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Transplantation (10):
Recent article
Transplantation
Abstract
I at varying ratios. Maturation of cardiac function in embryoid bodies formed from hESCs was documented in terms of spontaneous contractile behavior and the mRNA and protein expression of cardiac markers. Hydrogel with high ECM content (75% ECM, 25% collagen, no supplemental soluble factors) increas...
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PMID: 21744185
PDF is available here.
PDF is available here.
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Abstract
Transplant International (24 Suppl 3) 2011
Abstract
Circulation (124)11 Suppl 2011
Abstract
We previously showed that adenoviral-delivered overexpression of an endogenous inhibitor, the tissue inhibitor of metalloproteinases-3 (TIMP-3), significantly retarded intimal thickening in short-term autologous porcine arteriovenous interposition grafts (28 days). However, it is essential to determ...
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PMID: 21911803
PDF is available here.
PDF is available here.
Circulation (124)11 Suppl 2011
Abstract
We performed a cell trafficking experiment, which demonstrated significantly greater recruitment of bone marrow cells to the ischemic myocardium in the double-knockdown group. Fluorescence-activated cell sorting showed significantly higher activation of endogenous c-kit(+) cardiac progenitor cells....
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PMID: 21911818
PDF is available here.
PDF is available here.
Abstract
Circulation Research (109)4 2011
Abstract
Abstract
We investigated the effect of stable over-expression of constitutively active HIF-1α on cardiosphere-derived cell (CDC) engraftment and left ventricular function. CDCs were transduced with a lentivirus expressing a constitutively active mutant of human HIF-1α (LVHIF-1α). Two million male rat CDCs...
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PMID: 21538185
PDF is available here.
PDF is available here.
Abstract
We suggest the need for further elucidation of the biology of Schwann cell differentiation and the signals for their derivation from MSC, in order to resolve these obstacles and to enable transplantation of MSC-derived Schwann cells as a therapeutic strategy in CNS injury....
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PMID: 21495967
PDF is available here.
PDF is available here.
Abstract
Parkinson's disease (PD), a common degenerative disease in humans, is known to result from loss of dopamine neurons in the substantia nigra and is characterized by severe motor symptoms of tremor, rigidity, bradykinsia and postural instability. Although levodopa administration, surgi...
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PMID: 21495962
PDF is available here.
PDF is available here.
Abstract
We are just beginning to harness that potential using stem cells in bone tissue engineering. ASC are the primary focus of this review due to their abundance and relative ease of accessibility for autologous procedures. This article outlines the current knowledge base in bone mechanobiology to invest...
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PMID: 21338267
PDF is available here.
PDF is available here.
Abstract
To evaluate the therapeutic efficiency of tissue-engineered human corneal endothelia (TE-HCEs) on rabbit primary corneal endotheliopathy (PCEP), TE-HCEs reconstructed with monoclonal human corneal endothelial cells (mcHCECs) and modified denuded amniotic membranes (mdAMs) were transp...
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PMID: 21634043
PDF is available here.
PDF is available here.
Abstract
We compare the effectiveness of the differentiation protocols applied, the markers and functional assays used to characterize differentiated progeny, and the in vivo controls. We further speculate on how MSC derived from Wharton's jelly of human umbilical cord may represent a more promising regenera...
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PMID: 20972649
PDF is available here.
PDF is available here.
Abstract
We review the concept of standardization and propose an exhaustive framework for the proper management of technology on pluripotent stem cells based on studies of global and regional initiatives. We demonstrated detailed observational analysis on global initiatives for the standardization of related...
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PMID: 21086070
PDF is available here.
PDF is available here.
Abstract
We review the possible mechanisms of PSC-derived cardiomyocytes rejection, summarize the current knowledge pertaining to immunogenicity of such cells and describe the existing controversies. Myocardial graft rejection can be reduced by modifying PSCs prior to their differentiation into cardiomyocyte...
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PMID: 21086071
PDF is available here.
PDF is available here.
Liver Transplantation (17)6 2011
Abstract
We used sequential high-abundance protein depletion and isobaric tag for relative and absolute quantitation liquid chromatography-tandem mass spectrometry to characterize the serum proteome in serum samples of patients with or without ACR. Seven of the 41 proteins identified as differentially abunda...
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PMID: 21618694
PDF is available here.
PDF is available here.
Hereditas (Beijing) (33)6 2011
Abstract
Inheritable variation induced by plant grafting is a universal phenomenon; however, its mechanism has always been a controversial subject. In recent years, research on horizontal transfer of genetic materials between stock and scion has made great progress. The latest studies have found that genetic...
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PMID: 21684863
PDF is available here.
PDF is available here.
Abstract
We have investigated the role of IL-23/IL-17 pathway in acute and chronic airway allograft rejection. We used a rat OB model in orthotopic tracheal transplantation, and investigated the effects of anti-IL-23 blockade antibody on acute and chronic airway allograft rejection. Anti-IL-23 antibody impai...
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PMID: 21094688
PDF is available here.
PDF is available here.
Abstract
We propose a tissue engineering approach concerning the fabrication of an electrospun cardiac graft functionalized with G-CSF, in order to provide the correct signalling sequence to orientate myoblast differentiation and exert important systemic and local effects, positively modulating the infarctio...
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PMID: 20518852
PDF is available here.
PDF is available here.
Abstract
As important effector cells of the innate immune system, neutrophils are involved in rejection of solid organ and/or tissue transplants. But their role in rejection of oral mucosa transplantation (OMT) remains unclear. The aim of this study is to observe the spatial-temporal change o...
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PMID: 21196830
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We recently developed a new method termed VelociMouse for the production of F0-generation mice that are fully derived from gene-targeted ES cells. In the version of the VelociMouse method described here, laser ablation of a portion of the zona pellucid (zp) of a normal eight-cell-stage embryo facili...
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PMID: 19266341
PDF is available here.
PDF is available here.
Abstract
We develop a simplified procedure that can be useful for large-scale screening of factors that can modulate the hair formation ability of candidate cells. Newborn mouse cells are used. Dissociated epidermal and dermal cells in high-density suspension are allowed to reconstitute in vitro to generate...
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PMID: 21034159
PDF is available here.
PDF is available here.
Abstract
We have recently shown that allogeneic intrabone marrow-bone marrow transplantation + adult thymus transplantation (TT) is effective for hosts with malignant tumors. However, since thymic and hematopoietic cell functions differ with age, the most effective age for such intervention needed to be...
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PMID: 20672991
PDF is available here.
PDF is available here.
Abstract
Keratinocyte culture medium (KCM) has been used for the in vitro culture of keratinocytes and other types of epithelial cells, and the medium includes various ingredients. In this study, two modified KCMs were prepared. In the first, insulin, hydrocortisone and antibiotics that are n...
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PMID: 20740688
PDF is available here.
PDF is available here.
Abstract
We also investigated the multi-differentiation potentials of the dedifferentiated cells. TGF-β(1) pre-treated C2C12 myoblasts were implanted into mice to repair dystrophic skeletal muscle or injured bone. In addition to the C2C12 myoblasts, similar effects of TGF-β(1) were also observed in the pri...
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PMID: 20184662
PDF is available here.
PDF is available here.
Medicina Intensiva (35)2 2011
Abstract
Being a solid organ and hematopoietic stem cell transplant recipient as well as receiving chemotherapy for a malignant hematological disease clearly predispose the subject to a variety of viral infections, both common and opportunistic diseases. The patient may have acquired these infections from the...
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PMID: 21324552
PDF is available here.
PDF is available here.
Abstract
Biologic augmentation could promote rotator cuff tendon healing and improve the mechanical properties as well as reduce postoperative adhesion. Biologic augmentations play a vital role in rotator cuff repair and healing. However, most of the studies were performed on animals and clinical outcomes wer...
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PMID: 21485584
PDF is available here.
PDF is available here.
Abstract
We fabricated highly porous biodegradable poly(D,L-lactic-co-glycolic acid) or PLGA co-polymer scaffolds by combining the gas-foaming and salt-leaching methods, using ammonium bicarbonate as a porogen, which allowed us to generate polymer scaffolds with a high density of interconnected pores of 400-...
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PMID: 20603864
PDF is available here.
PDF is available here.
Abstract
Two novel, bionanocomposite scaffolds were evaluated in a rodent model over the course of three months to determine whether these scaffolds possessed adequate biocompatibility characteristics to warrant further evaluation as possible tissue reconstruction scaffolds. These bionanocomp...
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PMID: 21210516
PDF is available here.
PDF is available here.
Liver Transplantation (17)2 2011
Abstract
Biomedical Materials (6)1 2011
Abstract
We attained successful bone defect reparation with homemade TEP in an allogenic rabbit model. But its allogenic immunocompatibility remained unknown. In this study TEP was constructed by seeding osteogenically induced mesenchymal stem cells of rabbit onto porcine small intestinal submucosa (SIS). A...
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PMID: 21205993
PDF is available here.
PDF is available here.
Abstract
We evaluated the bone formation capacities of SVF. We implanted uncultured freshly isolated adipose-derived stem cells combined with demineralized bone matrix (DBM) to induce bone regeneration in a critically sized rat calvarial defect model. We used DBM (DBX(®)) and/or poly(70L-lactide-co-30DL-lac...
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PMID: 20528145
PDF is available here.
PDF is available here.
Abstract
We examined the potential for hASCs to stimulate autogenous repair of a mouse calvarial defect. Immunofluoresence, osteogenic stains, and surface electron microscopy were used to demonstrate osteogenic differentiation of hASCs. hASCs were engrafted into 4 mm calvarial defects in athymic mice using a...
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PMID: 20698749
PDF is available here.
PDF is available here.
American Surgeon (77)2 2011
Abstract
Abstract
We and others recently observed that lipopolysaccharide (LPS) administration, as other TLR ligands, induces MDSC. In this case, MDSC regulate immune response independently of L-arginine metabolism through heme oxygenase-1 activity. Manipulating MDSC as immunoregulators represents an attractive appro...
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PMID: 20941610
PDF is available here.
PDF is available here.
Abstract
Our aims were to examine the prevalence of HHV-6, to determine the variants, and to investigate the interaction between HHV-6 viraemia, human cytomegalovirus (HCMV) infection and clinical symptoms.
Variant-specific HHV-6 nested PCR and quantitative real-time PCR were used to examine...
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PMID: 21843348
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of iPSC transplantation on thioacetamide- (TAA-) induced acute/fulminant hepatic failure (AHF) in mice. Firstly, we demonstrated that iPSCs had the capacity to differentiate into hepatocyte-like cells (iPSC-Heps) that expressed various hepatic markers, including albumin,
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PMID: 21808596
PDF is available here.
PDF is available here.
Abstract
We analyzed their immune characteristics by mixed lymphocyte reactions (MLRs) and animal experiments.
hESC-MSCs show a homogenous fibroblastic morphology that resembles bone marrow-derived MSCs (BM-MSCs). The cell markers and differentiation potential of hESC-MSCs are also similar to...
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PMID: 21194182
PDF is available here.
PDF is available here.
Abstract
We describe the generation of fibrin-based EHT from a transgenic rat strain with ubiquitous expression of firefly luciferase (ROSA/luciferase-LEW Tg; ). Implantation is performed into the greater omentum of different rat strains to assess immune responses of the recipient organism following EHT impl...
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PMID: 21673633
PDF is available here.
PDF is available here.
Abstract
We explore the potential of human adipose tissue derived adult stem cells (h-ASCs) to differentiate into functional islet like cell aggregates (ICAs). Our stage specific differentiation protocol permit the conversion of mesodermic h-ASCs to definitive endoderm (Hnf3β, TCF2 and Sox17) and to PDX1, N...
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PMID: 21687731
PDF is available here.
PDF is available here.
Abstract
There are many conditions that can affect the normal structure of the urinary bladder wall and lead to the inadequate evacuation of urine or even disable urine excretion. In these cases, the essential task is to restore the function of the urinary bladder, most often through surgical...
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PMID: 21805017
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)1 2011
Abstract
We have developed a strategy for cultivating dermal papilla (DP) cells to form multiple arrayed spheroidal microtissues for transplantation on a micropatterned polydimethylsiloxane (PDMS)-based tissue culture polystyrene (TCPS) plate system. We also describe the behavior of dermal papilla cells on t...
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PMID: 20728585
PDF is available here.
PDF is available here.
Abstract
Abstract
Recent advances in pancreas organogenesis have greatly improved the understanding of cell lineage from inner cell mass to fully differentiated β-cells. Based upon such knowledge, insulin-producing cells similar to β-cells to a certain extent have been generated from various cell so...
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PMID: 20589399
PDF is available here.
PDF is available here.
BMC Medicine (9) 2011
Abstract
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking t...
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PMID: 21569277
PDF is available here.
PDF is available here.
BMC Medicine (9)1 2011
Abstract
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking t...
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PMID: 21569277
PDF is available here.
PDF is available here.
Abstract
Fetal rat epiglottis and its developmental potential in ectopic transplants under the influence of the epigenetic drug was investigated. Epiglottises from 17-days-old rat embryos were transplanted under kidney capsules of adult rats for 14 days. 5-azacytidine (5 mg/kg) was injected i...
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PMID: 21196336
PDF is available here.
PDF is available here.
World Neurosurgery (75)5-6 2011
Abstract
We report herein a previously unpublished operative case by Harvey Cushing's in which an autologous fat graft was used to close a traumatic wound resulting in a dural defect. This report predates currently known published reports of the use of fat to seal dural defects. Cushing recognized that a fac...
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PMID: 21704938
PDF is available here.
PDF is available here.
Abstract
We used a variety of methods, including FACS analysis, cytotoxicity assays, cell depletion, imaging of tumor growth, cytokine blockade, and survival experiments, to study how SV therapy affects Natural Killer (NK) cell function in SCID mice bearing human ovarian carcinoma tumors. Surprisingly, we fo...
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PMID: 21674047
PDF is available here.
PDF is available here.
Hepato-gastroenterology (58)107-108 2011
Abstract
We studied the long-term survival of intrasplenically transplanted hepatocytes in an attempt to provide a safe and effective support to the diseased native liver.
A preliminary study was performed to identify the optimal number of hepatocytes to be transplanted into the spleen of rat...
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PMID: 21830411
PDF is available here.
PDF is available here.
Abstract
We analyzed the steroid sensitivity of ovalbumin (OVA) reactive helper T (Th) cell clones both in vitro and in vivo.
For in vitro experiments, Th clones were cultured with antigen-presenting cells, OVA, and various concentrations of dexamethasone (DEX). The proliferative response of...
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PMID: 21646805
PDF is available here.
PDF is available here.
Abstract
I over time. In the group of animal treated with the LOX inhibitor, intimal hyperplasia was significantly inhibited.
LOX were overexpressed in late stages of intimal hyperplasia in the allografts. LOX inhibitors prevented the development of the neointimal layer, such that their modulation could redu...
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PMID: 20606470
PDF is available here.
PDF is available here.
Abstract
We believe this paradoxical "good-bad" role for IFN-γ may reflect an important physiological negative feedback loop....
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PMID: 20941618
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Abstract
We examine the participation of TLR4 in acute allograft rejection in an orthotopic mouse model of SIT.
Wild-type C57Bl/6 (H-2b) or TLR49(-/-) (H-2b) mice were transplanted with syngeneic (C57Bl/6), allogeneic (BALB/c; H-2d), or F1 (BALB/cxC57Bl/6; H-2d/b) vascularized, orthotopic small intestine gra...
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PMID: 21197709
PDF is available here.
PDF is available here.
Abstract
Sertoli cells (SCs) provide an immunoprotective environment to pancreatic islet grafts for treatment of insulin-dependent diabetes. Aim of this work was to verify whether intraperitoneal graft of SCs, enveloped in barium alginate-based microcapsules, would reverse overt spontaneous diabetes in nonob...
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PMID: 21197711
PDF is available here.
PDF is available here.
Abstract
As a significant determinant of T- and B-cell cooperation, CD154 has been used to identify allospecific T-cytotoxic memory cells (TcM) for rejection risk assessment with high sensitivity or specificity but not for alloreactive B-cells, especially among recipients predisposed to acute cellular and hu...
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PMID: 20881665
PDF is available here.
PDF is available here.
Abstract
We suggest that bFGF when combined with periosteal grafts may have excellent repair capacity in the restoration of osteochondral defects....
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PMID: 21067496
PDF is available here.
PDF is available here.