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Skin and Connective Tissue Diseases (2):
Recent article
Skin and Connective Tissue Diseases
Abstract
Bancroftian filariasis constitutes the principal mosquito-borne nematode infection of humans and the surface of adult of Wuchereria bancrofti seems to be especially important in the intricate interplay between host and parasite. The study of the parasite's surface structure might help to understand...
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PMID: 20236829
PDF is available here.
PDF is available here.
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Abstract
Dermal expression of nearly all parameters differed in hemodialysis patients compared with healthy controls. In comparison to hemodialysis patients and healthy participants, we found increased messenger RNA levels for TGF-beta, the profibrotic receptor-activated SMAD2 and SMAD3, CTGF, and TIMP-1 in...
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PMID: 20430497
PDF is available here.
PDF is available here.
Modern Pathology (23)5 2010
Abstract
Graft-versus-host disease is the leading cause of non-relapse mortality after allogeneic bone marrow transplantation. The cell-mediated immune mechanisms that underlie the pathogenesis of graft-versus-host disease remain unclear. In this study, 47 skin biopsies representing graft-versus-host disease...
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PMID: 20190732
PDF is available here.
PDF is available here.
Abstract
We present two patients with Crohn's disease and Sweet's syndrome diagnosed in our department at the time of CD diagnosis, as well as their response to treatment, subsequent course of the disease, and a review of the scientific literature....
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PMID: 20524763
PDF is available here.
PDF is available here.
Annales de Dermatologie et de Vénéréologie (137 Suppl 1) 2010
Abstract
Angiogenesis is a physiological process that allows the formation of new blood vessels, either from the local vascular structures, or from circulating endothelial progenitor cells, mobilized from the bone marrow, and attracted to the neovascularization site. This mechanism is controlled by pro-angio...
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PMID: 20435250
PDF is available here.
PDF is available here.
Biological Chemistry (391)4 2010
Abstract
Klk8 is a tryptic serine protease with limited substrate specificity. Klk8 mRNA is expressed in many developing organs, whereas its expression is confined to limited regions, including the hippocampus, in adults. In the hippocampus, Klk8 is involved in activity-dependent synaptic changes such as lon...
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PMID: 20180635
PDF is available here.
PDF is available here.
Abstract
Abstract The last few years have shown an increased demand for non-invasive skin tightening to improve body contour. Since light (lasers or intense pulsed light sources) has a limited ability to penetrate deep into the tissue, radio frequency (RF) modalities were introduced for the reduction of lax...
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PMID: 20331345
PDF is available here.
PDF is available here.
Archives de Pédiatrie (17)4 2010
Abstract
An echogenic tumor (22 x 22 mm) isolated from the anterior part of the left leg at 27 WA of pregnancy suggested an angiomatous structure. This mass appeared to be well vascularized on Doppler examination. Three-dimensional imaging showed connections with adjacent tissues. The limbs were mobile. Deli...
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PMID: 20189370
PDF is available here.
PDF is available here.
Molecular Medicine (16)3-4 2010
Abstract
We analyzed components of TGFbeta signaling pathway in biopsies from 10 patients with nonhealing venous ulcers (VUs). Using comparative genomics of transcriptional profiles of VUs and TGFbeta-treated keratinocytes, we found deregulation of TGFbeta target genes in VUs. Using quantitative polymerase c...
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PMID: 20069132
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (50)10 2009
Abstract
Rheumatology International (29)11 2009
Abstract
The purpose of this study is to study and systematize the current knowledge about the role of capillaroscopy in differentiation of primary and secondary Raynaud's phenomenon (RP) in rheumatic diseases. This method is a review of the literature. Capillaroscopy is of crucial value for diagnosis and di...
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PMID: 19547979
PDF is available here.
PDF is available here.
Abstract
We lack relevant in vivo or in vitro models to study many aspects of bacterial interaction with skin. The aim of this study was to develop three-dimensional models of normal human skin to study bacterial infection. The common dermatological pathogens Staphylococcus aureus and Pseudomonas aeruginosa...
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PMID: 19292658
PDF is available here.
PDF is available here.
Clinical Rheumatology (28)9 2009
Abstract
Scleroderma and other connective tissue diseases have rarely been reported among Africans. The objective of this paper is to have a retrospective study of the clinical and investigative characteristics of scleroderma patients seen in a rheumatology clinic. This was done in a private practice rheumat...
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PMID: 19437086
PDF is available here.
PDF is available here.
Abstract
UV radiation from the sun impacts skin health adversely through complex, multiple molecular pathways. Premature skin aging (photoaging) is among the most widely appreciated harmful effects of chronic exposure to solar UV radiation. Extensive damage to the dermal connective tissue is a hallmark of ph...
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PMID: 19675548
PDF is available here.
PDF is available here.
Abstract
We are presenting a case of a 50-year-old male requiring chronic peritoneal dialysis since the age of 43, due to end-stage renal disease resulting from chronic glomeluronephritis. The patient presented to our Dermatology Department with large and painful coalescent cutaneous lesions on both lower ex...
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PMID: 19856878
PDF is available here.
PDF is available here.
Abstract
We report on the first clinical study based on optical coherence tomography (OCT) in combination with multiphoton tomography (MPT) and dermoscopy. 47 patients with a variety of skin diseases and disorders such as skin cancer, psoriasis, hemangioma, connective tissue diseases, pigmented lesions, and...
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PMID: 19598177
PDF is available here.
PDF is available here.
Veterinary Pathology (46)4 2009
Abstract
We describe the clinical and pathologic features of NCM in a 4.5-year-old female cynomolgus macaque. Histopathologically, skin lesions showed foci of nests and cords of pigmented cells in the dermis similar to blue nevi in humans. In the brain, focal pigmented cell infiltration was observed in the c...
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PMID: 19276048
PDF is available here.
PDF is available here.
Journal of Pathology (217)4 2009
Abstract
We set out to examine the pathophysiological mechanisms of fibrosis in diffuse systemic sclerosis (SSc) using a tissue engineering approach. Skin fibroblasts were isolated from lesional skin of SSc patients with a disease duration of less than 1 year (early-stage SSc) or more than 10 years (late-sta...
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PMID: 19086038
PDF is available here.
PDF is available here.
Abstract
We examined a murine PXE model (Abcc6(-/-)) by transplanting muzzle skin from knockout (KO) and wild-type (WT) mice onto the back of WT and KO mice using mineralization of the connective tissue capsule surrounding the vibrissae as an early phenotypic biomarker. Grafting of WT mouse muzzle skin onto...
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PMID: 18685618
PDF is available here.
PDF is available here.
Abstract
We have selectively deleted TbetaRII postnatally in differentiated connective tissue fibroblasts using an inducible Cre-Lox strategy. Tamoxifen-dependent Cre recombinase linked to a fibroblast-specific regulatory sequence from the proalpha2(I)collagen gene permitted deletion of floxed TbetaRII allel...
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PMID: 18563179
PDF is available here.
PDF is available here.
Stomatologiia (88)4 2009
Abstract
In 30 Wistar rats divided in 3 groups with 10 rats in each skin defects were reproduced under anaesthesia and wound surface was fixed with the help of plastic rings. The wounds were contaminated with microbe dredge consisting of St. aureus, Ps. aeruginosa and E. coli in the concentration of 10(9) ce...
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PMID: 19738573
PDF is available here.
PDF is available here.
Wiadomosci Lekarskie (62)3 2009
Abstract
Alkaptonuria is a hereditary disease resulted from accumulation of homogentisic acid within the body due to deficiency of homogentisic acid oxidase. The main clinical feature is dark brown color of urine caused by high urinary output of homogentisic acid. There are no other symptoms or signs of the...
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PMID: 20229718
PDF is available here.
PDF is available here.
Przeglad lekarski (66)12 2009
Abstract
Scleroderma is a connective tissue disease characterized by fibrosis confined only to skin (scleroderma circumscripta, morphea) or to skin and internal organs (systemic sclerosis, SSc) as a result of vascular changes, immune dysfunction and increased production of collagen and other extracellular ma...
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PMID: 20514902
PDF is available here.
PDF is available here.
Abstract
We describe a newborn infant with multiple congenital skull fractures and intracranial hemorrhage. He also had multiple skin folds suggesting a connective tissue abnormality. Electron microscopy of the skin biopsy showed collagen abnormalities with a "hieroglyphic appearance." The analysis of the sy...
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PMID: 18973246
PDF is available here.
PDF is available here.
Abstract
We report these two cases because of their particularities as well as the rarity of papular elastorrhexix. The first exhibited large lesions and mucin deposits while the second was associated with Hodgkin's disease. Differential diagnosis of papular elastorrhexis includes Buschke-Ollendorff syndrome...
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PMID: 19061655
PDF is available here.
PDF is available here.
Minnesota medicine (91)11 2008
Abstract
Leprosy is uncommon in North America. Because it has a prolonged incubation period and can masquerade with a variety of manifestations, many patients with leprosy experience a significant delay in diagnosis and treatment. Lepra reactions are of 2 types: reversal (type 1) and erythema nodosum leprosu...
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PMID: 19108542
PDF is available here.
PDF is available here.
Abstract
After a minor trauma, radiologic examination of the left ankle of a 39-year-old woman revealed features of osteopoikilosis. Physical examination of the patient showed multiple asymptomatic nodules on both thighs, present since the age of 20 years, which had increased in size and number. Recently, a...
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PMID: 18986450
PDF is available here.
PDF is available here.
Rheumatology (47 Suppl 5) 2008
Abstract
PDGF functions as a primary mitogen and chemoattractant for cells of mesenchymal origin. Members of the PDGF family play an important role during embryonic development and contribute to the maintenance of connective tissue in adults. Deregulation of PDGF signalling has been linked to atherosclerosis...
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PMID: 18784131
PDF is available here.
PDF is available here.
Abstract
Blinded pathological and morphometric analysis of collagen fibres in skin biopsies was, in our hands, unable to discriminate reliably between patients with sCAD and controls on an individual basis but did show differences in collagen fibril morphometry on a group basis. Furthermore, systematic and b...
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PMID: 18223019
PDF is available here.
PDF is available here.
Abstract
We have previously established an animal model of skin fibrosis induced by exogenous application of growth factors. In this model, transforming growth factor-beta (TGF-beta) transiently induced subcutaneous fibrosis and serial injections of connective tissue growth factor (CTGF) after TGF-beta cause...
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PMID: 18481257
PDF is available here.
PDF is available here.
Abstract
We investigated the appearance of BMDFs in normal mouse skin after embryonic bone marrow cell transplantation (E-BMT) with green fluorescent protein-transgenic bone marrow cells (GFP-BMCs) via the vitelline vein, which traverses the uterine wall and is connected to the fetal circulation. At 12 weeks...
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PMID: 18688022
PDF is available here.
PDF is available here.
Abstract
We report a patient with IgAD and granulomatous involvement of lungs, spleen and medium-sized arteries of the skin. Although IgAD results from a failure of B-cell differentiation, we propose that deregulated immune response with production of cross-reactive antibodies and hyperstimulation of T cells...
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PMID: 18494827
PDF is available here.
PDF is available here.
Importance of the major Fli C antigenic site of Salmonella enteritidis as a subunit vaccine antigen.
Abstract
We determined histologically if the major antigenic site could be a candidate antigen for SE subunit vaccine. When Layermune SE, a commercial SE bacterin, was injected subcutaneously into the shoulder region as a positive control, the following histological changes were observed: formation of epithe...
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PMID: 18603341
PDF is available here.
PDF is available here.
Abstract
Our results indicate that K14hCXCR2WT transgenic mice exhibited a normal phenotype, while K14hCXCR2 331T/LL/AA/IL/AA transgenic mice were born with tails of normal length, but three to eight days after birth their tails degenerated, leaving only a short tail stub. The tissue degeneration in the tail...
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PMID: 18505935
PDF is available here.
PDF is available here.
Laboratory Investigation (88)8 2008
Abstract
We previously reported that CTMCs expressed signal transducer and activator of transcription (Stat) 4, but MMCs did not. Stat4 is also expressed in T cells and plays important roles in their homeostasis. In the present study, we show that Stat4 is involved in the homeostasis of CTMCs. The number of...
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PMID: 18521064
PDF is available here.
PDF is available here.
Arthritis & Rheumatism (58)8 2008
Abstract
Total and phosphorylated Smad1 levels were significantly elevated in SSc skin biopsy samples and in cultured SSc fibroblasts and correlated with elevated CCN2 protein and CCN2 promoter activity. DNA binding assays demonstrated that Smad1 was a direct activator of the CCN2 gene. Small interfering RNA...
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PMID: 18668566
PDF is available here.
PDF is available here.
Abstract
We found 36 cases (75% women, 63% Caucasian, aged 15 to 82 yr) of nonuremic calciphylaxis. Primary hyperparathyroidism, malignancy, alcoholic liver disease, and connective tissue disease were the most common reported causes. Preceding corticosteroid use was reported for 61% patients. Protein C and S...
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PMID: 18417747
PDF is available here.
PDF is available here.
Biophysical Journal (94)11 2008
Abstract
We report the integrated use of 3D second harmonic generation (SHG) imaging microscopy and Monte Carlo simulation as a combined metric to quantifiably differentiate normal and diseased tissues based on the physical properties of the respective extracellular matrix. To achieve this, we have identifie...
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PMID: 18281387
PDF is available here.
PDF is available here.
Abstract
Our method is able to measure the increased skin extensibility in classical type EDS. Increased skin extensibility is not present in sCAD patients....
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PMID: 18400501
PDF is available here.
PDF is available here.
Abstract
Cutaneous fibrosis and autoimmunity in TSK/+ mice are closely correlated with CD40/CD40L interactions....
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PMID: 17823201
PDF is available here.
PDF is available here.
Abstract
We tested Abcc6(-/-) mice, which serve as a model of PXE, for markers of the oxidative stress in the liver and serum. The total antioxidant capacity as well as markers of protein oxidation and lipid peroxidation suggested the presence of chronic oxidative stress. Feeding these mice for 5 months with...
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PMID: 18049453
PDF is available here.
PDF is available here.
Abstract
Iontophoresis appears to facilitate the transmission of dexamethasone to connective tissues in humans with skinfold thickness up to at least 30 mm. The absorption of the dexamethasone seemed to continue to occur for up to 4 hours after delivery. It is not clear why DEX-P was measured in only 7 of th...
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PMID: 18448879
PDF is available here.
PDF is available here.
Abstract
Abstract
This study reveals that T lymphocytes, Langerhans cells, and natural killer cells may play important roles in the pathogenesis of localized scleroderma....
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PMID: 18412858
PDF is available here.
PDF is available here.
Rheumatology (47)4 2008
Abstract
Dermal fibrosis was histologically observed at day 7 after injection and remained present at day 21. Tissue responses against BLM-PLA microspheres alone were mild. Soluble collagen content and expression level of alpha1(I) collagen mRNA were significantly elevated at day 21. Expression levels of MCP...
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PMID: 18316335
PDF is available here.
PDF is available here.
Journal of Immunology (180)7 2008
Abstract
We recently showed that the CD34(+) acute myeloid leukemia cell line MUTZ-3 supports differentiation of both DC-SIGN(+) IDC and Langerin-positive Birbeck granule-expressing LC. By comparative functional characterization of MUTZ-3 IDC and MUTZ-3 LC, we aimed to elucidate the relative abilities of the...
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PMID: 18354176
PDF is available here.
PDF is available here.
Journal of Neurology (255)3 2008
Abstract
We investigated dermal connective tissue abnormalities using a novel method. Transmission and immunogold electron microscopy were used to study mechanically generated fragments of dermal matrix suprastructures, in particular collagen fibrils. Analysis of dermal tissue of sCAD patients revealed struc...
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PMID: 18338201
PDF is available here.
PDF is available here.
Infection and Immunity (76)3 2008
Abstract
We show that both DbpA and DbpB are critical for the overall virulence of B. burgdorferi in the murine host. Disruption of the dbpBA locus led to nearly a 10(4)-fold increase in the 50% infectious dose (ID50). Complementation of the mutant with either dbpA or dbpB reduced the ID50 from over 10(4) to...
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PMID: 18195034
PDF is available here.
PDF is available here.
Abstract
I expression of the cells. The coding sequences of TGF-beta I and tTGFbetaRII were amplified using RT-PCR and then cloned into pGBKT7 and pGADT7 vectors. A yeast two-hybrid experiment and a glutathione S-transferase (GST)-pull down assay were performed to verify the affinity of tTGFbetaRII to TGF-be...
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PMID: 18382895
PDF is available here.
PDF is available here.
Abstract
This study confirmed the effects of acoustic wave therapy on biologic tissue, including stimulation of microcirculation and improvement of cell permeability. Ultrasound evaluation demonstrated increased density and firmness in the network of collagen/elastic fibers in the dermis and subcutis. Treatm...
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PMID: 19083577
PDF is available here.
PDF is available here.
Abstract
The study of microflora of skin, mucous tunic of nose and mouth, and the quantitative and qualitative structure of the intestinal and urinal microflora in cases of systemic connective tissues diseases, are reproduced. The decrease of the dominant state of typical representatives, and the increase of...
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PMID: 18488449
PDF is available here.
PDF is available here.
Revue medicale de Liege (63)7-8 2008
Abstract
The etiology of recurrent preterm premature rupture of fetal membranes (PPROM) is varied. Skin biopsies were performed in women who presented recurrent PPROM of unknown origin, searching for a possible general expression of a connective tissue disorder. In the majority of cases, ultrastructural abno...
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PMID: 18771231
PDF is available here.
PDF is available here.
Abstract
FP treatment was associated with a substantial improvement in the appearance of SD at 8 weeks post-treatment. The erythema index and melanin index of the treated SD lesions tended to converge with those of the control skin at 4-week follow-up. Skin elasticity was found to be partially normalized aft...
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PMID: 18092841
PDF is available here.
PDF is available here.
Abstract
Vasculitis is an inflammatory process affecting the vessel wall and leading to its compromise or destruction and subsequent hemorrhagic and ischemic events. Vasculitis can be classified as a primary phenomenon (e.g. idiopathic cutaneous leukocytoclastic angiitis or Wegener granulomatosis) or as a se...
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PMID: 18284262
PDF is available here.
PDF is available here.
Abstract
Lymphedema is a soft-tissue swelling that occurs following lymphatic fluid accumulation. Edema is due to insufficient lymphatic drainage that occurs because of lymphatic vessel obstruction or absence [1]. Chronic lymphedema can cause a clinical picture of tense non-pitting edema with thickened epide...
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PMID: 18627721
PDF is available here.
PDF is available here.
Abstract
We developed rat and mouse models to study SBI and the underlying cellular mechanisms. The animal modeling mimics a neurosurgical operation and causes commonly encountered postoperative complications such as brain edema following blood brain barrier (BBB) disruption, and neuronal cell death. Further...
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PMID: 18508474
PDF is available here.
PDF is available here.
Abstract
The identification of sclerosis in biopsies of skin lesions typical clinically for DM may be a harbinger for more severe autoimmune-based endothelial cell injury phenomenon. One could speculate that its basis may be attributable to elevated serum levels of the natural fibrogenic factor, transforming...
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PMID: 18095992
PDF is available here.
PDF is available here.
Przeglad lekarski (65)10 2008
Abstract
Tobacco smoking is considered to be one of the main factors that negatively affect the skin, mucous membranes and teeth, i.e. the body parts that decide on the so called 'healthy look' and 'attraction'. This paper is a review of literature on the subject of harmful and pathological influence of tobac...
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PMID: 19189590
PDF is available here.
PDF is available here.
Molecular Vision (14) 2008
Abstract
Our results support that ABCC6 is the most important, and probably the only, causative gene of PXE. In total, 188 different ABCC6 mutations have now been reported in PXE in the literature....
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PMID: 18253096
PDF is available here.
PDF is available here.
Abstract
Changes in skin elasticity have been analyzed under different conditions (upon skin stretching, at different thickness of the skin, at different contents of collagen, intercellular and endocellular liquids, upon changes of venous pressure, and during contraction and relaxation of smooth muscles in s...
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PMID: 18488513
PDF is available here.
PDF is available here.