Abstract
Postoperative radiotherapy remains controversial in non-small cell lung cancer. The conclusions of several meta-analysis are still questioned, partly because of flaws in the randomized trials taken into account. The technological improvements of modern radiotherapy and several clinical observations h...
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PMID: 21820931
PDF is available here.
Abstract
Various subgroups of breast tumours have been identified during the last 10 years according to the risk of local relapse. Prognostic factors for local relapse are age, surgical margins, tumour size, Her2 expression and hormonal receptors status. For tumours with a high risk of local relapse, an incre...
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PMID: 21820932
PDF is available here.
Abstract
We report an unusual, rare case of primary epithelioid rhabdomyosarcoma of a lymph node in the parotid basin. A 72-year-old man with a history of squamous cell carcinoma of the forehead and cheek had a 5-cm mobile nontender mass of the parotid tail and right level II region. A positron emission tomog...
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PMID: 21917681
PDF is available here.
Abstract
To evaluate the feasability of immediate breast reconstruction (IBR) following mastectomy after neoadjuvant chemotherapy (NACT) and radiation therapy (RT) for operable invasive breast cancer (OIBC), in terms of incidence of local complications, locoregional control and survival.
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PMID: 21843920
PDF is available here.
Abstract
We present our early experience with an attempt to optimize extracorporeal membrane oxygenation, emphasizing reduced adjunctive mechanical ventilatory support and aggressive rehabilitation, with a goal of ambulation. This strategy has been enabled by the introduction of a dual-lumen draw and return...
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PMID: 21924145
PDF is available here.
Abstract
We studied the combined effect of MSC and IBD drugs in in vitro functionality assays.
The effects of azathioprine, methotrexate, 6-mercaptopurine and anti-tumor necrosis factor (TNF)-α on MSC phenotype, survival, differentiation capacity and immunosuppressive capacity were studied....
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PMID: 21846292
PDF is available here.
Abstract
Clinical studies of the last 15years have shown the benefit of pharmacological interventions on the progression of chronic kidney disease, confirming the concept of nephroprotection. Pharmacological blockade of the renin angiotensin system remains the cornerstone of the nephroprotect...
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PMID: 21981881
PDF is available here.
Abstract
Relief of post-operative pain has a bearing on the patient's well-being, mobilisation and time confined to bed. The article discusses indications, contraindications and the efficacy of the various treatment modalities.
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PMID: 21946595
PDF is available here.
Abstract
A 77 year-old male presented a locally advanced small cell anal cancer and simultaneous hepatic and glandular deposits. Due to metastatic disease, chemotherapy with carboplatin and etoposide was the primary choice of treatment. Small cell cancer of the gastrointestinal tract exerts an aggressive clin...
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PMID: 21936979
PDF is available here.
Abstract
We have previously created a novel interaction database for oncology prescriptions (OncoRx). In this project, we leverage on 3G networks to further develop this database into an iPhone-specific application for the mobile internet (OncoRx-MI)....
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PMID: 21848450
PDF is available here.
Abstract
We provide the first report outlining toxicities and survival outcomes in a series of 19 patients. Our experience suggests that initial surgery provides durable local control rates in two-thirds of patients, with low risk for significant permanent deficits. Salvage therapy with surgery and/or radiat...
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PMID: 21824889
PDF is available here.
Maura M Massimino,
Carlo Lazzaro CL Solero,
Maria Luisa ML Garrè,
Veronica V Biassoni,
Armando A Cama,
Lorenzo L Genitori,
Concezio C Di Rocco,
Iacopo I Sardi,
Elisabetta E Viscardi,
Piergiorgio P Modena,
Paolo P Potepan,
Salvina S Barra,
Giovanni G Scarzello,
Ercole E Galassi,
Felice F Giangaspero,
Manila M Antonelli and
Lorenza L Gandola
Abstract
Object Complete ependymoma resection ensures a better prognosis for children with this tumor, but the complete excision of infratentorial ependymomas involves serious risks. Second-look surgery for tumor remnants may be less harmful and enable complete removal. There is a potential,...
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PMID: 21882914
PDF is available here.
Abstract
Object Brain tumors in infants are often large, high grade, and vascular, making complete resection difficult and placing children at risk for neurological complications and excessive blood loss. Neoadjuvant chemotherapy may reduce tumor vascularity and volume, which can facilitate r...
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PMID: 21882915
PDF is available here.
Abstract
Objectives and design This study describes a randomized controlled trial which aimed to evaluate whether 16 sessions of psychotherapy combined with pharmacotherapy is more effective in relieving depression and improving social functioning than 8 sessions of psychotherapy combined with pharmacothera...
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PMID: 21810106
PDF is available here.
Abstract
To compare the efficacy difference in treatment of acute gouty arthritis between acupuncture combined with infrared irradiation and Indomethachin as well as observe the impacts on liver function.
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PMID: 21972623
PDF is available here.
Abstract
To evaluate the clinical therapeutic effect of depression treated by acupuncture and electroacupuncture combined with western medicine.
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PMID: 21972619
PDF is available here.
Abstract
Rectal cancer is characterized by a high rate of local recurrence. Although it is widely believed that local control results in improved patient outcome, its strategy is still controversial. In Japan, total mesorectal excision (TME) or tumor-specific mesorectal excision (TSME) with p...
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PMID: 21941821
PDF is available here.
Abstract
Mineral metabolism abnormalities are frequently observed in patients with chronic kidney disease (CKD). The bone and cardiovascular consequences should lead to the implementation of some adapted strategies for the prevention and treatment on the basis of the physiopathology of the di...
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PMID: 21885239
PDF is available here.
Abstract
We determined that if mCRC patients remain cancer-free for 28 months after curative surgery, their chance of long-term survival is significantly better....
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PMID: 21894352
PDF is available here.
Abstract
We studied a series of 55 patients with AVMs of the head and neck that were treated surgically between 1999 and 2009....
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PMID: 21834473
PDF is available here.
Abstract
The effect of ezetimibe-statin combination on inflammatory markers in acute coronary syndrome is unknown. The aim of our study is to evaluate the effect of this combination on the lipid profile, the CRP hs and the sCD40 ligand levels in acute coronary syndrome (ACS) patients.
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PMID: 21834489
PDF is available here.
Abstract
Neurocardiogenic syncope is a relatively common cause of syncope and is diagnosed by head-up tilt testing. A 21-year-old man was examined for frequent syncope episodes which occurred after episodes of blood drawing and standing in queue. Syncope developed in tilt table testing. After about 68 seconds...
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PMID: 21894812
PDF is available here.
Abstract
We describe a case of Listeria pericarditis, which occurred in a 60-year-old man with Child-Pugh B cirrhosis who presented to the emergency department with asthenia, anorexia, and respiratory distress. The echocardiogram showed severe pericardial effusion and after pericardiocentesis, L. monocytogen...
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PMID: 21894816
PDF is available here.
Abstract
Cerebral aneurysms of an infectious etiology, so-called "mycotic" aneurysms, are rare neurovascular pathologies. Primary treatment may be targeted on the aneurysm, but care has to be driven by the underlying pathology to prevent an often fatal clinical course with a mortality rate reaching 90%. 2 cas...
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PMID: 21830179
PDF is available here.
Abstract
Context.-Advanced cases of retinoblastoma are treated with chemoreduction followed by enucleation. Further adjuvant therapy is recommended in patients with known pathologic risk factors (PRFs). Objectives.-To determine the PRFs in enucleated specimens after chemoreduction and their association for ad...
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PMID: 21809993
PDF is available here.
Ron H N RH van Schaik,
Marleen M Kok,
Fred C G J FC Sweep,
Martin M van Vliet,
Marianne M van Fessem,
Marion E ME Meijer-van Gelder,
Caroline C Seynaeve,
Jan J Lindemans,
Jelle J Wesseling,
Laura J LJ Van 't Veer,
Paul N PN Span,
Hanneke H van Laarhoven,
Stefan S Sleijfer,
John A JA Foekens,
Sabine C SC Linn and
Els M J J EM Berns
Abstract
Tamoxifen is metabolized by cytochrome P450s, with an important role for CYP2D6. Recently, we demonstrated in 80 patients that CYP2C19*2 is associated with increased survival in breast cancer patients using tamoxifen. Here, we aimed to confirm this in a large group of 499 patients.
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PMID: 21830868
PDF is available here.
Abstract
Colorectal cancer represents a major public health problem due to its frequency and mortality rate. Adjuvant chemotherapy has improved the prognosis of colon cancer. Six months of oxaliplatin and fluoropyrimidine in combination is the standard adjuvant treatment in stage III patients...
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PMID: 21810511
PDF is available here.
Abstract
Patients with an abdominal catastrophe are in urgent need of early, interdisciplinary medical help. The treatment plan should be based on medical priorities and clear leadership. First priority should be given to achieve optimal oxygenation of blood and stabilization of circulation during all treatme...
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PMID: 21796602
PDF is available here.
S Chiacchio,
S Mazzarri,
A Lorenzoni,
N Nyakale,
G Boni,
E Borsò,
A Alsharif,
M Grosso,
G Manca,
C Greco,
D Volterrani and
G Mariani
Abstract
Bone metastases are responsible for most of the morbidity and mortality associated with solid malignant tumors, occurring in about 65-70% of the patients with advanced breast or prostate cancer. The pathophysiology of skeletal metastasis is a complex process that involves several bio...
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PMID: 21738116
PDF is available here.
Abstract
To study the clinical characteristics, treatment and outcome of childhood rhabdomyosarcoma.
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PMID: 21849118
PDF is available here.
Abstract
Compared to other chronic inflammatory diseases, gout appears to based on a rather "simple" pathophysiology and therefore the amount of teaching time in medical school and during internship is rather limited. On the other hand, several problems in short- and long-term management stil...
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PMID: 21833886
PDF is available here.
Abstract
The patient, a 58-year-old woman, underwent a partial excision of the right breast and an axillary lymph node dissection in October 2004. The histopathological findings were: solid tubular carcinoma with metastasis to 17 axillary lymph nodes; triple negative-type breast cancer. As ad...
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PMID: 21829078
PDF is available here.
Abstract
Participants in walking (P=.05), light (P=.04), and combination treatment (P=.01) had significantly greater improvements in total wake time at posttest (effect size 0.51-0.63) than controls but no significant improvement on the SDI. Moderate effect size improvements in actigraphic sleep percentage w...
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PMID: 21797835
PDF is available here.
Abstract
We describe the combined use of rhBMP-2 and the bisphosphonate zoledronic acid in a mouse model of NF1-deficient fracture repair. Fractures were generated in the distal tibiae of neurofibromatosis type 1-deficient (Nf1(+/-)) mice and control mice. Fractures were open and featured periosteal strippin...
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PMID: 21768643
PDF is available here.
Abstract
To discuss the current role of laser therapies in the management of retinal vascular and neovascular diseases.
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PMID: 21742309
PDF is available here.