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Chronotherapy (1):
Recent article
Chronotherapy
Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology (12)1 2010
Abstract
The statement that circadian rhythmicity is an important component of mood regulation as well as a drive of mood disorders is supported by a growing body of evidence. Diurnal rhythms of the positive and negative components of mood as well as of the level of arousal depend on the circadian phase, the...
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PMID: 20305303
PDF is available here.
PDF is available here.
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Nutritional Neuroscience (13)1 2010
Abstract
Continuous levodopa replacement still is the most efficacious treatment for patients with Parkinson's disease. Unfortunately, the neutral aromatic amino acids contained in dietary proteins may compete with this drug for intestinal absorption and transport across the blood-brain barrier, thus limitin...
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PMID: 20132652
PDF is available here.
PDF is available here.
Abstract
The objective of this work was to develop a scientifically sound rationale for the method of reflex correction of biliary tract dysfunction based on chronobiological data concerning functioning of the acupuncture points corresponding to biliary ducts. It was shown that patients presenting with bilia...
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PMID: 21086595
PDF is available here.
PDF is available here.
Lakartidningen (107)36 2010
Abstract
Abstract
Practical circadian therapy for the cancer patient involves 3 spheres of intervention-improving lifestyle, optimizing internal biochemical milieu, and adjusting treatment times. The potential value of improving overall circadian functioning is shown in the work of Mormont et al in wh...
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PMID: 20042412
PDF is available here.
PDF is available here.
Abstract
The mean 24-h systolic BP (sBP) on regimen B was more than 1 SDS higher than on regimen A (0.92 +/- 1.17 vs. -0.13 +/- 1.23, p < 0.05). The difference was seen both in daytime and night-time BP. Regimen B significantly increased sBP in four patients and diastolic BP in two patients. Mean drop in nig...
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PMID: 19694198
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (89)12 2009
Abstract
STAT1 ASON administered in the early stage helps depress the pulmonary fibrosis procedure, and the earlier the drug is administrated the better effect would be obtained. Aerosolized STAT1 ASON can be used as a therapeutic method for pulmonary fibrosis....
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PMID: 19595124
PDF is available here.
PDF is available here.
Brain and Development (31)4 2009
Abstract
The bedtime of preschoolers/pupils/students in Japan has become progressively later with the result sleep duration has become progressively shorter. With these changes, more than half of the preschoolers/pupils/students in Japan recently have complained of daytime sleepiness, while approximately one...
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PMID: 18757146
PDF is available here.
PDF is available here.
Abstract
To produce a compromise circadian phase position for permanent night shift work in which the sleepiest circadian time is delayed out of the night work period and into the first half of the day sleep period. This is predicted to improve night shift alertness and performance while permitting adequate l...
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PMID: 19090319
PDF is available here.
PDF is available here.
Abstract
Given the growing obesity epidemic, pressure to develop an effective pharmacologic treatment is mounting. Following the completion of a randomized, double-blind, placebo controlled trial as well as two small open label trials, gamma vinyl-GABA (GVG) has been shown to be safe and effective for treati...
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PMID: 18720383
PDF is available here.
PDF is available here.
Abstract
We examine the physiological basis for bright light therapy, and we discuss the application of light in the treatment of circadian rhythm sleep disorders including advanced and delayed sleep-phase disorder, free-running disorder (nonentrained type), shiftwork disorder and jet lag disorder. We review...
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PMID: 18797560
PDF is available here.
PDF is available here.
Abstract
These results indicated that the PK/PD of prednisolone are time- and dose-dependent, and suggested that it is necessary to consider the application of chronotherapy to achieve better clinical outcomes with fewer side effects of prednisolone, and a PK/PD simulation approach could provide a valuable t...
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PMID: 18581240
PDF is available here.
PDF is available here.
Annals of Oncology (19)6 2008
Abstract
We have started a Nordic randomised phase II study comparing XELOX(30) and XELOX(30chron) as first-line therapy in patients with mCRC....
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PMID: 18281265
PDF is available here.
PDF is available here.
YAKUGAKU ZASSHI (128)5 2008
Abstract
A novel elementary osmotic pump tablet was developed. The system uses the core of drug-resin complexes (DRCs) loaded with propranolol hydrochloride (PNH) for time-controlled delivery. In traditional osmotic pump tablets (OPTs), the lag time was always minimized. However, in the DRCs...
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PMID: 18451626
PDF is available here.
PDF is available here.
Abstract
A total of 206 patients were randomized to the glargine group, and 199 to the oral agents group. In total, 145 patients were followed by experts and 260 by FPs. Mean reductions in HbA1c and fasting plasma glucose levels and rates of hypoglycemia were comparable in the 2 groups. Patients of both type...
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PMID: 18411384
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Patients with cancer experience a host of behavioral alterations that include depression, fatigue, sleep disturbances, and cognitive dysfunction. These behavioral comorbidities are apparent throughout the process of diagnosis and treatment for cancer and can persist well into the survivorship period...
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PMID: 18281672
PDF is available here.
PDF is available here.
Abstract
Atenolol and metoprolol succinate, dosed once daily, have different pharmacokinetic profiles. This study tests the hypothesis that differences that are especially noted in the early morning period, when cardiovascular risk is highest, in 24-hour blood pressure (BP) control exist betw...
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PMID: 18259123
PDF is available here.
PDF is available here.
Abstract
Nonpharmacologic modalities may be used alone or in combination with pharmacologic therapy for effective treatment of insomnia in the elderly. Nondrug treatments involve behavioral, cognitive, and physiologic interventions. Common methods of cognitive behavior therapy for insomnia include: relaxatio...
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PMID: 18035235
PDF is available here.
PDF is available here.
The Lancet (371)9608 2008
Abstract
Terapevticheskii arkhiv (80)9 2008
Abstract
The normal type of the circadian BP profile (dipper) was found only in 44.4% patients; 36, 120.2 and 9.3% patients were non-dippers, night-peakers and over-dippers, respectively. Only 51.6% patients had adaptive types of reaction to the disease. After half a year of individual antihypertensive treat...
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PMID: 19555033
PDF is available here.
PDF is available here.
Medical Hypotheses (71)1 2008
Abstract
We hypothesize that nanodrugs (i.e. Caelyx and/or Abraxane) given at the proper menstrual stage with predicted highest VEGF expression and cancer vascular permeability allow significantly increased drug retention in breast cancer, and subsequently result in the maximal cancer growth control and mini...
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PMID: 18299174
PDF is available here.
PDF is available here.
Abstract
In present time, to classify the healthy as potencional possibility of the organism to accept variable environment influences without the break of the biological important functions is not satisfactory. Examples from the different field of the clinical medicine refer to importance of the knowledge's...
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PMID: 18630138
PDF is available here.
PDF is available here.
Abstract
Resonance chronophytotherapy (RCT) was carried out to patients with epilepsy, bronchial asthma, rheumatism, scleroderma, hypertension, chronic glomerulonephritis, vegetovascular dystonia, female sterility, round-type alopecia, vitiligo, eczema, psoriasis, onychomycosis. Special medicine technology R...
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PMID: 18822854
PDF is available here.
PDF is available here.
Abstract
The course of time itself in alive organisms is treated from positions of the special theory of the relativity created by A. Einstein in 1905 and added by the Nobel winners H.A.Lorentsem, M. Plankom, M. fon Laue. These achievements of fundamental physics have been put in a basis of special medical t...
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PMID: 19145832
PDF is available here.
PDF is available here.
Abstract
Efficient treatment of diseases is expected when the timing of drug delivery is taken into account and adjusted in a proper way. This implies an easy to use, noninteractive and user independent drug delivery system that allows delivery at anytime. This article discusses developments in chronotherape...
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PMID: 18557410
PDF is available here.
PDF is available here.
Hypertension (51)1 2008
Abstract
We have evaluated the impact on the circadian pattern of blood pressure on modifying the time of treatment without increasing the number of prescribed drugs. We studied 250 hypertensive patients who were receiving 3 antihypertensive drugs in a single morning dose. Patients were randomly assigned to...
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PMID: 17968001
PDF is available here.
PDF is available here.
Journal of Hypertension (25)12 2007
Abstract
Sleep Medicine Reviews (11)6 2007
Abstract
Sleep Medicine Reviews (11)6 2007
Abstract
Psychiatric chronotherapeutics is the controlled exposure to environmental stimuli that act on biological rhythms in order to achieve therapeutic effects in the treatment of psychiatric conditions. In recent years some techniques (mainly light therapy and sleep deprivation) have passed the experimen...
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PMID: 17689120
PDF is available here.
PDF is available here.
Abstract
I trial was initiated to establish the dose-limiting toxicities (DLTs) and the maximum tolerated dose (MTD) of chronomodulated 5-fluorouracil and cisplatin given concurrently with preoperative radiotherapy in patients with esophageal cancer. Patients with stage I or II esophageal cancer received pre...
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PMID: 17976948
PDF is available here.
PDF is available here.
Abstract
The circadian clock modulates timing of sleep and wakefulness. In certain situations, the circadian potentiation of wakefulness may interfere with desired sleep-scheduling, particularly in the elderly and shift workers. Known abnormalities of circadian regulation are defined by their impact on sleep...
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PMID: 18041873
PDF is available here.
PDF is available here.
Drug Delivery (14)7 2007
Abstract
We found that the effect of plug thickness on the onset of release is more important when the membrane is thicker. The results showed that the presence of caster oil in coating formulation (cellulose acetate 10% or 15%) increased the onset of release (t(o) values). The onset of release varied from 0...
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PMID: 17994364
PDF is available here.
PDF is available here.
Sleep Medicine (8)6 2007
Abstract
Circadian rhythms have a strong effect on the ability to sleep across the 24-h period. Maximum sleepiness occurs at the phase of lower endogenous core body temperature. This period is bracketed by two periods of alertness: a "wake-maintenance zone" occurring 6-10h before the time of core temperature...
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PMID: 17383935
PDF is available here.
PDF is available here.
Sleep Medicine (8)6 2007
Abstract
People who are blind, in addition to having to cope with partial or no sight, have an added handicap; the transmission of ocular light from the retina to their circadian clock is impaired. At its worse, for example in people with both eyes enucleated, this lesion results in desynchronisation of the...
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PMID: 17420154
PDF is available here.
PDF is available here.
Abstract
The study suggests a potential benefit for implementation of chronotherapy using steroid treatment for acute multiple sclerosis relapse, with implications for other immune-mediated disorders....
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PMID: 17056624
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To study the endogenous hormone of testosterone and cortisol that secretes volume and rhythm in sports fatigued human bodies and animals. To determine secretory volume and rhythm in sports fatigued human bodies and animals when Shixiang yaofa's drug are used. METHOD: Radio-immunity method...
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PMID: 17972589
PDF is available here.
PDF is available here.
Abstract
The children receiving the week of Diet C (with the day/night formulas in synchrony with the environment) showed increased hours of actual sleep (7.68 +/- 0.54 h vs. 6.77 +/- 0.12 h for the Diet A control) and improved sleep latency (0.44 +/- 0.04 h vs. 0.60 +/- 0.08 h for the Diet A control). The s...
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PMID: 17693960
PDF is available here.
PDF is available here.
Harvard Men's Health Watch (11)12 2007
Abstract
Abstract
Mammalians circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN). Clock genes are the genes that control the circadian rhythms in physiology and behavior. The effectiveness and toxicity of many drugs vary depending on dosing time associated with 24-hr rhythms of biochemical, physiol...
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PMID: 17633520
PDF is available here.
PDF is available here.
Abstract
Ambulatory blood pressure measurements (ABPM) correlate more closely with target organ damage and cardiovascular events than clinical cuff measurements. ABPM reveals the significant circadian variation in BP, which in most individuals presents a morning increase, small post-prandial decline, and mor...
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PMID: 17489671
PDF is available here.
PDF is available here.
Harvard Heart Letter (17)8 2007
Abstract
Abstract
We applied a periodic perturbation to the y variable to take the Rössler system from a chaotic behavior to a simple periodic one, varying the period and amplitude of forcing. Two types of chaos were considered, spiral and funnel chaos. As a result, the periodical windows reduced their areas as the...
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PMID: 17658922
PDF is available here.
PDF is available here.
Physiology & Behavior (90)2-3 2007
Abstract
Chronobiotics are substances that adjust the timing of internal biological rhythms. Many classes of drugs have been claimed to possess such properties and arouse growing interest as the circumstances for their use in sleep disturbances caused by circadian rhythms alterations (delayed or advanced sle...
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PMID: 17056076
PDF is available here.
PDF is available here.
Abstract
Abstract
We found significant interactions of treatment (before and after), response to treatment (Hamilton Depression Rating Scale score <8), and moral valence of the stimuli (positive or negative) in the anterior cingulate cortex, dorsolateral prefrontal cortex, insula, and parietal cortex. In these areas,...
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PMID: 17283285
PDF is available here.
PDF is available here.
Abstract
The mammalian circadian system is organized in a hierarchical manner in that a central pacemaker in the suprachiasmatic nucleus (SCN) of the brain's hypothalamus synchronizes cellular circadian oscillators in most peripheral body cells. Fasting-feeding cycles accompanying rest-activity rhythms are t...
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PMID: 17209800
PDF is available here.
PDF is available here.
Medical Hypotheses (68)6 2007
Abstract
We can assume that daytime OAD plus bedtime insulin therapy might be more atherogenic than daytime insulin plus bedtime OAD therapy. The rationale for combination therapy is based on the assumption that, if evening insulin lowers the fasting glucose concentration to normal, then daytime oral agents...
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PMID: 17145138
PDF is available here.
PDF is available here.
Abstract
Circadian rhythms of cardiovascular system vegetative provision, indices of rheohepatography and pancreas exocrine function of 417 patients with chronic pancreatitis were studied. Signs of desynchronosis were registered in more than one third of the cases. Presence of vibration disease leads to esca...
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PMID: 18274110
PDF is available here.
PDF is available here.
Abstract
We review the anatomical and neurophysiologic bases of sleep regulation in mammals as well as similarities and differences between the sleep of humans and that of other organisms. We outline how human sleep is measured, the role of the circadian system in models of human sleep regulation, and human...
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PMID: 18419261
PDF is available here.
PDF is available here.
Abstract
The circadian clock orchestrates cellular functions over 24 hours, including cell divisions, a process that results from the cell cycle. The circadian clock and cell cycle interact at the level of genes, proteins, and biochemical signals. The disruption or the reinforcement of the host circadian tim...
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PMID: 18419306
PDF is available here.
PDF is available here.
Abstract
Klinicheskaia meditsina (85)8 2007
Abstract
The authors evaluated the influence of three alternative methods of treatment of coronary artery disease (CAD) and stable exertional stenocardia accompanied by arterial hypertension on systolic and diastolic left ventricular (LV) function. The three methods were: conventional therapy with monocinque...
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PMID: 17926489
PDF is available here.
PDF is available here.
Abstract
The Multimag-M microprocessor chronomagne-totherapy system of the new generation is described. The system provides on-line diagnosis of the pulse parameters and the breathing rate during a biotechnical feedback session. The requirements to the system software, as well as its specific features and de...
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PMID: 18274101
PDF is available here.
PDF is available here.
Abstract
Seven stages of high-technology medical equipment life cycle are described. The Multimag chronomagnetotherapy system is used as an example to trace the implementation of the seven stages of the system life cycle by a collaboration team from Ryazan State Radio Engineering University and Kasimov Instr...
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PMID: 18277401
PDF is available here.
PDF is available here.
Abstract
The procedure used by medical equipment developer for assessing the risks involved in operation and maintenance of medical equipment is described. Methods for risk assessment and management are delineated. An example of the procedure implementation is given.
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PMID: 18274104
PDF is available here.
PDF is available here.
Abstract
The purpose of this work was to develop hollow calcium pectinate beads for floating-pulsatile release of diclofenac sodium intended for chronopharmacotherapy. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. To...
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PMID: 16971097
PDF is available here.
PDF is available here.
Abstract
There are sufficient data to support evening administration of simvastatin to achieve optimal lowering of LDL-C levels. Rigorous and robust trials are necessary to determine the best administration time to achieve optimal LDL-C lowering for lovastatin, pravastatin, rosuvastatin, atorvastatin, and fl...
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PMID: 17200427
PDF is available here.
PDF is available here.
Pathologie Biologie (55)3-4 2007
Abstract
The authors evaluated the impact of a chronotherapy with 5-FU, folinic acid and carboplatine (chronomodulated infusions by ambulatory pumps; 5/21 days) for the management of oesophagus (52 cases) and gastric (56 cases) cancer patients. The overall tolerance of treatment was gauged excellent (grade 3...
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PMID: 17418504
PDF is available here.
PDF is available here.