Abstract
In the studied neonatal population (term and preterm neonates with gestational ages up to 10 days), gestational age and bodyweight were closely related. Therefore, the effects of allometry and maturation on lidocaine pharmacokinetics could not be described independently and were described by a combi...
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PMID: 21651313
PDF is available here.
Abstract
A plasmapheresis-free protocol for desensitization of donor kidney transplant candidates with high Calculated Panel Reactive Antibody (CPRA) was initiated at our center. The protocol was adopted from previously published work by Vo, Jordan et al.
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PMID: 21716181
PDF is available here.
Abstract
Management of patients affected with aggressive periodontitis is complicated by several poorly understood etiological and modifying factors that create difficulty in establishing a universal treatment recommendation. The goal of this manuscript is to underscore the complexity of therapy and to provid...
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PMID: 21823498
PDF is available here.
Abstract
The Canadian Orthopaedic Trauma Society was started in an endeavour to answer the difficult problem of obtaining enough patients to perform top-quality research into fractures. By maintaining a high standard, including randomised study design, inclusivity, open discussion among surgeons and excellent...
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PMID: 21586767
PDF is available here.
Abstract
Burned patients have altered vancomycin pharmacokinetics necessitating adjusted dosing. Published initial dosing recommendations to target troughs of 15-20mg/L for this population are lacking.
This study was conducted to develop initial vancomycin dosing recommendatio...
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PMID: 21095062
PDF is available here.
Abstract
Treatment and follow-up protocols of differentiated thyroid carcinoma patients in the Spanish Radiometabolic Therapy Units show variability in aspects such as surgery and ablation indications, patient preparation for radioiodine therapy and follow-up. Our clinical practice differs in several aspects...
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PMID: 21439688
PDF is available here.
Abstract
We sought to compare rates of recurrent spontaneous preterm birth (PTB) and neonatal morbidity between women enrolled in a recurrent PTB prevention clinic compared to those receiving usual care.
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PMID: 21345407
PDF is available here.
Abstract
We report an update on obstetric patient safety efforts and results in the nation's largest obstetric health care delivery system. The application of principles advocated by the Institute of Medicine a decade ago has resulted in reduced adverse outcomes, as reflected by claims experience. Particular...
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PMID: 21306701
PDF is available here.
Abstract
We report results on secondary prophylactic VWF replacement therapy applied in 32 patients [children n=13; adolescents n=7; adults n=12] with VWD [type 1: 4; type 2: 15; type 3: 13], 15 of which were females, and nine of these at the reproductive period. Eight patients were treated with Humate P® o...
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PMID: 21301780
PDF is available here.
Abstract
We conducted a randomized trial of a warfarin management protocol using facilitated telephone communication between nurses and physicians in 26 nursing homes in Connecticut in 2007-2008. Intervention facilities received a warfarin management communication protocol using the approach "Situation, Back...
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PMID: 21295198
PDF is available here.
Abstract
We report our experience with 81 individuals who were diagnosed and treated in our institution between 2001 and 2007. Only patients who received transplants had good long-term outcomes, and we noted significant inconsistencies in the management of patients with similar stages of disease and degrees...
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PMID: 21337882
PDF is available here.
Abstract
To report the outcomes of zone 1 aggressive posterior retinopathy of prematurity (ROP) treated with aggressive laser photocoagulation by a protocol-based approach over a 10-year period.
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PMID: 21257156
PDF is available here.
Abstract
It was the objective of this work to systematically evaluate the role of vitamin E supplementation in the prevention of stroke. Eligible studies were identified from Medline, Embase and Cochrane Library. The efficacy data is the relative risk (RR) for the events of stroke. Thirteen randomised control...
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PMID: 21264448
PDF is available here.
Abstract
ABSTRACT: The early identification of pre-lingual deafness is necessary to minimize the consequences of hearing impairment on the future communication skills of a baby. According to the most recent international guidelines the deafness diagnosis must occur before the age of three mon...
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PMID: 21481246
PDF is available here.
Abstract
: To determine, with respect to measurement of maximal isometric torque (MIT) using a specific hand-held dynamometer (HHD) protocol, (1) protocol feasibility over a wide age range, (2) intra- and interrater reliability, (3) standard error of measurement, and (4) concurrent validity.
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PMID: 21829128
PDF is available here.
Abstract
The Centers for Disease Control recently updated the National Trauma Triage Protocol. This field triage algorithm guides emergency medical service providers through four decision steps (physiologic [PHY], anatomic [ANA], mechanism, and special considerations) to identify patients who would benefit f...
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PMID: 21217479
PDF is available here.
Abstract
We inserted in our surgical protocol include the following: short-term antibiotic prophylaxis, perioperative infusion of concentrated platelets, not opening the hernia sac, application of human fibrin glue, elastic compression. All patients were treated according to the same protocol and the data wa...
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PMID: 21780561
PDF is available here.
Abstract
We have been using selective immunoadsorption in the two ABO-incompatible kidney transplants performed in our institution. No acute rejection was experienced at 6 and 26 month follow-up and both grafts are functioning well. Despite the ABO-incompatible kidney transplant widespread use, the best dese...
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PMID: 21834478
PDF is available here.
Abstract
We evaluated four key attributes of NYC's HIV incidence surveillance system-simplicity, data quality, timeliness, and acceptability--using CDC's guidelines for surveillance system evaluation. The evaluation revealed that the system could potentially provide HIV incidence estimates stratified by boro...
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PMID: 21337929
PDF is available here.
Abstract
The aim of this study was to assess the level of agreement between an institutional protocol and the Manchester protocol for the risk assessment of patients attended in an emergency room of a public hospital in Belo Horizonte - MG - Brazil. This is a descriptive and comparative study, in which 382 pa...
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PMID: 21412626
PDF is available here.
Abstract
We collected camp clinic records on outpatient malaria diagnoses from 2004 through 2007 and compared the morbidity percentages attributed to malaria during these years, as well as the actual incidence of malaria in 2006 and 2007. Our analyses demonstrate that malaria accounted for 45.8% of all morbi...
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PMID: 21308578
PDF is available here.
Abstract
A total of 31 implants were placed and restored for the 10 patients involved. Followup averaged 108.4 months (61-155 months) after implant prosthetic functioning. With the multidisciplinary approach, a satisfactory treatment for these patients was acquired, with follow-up for more than 5 years. The...
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PMID: 21734944
PDF is available here.
Abstract
A project to assist nurses in preventing and treating skin issues was implemented using the Transforming Care at Bedside (TCAB) Method. Using the TCAB Method, which included a dedicated Skin Care Resource Nurse, the medical-surgical unit was successful in reducing nosocomial pressure ulcers.
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PMID: 21560959
PDF is available here.
Abstract
We found that most patients did not require surgery. We hypothesize that most spine fractures can be treated safely and effectively by the trauma team, without neurosurgical consultation, using a protocol to guide diagnosis and treatment.
A treatment protocol was designed, which used radiologic crit...
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PMID: 21150528
PDF is available here.
Abstract
• To compare prostate cancer detection rates using the Vienna nomogram versus an 8-core prostate biopsy protocol. To compare the complication rates of transrectal prostate biopsy in the two groups.
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PMID: 21087452
PDF is available here.
Abstract
Hyperglycemia is highly prevalent in the acute-care setting and is associated with an increased risk of morbidity and mortality. Evidence suggests that glycemic control in this population is suboptimal, due in part to continued use of nonphysiologic sliding-scale insulin strategies without scheduled...
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PMID: 21068533
PDF is available here.
Abstract
Research conducted during the first 20 years of the AIDS epidemic provided a solid foundation of data supporting methadone treatment as HIV prevention. Drug users in methadone treatment were consistently found to reduce the frequency of drug use, risk behaviors, and infections. These data have been c...
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PMID: 20803321
PDF is available here.
Abstract
The European Hernia Society (EHS) presented the EHS Guidelines for the Treatment of Inguinal Hernia in Adult Patients. The Guidelines contain recommendations for the management of inguinal hernia from diagnosis to aftercare. These have been developed by a Working Group consisting of expert surgeons w...
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PMID: 20965861
PDF is available here.
Abstract
I trauma center. A critical care devastating brain injury protocol and a DCD policy were instituted. Best performance benchmarks were evaluated before and after establishment of the ODC. At our center, the total number of referrals increased from 96 in 2006 to 139 in 2007 and 143 in 2008. Timely not...
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PMID: 21105609
PDF is available here.
Abstract
We calculated interrater agreement for recording of the Mallampati score, thyromental distance less than 6 cm, thick neck, kyphosis, small mouth, macroglossia, and dental prosthesis during the preanesthesia examination (by an anesthetist) and on the day of the operation (by an anesthetist and a resi...
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PMID: 21033453
PDF is available here.
Abstract
Mortality from severe sepsis can be improved by timely diagnosis and treatment. This study investigates the effectiveness of a comprehensive management protocol for recognition and initial treatment of severe sepsis that spans from the emergency department (ED) to the intensive care unit.
Interventi...
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PMID: 20671074
PDF is available here.
J M Taekman,
M Stafford-Smith,
E J Velazquez,
M C Wright,
B G Phillips-Bute,
M A Pfeffer,
M A Sellers,
K S Pieper,
M F Newman,
F Van de Werf,
R Diaz,
J Leimberger and
R M Califf
Abstract
Recognition of learning curves in medical skill acquisition has enhanced patient safety through improved training techniques. Clinical trials research has not been similarly scrutinised. The VALsartan In Acute myocardial iNfarcTion, a large multinational, pragmatic, randomised, double-blind, multice...
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PMID: 20702441
PDF is available here.
Abstract
Recent increases in caries prevalence in young children, especially among minorities and the economically disadvantaged, highlight the need for early establishment of dental homes and simple, effective infant oral care preventive programs for all children as part of a medical disease prevention mana...
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PMID: 21162350
PDF is available here.
Abstract
The purpose of this article is to provide the dental health professional with sound science related to sealants so that he/she can provide the best care to his/her patients. This article will synthesize the recommendations made by the American Academy of Pediatric Dentistry and the American Dental A...
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PMID: 21162347
PDF is available here.
Abstract
Care pathways are defined as 'a methodology for the mutual decision making and organisation of care for a well-defined group of patients during a well-defined period'. Although most often used in Europe as a tool to improve the quality of care and to aid the continuity of care between disciplines an...
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PMID: 20829864
PDF is available here.
Abstract
We use intra-articular injections delivered directly into the soft tissue of the knee. Our current intra-articular injection is 60 mL of 0.5% ropivacaine with 0.5 mg of epinephrine. In patients with a normal renal function, 30 mg of ketorolac is added. The injection is administered throughout all of...
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PMID: 20839683
PDF is available here.
Abstract
We describe the development of a protocol for returning research results to participants at one site of a multicenter study of the genetic epidemiology of melanoma. Protocol development involved numerous challenges: (1) deciding whether genotype results merited disclosure; (2) achieving an appropria...
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PMID: 20831418
PDF is available here.
Abstract
We describe the development of a protocol for returning research results to participants at one site of a multicenter study of the genetic epidemiology of melanoma. Protocol development involved numerous challenges: (1) deciding whether genotype results merited disclosure; (2) achieving an appropria...
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PMID: 20831418
PDF is available here.
Abstract
We frame the diabetes patient's quality-of-care problem as an ongoing scientific investigation aimed at quantifying and predicting relationships between specific care-management actions and their outcomes for individual patients in their ordinary course of life.
Framing diabetes qual...
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PMID: 20920451
PDF is available here.
Abstract
To determine the effectiveness of Flammacérium, a topical treatment used in the treatment of burns, in the stabilisation of necrosis in non-healing wounds. The therapy is designed to prevent the risk of infection, stop necrosis from spreading and improve the patient's quality of life.
This retrospe...
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PMID: 20852565
PDF is available here.
Abstract
We assessed medical students' perceptions of a newly developed emergency medicine clerkship rotation involving multiple learning modalities. The evaluation process included assessment of the rotation's instructional elements and overall educational value.
The first cohort of medical students to comp...
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PMID: 20880435
PDF is available here.
Abstract
The experience sampling method (ESM) represents a valuable way of assessing clinical phenomena in real world settings and across time. Despite its theoretical advantages, using this methodology in psychiatric populations is challenging. This paper acts as a guide to researchers wishing to employ this...
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PMID: 20712828
PDF is available here.
Abstract
This study examined the effects of step therapy for antidepressants on prescription drug and other medical utilization and spending. Step therapy is a type of pharmaceutical benefit design that requires that patients try certain specified medications (typically generic medications) prior to using alt...
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PMID: 20713497
PDF is available here.
Abstract
The clinical utility of the DSM-IV eating disorder (ED) diagnostic criteria among practicing clinicians has not been formally evaluated, despite the considerable diagnostic challenges these disorders present. This study evaluated inter-rater reliability between research and clinical diagnoses, ident...
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PMID: 20591498
PDF is available here.
Hsin-Chieh HC Yeh,
Jeanne M JM Clark,
Karen E KE Emmons,
Reneé H RH Moore,
Gary G GG Bennett,
Erica T ET Warner,
David B DB Sarwer,
Gerald J GJ Jerome,
Edgar R ER Miller,
Sheri S Volger,
Thomas A TA Louis,
Barbara B Wells,
Thomas A TA Wadden,
Graham A GA Colditz and
Lawrence J LJ Appel
Abstract
The Collaborative Research Group established common components to facilitate potential cross-site comparisons. The main advantage of this approach is to develop and evaluate several interventions, when there is insufficient evidence to test one or two approaches, as would be done in a traditional mu...
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PMID: 20573639
PDF is available here.
Abstract
The median duration of mechanical ventilation was 40 and 72 hrs in protocol-directed and physician-directed groups, respectively (p < 0.001). Two patients in the protocol-directed group and three patients in the physician directed group were re-intubated within the first 72 hours after extubation (p...
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PMID: 20718169
PDF is available here.
Abstract
This paper outlines the process of developing a transcranial magnetic stimulation (rTMS) service in a private hospital setting, to provide a model for similar services elsewhere in Australia and New Zealand.
The practical issues involved in setting up the service, including funding, staffing, equipm...
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PMID: 20367316
PDF is available here.
James C Jackson,
Timothy D Girard,
Sharon M Gordon,
Jennifer L Thompson,
Ayumi K Shintani,
Jason W W Thomason,
Brenda T Pun,
Angelo E Canonico,
Janet G Dunn,
Gordon R Bernard,
Robert S Dittus and
E Wesley Ely
Abstract
In this trial, management of mechanically ventilated medical ICU patients with a wake up and breathe protocol resulted in similar cognitive, psychological, and functional outcomes among patients tested 3 and 12 months post-ICU. The proven benefits of this protocol, including improved 1-year survival...
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PMID: 20299535
PDF is available here.