Abstract
Current anti-cancer research is focused on cell surface receptors targeting, mainly epidermal growth factor receptor and vascular endothelial growth factor receptor, against which a few targeted agents are now available in clinical practice. Recent improvements of our understanding on the intracellu...
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PMID: 20381956
PDF is available here.
Abstract
Airway stenting is highly effective in palliating symptoms of airway obstruction. There are several types of stents available with different advantages and disadvantages depending mainly on the material they are made from. Clinical outcomes seem to be comparable between silicone and self-expanding m...
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PMID: 20531080
PDF is available here.
Abstract
The use of the antiangiogenesis drug bevacizumab along with radiation therapy have been linked to the development of malignant tracheoesophageal fistula/malignant bronchoesophageal fistula in patients treated for both small-cell and nonsmall-cell lung carcinoma. Three case series have been published...
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PMID: 20531081
PDF is available here.
Abstract
Although squamous cell carcinoma is the most frequent malignant diagnosis made with upper aerodigestive tract specimens, a myriad of neoplasms can occur throughout the area. Very uncommonly, one encounters adenocarcinomas that cannot be better classified as salivary gland-type neoplasia. This manusc...
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PMID: 20574171
PDF is available here.
Abstract
The slightly lower survival of Danish lung cancer patients may be related to a less favourable stage distribution and to an increased prevalence of causal factors, affecting the mortality due to competing risks of death. A reclassification of official causes of death at the cancer registry may be ne...
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PMID: 20170292
PDF is available here.
Abstract
In the past decade, rapid technical developments and advancements of multidetector computed tomography (MDCT) have revolutionized the preoperative imaging evaluation of thoracic vascular and tracheobronchial anomalies and abnormalities in infants and children. Multidetector computed tomography enabl...
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PMID: 20385293
PDF is available here.
Abstract
ProEx C is a clean and reliable stain in laryngeal tissue, and stains positive in RRP. This study could not definitively correlate positive ProEx C staining in areas of greater dysplasia, although a trend was observed. Further studies are necessary to determine whether ProEx C can be used in triage...
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PMID: 20336920
PDF is available here.
Abstract
Intralesional cidofovir injection has been shown to be an effective an safe therapy for laryngeal papilloma and should be considered in those patients who experienced disease relapse....
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PMID: 20568538
PDF is available here.
Abstract
We examined the expression of EBV latent membrane protein-1 (LMP-1) and EBV EBNA-2 as well as the immunohistochemical profile of AE-1/AE-3, vimentin, desmin, CK 5-6, smooth muscle actin (SMA), p63, S-100, p53 and CD-117 with the clinicopathological correlation of eight patients of sarcomatoid carcin...
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PMID: 21045407
PDF is available here.
Abstract
Dysplasia was discovered in more than 20% of adult patients with RRP studied over a 6-year period. Age, gender, tobacco history, and operative frequency were not identifiable risk factors for the presence of dysplasia....
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PMID: 19708485
PDF is available here.
Abstract
The database revealed severity factors relating to human papillomavirus (HPV) type and age at diagnosis. While not exhaustive, the database is easy to use and could serve for a European multicentre epidemiological study. OBJECTIVES: To propose a database as a starting point for a national registry a...
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PMID: 19235575
PDF is available here.
Abstract
Recurrent respiratory papillomatosis (RRP) is a chronic, frequently debilitating, and potentially life-threatening disease. Therapy for RRP has evolved from simply inserting a tracheotomy to provide an airway and plucking out papillomata with cup forceps to provide some degree of voice to the presen...
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PMID: 19134490
PDF is available here.
Abstract
This is the first report that cidofovir can both increase cell survival and induce alterations in gene expression that are known to be associated with malignant transformation in cells transduced only with the E6 gene from low-risk HPV. It is our belief that these data provide cause for concern over...
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PMID: 19918098
PDF is available here.
Abstract
The objective of this study was to evaluate the frequency of infection of pharyngeal mucosa, palatal and pharyngeal tonsils with types 6, 11, 16, 18, 31, and 33 human papilloma virus (HPV). A total of 57 children (30 boys and 27 girls) aged from 2 yr 10 mo to 14 yr 5 mo (mean 82+/-28.9 months) were...
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PMID: 19365356
PDF is available here.
Abstract
This paper updates information on epidemiology, etiology, clinical features, surgical and anti-relapse treatment of recurrent respiratory papillomatosis in children.
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PMID: 19738596
PDF is available here.
Abstract
Recent investigations have resulted in the following more accurate prevalence estimates of human papilloma virus in women in the United States; correlation of socioeconomic status and disease severity; the malignant potential of human papilloma virus in head and neck cancer; the role of the host imm...
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PMID: 19005325
PDF is available here.
Abstract
Our results suggested a direct concentration effect from inhaled inorganic arsenic, whereby the excess relative risk for a fixed cumulative exposure was greater when delivered at a higher concentration and shorter duration than when delivered at a lower concentration and longer duration....
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PMID: 19079717
PDF is available here.
Abstract
The results of the current study indicate that long-term use of incense is associated with an increased risk of squamous cell carcinoma of the respiratory tract....
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PMID: 18726993
PDF is available here.
Abstract
We estimated the health and economic benefits of preventing recurrent respiratory papillomatosis (RRP) through quadrivalent human papillomavirus (HPV) vaccination. We applied a simple mathematical model to estimate the averted costs and quality-adjusted life years (QALYs) saved by preventing RRP in...
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PMID: 18598734
PDF is available here.
Abstract
We study the CIIT model to identify key biological and statistical uncertainties that need careful evaluation if such two-stage clonal expansion models are to be used for extrapolation of cancer risk from animal bioassays to human exposure. Broadly, these issues pertain to the use and interpretation...
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PMID: 18564991
PDF is available here.
Hiroki Furue,
Hiroshi Kumimoto,
Keitaro Matsuo,
Takeshi Suzuki,
Yasuhisa Hasegawa,
Masayuki Shinoda,
Tomotaka Sugimura,
Kenji Mitsudo,
Iwai Tohnai,
Minoru Ueda,
Kazuo Tajima and
Kanji Ishizaki
Abstract
We analyzed the association between NKG2D genotype and aerodigestive tract cancer risk. Subjects were 502 aerodigestive tract cancer patients (276 with head and neck, 226 with esophageal) and 1,004 sex-age matched noncancer controls. Exposures to 2 lifestyle factors, smoking and drinking, were evalu...
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PMID: 18398831
PDF is available here.
Abstract
Thirteen articles were identified between 1998 and 2006, representing the treatment of 142 patients. Cidofovir did result in a significant improvement of papillomatous lesions in the majority (60%) of patients despite the use of different regimes of cidofovir administration. There was no unifying pr...
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PMID: 18502519
PDF is available here.
Abstract
A randomized, blinded, placebo-controlled trial is necessary in the study of RRP, because the natural history of the disease can include remissions and reactivations. We found a significant improvement in the Derkay Severity Score 12 months after the baseline assessment in patients treated with cido...
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PMID: 18700421
PDF is available here.
Abstract
I came across in my 15 years of surgical and molecular pathology practice. The study raises several notions. Extracutaneous malignant melanomas are rare but extremely aggressive lesions with a grim outcome. They include ocular, metastatic, anorectal, mucosal, nail beds, conjunctival, vaginal, urogen...
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PMID: 18568775
PDF is available here.
Abstract
The economic burden that was associated with noncervical HPV-6-, -11-, -16-, and -18-related conditions in the US population in the year 2003 approximates $418 million (range, $160 million to $1.6 billion). CONCLUSION: The economic burden of noncervical HPV disease is substantial. Analyses that asse...
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PMID: 18455524
PDF is available here.
Abstract
In summary, no mortality outcome of a priori interest, principally respiratory system cancer, is associated with increased AN exposure among fiber production workers over five decades of follow-up....
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PMID: 18469624
PDF is available here.
Abstract
The multivariate logistic regression analyses demonstrated no significant differences between groups for all three polymorphisms when analyzed separately. However, the gene-environment interactions analyses revealed significant interactions among tobacco smokers (11-20 pack years), 20-40 pack years...
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PMID: 18466102
PDF is available here.
Abstract
We present a review of the thoracic CT findings in 16 patients with histopathologically confirmed osteosarcoma with unusual thoracic manifestations. The 16 patients were selected out of a total 136 patients who received a chest CT scan for osteosarcoma during a period of 3 years in a tertiary care h...
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PMID: 18246342
PDF is available here.
Abstract
The purpose of the study was to assess whether non-enhancing adjacent cortical signal intensity abnormality detected on fluid-attenuated inversion recovery (FLAIR) can differentiate between multicentric and/or multifocal glioma and non-glioma pathology in patients with multiple enhancing cerebral le...
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PMID: 18373804
PDF is available here.
Abstract
We briefly described microRNA biogenesis, function and the principal approaches for studying the function of microRNAs (miRNA) in solid cancers. There are currently hundreds of confirmed miRNAs in humans, and computational predictions suggest that the total count might be more than thousand. The reg...
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PMID: 18296065
PDF is available here.
Karin Bink,
Eugenia Haralambieva,
Marcus Kremer,
German Ott,
Christine Beham-Schmid,
Laurence de Leval,
Suat Cheng Peh,
Hubert R Laeng,
Uta Jütting,
Peter Hutzler,
Leticia Quintanilla-Martinez and
Falko Fend
Abstract
We studied 38 cases of this type of neoplasm by fluorescence in situ hybridization. Fourteen cases (37%) contained IGH breaks, including six with a t(4;14) translocation. No translocations t(11;14), t(14;16), t(8;14), nor breaks involving MALT1, BCL6 or FOXP1 were found. Loss of 13q (40%), as well a...
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PMID: 18326524
PDF is available here.
Abstract
Despite its growing popularity, the potential risks related to cidofovir use in recurrent respiratory papillomatosis have not been well documented. It is known to be nephrotoxic when administered intravenously and there remains concern that cidofovir has carcinogenic potential based on animal studie...
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PMID: 18197029
PDF is available here.
Abstract
Mesothelioma incidence has increased in South East England, particularly for men aged over 70 years. The highest incidence occurs along the Thames and its estuary, reflecting areas of asbestos use in shipbuilding and industry in the past. More research is needed to understand the interrelationships...
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PMID: 17675318
PDF is available here.
Abstract
Mib1 and Bcl2 significantly discriminate between recurrent versus nonrecurrent tumors, producing a biologically plausible, diagnostically suitable immunohistochemical pattern....
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PMID: 18172265
PDF is available here.
Abstract
Despite reports of successful treatment of oncological diseases of the upper respiratory tract, many patients with this pathology still apply for medical aid too late. Squamous cell carcinoma remains the predominant problem. Clinical symptoms of metastases are absent in 60% of the lethal cases with...
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PMID: 19008834
PDF is available here.
Abstract
We report the case of a 7 week-old boy with a pleuropulmonary blastoma classified as type I. Disease was discovered at a chest X-ray performed as a work-up for a benign acute viral bronchiolitis. The final diagnosis was brought by pathology: a bronchopulmonary malformation had not been ruled out by...
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PMID: 17935952
PDF is available here.
Abstract
The finding of an excess of tumors in the respiratory system is in agreement with earlier findings in other studies on rubber tire workers. The results on other cancer types are compared to earlier findings and related to work processes and chemical exposures of possible causal importance....
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PMID: 17972254
PDF is available here.
Abstract
We analysed the evolution of different cytokines (IL-4, IL-6, tumour necrosis factor alpha and vascular endothelial growth factor; VEGF) involved in the development of Kaposi's sarcoma in two patients in whom HIV infection presented with disseminated Mycobacterium tuberculosis infection. They simult...
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PMID: 17721110
PDF is available here.
Abstract
Patients carrying CYP2D6*10/*10 (n = 49) demonstrated significantly lower steady-state plasma concentrations of 4-hydroxy-N-desmethyltamoxifen and 4-hydroxytamoxifen than did those with other genotypes (n = 153; 4-hydroxy-N-desmethyltamoxifen: 7.9 v 18.9 ng/mL, P < .0001; 4-hydroxytamoxifen: 1.5 v 2...
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PMID: 17761971
PDF is available here.
Abstract
The authors considered the incidence of second neoplasms among 1,672 oesophageal cancers diagnosed between 1974 and 2004 in the Cancer Registries of the Swiss Cantons of Vaud and Neuchâtel, and followed-up to 2004. A total of 141 second neoplasms were observed versus 38.5 expected, corresponding to...
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PMID: 17417783
PDF is available here.
Gwenn G Menvielle,
Anton E AE Kunst,
Irina I Stirbu,
Carme C Borrell,
Matthias M Bopp,
Enrique E Regidor,
Bjørn B Heine Strand,
Patrick P Deboosere,
Olle O Lundberg,
Annette A Leclerc,
Giuseppe G Costa,
Jean-Francois JF Chastang,
Santiago S Esnaola,
Pekka P Martikainen and
Johan P JP Mackenbach
Abstract
We aim to study socioeconomic inequalities in alcohol related cancers mortality [upper aerodigestive tract (UADT) (oral cavity, pharynx, larynx, oesophagus and liver)] in men and to investigate whether the contribution of these cancers to socioeconomic inequalities in cancer mortality differs within...
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PMID: 17415714
PDF is available here.
Abstract
The incidence of pulmonary and gastrointestinal carcinoids has dramatically increased since 1981. Tumor location and age > or = 60 years are the strongest predictors of mortality....
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PMID: 17429568
PDF is available here.
Abstract
The tumours of the disseminated/diffuse neuroendocrine cell system are a group of neoplasms sharing uniformly appearing cells which differ from each other in their biology, prognosis and genetics. In the lung they are called carcinoid and small/large-cell neuroendocrine carcinomas. In the gastroente...
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PMID: 17382263
PDF is available here.
Abstract
Increased risks from lung and bladder cancers were found in PAH-related occupations. These were modest in most industries, apart from those for coal gasification, and whether they are due at least partially to some bias or confounding remains open to discussion....
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PMID: 16936186
PDF is available here.
Abstract
A compromised cell-mediated immune response may be associated with repeated or persistent human papillomavirus infections, leading to the development of recurrent respiratory papillomatosis. Patients with an aggressive clinical course may have underlying cell-mediated immunodeficiency. Long-term pro...
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PMID: 17419519
PDF is available here.
Abstract
We will summarize the current knowledge regarding the implication of AP-1 proteins in respiratory epithelium carcinogenesis, highlight the ongoing research, and consider the future perspectives of their potential therapeutic interest....
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PMID: 17314269
PDF is available here.