Abstract
We explain the background of functional MRI, compare it to other clinical mapping methods, explain the intricacies of paradigm selection, and show the limitations of the technique while also pointing out alternative uses....
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PMID: 22059362
PDF is available here.
Abstract
We investigated whether the exercise response varied by the prior duration of exposure to androgen suppression therapy, that is acute-less than 6 months vs later-6 months or greater....
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PMID: 21849187
PDF is available here.
Abstract
To bring together information concerning the epidemiology and the economic and individual burdens of glaucoma.
Interpretive essay.
Review and synthesis of selected literature published from 1991 through December 2010.
An estimated 3% of...
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PMID: 21961848
PDF is available here.
Abstract
Kidney transplantation is an efficient treatment of end stage renal disease, decreasing patient mortality by comparison with mortality in dialysis and improving patient quality of life. The number of patients living in France with a functioning transplant is almost as high as the num...
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PMID: 21964044
PDF is available here.
Abstract
We describe a modified form of WBT which has been applied for the first time to children suffering from emotional and behavioral disorders in order to test its feasibility and potential effects in reducing symptoms and in improving new skills. Four cases particularly interesting by a clinical point...
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PMID: 21938080
PDF is available here.
Abstract
There have been very few studies on inflammatory bowel disease (IBD) in Sri Lanka. This study was undertaken to determine the clinical presentation and whether a western style diet or infection with geo-helminths were associated with the condition.
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PMID: 21922853
PDF is available here.
Abstract
This study assessed outcomes of individuals with advanced cancer who required admission to an intensive care unit (ICU) after referral for an early clinical trial because they did not respond to conventional therapy.
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PMID: 21844494
PDF is available here.
Abstract
We hypothesized that early EUS-CPN would reduce pain and morphine consumption, increase quality of life (QOL), and prolong survival....
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PMID: 21844506
PDF is available here.
Abstract
The benefits of reflexology are explored in the fourth article in our series on complementary and alternative therapies.
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PMID: 21905374
PDF is available here.
Abstract
This article provides an overview of the care of patients following liver transplantation. It focuses on the immediate post-operative care, the role of the transplant co-ordinator in providing support and education and the long-term follow up required to promote health and quality of life in this spe...
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PMID: 21905380
PDF is available here.
Abstract
We examine how public health has integrated health promotion by exploring examples of changes in public health systems and practice at international and national levels of governance. Nevertheless, an important challenge remains for health promotion: better use of research to understand how the valu...
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PMID: 21913576
PDF is available here.
Abstract
Ageing of the population, together with prolonged retention of teeth, has brought new challenges to dentistry. Whereas in the past oral care for the elderly was restricted to provision of dentures, older patients are now presenting with dental caries and failed restorations. These problems may have a...
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PMID: 21905350
PDF is available here.
David J Thurman,
Ettore Beghi,
Charles E Begley,
Anne T Berg,
Jeffrey R Buchhalter,
Ding Ding,
Dale C Hesdorffer,
W Allen Hauser,
Lewis Kazis,
Rosemarie Kobau,
Barbara Kroner,
David Labiner,
Kore Liow,
Giancarlo Logroscino,
Marco T Medina,
Charles R Newton,
Karen Parko,
Angelia Paschal,
Pierre-Marie Preux,
Josemir W Sander,
Anbesaw Selassie,
William Theodore,
Torbjörn Tomson and
Samuel Wiebe
Abstract
We discuss: (1) conceptual and operational definitions of epilepsy, (2) data resources and recommended data elements, and (3) methods and analyses appropriate for epidemiologic studies or the surveillance of epilepsy. Variations in these are considered, taking into account differing resource availab...
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PMID: 21899536
PDF is available here.
William C WC Reeves,
Tara W TW Strine,
Laura A LA Pratt,
William W Thompson,
Indu I Ahluwalia,
Satvinder S SS Dhingra,
Lela R LR McKnight-Eily,
Leslie L Harrison,
Denise V DV D'Angelo,
Letitia L Williams,
Brian B Morrow,
Deborah D Gould,
Marc A MA Safran and
Abstract
Mental illnesses account for a larger proportion of disability in developed countries than any other group of illnesses, including cancer and heart disease. In 2004, an estimated 25% of adults in the United States reported having a mental illness in the previous year. The economic co...
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PMID: 21881550
PDF is available here.
Abstract
Baseline patient-reported kidney cancer symptoms are linked to mPFS and mOS in a clear and interpretable way. These results support the evaluation of patient-reported symptoms at baseline in clinical trials and in clinical practice to measure symptom severity and potentially predict progression-free...
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PMID: 21476015
PDF is available here.
Abstract
Policies focused on enhancing the palliative care workforce, investing in the field's science base, and increasing the availability of services in U.S. hospitals and nursing homes are needed to ensure equitable access to optimal care for seriously ill patients and those with multiple chronic conditi...
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PMID: 21933272
PDF is available here.
Abstract
Sexual dysfunction in patients diagnosed with depressive disorders affect all phases of sexual response: a decline in libido, erectile dysfunction, ejaculation disorders in men and orgasm and menstruation in women. It is estimated that are present in approximately 70% of patients, af...
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PMID: 21991854
PDF is available here.
Anthony J AJ Lembo,
Harvey A HA Schneier,
Steven J SJ Shiff,
Caroline B CB Kurtz,
James E JE MacDougall,
Xinwei D XD Jia,
James Z JZ Shao,
Bernard J BJ Lavins,
Mark G MG Currie,
Donald A DA Fitch,
Brenda I BI Jeglinski,
Paul P Eng,
Susan M SM Fox and
Jeffrey M JM Johnston
Abstract
Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase C receptor. In two trials, we aimed to determine the efficacy and safety of linaclotide in patients with chronic constipation.
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PMID: 21830967
PDF is available here.
Abstract
Study Type - Therapy (case series). Level of Evidence: 4. What's known on the subject? and What does the study add? Bilateral nerve-sparing radical prostatectomy still represents an issue for urologists as the indications to perform it depend oft from the personal clinical experience. Moreover, unt...
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PMID: 21091973
PDF is available here.
Abstract
Depressive symptoms are known to compromise health status in cardiac disease, but this relationship has not been described in peripheral artery disease (PAD). Depressive symptoms (PHQ-9) and disease-specific health status (Peripheral Artery Questionnaire, PAQ) were assessed in 242 PAD patients underg...
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PMID: 21828173
PDF is available here.
Abstract
Nowadays, measuring score in the form ofsubjective questionnaires is the important toolfor clinical evaluation ofthe foot and ankle-related problems. VisualAnalogue Scale-Foot and Ankle (VAS-FA) is the newly developed subjective questionnaire, which has sufficiency ofvalidity and rel...
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PMID: 21863677
PDF is available here.
Abstract
To investigate, using Rasch analysis, whether the 15-item Glaucoma Quality of Life-15 (GQL-15) forms a valid scale and to optimize its psychometric properties.
One hundred eighteen glaucoma patients (mean age, 65.7 years) completed the German-version of the GQL-15. Ra...
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PMID: 21810983
PDF is available here.
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease that disproportionately affects women of childbearing age during their most productive years. Current therapeutic measures have improved patient survival; however, the impact of interventions on general and specific domains...
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PMID: 21633837
PDF is available here.
Abstract
Valid patient-based outcome instruments are necessary for comprehensive patient care that focuses on all aspects of health, from impairments to participation restrictions.
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PMID: 21828379
PDF is available here.
Abstract
To evaluate open-label adalimumab therapy for clinical effectiveness, fistula healing, patient-reported outcomes and safety in Canadian patients with moderate to severe Crohn's disease (CD) who were either naive to or previously exposed to antitumour necrosis factor (anti-TNF) therapy.
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PMID: 21912766
PDF is available here.
Abstract
This review describes the fact that many elderly people enjoy an active sex life and examines the evidence against the general perception of an 'asexual' old age. It offers an overview of the evidence for healthcare professionals who had not previously considered the sexuality of the...
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PMID: 21778176
PDF is available here.
Abstract
Although children with unilateral hearing loss (UHL) are at risk for educational difficulties and behavioral problems, the research on treatment outcomes is limited. Previous studies suggested that children with UHL would benefit from frequency-modulated assistive devices only. The o...
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PMID: 21859053
PDF is available here.
Abstract
These results provide new and valuable insights regarding the onset, course, progression, and treatment of SD....
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PMID: 21859056
PDF is available here.
Abstract
SummaryBackground and objectives Demand for hemodialysis among elderly patients is increasing worldwide. Although clinical care of this high-risk group is complex and challenging, no guidelines exist to inform hemodialysis practices. The Dialysis Outcomes and Practice Patterns Study...
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PMID: 21734085
PDF is available here.
Abstract
Atrial fibrillation (AF) is common in patients with heart failure (HF) and portends a worsened prognosis. Because of the low enrollment of African American subjects (AAs) in randomized HF trials, there are little data on AF in AAs with HF. This post hoc analysis reviews characteristics and outcomes o...
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PMID: 21742102
PDF is available here.
Abstract
We evaluated whether this risk can be minimized by using trial metal wedges. Using our study's evaluation tools, the incidence of postoperative plantar lateral foot discomfort before and after using trial metal wedges was determined....
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PMID: 21972760
PDF is available here.
Abstract
Personality factors have shown to be related to mortality, morbidity, and psychological aspects in chronic disorders. Little is known about the effect of personality on disease severity in sarcoidosis and idiopathic pulmonary fibrosis (IPF). The aim of this study was to assess the pr...
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PMID: 21796893
PDF is available here.
Abstract
Purpose. Adolescents with inflammatory bowel disease (IBD) may be at heightened risk for developing anxiety and depression. This cross-sectional pilot study examined the relationship between anxiety and depression and health-related behaviors. Methods. Thirty-six adolescents wi...
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PMID: 21702881
PDF is available here.
Abstract
We created a simple prognostic tool to estimate this combined outcome. Methods and Results We identified factors associated with 6-month mortality or persistently unfavorable QoL, defined by Kansas City Cardiomyopathy Questionnaire (KCCQ) scores <45 at 1 and 24 weeks after hospital discharge, among...
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PMID: 21693723
PDF is available here.
Abstract
Patients exhibited greater fatigue, reduced cardiorespiratory function, higher Medical Research Council (MRC) scores and higher plasma TNF-α concentrations than controls at all times. Plasma IL-1β levels did not differ between cohorts. Patients exhibited a 28% increase (statistically not signif...
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PMID: 21679351
PDF is available here.
Abstract
The objective of this study was to identify patterns of interest in receiving care for sexual concerns among women who were survivors of gynecologic and breast cancers.
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PMID: 21656742
PDF is available here.
Abstract
Despite substantial improvements in trauma care, severe injuries often result in significant long-term consequences for otherwise young, healthy individuals. Providing patient-centered care and extensive psychosocial support services is difficult for trauma centers.
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PMID: 21817993
PDF is available here.
Jennifer Steel,
David A Geller,
Allan Tsung,
J Wallis Marsh,
Mary Amanda Dew,
Michael Spring,
Jonathan Grady,
Sonja Likumahuwa,
Andrea Dunlavy,
Michael Youssef,
Michael Antoni,
Lisa H Butterfield,
Richard Schulz,
Richard Day,
Vicki Helgeson,
Kevin H Kim and
T Clark Gamblin
Abstract
Collaborative care interventions to treat depression have begun to be tested in settings outside of primary care. However, few studies have expanded the collaborative care model to other settings and targeted comorbid physical symptoms of depression.
The aims of this...
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PMID: 21730078
PDF is available here.
Abstract
Hereditary hemorrhagic telangiectasia (HHT) is associated with recurrent epistaxis in 90% of the cases. Good response to hormone treatment has been documented, although its use remains controversial. The aim of this study was to examine the efficacy of an anti-estrogenic agent, tamoxifen, in the trea...
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PMID: 21743879
PDF is available here.
Abstract
Hand-foot syndrome is a highly unpleasant adverse reaction caused by treatment protocols containing capecitabine (an orally administered drug), docetaxel, liposomal doxorubicin infusions or continuously infused 5-fluorouracil. It affects the skin of the palms and soles manifesting characteristic symp...
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PMID: 21655474
PDF is available here.
Abstract
I psychiatric disorders after adjusting for medical conditions, health-related quality of life, and stressful life events. Community-dwelling respondents from nationally representative US samples (n = 33,231) were interviewed in 2000-2001 and 2004-2005. Past-year disordered gambling at baseline was...
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PMID: 21467151
PDF is available here.
Claudio Marcocci,
George J Kahaly,
Gerasimos E Krassas,
Luigi Bartalena,
Mark Prummel,
Matthias Stahl,
Maria Antonietta Altea,
Marco Nardi,
Susanne Pitz,
Kostas Boboridis,
Paolo Sivelli,
George von Arx,
Maarten P Mourits,
Lelio Baldeschi,
Walter Bencivelli,
Wilmar Wiersinga and
European Group on Graves' Orbitopathy
Abstract
We carried out a randomized, double-blind, placebo-controlled trial to determine the effect of selenium (an antioxidant agent) or pentoxifylline (an antiinflammatory agent) in 159 patients with mild Graves' orbitopathy. The patients were given selenium (100 μg twice daily), pentoxifylline (600 mg t...
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PMID: 21591944
PDF is available here.
Abstract
Incontinence after radical prostatectomy is common yet poorly defined in the current literature. We aimed to accurately characterize incontinence after robot-assisted radical prostatectomy to achieve improved preoperative patient counseling.
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PMID: 21575975
PDF is available here.
Thierry Conroy,
Françoise Desseigne,
Marc Ychou,
Olivier Bouché,
Rosine Guimbaud,
Yves Bécouarn,
Antoine Adenis,
Jean-Luc Raoul,
Sophie Gourgou-Bourgade,
Christelle de la Fouchardière,
Jaafar Bennouna,
Jean-Baptiste Bachet,
Faiza Khemissa-Akouz,
Denis Péré-Vergé,
Catherine Delbaldo,
Eric Assenat,
Bruno Chauffert,
Pierre Michel,
Christine Montoto-Grillot,
Michel Ducreux,
Groupe Tumeurs Digestives of Unicancer and
PRODIGE Intergroup
Abstract
We randomly assigned 342 patients with an Eastern Cooperative Oncology Group performance status score of 0 or 1 (on a scale of 0 to 5, with higher scores indicating a greater severity of illness) to receive FOLFIRINOX (oxaliplatin, 85 mg per square meter of body-surface area; irinotecan, 180 mg per...
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PMID: 21561347
PDF is available here.
Abstract
Surgical ligation and stripping of varicose veins has been the accepted treatment for almost a century but within the last decade this has been challenged by endovenous thermal and chemical ablation methods. Surgery is not without significant complications including paraesthesia and has reflux recurr...
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PMID: 21550521
PDF is available here.
Abstract
Eosinophilic esophagitis (EoE) is an inflammatory disorder with increasing prevalence. It typically presents with swallowing difficulties, heartburn or dyspepsia, and in toddlers, failure to thrive. EoE is characterized by eosinophilic infiltrates of the esophageal mucosa, and endosc...
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PMID: 21678636
PDF is available here.
Abstract
To establish feasibility for the hypothesis that patients in acute rehabilitation who are hospitalized for disorders not known to involve cerebral injury can have significant cognitive impairment.
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PMID: 21570030
PDF is available here.