Abstract
Acromegaly is a rare disease with typical clinical manifestations. Untreated acromegaly carries a 2-4-fold increase in mortality in long-term outcome. The goal of treatment is double, including biochemical control of the disease (normalization of serum IGF1 levels compared to age and gender matched c...
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PMID: 21498160
PDF is available here.
Abstract
Physiological changes in lipoprotein levels occur in normal pregnancy. Women with hyperlipoproteinemia are advised to discontinue statins, fibrates already when they consider pregnancy up to and including breast-feeding the newborn, because of the fear for teratogenic effects. Hypertriglyceridemia in...
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PMID: 21498165
PDF is available here.
Tamás T Schneider,
Erika E Tóth,
József J Lovey,
Zsuzsanna Z Molnár,
Beáta B Deák,
Erika E Várady,
Judit J Csomor,
András A Matolcsy,
Zsolt Z Lengyel,
Klára K Petri,
István I Gaudi and
András A Rosta
Abstract
Primary mediastinal lymphoma (PMBCL) is an aggressive diffuse large B-cell lymphoma entity. It is a rare disease with specific clinical symptoms. The tumor is predominantly localized in the mediastinum but grows rapidly and infiltrates the surrounding tissues and organs. Two thirds of the patients ar...
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PMID: 21498163
PDF is available here.
Siqing S Fu,
Wei W Hu,
Revathy R Iyer,
John J JJ Kavanagh,
Robert L RL Coleman,
Charles F CF Levenback,
Anil K AK Sood,
Judith K JK Wolf,
David M DM Gershenson,
Maurie M Markman,
Bryan T BT Hennessy,
Razelle R Kurzrock and
Robert C RC Bast
Abstract
Sequential treatment with azacitidine can induce re-expression of epigenetically silenced genes through genomic DNA hypomethylation and reverse carboplatin resistance of epithelial ovarian cancer cells. A phase 1b-2a clinical trial of this sequential combination of azacitidine and carboplatin was ini...
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PMID: 21472713
PDF is available here.
Abstract
There is increasing evidence that paclitaxel and carboplatin are clinically active in the treatment of metastatic melanoma (MM). ABI-007 is an albumin-bound formulation of paclitaxel that has demonstrated single-agent activity against metastatic melanoma.
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PMID: 21472717
PDF is available here.
Abstract
This study evaluated the safety and feasibility of the addition of pamidronate to chemotherapy for treatment of osteosarcoma.
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PMID: 21472721
PDF is available here.
Abstract
We conclude that inhibition of SP activity with a NK1 tachykinin receptor antagonist is effective in reducing cerebral oedema, BBB permeability and functional deficits following reversible ischemia, and may therefore represent a novel therapeutic approach to the treatment of ischaemic stroke....
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PMID: 21466790
PDF is available here.
Abstract
In recent years carotid and vertebral artery dissections have been diagnosed more frequently, probably because new imaging techniques are more reliable and they are certainly less invasive. The cause of cervical artery dissections is largely unexplained but probably involves a combination of genetic...
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PMID: 21451203
PDF is available here.
Abstract
By the end of the treatment period, both acne and hirsutism scores improved significantly in both treatment groups (P...
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PMID: 21454179
PDF is available here.
Abstract
This study was performed with an aim to understand the conditions causing the ambivalence of the person with bipolar affective disorder (BAD) regarding following the drug treatment. A qualitative approach was used, with the Grounded Theory as the methodology framework, under the ligh...
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PMID: 21655795
PDF is available here.
Abstract
Tight glycemic control is central to reducing the risk of long-term macrovascular and microvascular complications of type 2 diabetes and the associated morbidity and mortality. However majority of the patients do not achieve glycemic targets (HbA1c < 7%). Once insulin treatment has b...
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PMID: 21818994
PDF is available here.
Abstract
Searching for novel strategies to modulate apoptosis in neuroblastoma, we investigated the potential of the proteasome inhibitor bortezomib.
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PMID: 21459798
PDF is available here.
Abstract
Chronic non-terminal diseases, including postmenopausal osteoporosis, are associated with poor treatment compliance and persistence. The longer a patient with osteoporosis complies and persists with treatment, the lower the risk of fracture. Retrospective studies with emphasis on real-world data have...
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PMID: 21553400
PDF is available here.
Abstract
Pregabalin (PGB) was licensed in Europe as an add-on antiepileptic drug (AED) for the treatment of partial-onset seizures in 2004. This audit assessed the response to adjunctive PGB in patients with uncontrolled seizures.
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PMID: 21434875
PDF is available here.
Abstract
To investigate the predictors of success in step-down of proton pump inhibitor and to assess the quality of life (QOL).
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PMID: 21472108
PDF is available here.
Abstract
To compare the effects of a combined oral contraceptive (COC) taken continuously with those of one of similar composition taken cyclically on 30 variables related to haemostasis, lipids, carbohydrates, bone metabolism, and sex hormone-binding globulin (SHBG).
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PMID: 21417560
PDF is available here.
Abstract
We aimed to determine if use of 5-aminosalicylates (5-ASA) was associated with a reduced risk of colorectal cancer (CRC) in people with inflammatory bowel disease (IBD).
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PMID: 21407180
PDF is available here.
Abstract
Scheduled maintenance therapy with infliximab decreases the risk of infusion reactions. Many centers have accelerated infusion times to 1 h in selected patients who tolerate 5 mg/kg infliximab infusions. The aim of this study was to compare the tolerability of 1-h and 2-h infliximab infusions in...
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PMID: 21407184
PDF is available here.
Abstract
To assess the effectiveness and safety of zoledronate (ZOL) in preventing glucocorticoid therapy-associated bone loss in patients with acute flare of Crohn's disease (CD) in a randomized, double-blind, placebo-controlled trial.
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PMID: 21386830
PDF is available here.
Abstract
Patients aged 70 and over represent the third of the population of patients with lung cancer. There has been for a long time a certain nihilism regarding the treatment of elderly patients with advanced lung cancer as well from medical doctors but also from families and patients themselves with the fa...
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PMID: 21388776
PDF is available here.