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Pulse Therapy, Drug (0):
Recent article
Pulse Therapy, Drug
Abstract
We would like to report our experience of using rituximab in cyclophosphamide refractory, rapidly progressive interstitial lung disease (ILD) in a patient with limited scleroderma. A 40-year-old man presented with 10-week history of inflammatory polyarthritis, which responded to a short course of or...
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PMID: 21593063
PDF is available here.
PDF is available here.
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Abstract
Aim: While the best treatment of nephrosis-inducing idiopathic membranous nephropathy (IMN) is controversial, some trials have suggested positive outcomes following treatment with oral cyclophosphamide used in combination with steroids. However, data on i.v. cyclophosphamide plus steroids in treat...
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PMID: 21091923
PDF is available here.
PDF is available here.
Abstract
We succeeded to decrease 30% to less than 10% in the death rate during the ten years. The steroid might take an important role on prevention of "the sudden and excessive inflammatory cytokines production in the whole body and the central nerve"....
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PMID: 21400847
PDF is available here.
PDF is available here.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (22)2 2011
Abstract
We report the clinical features and outcome of a 50-year-old woman who presented with KS 18 weeks after starting immunosuppressive therapy for vasculitis. She had positive-titer IgG antibody to human herpes virus 8. Cyclophosphamide pulses were interrupted, and prednisone was decreased gradually to...
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PMID: 21422634
PDF is available here.
PDF is available here.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (22)2 2011
Abstract
We describe a 42-year-old male patient who presented with high grade fever associated with acute renal failure requiring hemodialysis. Renal biopsy revealed that he had focal proliferative glomerulonephritis on light microscopy, dominant mesangial deposition of C1q by immunofluorescent staining, and...
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PMID: 21422635
PDF is available here.
PDF is available here.
Abstract
Primary Sjogren's is a multisystem autoimmune disease which predominantly affects the exocrine glands. pSS may occasionally present in an atypical way which may defy correct diagnosis for a considerable period of time. Clinically important immune-mediated cytopenia (or a combination of cytopenias) ma...
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PMID: 21751649
PDF is available here.
PDF is available here.
Rinsho Ketsueki (52)1 2011
Abstract
A 60-year-old man demonstrated a bleeding tendency at enterostomy about 7 months after aortic arch replacement. Abdominal muscle hematoma and pelvic hematoma were also detected. He was diagnosed as having acquired hemophilia A based on prolonged APTT (65.9 sec), reduced FVIII activity (>1%), and the...
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PMID: 21378475
PDF is available here.
PDF is available here.
Nippon Jinzo Gakkai shi (53)2 2011
Abstract
We report a case of a 47-year-old man with multicentric Castleman's disease (MCD) and progressive renal dysfunction due to mesangial proliferative glomerulonephritis, possibly from IgA nephropathy. At age 36 years, he was referred to a hematologist due to hypergammaglobulinemia. Because of systemic...
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PMID: 21516705
PDF is available here.
PDF is available here.
Abstract
Nippon Jinzo Gakkai shi (53)2 2011
Abstract
Nippon Jinzo Gakkai shi (53)1 2011
Abstract
We diagnosed a focal segmental glomerulosclerosis collapsing variant. After steroid pulse therapy and LDL apheresis, his serum Cre level had decreased to 1.1 mg/dL and the urinary protein level to 2.5 g/gCr. Patients with a focal segmental glomerulosclerosis collapsing variant are poor responders to...
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PMID: 21370578
PDF is available here.
PDF is available here.
Abstract
Abstract
We suspected ANCA-associated disease with interstitial pneumonia. Prednisolone was begun at 30 mg/day and his lung opacities partially disappeared. Six weeks later, he complained of headache, dysphagia and hoarseness, and was admitted to the neurology department of the hospital. Under a diagnosis of...
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PMID: 21141070
PDF is available here.
PDF is available here.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (21)5 2010
Abstract
Our study revealed that there was a high prevalence of iSRNS and preponderance of non-MCD lesions, with MPGN and FSGS being the major morphologic lesions. The outcome with steroid and cyclophosphamide-based treatment for iSRNS was further enhanced with addition of either lisinopril or spironolactone...
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PMID: 20814150
PDF is available here.
PDF is available here.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (21)5 2010
Abstract
We report a case of lupus interstitial cystitis with bladder irritation and bilateral hydroureteronephrosis in an adolescent female who was treated with intravenous methylprednisolone pulse therapy followed by oral prednisolone and mycofenolate mofetil (MMF). Her symptoms ameliorated, and the hydrou...
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PMID: 20814138
PDF is available here.
PDF is available here.
Archives de Pédiatrie (17)9 2010
Abstract
We report 3 cases of CIDP in children with good outcome after MP pulse therapy. One male (7 years of age) and 2 females (4 and 5 years of age) presented with recurring episodes of functional impotence of both lower limbs and walking impairment, partially reversible without treatment. Clinical and el...
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PMID: 20709511
PDF is available here.
PDF is available here.
Abstract
Pulsatile drug delivery system capable of releasing the drug after a predetermined lag period in pulsed or controlled release manner recently has drawn the attention of both academic and industrial research. Depending on the effective therapeutic application of the drug, a variety of design strategi...
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PMID: 20156177
PDF is available here.
PDF is available here.
Rinsho Ketsueki (51)6 2010
Abstract
A 63-year-old woman, without a family history of hemophilia, was admitted to our hospital because of subcutaneous bleeding, intramuscular and intra-articular hematoma, and macroscopic hematuria. On routine blood analysis, a prolonged activated partial thromboplastin time, decreased concentration of...
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PMID: 20622487
PDF is available here.
PDF is available here.
Rinsho Shinkeigaku (50)5 2010
Abstract
We regarded this case as one of chronic progression of Encephalo-myelo-radiculo-neuropathy....
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PMID: 20535982
PDF is available here.
PDF is available here.
Rinsho Ketsueki (51)5 2010
Abstract
An 83-year-old woman had been suffering from palpitations and fatigue for a month. An annual screening test revealed an increased WBC count so she was referred to our hospital. CBC showed extremely elevated WBC count (186,300/microl), in which the population of blastic eosinophils was over 90%. The...
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PMID: 20534953
PDF is available here.
PDF is available here.
Rinsho Shinkeigaku (50)4 2010
Abstract
We diagnosed him with neuro-Sweet disease (NSD) based on human leukocyte antigen (HLA) B-54/Cwl positivity and neutrophilic infiltration into the dermis in a biopsied skin plaque. Intravenous methylprednisolone and oral prednisolone markedly improved his fever and CSF pleocytosis. Five years later h...
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PMID: 20411809
PDF is available here.
PDF is available here.
Rinsho Shinkeigaku (50)3 2010
Abstract
We report the case of a 31-year-old woman who presented with neuromyelitis optica (NMO) associated with Sjögren syndrome and distal renal tubular acidosis. She was hospitalized because of cervical transverse myelopathy and right optic neuritis. She had been clinically diagnosed with Sj6gren syndrom...
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PMID: 20235486
PDF is available here.
PDF is available here.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (21)2 2010
Abstract
We studied 39 patients of lupus nephritis on IVC therapy between 1998 to 2002. Single monthly cyclophosphamide (0.75-1 g/m(2)) was infused intravenously with oral prednisolone (0.5 mg/kg per day) and appropriate hydration. Of the 39 patients 25 (86.2%) patients were females and 4 (13.8%) were males....
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PMID: 20228536
PDF is available here.
PDF is available here.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (21)2 2010
Abstract
We report a patient who presented at the Selcuk University Meram School of Medicine, Meram, Konya, Turkey, with the pulmonary-renal syndrome. He was also found to have idiopathic dilated cardiomyopathy (DCM). To our knowledge, this is the first report describing co-existence of DCM and anti-GBM dise...
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PMID: 20228524
PDF is available here.
PDF is available here.
Modern Rheumatology (20)1 2010
Abstract
We should be alert to the possibility that ARDS can occur as an acute-type pulmonary complication of RA, particularly when patients show rapid aggravation of rheumatic activity....
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PMID: 19784543
PDF is available here.
PDF is available here.
Modern Rheumatology (20)1 2010
Abstract
A 52-year-old woman with a 6-year history of systemic lupus erythematosus (SLE) developed acute abdominal pain, nausea, vomiting, and diarrhea accompanied by hypocomplementemia. Herpes simplex virus (HSV) esophagitis and lupus enteritis were diagnosed on the basis of the results of endoscopic and hi...
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PMID: 19802650
PDF is available here.
PDF is available here.
Modern Rheumatology (20)1 2010
Abstract
We retrospectively analyzed 27 RPGN patients who were admitted in our hospital over the past 11 years and who could be basically followed for more than 1 year, concerning the incidence of ANCA-related vasculitis, the presence of (MPO)/proteinase 3 (PR3)-ANCA and their clinical outcomes. As there wer...
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PMID: 19821007
PDF is available here.
PDF is available here.
Abstract
The clinical course of focal segmental glomerulosclerosis (FSGS) is heterogeneous in children. To evaluate the clinical course and the predictors of outcome in Turkish children with primary FSGS, a retrospective study was conducted by the Turkish Pediatric Nephrology Study Group in 14 pediatric neph...
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PMID: 20718182
PDF is available here.
PDF is available here.
Abstract
This survey shows that in Japan, pulse steroid therapy is used for a relatively large number of children with UC and is as an effective method of remission induction that has few side effects.
Copyright 2010 S. Karger AG, Basel....
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PMID: 20090334
PDF is available here.
PDF is available here.
Reumatismo (62)3 2010
Abstract
To evaluate the long- term outcome of a group of systemic lupus erythematosus (SLE) patients with diffuse proliferative glomerulonephritis (DPGN) treated with pulse steroids and a short course of pulse cyclophosphamide (Cyc) in order to find out baseline predictor variables of disease outcome at the...
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PMID: 21052569
PDF is available here.
PDF is available here.
Rinsho Ketsueki (51)1 2010
Abstract
Sequential high-dose chemotherapy with in vivo rituximab-purged stem cell autografting was designed for previously untreated mantle cell lymphoma (MCL). The response rate, disease-free survival (DFS), overall survival (OS) and toxicity were investigated in this trial. Between November 2001 and Augus...
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PMID: 20134141
PDF is available here.
PDF is available here.
Abstract
Abstract
A 5-year-old girl presented with a two-month-history of skin rash and general fatigue. She had a slight fever, progressive muscle weakness and liver dysfunction. Gottron's papules on her fingers and purple-reddish papules on her elbows were noted. Serum aldolase levels were highly elevated, however,...
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PMID: 20110203
PDF is available here.
PDF is available here.
Abstract
Necrotizing retinopathies simulating acute retinal necrosis have not been reported before in patients with sarcoidosis....
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PMID: 19882539
PDF is available here.
PDF is available here.
Abstract
We report the case of a 46-year old woman with classical features of AOSD. Severe pancytopenia and jaundice associated with extreme hyperferritinemia occurred during high-dose steroid treatment. Bone marrow biopsy showed typical pathological features of hemophagocytosis, which confirmed the coexiste...
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PMID: 20123591
PDF is available here.
PDF is available here.
Abstract
We commenced the initial treatment-steroid pulse therapy with 60 mg/day of prednisolone and 3 mg/day of tacrolimus. We also induced abortion. The treatment of corticosteroids and tacrolimus was, however, ineffective even after increasing the tacrolimus dose to 6 mg/day. On July 30, she suddenly expe...
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PMID: 20601834
PDF is available here.
PDF is available here.
Abstract
We also used MPT for another 12 cases of HNL. All patients became afebrile within 1 day without adverse events. Four patients relapsed after the initial MPT, but only 1 patient relapsed during the following year. Our results suggest that MPT is warranted in HNL patients with prolonged fever....
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PMID: 20962448
PDF is available here.
PDF is available here.
Nippon Jinzo Gakkai shi (52)7 2010
Abstract
Nippon Jinzo Gakkai shi (52)7 2010
Abstract
Nippon Jinzo Gakkai shi (52)7 2010
Abstract
Nippon Jinzo Gakkai shi (52)1 2010
Abstract
We report here a 37-year-old female patient with HSP nephritis (HSPN) associated with steroid-resistant nephrotic syndrome and renal dysfunction despite conventional therapy. The patient was successfully treated with intravenous cyclophosphamide following treatment with intravenous pulse methylpredn...
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PMID: 20166544
PDF is available here.
PDF is available here.
Nippon Jinzo Gakkai shi (52)2 2010
Abstract
We report a case of biopsy-proven lupus vasculopathy, with lupus nephritis class IV-G (A). She developed SLE at 15 years of age, and was treated with prednisolone(PSL) and cyclophosphamide (CTX). Sometimes she experienced a flare-up clinically or serologically, requiring a dose increase of oral PSL....
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PMID: 20415236
PDF is available here.
PDF is available here.
Rinsho Shinkeigaku (49)11 2009
Abstract
We believe this criteria has disadvantages for making early diagnosis in patients who fail to meet the criteria yet have the same disease process. Therefore we propose a simple new criteria which requires one of the following two: (1) centrally located, fully contiguous long spinal cord lesion (LCL)...
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PMID: 20030244
PDF is available here.
PDF is available here.
Abstract
A 78-year-old man was admitted for obstructive jaundice and unresectable bile duct cancer on March 4, 2008. Since biliary drainage was extremely difficult, he began 2 treatment courses of gemcitabine hydrochloride (GEM 800 mg/m(2) on days 1, 8, 15 every 4 weeks). He suffered from dry cough and dyspn...
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PMID: 19838043
PDF is available here.
PDF is available here.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation (7)3 2009
Abstract
We describe a case of concomitant Cytomegalovirus infection and Aspergillus pneumonia in a heart transplant patient who received pulsed steroids as therapy for rejection, and we describe the successful treatment of that coinfection with ganciclovir and voriconazole....
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PMID: 19715527
PDF is available here.
PDF is available here.
Abstract
We reported 3 cases of hypersensitivity pneumonitis who had been exposed to polyurethane material containing diphenylmethane diisocyanate (MDI) for 1-12 weeks. They had cough, fever and dyspnea before admission. All 3 cases were diagnosed immunologically using anti-MDI antibodies. Chest HRCT finding...
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PMID: 19827591
PDF is available here.
PDF is available here.
Abstract
Pediatric Nephrology (24)6 2009
Abstract
Abstract
Clinical Nephrology (71)6 2009
Abstract
Methylprednisolone and cyclophosphamide in children with Grade IV IgA nephropathy stabilized renal function and significantly reduced hematuria, proteinuria, mesangial IgA deposition, and the renal pathological activity index....
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PMID: 19473630
PDF is available here.
PDF is available here.
Clinical Nephrology (71)6 2009
Abstract
We herein report the case of a 12-year-old boy with dense deposit disease (DDD) evoked by streptococcal infection. He had been diagnosed to have asymptomatic hematuria syndrome at the age of 6 during school screening. At 12 years of age, he was found to have macrohematuria and overt proteinuria with...
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PMID: 19473640
PDF is available here.
PDF is available here.
Abstract
We encountered a case of severe M. pneumoniae pneumonia, which induced acute respiratory failure even though the patient was receiving appropriate antibiotic treatment. The patient was recovered with steroid pulse therapy....
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PMID: 19601521
PDF is available here.
PDF is available here.
Annals of Internal Medicine (150)10 2009
Abstract
Groups did not differ in time to remission (hazard ratio, 1.098 [95% CI, 0.78 to 1.55]; P = 0.59) or proportion of patients who achieved remission at 9 months (88.1% vs. 87.7%). Thirteen patients in the pulse group and 6 in the daily oral group achieved remission by 9 months and subsequently had rel...
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PMID: 19451574
PDF is available here.
PDF is available here.
Journal of Rheumatology (36)5 2009
Abstract
Abstract
We discovered serum autoantibodies against the NH2-terminal of a-enolase (NAE) as a specific diagnostic marker for HE. We analyzed these serum anti-NAE autoantibodies and the clinical features in 84 cases of HE. The 84 patients consisted of 26 men and 58 women, from many institutions throughout Japa...
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PMID: 19363998
PDF is available here.
PDF is available here.
Abstract
We report a patient with antineutrophil cytoplasmic antibody-associated vasculitis with oculomotor nerve palsy. The patient presented with a high fever, diplopia, blepharoptosis and impairment of ocular movement of the left eye except for lateral gaze. Multiple erythematous and livedoid lesions were...
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PMID: 19187297
PDF is available here.
PDF is available here.
Abstract
We have previously reported a predictive method for identifying IVIG-non-responsive patients (high-risk KD patients). We determined the safety and effectiveness of pulse methylprednisolone with high-dose IVIG (mPSL+IVIG) as a primary treatment for high-risk KD patients. Sixty-two high-risk KD patien...
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PMID: 18446365
PDF is available here.
PDF is available here.
Abstract
We quantitatively characterize successful drugs or drug combinations, both theoretically and numerically. We also consider certain optimization problems, motivated for instance, by the fact that eradication should be achieved at acceptable toxicity levels to the patient. It turns out that these opti...
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PMID: 19083064
PDF is available here.
PDF is available here.
Abstract
The study group consisted of 31 men (28.2%) and 79 women (71.8%). Average age was 40 +/- 13.6 years. Mild hypokalemia was present in 19 patients (17.27% [95% CI 9.75-24.79]); moderate potassium levels were found in just one patient 0.9% [IC 95 0.023-4.96]); no cases of severe hypokalemia occurred. T...
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PMID: 19736807
PDF is available here.
PDF is available here.
Terapevticheskii arkhiv (81)6 2009
Abstract
Mechanisms of action, clinical efficacy and safety of superhigh doses of methylprednisolone (pulse-therapy) in patients with SLE, RA, systemic vasculitis, Sjogren's disease are outlined.
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PMID: 19663198
PDF is available here.
PDF is available here.