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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Drug Chronotherapy (0):
Recent article
Drug Chronotherapy
Anesthesia & Analgesia (111)4 2010
Abstract
Eighty-two women were included in the study. Examination of the raw data using 3 smoothing functions revealed a bimodal pattern, with a peak at approximately 0630 and a subsequent peak in the afternoon or evening, depending on the smoother. Analysis of variance did not identify any statistically sig...
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PMID: 20442259
PDF is available here.
PDF is available here.
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Abstract
There is growing interest on how to best tailor blood pressure (BP)-lowering medications according to the circadian (24 h) BP pattern of individual patients, that is, chronotherapy. Significant and clinically meaningful treatment-time differences in the beneficial and/or adverse effects of at least...
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PMID: 20571367
PDF is available here.
PDF is available here.
Abstract
Pulsatile drug delivery system capable of releasing the drug after a predetermined lag period in pulsed or controlled release manner recently has drawn the attention of both academic and industrial research. Depending on the effective therapeutic application of the drug, a variety of design strategi...
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PMID: 20156177
PDF is available here.
PDF is available here.
Klinicheskaia meditsina (88)2 2010
Abstract
The aim of the work was to compare efficiency of traditional therapy with prestarium (tert-butylamine salt) and chronotherapy with prestarium A (arginine salt) in elderly patients with polymorbidity syndrome (diabetes mellitus, nephropathy, grade I-II chronic hepatic insufficiency). All patients und...
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PMID: 21105478
PDF is available here.
PDF is available here.
Voprosy onkologii (56)2 2010
Abstract
Abstract
During the course of the day all patients showed on average an additional decline in these values compared to the 9:00 am serum level of 41%. In only a third of the patients did the 24-hour profile exhibit an average increase that exceeded the 9:00 am value by as much as 4%. In the case of the 24-ho...
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PMID: 19640350
PDF is available here.
PDF is available here.
Hypertension (54)1 2009
Abstract
We studied 115 untreated hypertensive patients, 46.7+/-11.2 years of age, randomly assigned to receive ramipril (5 mg/d) as a monotherapy either on awakening or at bedtime. Blood pressure was measured for 48 hours before and after 6 weeks of treatment. The blood pressure reduction during diurnal act...
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PMID: 19433778
PDF is available here.
PDF is available here.
Abstract
Bioavailability of the extended-release tramadol capsules for once daily administration is not affected by the time-point of administration. Total and maximum exposure of the product was bioequivalent after intake in the morning and at night. Thus, the time-point of administration may be adjusted to...
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PMID: 19473603
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To prepare the gastric retenting and chronopharmacologic drug delivery tablets containing sinomenine hydrochloride as a model drug, evaluate the effects of the coating layers formulation and technics on drug release behavior, and to elucidate the mechanism of drug release based on obtaine...
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PMID: 19526781
PDF is available here.
PDF is available here.
Der Schmerz (23)1 2009
Abstract
The median age of the patients was 12.6 years and they mainly suffered from forms of acute leukemia. Daily morphine equivalent dose (MED) requirements increased with the start of the PCA therapy from 14.5 mg/day to 18.7 mg/day (p=0.021; Wilcoxon test). Children required more opioids by bolus request...
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PMID: 19083025
PDF is available here.
PDF is available here.
Abstract
It has been proven that the body follows a 24-hour cycle called a circadian rhythm. This cycle is coordinated by the suprachiasmatic nucleus and controls nearly all bodily functions including those related to drug delivery. Knowledge of the body's circadian rhythm leads to an improved understanding...
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PMID: 19883249
PDF is available here.
PDF is available here.
AAPS PharmSciTech (10)4 2009
Abstract
These results exhibit uniqueness in achieving the least drug release of 0.98%, an ideal one, without using any release modifiers, making it distinct from other approaches/technologies for time and controlled release and for chronotherapy....
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PMID: 19936939
PDF is available here.
PDF is available here.
AAPS PharmSciTech (10)4 2009
Abstract
These results exhibit uniqueness in achieving the least drug release of 0.98%, an ideal one, without using any release modifiers, making it distinct from other approaches/technologies for time and controlled release and for chronotherapy....
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PMID: 19936939
PDF is available here.
PDF is available here.
AAPS PharmSciTech (10)4 2009
Abstract
These results exhibit uniqueness in achieving the least drug release of 0.98%, an ideal one, without using any release modifiers, making it distinct from other approaches/technologies for time and controlled release and for chronotherapy....
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PMID: 19936939
PDF is available here.
PDF is available here.
AAPS PharmSciTech (10)4 2009
Abstract
These results exhibit uniqueness in achieving the least drug release of 0.98%, an ideal one, without using any release modifiers, making it distinct from other approaches/technologies for time and controlled release and for chronotherapy....
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PMID: 19936939
PDF is available here.
PDF is available here.
Abstract
Currently only a few package inserts of once-daily medications specially define the dosing time, although sporadic studies have demonstrated administration time-dependent effects on the therapeutic outcome. Some chronotherapeutic approaches aim to diminish the occurrence of adverse drug reactions (A...
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PMID: 18822026
PDF is available here.
PDF is available here.
Abstract
Hypertension is a global condition affecting billions worldwide. It is a significant contributor to cardiovascular events, cardiac death and kidney disease. A number of medication classes exist to aid healthcare providers and their patients in controlling hypertension. Nifedipine, a dihydropyridine...
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PMID: 19337538
PDF is available here.
PDF is available here.
Abstract
Developments of chronobiology abroad are forging ahead in elucidating the cellular and molecular basis and the influential factors of circadian clock such as light, jet lag, pharmaceutical. This article also reviews the influence of circadian system on human physiology and disease occurrence. The ci...
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PMID: 15762146
PDF is available here.
PDF is available here.