individual environmental fac...
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PMID: 20084841
PDF is available here.
PDF is available here.
Abstract
The study confirmed the high frequency of asthma in Guadeloupe (14.1%) with high indicators of severity and it allowed a comparison to be made between Guadeloupe and the other regions which have carried out the ISAAC 1 study....
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PMID: 19953040
PDF is available here.
PDF is available here.
Abstract
It is well documented that patients suffering from asthma have rhinitis more often than those without. Likewise, those suffering from nose and sinus disease, e.g. allergic rhinitis, sinusitis and nasal polyposis, have an increased incidence of asthma. Treatment of disorders in one airway compartment...
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PMID: 19823201
PDF is available here.
PDF is available here.
Abstract
OVA-sensitized DKO mice exhibited impaired T(H)2-driven responses with undetectable OVA-specific IgE levels and severely diminished eosinophil infiltration at sensitized skin sites but intact dermal infiltration with CD4(+) cells. DKO mice mounted exaggerated IL-17A but normal IFN-gamma and IL-5 sys...
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PMID: 19815118
PDF is available here.
PDF is available here.
Public Health Nutrition (12)9A 2009
Abstract
Findings from recent studies suggest that a high level of adherence to the Mediterranean diet early in life protects against the development of asthma and atopy in children. Further studies are needed to better understand the mechanisms of this protective effect, to evaluate the most relevant window...
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PMID: 19689832
PDF is available here.
PDF is available here.
La Tunisie medicale (87)9 2009
Abstract
Abstract
Clinically relevant lupin allergy often occurs in patients without atopic background or other food allergies, although lupin sensitization most commonly seems to represent cross-reactivity to other legumes. The occurrence of lupin allergy in a country where lupin has not been traditionally used is s...
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PMID: 19788021
PDF is available here.
PDF is available here.
Abstract
Epidemiologic research shows that pets influence human health, demonstrating both protective and deleterious health risks; therefore, valid definitions of pet exposure would enhance research. The authors determined how well young adults aged 18 years report their early childhood pets. Subjects in an...
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PMID: 19515795
PDF is available here.
PDF is available here.
Abstract
Recognition of risk factors and educating (enabling) the patient remain the most effective ways of preventing AVN caused by corticosteroid use....
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PMID: 19739420
PDF is available here.
PDF is available here.
Abstract
We investigated whether the Th2-promoting cytokine IL-4 played a permissive role that superseded Treg function, thereby allowing the development of allergic inflammation. IL-4 signaling via the IL-4Ralpha-STAT6 axis was required to maintain Foxp3 expression in Tregs and promote their proliferation....
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PMID: 19535633
PDF is available here.
PDF is available here.
Abstract
The 5 MAs included 43 studies; 17 were used in more than one MA. There were discrepancies among the MAs in the data reported from the same original studies: the MAs reported different estimates for the same outcome or the same estimates for different outcomes in 16 of those 17 studies. The MAs evalu...
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PMID: 19500824
PDF is available here.
PDF is available here.
Abstract
The adjuvant effects of ambient UFP is determined by their oxidant potential, which likely plays a role in changing the redox equilibrium in the mucosal immune system....
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PMID: 19654922
PDF is available here.
PDF is available here.
Abstract
We investigated the mechanism of chemical-induced selective type II (T(H)2) allergy by using three different sensitization protocols and the well-known respiratory sensitizer trimellitic anhydride (TMA). Mice were sensitized for either 1, 2, or 3 weeks. For each sensitization schedule, the mice were...
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PMID: 19589094
PDF is available here.
PDF is available here.
Abstract
We report two patients who developed a systemic anaphylactic reaction following subcutaneous grass pollen immunotherapy, resulting in discontinuation of treatment. Following treatment of the acute anaphylactic episode, both patients were subsequently safely commenced on sublingual grass pollen immun...
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PMID: 18501039
PDF is available here.
PDF is available here.
Abstract
Existing literature on the subject of safe vial preparation suggests that the incidence of bacterial contamination of allergen vials is very low. Historically, there is no report of bacterial infection for subcutaneous immunotherapy using vials prepared in the office setting or otherwise when using...
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PMID: 19395969
PDF is available here.
PDF is available here.
Medizinische Klinik (104)5 2009
Abstract
A 17-year-old patient was transferred to the emergency room with an impacted food bolus by colleagues from the Department of Otorhinolaryngology. The examination of ear, nose and throat revealed significant amounts of saliva in both recessus piriformis, a radiologic examination of the esophagus show...
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PMID: 19444419
PDF is available here.
PDF is available here.
Abstract
Allergic diseases emerge as a substantial health problem of the 21(st) century. Current therapies including combination therapies of corticosteroids and beta(2)-agonists are highly effective, inexpensive and relatively safe. However, these medicaments only relieve symptoms but are no...
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PMID: 19519405
PDF is available here.
PDF is available here.
Abstract
A sample of 505 patients, mean age 24 years, consulting for rhinitis or asthma, monosensitized (36%) or polysensitized (64%), was evaluated. The percentage of polysensitized patients was similar in asthmatics, patients with rhinitis, and patients with both asthma and rhinitis (60%, 65%, and 63%, res...
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PMID: 19543170
PDF is available here.
PDF is available here.
Abstract
Explanations are sought for the negative outcomes in these reviews and shortcomings are discussed. New pediatric studies - not included in the previous reviews -designed taking into account the golden rules for SLIT (high daily dose, starting at least 4 months before pollen season) do show statistic...
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PMID: 19326509
PDF is available here.
PDF is available here.
Laryngoscope (119)4 2009
Abstract
Laryngeal dysfunction is common in chronic cough, where it is manifest as paradoxical vocal cord movement and extrathoracic airway hyperresponsiveness. Laryngeal dysfunction in chronic cough is associated with reduced quality of life. Laryngeal hypersensitivity may be a common mechanism that can be...
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PMID: 19205007
PDF is available here.
PDF is available here.
Abstract
Cavernous sinus thrombosis (CST) is a rare and serious complication secondary to invasive fungal sinusitis, but rarer still in cases of allergic fungal sinusitis. Current recommendations for cavernous sinus thrombosis are controversial, especially regarding anticoagulation, secondary to the rarity o...
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PMID: 19382506
PDF is available here.
PDF is available here.
Abstract
Laryngo-Rhino-Otologie (88)3 2009
Abstract
Nanotechnology is an "emerging industry" and becomes more widely used. As a result human exposure to nanoparticles is inevitable. Exposure to nanoparticles can affect the upper aerodigestive tract, before particles reach lung, stomach and intestine. The effects of this passage depend on particle siz...
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PMID: 19247893
PDF is available here.
PDF is available here.
Abstract
The pharmacological and pathophysiological characteristics of rat antigen-induced late airway response (LAR) are not yet fully understood. In this study, the pharmacological properties of rat ovalbumin (OVA)-induced LAR and effects of the clinically used anti-asthmatic drugs salbutamol (beta2-agonis...
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PMID: 19252284
PDF is available here.
PDF is available here.
Abstract
We found no association of neuroticism, exposure to stressful life events, and quality of life with atopy and allergic symptoms....
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PMID: 19329381
PDF is available here.
PDF is available here.
Abstract
We observed a slight, nonsignificant increase in minimal pH values (6.95, 7.10, 7.20, 7.37). Median EBC pH values with interquartile range in the total sample (7.72; 7.63 to 7.76) were within the range previously reported by other authors. They did not differ regarding sex, smoking habit and atopic...
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PMID: 19329380
PDF is available here.
PDF is available here.
Abstract
Lower occupational limit levels to beryllium exposure and more stringent preventive measures can decrease the risk for development of BeH and CBD. Beryllium sensitization is determined by a positive beryllium lymphocyte proliferation test (BeLPT). Longitudinal data suggest that BeH progresses to CBD...
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PMID: 19532033
PDF is available here.
PDF is available here.
Abstract
We have demonstrated that ECM may affect the growth of airway epithelial cells and fibroblasts in vitro and may influence epithelial thickness in the mouse. These findings may have implications for understanding the pathogenesis of asthma and future therapeutic targeting of airway remodeling....
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PMID: 19354071
PDF is available here.
PDF is available here.
Abstract
Clustered regimens with IR-standardized extracts are an alternative to classic immunotherapy thanks to their low incidence of SRs compared with other rapid regimens during the induction phase. The ideal clustered regimen should start at an initial dose no greater than 0.35 IR to minimize the inciden...
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PMID: 19354072
PDF is available here.
PDF is available here.
Abstract
Abstract
Groups treated with low-dose DEX decreased eosinophilia in BAL to the same extent as the pharmacological dose, but only when administered before challenge. The most prominent decrease of eosinophils in BAL was seen in mice treated with the low dose 2 h before challenge. A similar response pattern as...
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PMID: 18607910
PDF is available here.
PDF is available here.
Arerugi = [Allergy] (58)2 2009
Abstract
Abstract
We have observed that infants colonised in the first week(s) of life with Staphylococcus aureus have lower risk of developing food allergy. As many S. aureus strains produce superantigens with T-cell stimulating properties, we here investigate whether neonatal mucosal exposure to superantigen could...
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PMID: 19130476
PDF is available here.
PDF is available here.