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Articles on Placebos
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Dietary sodium citrate supplementation enhances rehydration and recovery from rapid body mass loss in trained wrestlers.
Appl Physiol Nutr Metab 37(6):1028-37 (2012) PMID 22871128
This study assessed the effects of dietary sodium citrate supplementation during a 16 h recovery from 5% rapid body mass loss (RBML) on physiological functions, affective state, and performance in trained wrestlers. Sixteen wrestlers performed an upper body intermittent sprint perfor... -
Dietary sodium citrate supplementation enhances rehydration and recovery from rapid body mass loss in trained wrestlers.
Appl Physiol Nutr Metab 37(6):1028-37 (2012) PMID 22871128
This study assessed the effects of dietary sodium citrate supplementation during a 16 h recovery from 5% rapid body mass loss (RBML) on physiological functions, affective state, and performance in trained wrestlers. Sixteen wrestlers performed an upper body intermittent sprint perfor... -
A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of rem...
Anesth Analg 115(2):274-83 (2012) PMID 22190555
We report on the safety and efficacy of the first human study. A phase I, single-center, double-blind, placebo- and active-controlled, randomized, single-dose escalation study was conducted. Up to 10 cohorts of healthy subjects were scheduled to receive a single 1-minute IV infusion... -
A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of rem...
Anesth Analg 115(2):274-83 (2012) PMID 22190555
We report on the safety and efficacy of the first human study. A phase I, single-center, double-blind, placebo- and active-controlled, randomized, single-dose escalation study was conducted. Up to 10 cohorts of healthy subjects were scheduled to receive a single 1-minute IV infusion... -
A novel extract from bovine colostrum whey supports innate immune functions. II. Rapid changes in cellular immune function in humans.
Prev Med (2012) PMID 22285946
To evaluate acute effects of bovine colostrum low-molecular weight fraction (CLMWF) on selected aspects of innate immune function in healthy human subjects. A placebo-controlled, double-blinded, randomized cross-over trial involving 12 healthy subjects, age 22-72, was... -
A novel extract from bovine colostrum whey supports innate immune functions. II. Rapid changes in cellular immune function in humans.
Prev Med (2012) PMID 22285946
To evaluate acute effects of bovine colostrum low-molecular weight fraction (CLMWF) on selected aspects of innate immune function in healthy human subjects. A placebo-controlled, double-blinded, randomized cross-over trial involving 12 healthy subjects, age 22-72, was... -
Evidence-based somatic treatment of depression in adults.
Psychiatr Clin North Am 35(1):131-42 (2012) PMID 22370495
The efficacy of antidepressants has become a contentious topic over the last decade, and yet a review of the literature shows that they are consistently more effective than placebo. Although the average magnitude of this effect is unclear, many individual patients respond well to a c... -
Significant differences in pediatric psychotropic side effects: Implications for school performance.
School Psychology Quarterly: The Official J... 27(1):4-28 (2012) PMID 22582933
Some side effects (SEs) of increasingly prescribed psychotropic medications can impact student performance in school. SE risk varies, even among drugs from the same class (e.g., antidepressants). Knowing which SEs occur significantly more often than others may enable school psychologists to enhance c... -
Hypocritical oaths.
Nature 482(7384):132 (2012) PMID 22318566
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Efficacy of chlorhexidine varnish for the prevention of adult caries: a randomized trial.
J Dent Res 91(2):150-5 (2012) PMID 22156917
We excluded participants for whom the study treatment was contraindicated or whose health might affect outcomes or ability to complete the study. Participants were randomly assigned to receive either the CHX coating (n = 490) or a placebo control (n = 493). Coatings were applied weekly for 4 weeks a...
