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Taste Buds (0):
Recent article
Taste Buds
Otolaryngologia Polska (65)2 2011
Abstract
Electrogustometry is a method for taste diagnosis and measurement. The EG-2 project is being developed in cooperation between Warsaw University of Technology and Military institute of Medicine in Warsaw. The device is an evolution of the recent universal electrogustometer EG-1 protot...
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PMID: 21735666
PDF is available here.
PDF is available here.
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Abstract
We observed the external surface and connective tissue cores (CTCs), after exfoliation of the epithelium of the lingual papillae (filiform, fungiform, foliate and vallate papillae) of the common raccoon (Procyon lotor) using scanning electron microscopy and light microscopy. The tongue was elongated...
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PMID: 20882769
PDF is available here.
PDF is available here.
Auris Nasus Larynx (37)4 2010
Abstract
This exploratory in vivo study revealed changes in taste bud volumes in healthy humans with age-related gustatory sensitivity. These findings need to be considered when studying the effect of denervation of fungiform papillae in vivo using confocal microscopy.
Crown Copyright 2009. Published by Else...
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PMID: 20031354
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)25 2010
Abstract
We show that GPR120 and GPR40 are expressed in the taste buds, mainly in type II and type I cells, respectively. Compared with wild-type mice, male and female GPR120 knock-out and GPR40 knock-out mice show a diminished preference for linoleic acid and oleic acid, and diminished taste nerve responses...
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PMID: 20573884
PDF is available here.
PDF is available here.
Abstract
We have detected glycochains by lectin histochemistry. We have also identified Types II and III by immunohistochemistry. Then, we combined lectin histochemistry and immunohistochemistry to determine which types of cells have which glycochains. In addition, we have compared these reactions in differe...
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PMID: 20145374
PDF is available here.
PDF is available here.
Abstract
Abstract
Taste dysfunction that develops after radiotherapy for head and neck cancer impairs patients' quality of life. Although taste cells have been shown to degenerate after exposure to X-ray irradiation, the alteration in taste cell population is unclear. This study investigated the histo...
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PMID: 19702869
PDF is available here.
PDF is available here.
Abstract
We hypothesized that other components of the GABA signaling pathway are likely expressed in this system. GABA signaling is initiated by the activation of either ionotropic receptors (GABA(A) and GABA(C)) or metabotropic receptors (GABA(B)) while it is terminated by the re-uptake of GABA through tran...
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PMID: 21049022
PDF is available here.
PDF is available here.
Abstract
We review in this chapter the hypothesis of gastrointestinal taste signaling and discuss the potential for T1R2/T1R3 and TRPM5 as targets of therapeutic intervention in obesity and diabetes. Critical to the development of a drug discovery program is the creation of libraries that enhance the likelih...
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PMID: 20691962
PDF is available here.
PDF is available here.
Abstract
Taste receptor cells detect chemical compounds in the oral cavity and transfer their messages to gustatory afferent nerve fibers. Considering the coding of taste information, the sensitivity of taste cells and the connection between taste cells and gustatory fibers may be critical in...
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PMID: 20797678
PDF is available here.
PDF is available here.
BMC Neuroscience (11) 2010
Abstract
We utilized transgenic mice with LacZ under the control of the BMP4 promoter to reveal the expression of BMP4 in the tongues of adult mice. Further we evaluate the pattern of BMP4 expression with that of markers of specific taste bud cell types and cell proliferation to define and compare the cell p...
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PMID: 20942907
PDF is available here.
PDF is available here.
BMC Neuroscience (11) 2010
Abstract
Taken together, the results suggest that glutamate may be released from gustatory nerve fibers using a vesicular mechanism to modulate Type III taste cells via GluR7....
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PMID: 20565975
PDF is available here.
PDF is available here.
BMC Neuroscience (11) 2010
Abstract
Our results show that LPS-induced inflammation inhibits taste progenitor cell proliferation and interferes with taste cell renewal. LPS accelerates cell turnover and modestly shortens the average life span of taste cells. These effects of inflammation may contribute to the development of taste disor...
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PMID: 20537148
PDF is available here.
PDF is available here.
Pediatric Dermatology (27)4 2010
Abstract
We describe an 11-year-old boy presenting typical features of pigmented fungiform papillae of the tongue....
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PMID: 20653864
PDF is available here.
PDF is available here.
Stomatologiia (89)3 2010
Abstract
Condition of the gustatory perception in diabetes mellitus patients with compensated (51,9%), sub- (39,0%) and decompensated (9,1%) forms of glycolitic disorders was studied. Results allow to note that in the group of patients with decompensated form of the glucose homeostasis disorders reduction of...
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PMID: 20559230
PDF is available here.
PDF is available here.
Endocrine Journal (57)6 2010
Abstract
The present study summarized recent findings on roles of leptin and endocannabinoids as modulators of the peripheral components of sweet taste. The positive effect of endocannabinoids on sweet sensitivity was opposed to that of leptin which suppresses sweet sensitivity. Leptin and endocannabinoids,...
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PMID: 20431269
PDF is available here.
PDF is available here.
Missouri medicine (107)4 2010
Abstract
This paper reviews the physiology of taste processing and ingestive decisions.
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PMID: 20806835
PDF is available here.
PDF is available here.
Abstract
Although a number of brief, fragmented descriptions have been provided on the gross morphology of the ratite tongue, very few studies have documented the histological structure of this organ. This paper presents the first definitive histological description of the emu tongue and revi...
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PMID: 21344785
PDF is available here.
PDF is available here.
Abstract
The data obtained indicate the potential application of this non-invasive imaging modality: to evaluate variation of taste bud volume in human fungiform papillae with ageing; to study the effects of chorda tympani nerve transection on taste bud volume; and to demonstrate recovery of taste buds in pa...
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PMID: 19470187
PDF is available here.
PDF is available here.
Abstract
We have little understanding of how these interactions influence taste perception directly or indirectly. This limited understanding is evident by the lack of even a basic knowledge of the resident immune cell populations in or near taste tissues. The present study characterized the distribution and...
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PMID: 19268521
PDF is available here.
PDF is available here.
Abstract
The act of eating and drinking brings food-related chemicals into contact with taste cells. Activation of these taste cells, in turn, engages neural circuits in the central nervous system that help animals identify foods and fluids, determine what and how much to eat, and prepare the body for digest...
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PMID: 19674892
PDF is available here.
PDF is available here.
Abstract
We observed the three-dimensional structures of the external surface and connective tissue cores CTCs, after exfoliation of the epithelium of the lingual papillae (filiform, fungiform, and foliate papillae) of the common hippopotamus (Hippopotamus amphibius amphibius) using scanning electron microsc...
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PMID: 19548302
PDF is available here.
PDF is available here.
Neuroreport (20)10 2009
Abstract
We investigated the expression patterns of transduction components and the contribution of intracellular Ca2+ stores. Of 64 cells responding to bitter compounds, 63% of the cells expressed the taste tissue-specific G-protein alpha-gustducin. Of the alpha-gustducin immunoreactive cells, 78% expressed...
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PMID: 19562832
PDF is available here.
PDF is available here.
Abstract
The present study was designed to examine the histochemical changes and occurrence of apoptosis in taste buds of rat circumvallate papillae following bilateral transection of the glossopharyngeal nerve. Following transection of the glossopharyngeal nerve, the number of taste buds was not altered unt...
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PMID: 20009345
PDF is available here.
PDF is available here.
Otolaryngologia Polska (63)3 2009
Abstract
Electrogustometry has been used as a clinical tool for diagnosis and assessment of a variety of conditions. Since the lack of versatile electrogustometer for research and diagnosis, the new electrogustometer EG-1 was developed in 2006. It was done in cooperation between Warsaw University of Technolo...
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PMID: 19886533
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1791)3 2009
Abstract
The sense of taste informs the organism about the quality of ingested food. Five basic taste modalities, e.g., sweet, sour, bitter, salty and umami have so far been identified. Recent compelling evidence from rodent and human studies raise the possibility for an additional sixth taste modality devot...
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PMID: 19367762
PDF is available here.
PDF is available here.
Neuroreport (20)3 2009
Abstract
Although a critical component of taste perception, the neural basis of aftertaste perception has yet to be elucidated with neuroimaging. This functional neuroimaging study assessed the temporal dynamics of neural responses to sucrose and aspartame in eight healthy volunteers. Aspartame has a sweetne...
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PMID: 19444946
PDF is available here.
PDF is available here.
Saudi medical journal (30)2 2009
Abstract
In rabbits, oral metronidazole (13.6%) or tinidazole (7%) resulted in a significant reduction in serum zinc. Reductions in captopril (6.7%) and valsartan (4.2%) were smaller and insignificant. Body weight increased by 15.5gm (1391+/-225.3 gm to 1407+/-223.2 gm) in the control group, a lesser increas...
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PMID: 19198707
PDF is available here.
PDF is available here.
Abstract
We propose another system for calcium taste involving the extracellular calcium-sensing receptor (CaSR). This G protein-coupled receptor that responds to calcium and magnesium cations is involved in calcium homeostasis regulating parathyroid and kidney functions. In this study, CaSR was found in iso...
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PMID: 19056349
PDF is available here.
PDF is available here.
Abstract
We sought to identify genes that were selectively expressed in taste cells at different maturation stages. Here we report the expression of the voltage-gated potassium channel KCNQ1 in mammalian taste buds of mouse, rat, and human. Immunohistochemistry and nuclear staining showed that nearly all rod...
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PMID: 19006182
PDF is available here.
PDF is available here.
Abstract
We have isolated a subpopulation of cells in the basal epithelial layer of the mouse tongue with a high efficiency of generating holoclones of undifferentiated cells in culture with a feeder layer. Krt5-GFP(hi) cells can both self renew and give rise to differentiated stratified keratinized epitheli...
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PMID: 18830772
PDF is available here.
PDF is available here.
Abstract
The Journal of Medical Investigation (56 Suppl) 2009
Abstract
Type III cells in taste buds form chemical synapses with intragemmal afferent nerve fibers and are characterized by the presence of membrane-bound vesicles in the cytoplasm. Although the vesicles differ in shape and size among species, they are primarily categorized into small clear (40 nm in diamet...
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PMID: 20224182
PDF is available here.
PDF is available here.
BMC Physiology (9)1 2009
Abstract
We first ascertained that lactisole exerted similar suppression of sweetness in M. fascicularis, as reported in humans, by recording their preference of sweeteners and non- sweeteners with and without lactisole in two-bottle tests. The addition of lactisole significantly diminished the preference fo...
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PMID: 19224647
PDF is available here.
PDF is available here.
BMC Neuroscience (10)1 2009
Abstract
We describe the molecular and histological expression profiles of cation channels involved in electrical signal transmission from apical to basolateral membrane domains. TRPM5 was positioned immediately beneath tight junctions to receive calcium signals originating from sweet, bitter, and umami rece...
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PMID: 19284629
PDF is available here.
PDF is available here.
BMC Neuroscience (10)1 2009
Abstract
In situ hybridization analysis showed that all three ENaC subunit mRNAs were found in the rat fungiform taste buds and lingual epithelia, but in the vallate and foliate taste buds, only alpha ENaC mRNA was easily detected, while beta and gamma ENaC mRNAs were much less than those in the fungiform ta...
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PMID: 19284620
PDF is available here.
PDF is available here.
Journal of Biology (8)4 2009
Abstract
Taste cells regularly generate action potentials, but their functional significance in taste signaling is unclear. A paper in BMC Neuroscience reveals the identity of the voltage-gated Na+ channels underlying action potentials, providing the foundation for insights into their function.
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PMID: 19439032
PDF is available here.
PDF is available here.
Abstract
We consider receptor mechanisms and conjugated primary signal processes of stimulation of taste receptor cells by stimuli of various taste modalities....
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PMID: 19377517
PDF is available here.
PDF is available here.
Acta Oto-Laryngologica (129)1 2009
Abstract
Branches of CN IX were observed that extended anteriorly beyond the sulcus terminalis and the circumvallate papillae, with extensions occurring along the lateral lingual margin anterior to the foliate papillae. Anastomoses were identified between CN IX and the lingual nerve, raising the possibility...
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PMID: 18607984
PDF is available here.
PDF is available here.
Abstract
We discuss some of the mechanisms underlying the detection of sweeteners by mammals, with a particular focus on the function and role of the T1R2:T1R3 receptor in these processes....
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PMID: 19083128
PDF is available here.
PDF is available here.
Abstract
Bitter taste in mammals is achieved by a family of approximately 30 bitter taste receptor genes. The main function of bitter taste is to protect the organism against the ingestion of, frequently bitter, toxic food metabolites. The field of taste research has advanced rapidly during the last several...
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PMID: 19145413
PDF is available here.
PDF is available here.
Abstract
Obesity constitutes a major public health problem for the twenty-first century, with its epidemic spread worldwide, particularly in children. The overconsumption of fatty foods greatly contributes to this phenomenon. Rodents and humans display a spontaneous preference for lipid-rich foods. However,...
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PMID: 19083126
PDF is available here.
PDF is available here.
Abstract
The term transient lingual papillitis (TLP) was suggested by Whitaker et al. in 1996. It describes a condition of the tongue that is relatively common but with few documented cases. It is seen more in young women as a painful enlargement of one or more fungiform papillae that resolve quickly within...
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PMID: 19774866
PDF is available here.
PDF is available here.
Chemical Senses (34)1 2009
Abstract
The aim of this study was to investigate the relationship of fungiform papillae density with taste detection thresholds for sucrose of young male adults. One hundred and eighty two subjects aged 18-23 years (mean age: 21.9 +/- 1.2 years) were included. The densities of fungiform papillae were record...
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PMID: 18854510
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)49 2008
Abstract
We recorded robust responses from NE biosensors when they were positioned against mouse circumvallate taste buds and the taste buds were stimulated with KCl (50 mm) or a mixture of taste compounds (cycloheximide, 10 microm; saccharin, 2 mm; denatonium, 1 mm; SC45647, 100 microm). NE biosensor respon...
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PMID: 19052199
PDF is available here.
PDF is available here.
Abstract
We show that ion channels responsible for voltage-gated (VG) outward currents in type II cells are ATP permeable and demonstrate a strong correlation between the magnitude of the VG current and the intensity of ATP release. These findings suggest that slowly deactivating ion channels transporting th...
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PMID: 19029378
PDF is available here.
PDF is available here.
FEBS Letters (582)27 2008
Abstract
We suggest a different role for Galpha-gus. In taste buds of alpha-gus-knockout mice, basal (unstimulated) cAMP levels are high compared to those of wild-type mice. Further, H-89, a cAMP-dependent protein kinase inhibitor, dramatically unmasks responses to the bitter tastant denatonium in gus-lineag...
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PMID: 18930056
PDF is available here.
PDF is available here.
Journal of Anatomy (213)5 2008
Abstract
We examined the epithelial surface and connective tissue cores (CTCs) of each lingual papilla on the Paenungulata, Cape hyrax (Procavia capensis), by scanning electron microscopy and light microscopy. The tongue consisted of a lingual apex, lingual body and lingual root. Filiform, fungiform and foli...
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PMID: 18713236
PDF is available here.
PDF is available here.
Abstract
This synchronization of diurnal variation in leptin levels and sweet taste recognition thresholds suggests a mechanistic connection between these two variables in humans....
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PMID: 18633111
PDF is available here.
PDF is available here.
Abstract
We summarized the data from recent studies that further addressed this issue by using different experimental techniques. Some of the studies provided additional evidence for the existence of umami receptor systems mediated by mGluR1 and mGluR4 in addition to T1R1/T1R3. It is proposed that the signal...
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PMID: 18827337
PDF is available here.
PDF is available here.
Journal of Neurophysiology (100)4 2008
Abstract
We used calcium imaging to characterize the role of mitochondria in buffering calcium levels in taste cells. We discovered that mitochondria make important contributions to the maintenance of resting calcium levels in taste cells by routinely buffering a constitutive calcium influx across the plasma...
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PMID: 18684902
PDF is available here.
PDF is available here.
Developmental Dynamics (237)9 2008
Abstract
We tested roles of epidermal growth factor (EGF) and the receptor EGFR in papilla development. Developmentally, EGF was localized within and between papillae whereas EGFR was progressively restricted to inter-papilla epithelium. In tongue cultures, EGF decreased papillae and increased cell prolifera...
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PMID: 18729215
PDF is available here.
PDF is available here.
Journal of Neurochemistry (106)5 2008
Abstract
We have identified the calcium- and integrin-binding protein 1 (CIB1) as specific binding partner of the intracellular carboxyterminal domain of the rat sweet taste receptor subunit Tas1r2. In heterologous human embryonic kidney 293 (HEK293) cells, the G protein chimeras Galpha(16gust44) and Galpha(...
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PMID: 18627437
PDF is available here.
PDF is available here.
Neuroreport (19)12 2008
Abstract
We performed physiological investigations to determine whether umami-responding cells in taste buds possess G protein-coupled receptors and to determine what type of G proteins exist if any. To clarify the components that participate in intracellular umami signal transduction in mouse, we recorded t...
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PMID: 18628659
PDF is available here.
PDF is available here.
Journal of Food Science (73)6 2008
Abstract
A greater understanding of the molecular mechanisms of sweet taste has profound significance for the food industry as well as for consumers. Understanding the mechanism by which sweet taste is elicited by saccharides, peptides, and proteins will assist science and industry in their search for sweet...
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PMID: 19241531
PDF is available here.
PDF is available here.
Journal of Neurochemistry (106)3 2008
Abstract
We analyzed the Asn-linked glycosylation of hTAS2Rs at a consensus sequence in the second extracellular loop, which is conserved among all 25 hTAS2Rs. Non-glycosylated receptors exhibit substantially lower cell surface localization and reduced association with the cellular chaperone calnexin. As the...
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PMID: 18466324
PDF is available here.
PDF is available here.
Abstract
These results indicate that bitter-responsive rNST neurons critical for triggering gaping may not express FLI and imply an alternate function for bitter-responsive neurons that do....
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PMID: 18495833
PDF is available here.
PDF is available here.
Brain Research (1221) 2008
Abstract
We examined the influence of bilateral stimulation of the VPMpc on taste-responsive neurons in the NST. Extracellular single unit activity was recorded from the urethane-anesthetized hamster. Taste responses were confirmed by delivery of four basic tastants to the anterior tongue. After identifying...
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PMID: 18565498
PDF is available here.
PDF is available here.
Abstract
These results suggest that basal cell differentiation occurs synchronously with the patterning of Shh spots both in the anterior tongue and in the soft palate. In contrast, Mash1 expression lagged behind the expression of Shh and Prox1 and began after the number of Shh spots had reached its peak lev...
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PMID: 18465790
PDF is available here.
PDF is available here.