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Jaw Diseases (8):
Recent article
Jaw Diseases
Abstract
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Clinical calcium (20)11 2010
Abstract
Clinical calcium (20)11 2010
Abstract
Abstract
Treatment options in cases of severe craniofacial disorders with bone loss and tissue damage are usually limited to vascularized and nonvascularized tissue transfers, allografts, mechanical devices and, more recently, facial transplantation. Despite the therapies available, the demand for new approa...
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PMID: 21042127
PDF is available here.
PDF is available here.
Abstract
RANKL was expressed in all cases with a cytoplasmic staining pattern, whereas OPG expression was detected in 21 of the 22 cases examined. Active multinucleated giant cells exhibited intense immunoreactivity for both proteins.Conclusion: RANKL and OPG are expressed in peripheral giant cell granulomas...
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PMID: 20701665
PDF is available here.
PDF is available here.
Abstract
There are no previously published reports on fibro-osseous jaw lesions in Thailand. The aims of this study were to determine the relative frequencies and the clinicopathologic features of these lesions in Thailand, and to compare these data with information available in the literature.
A total of 12...
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PMID: 20819127
PDF is available here.
PDF is available here.
Abstract
I (control, 20 rats without drug treatment), group II (60 animals administered dexamethasone 1 mg/kg/day for 7, 14 and 21 days, in subgroups of 20 animals each), group III (60 animals administered pamidronate daily at a dose of 3 mg/kg) and group IV (60 animals administered pamidronate and dexametha...
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PMID: 20819131
PDF is available here.
PDF is available here.
Abstract
The results of this case series demonstrated that age and poor oral health status are significant risk factors of BRONJ for oncology patients on long-term frequent dosing schedule of i.v. bisphosphonates....
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PMID: 20522306
PDF is available here.
PDF is available here.
Abstract
We report 12 cases of JONOBP observed from January 2007 to January 2009.
A pluridisciplinary committee including odontologists, stomatologists, and maxillofacial surgeons from two Paris hospitals was asked to manage patients treated by BP. Twelve patients presenting with JONOBP were included from Ja...
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PMID: 20810140
PDF is available here.
PDF is available here.
Abstract
We retrieved 2,408 cases, 88% of which were associated with intravenous therapy, primarily with zoledronate. Of the total number of cases, 89% were associated with the treatment of a malignant condition, particularly multiple myeloma (43% of the cases). Of all the BIOJ cases, 67% were preceded by to...
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PMID: 20508948
PDF is available here.
PDF is available here.
Abstract
We studied 25 consecutive patients treated with bisphosphonates for osteoporosis or tumoral pathologies. We provide good evidence of hyperactive osteoclastic bone resorption and suggest a direct cytotoxic effect of bisphosphonates on bone tissue through induction of osteocyte cell death. We also dem...
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PMID: 20594040
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Abstract
Experimental research is scarce, and clinical studies are especially lacking in terms of randomized controlled studies. Although discussions on the subject are ongoing, most studies suggest a beneficial role for HBO in previously irradiated tissue. CONCLUSION: Further research, both experimental and...
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PMID: 20493616
PDF is available here.
PDF is available here.
Abstract
Medical Oncology (27)2 2010
Abstract
Medical Oncology (27)2 2010
Abstract
We reviewed data relating to 398 patients treated with intravenous BP for bone metastases, checking their serum creatinine levels throughout the treatment period in order to assess renal function, and seeking any signs and symptoms of ONJ recorded in their medical records. We also analysed other ris...
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PMID: 19330470
PDF is available here.
PDF is available here.
Lancet Oncology (11)6 2010
Abstract
Abstract
A careful dental clinical examination and appropriate imaging study is recommended before starting bisphosphonate therapy. The doctors prescribing Bisphosphonates especially intravenous preparations should not only counsel the patients but also routinely examine patient's oral cavity....
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PMID: 20071132
PDF is available here.
PDF is available here.
Abstract
Abstract
This study was conducted to determine if microbial infection was a significant factor in patients with undiagnosed craniofacial pain. Of the 150 patients from whom intra-bony cultures were obtained, 23 different groups of isolates were obtained. There were 49 (32.67%) patients whose cultures exhibit...
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PMID: 20491231
PDF is available here.
PDF is available here.
Abstract
We describe two patients exhibiting the clinical manifestations of bisphosphonate-associated osteonecrosis of the jaw. A brief review of the literature on the incidence, possible risk factors, and practice guidelines is also presented....
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PMID: 20354251
PDF is available here.
PDF is available here.
Abstract
The eNOS T-786C polymorphism affecting NO production is associated with NICO, may contribute to the pathogenesis of NICO, and may open therapeutic medical approaches to treatment of NICO through provision of L-arginine, the amino-acid precursor of NO.
Copyright 2010 Mosby, Inc. All rights reserved....
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PMID: 20185342
PDF is available here.
PDF is available here.
Abstract
While there is a hereditary component to tori, this does not explain all cases. Tori tend to appear more frequently during middle age of life; the torus palatinus is more commonly observed in females, but this is not the case with the torus mandibularis. Certain ethnic groups are more prone to one t...
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PMID: 19767716
PDF is available here.
PDF is available here.
Abstract
The aim of this paper is to explore the current theories about definition, classification, incidence and physiopathology of osteoradionecrosis (ORN) of the jaws. Moreover, it is discussed the predisposing and risk factors for the development of osteoradionecrosis based on the literat...
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PMID: 20119841
PDF is available here.
PDF is available here.
Abstract
Microbial biofilms have been observed and described in bone specimens of patients with bisphosphonate (BP)-associated osteonecrosis of the jaw (BONJ) and investigators are more recently suggesting that this condition essentially represents an osteomyelitis of the jaw clinically, with...
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PMID: 20425090
PDF is available here.
PDF is available here.
Abstract
We first attempted to investigate the SH3BP2 gene in peripheral giant cell lesion (PGCL). The effect of SH3BP2 gene mutations on the transcription of the downstream genes nuclear factor of activated T cells (NFATc1) and the cytokine tumor necrosis factor-alpha (TNF-alpha) was also investigated toget...
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PMID: 20002873
PDF is available here.
PDF is available here.
Abstract
We describe the cases of 2 patients affected by this condition. For one patient, a recurrence occurred 4 years after the elimination of cranial hyperostosis. In the second patient, although we observed macrosomia and peculiar countenance in the context of craniofacial hyperostosis, the patient did n...
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PMID: 20216456
PDF is available here.
PDF is available here.
Abstract
The effects of antiresorptive agents (e.g., alendronate [Aln], osteoprotegerin [OPG]) on bone infection are unknown. Thus, their effects on implant-associated osteomyelitis (OM) were investigated in mice using PBS (placebo), gentamycin, and etanercept (TNFR:Fc) controls. None of the drugs affected h...
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PMID: 20392222
PDF is available here.
PDF is available here.
Dental update (37)2 2010
Abstract
Abstract
Abstract
Abstract
We have developed a mouse model of BRONJ-like disease that recapitulates major clinical and radiographic manifestations of the human disease, including characteristic features of an open alveolar socket, exposed necrotic bone or sequestra, increased inflammatory infiltrates, osseous sclerosis, and r...
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PMID: 20200952
PDF is available here.
PDF is available here.
Implant Dentistry (19)1 2010
Abstract
We conclude that the serum CTX is not a valid preoperative test to accurately assess the level of risk of developing ONJ and is not indicated in the oral surgery patient....
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PMID: 20147814
PDF is available here.
PDF is available here.
Abstract
Hemophilic pseudotumors are observed in 1 to 2 % of severe hemophilia cases. They are very rare in the maxilla and mandible. Traumatic etiology is the most frequent. Osteolysis is the main radiological aspect. The treatment is usually enucleation, curettage, or intralesional fibrin glue injection....
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PMID: 20080276
PDF is available here.
PDF is available here.
Abstract
Abstract
We recommend the administration during the haemodialysis session. When bisphosphonates are given to 4-5 CKD patients it seems reasonable to reduce the dose to 50%. No renal pathology has been associated to oral administration. The indications of bisphosphonates in CKD include: hypercalcemia episodes...
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PMID: 20514097
PDF is available here.
PDF is available here.
Abstract
Abstract
The aim of this retrospective analysis was to determine the age, gender, frequency and distribution of trauma-associated hard tissue and soft tissue lesions of the oral and maxillofacial region in a population from southern Taiwan.
Approximately 10% of the 27,995 biopsy records of patients with hist...
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PMID: 20379675
PDF is available here.
PDF is available here.
Abstract
Osteoporosis is very common, particularly in post-menopausal women and is characterized by a decrease in bone mass and strength. Osteoporosis also affects the jawbone and it is considered a potential contraindication to placement of dental implants. The present paper reviews the literature regarding...
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PMID: 19767691
PDF is available here.
PDF is available here.
Abstract
Bisphosphonates inhibit bone resorption and are used to treat a range of pathologies, including Paget disease, osteoporosis, multiple myeloma and metastases associated with breast or prostate cancer. At present, there is no effective treatment for bisphosphonate induced osteonecrosis, so prevention...
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PMID: 19767707
PDF is available here.
PDF is available here.
Abstract
A case of black-grain mycetoma occurring on the lower jaw with an odontogenic origin, which to our knowledge is the first case reported in China, is presented here. The clinical manifestation, histopathological morphology, and microbiological features are described. The new species, Madurella pseudo...
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PMID: 19923486
PDF is available here.
PDF is available here.
Abstract
Orthopaedic Nursing (29)3 2010
Abstract
An emerging problem for patients taking bisphosphonate (BSP) medications for osteoporosis or cancer therapies has been the occurrence of osteonecrosis of the jaws (ONJ), most often after dental surgical procedures. ONJ can be a persistent and discomforting condition that can also be refractory to va...
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PMID: 20505486
PDF is available here.
PDF is available here.
Abstract
Abstract
The efficacy of bisphosphonate in controlling skeletally-related event in cancer patients without a great number of adverse events has resulted in a widespread use of these medications in oncology. Zoledronic acid and pamidronate are the most common bisphosphonates intravenously administered as a pr...
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PMID: 20487624
PDF is available here.
PDF is available here.
Abstract
We divided the 25 patients into two groups: those who had not received any treatment and those who had received treatment. The first group of 13 patients had been treated only with spiramycin (S). The results from this group were only evaluated to test the efficacy of spiramycin and were not conside...
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PMID: 20646357
PDF is available here.
PDF is available here.
Abstract
Cancer Investigation (27)10 2009
Abstract
The primary outcome was 30%. The secondary outcome was 3%, while six patients (5%) were referred to a dentist for suspected ONJ. CONCLUSION: There appears to be a continued benefit when intravenous bisphosphonates are given for longer than 21 months....
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PMID: 19909013
PDF is available here.
PDF is available here.
Implant Dentistry (18)6 2009
Abstract
I collagen is a marker of osteoclast activity and is used to assess the level of bone resorption. Recently, in oral and maxillofacial surgery, it was proposed that the levels of serum cross-linked C-telopeptide of type I collagen may predict the subsequent risk of developing osteonecrosis of the jaw...
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PMID: 20009603
PDF is available here.
PDF is available here.
Dental update (36)10 2009
Abstract
We provide an overview of the impact of the treatments of malignant diseases on the oral structures. Whilst some of the complications, such as oral mucositis and oral infection, are of short duration and respond once chemotherapy has been completed, other treatments have a prolonged effect. Of parti...
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PMID: 20166375
PDF is available here.
PDF is available here.
Abstract
Clinical calcium (19)9 2009
Abstract
Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a newly emerging condition in a long-term administration of mainly intravenous bisphosphonates for the treatment of hypercalcemia associated with malignancy, multiple myeloma, and metastatic breast and prostate cancers. The incidence of BRO...
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PMID: 19721206
PDF is available here.
PDF is available here.
Dental update (36)7 2009
Abstract
Bisphosphonates are increasingly being used in a number of bone conditions, including osteoporosis and metastatic cancer. As a consequence, the reported cases of bisphosphonate-related osteonecrosis of the jaw (BONJ) have increased. BONJ remains rare in patients being treated for osteoporosis, but i...
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PMID: 19810397
PDF is available here.
PDF is available here.
Abstract
Texas dental journal (126)7 2009
Abstract
Abstract
Abstract
Abstract
Multiple myeloma causes debilitating clinical symptoms including intractable bone pain, disabling multiple fractures and hypercalcemia. Bisphosphonates, potent inhibitors of osteoclast-mediated bone destruction, prevent skeletal-related events in myeloma. However, the impact of long-term bisphosphon...
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PMID: 19432122
PDF is available here.
PDF is available here.