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Hemodilution (0):
Recent article
Hemodilution
Abstract
Our randomized, double blinded case control study suggested that patients receiving autologous blood (ANH group) following CABG had significantly lower bilirubin levels compared to patients who received homologous transfusion. However larger studies with more patients are needed to confirm the resul...
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PMID: 21612140
PDF is available here.
PDF is available here.
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Abstract
The effect of low and high viscosity hemodilution with plasma expanders on the extent of the cell free layer (CFL) width was analyzed in the microcirculation of the exteriorized cremaster muscle preparation of Sprague-Dawley male rats. Anesthetized animals were subjected to 40% hemodilution by blood...
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PMID: 21811016
PDF is available here.
PDF is available here.
Annals of Surgery (252)6 2010
Abstract
Pancreaticoduodenectomy (PD) can be associated with significant blood loss and transfusion requirements, with potential adverse short- and long-term consequences. The aim of this study was to determine whether acute normovolemic hemodilution (ANH), an established blood conservation technique, reduce...
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PMID: 21107104
PDF is available here.
PDF is available here.
Journal of Trauma (69)5 2010
Abstract
Colloid plasma expanders are used to maintain blood pressure and ensure tissue perfusion during hypovolemia, e.g., caused by traumatic bleeding. Although colloids stabilize the cardiovascular system, they can also potentially cause coagulopathy. Consequently, bleeding tendency may increase, as well...
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PMID: 20032791
PDF is available here.
PDF is available here.
Anesthesia & Analgesia (111)5 2010
Abstract
Anesthesiology (113)4 2010
Abstract
In a translational model of chronic hypertension, clinically relevant levels of acute anemia were associated with an age-dependent visuospatial working memory and learning impairment that was matched by an age-dependent cellular sensitivity to anemic hypoxia. These data offer support for a possible...
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PMID: 20808217
PDF is available here.
PDF is available here.
Abstract
Fibrinogen is the first coagulation factor becoming critical in dilution coagulopathy. Volume replacement in major blood loss is performed with large volumes of crystalloid and colloid solutions. The latter has been shown to compromise accurate photo-optical measurement of fibrinogen. This study det...
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PMID: 19617247
PDF is available here.
PDF is available here.
Abstract
Evidence continues to demonstrate that anemia increases morbidity and mortality, possibly via hypoxic mechanisms. A potential strategy for assessing "anemic stress" was derived from experimental data based on a readily measurable biomarker, methemoglobin. New methods for measuring real-time hemoglob...
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PMID: 20512540
PDF is available here.
PDF is available here.
Abstract
During the last decade, minimized extracorporeal circulation (MECC) systems have shown beneficial effects to the patients over the conventional cardiopulmonary bypass (CECC) circuits. This is a prospective randomized study of 99 patients who underwent coronary artery bypass grafting (CABG) surgery,...
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PMID: 20515982
PDF is available here.
PDF is available here.
Anesthesiology (113)1 2010
Abstract
Arterial and pulse oximetry respiratory-induced changes in waveform variables are reliable indicators of mild hypovolemia in anesthetized patients. The pulse oximetry plethysmographic waveforms accurately reflect arterial waveforms during more progressive hypovolemia....
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PMID: 20526193
PDF is available here.
PDF is available here.
Abstract
We embarked on a mission of reduced prime volume in an effort toward bloodless cardiac surgery to meet the needs of the Jehovah's Witness patient. The same bloodless surgical and perfusion techniques were applied to all patients undergoing cardiopulmonary bypass beginning in 2006. Circuit size was m...
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PMID: 20648896
PDF is available here.
PDF is available here.
Journal of Trauma (68)5 2010
Abstract
In a pilot study involving an in vivo large-animal model of spleen trauma, PCC accelerated hemostasis and augmented thrombin generation compared with rFVIIa. Further investigations are warranted on PCC as a hemostatic agent in trauma....
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PMID: 19996804
PDF is available here.
PDF is available here.
Abstract
The implication for clinical management is discussed supposing glial cell dysfunction is an underlying mechanism responsible for the vascular spasm....
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PMID: 20131107
PDF is available here.
PDF is available here.
Anaesthesist (59)4 2010
Abstract
The religious organization of Jehovah's Witnesses numbers more than 7 million members worldwide, including 165,000 members in Germany. Although Jehovah's Witnesses strictly refuse the transfusion of allogeneic red blood cells, platelets and plasma, Jehovah's Witness patients may nevertheless benefit...
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PMID: 20379694
PDF is available here.
PDF is available here.
Abstract
No differences in hemodynamics after ANH reveal that 2 plasma substitutes used in this study have almost the same quality in maintaining intravascular volume. Blood lactate level is generally recognized as an indicator of tissue hypoxia. A possible explanation for the significantly higher blood lact...
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PMID: 20169951
PDF is available here.
PDF is available here.
Abstract
Hematocrit decreased significantly by 23.7%, 19.8%, and 16.1% in the first hour, on the first day, and the seventh day after hemodilution, respectively (P < 0.001). The ocular perfusion pressure of the healthy eye and the eye with retinal vein occlusion decreased by 7.7% and 7.2% after 1 hour and by...
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PMID: 20175271
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (103)2 2010
Abstract
Prolonged standing activates the coagulation cascade by the activation of endothelial cells, and probably the haemoconcentration effect contributes to this "orthostatic hypercoagulability". It was the objective of this study to assess whether rehydration (haemodilution) prevents or attenuates orthos...
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PMID: 20126831
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (103)2 2010
Abstract
We hypothesised that, in the acquired dilutional coagulopathy, insufficient haemostasis is due to either insufficient thrombin generation or insufficient fibrin clot formation. In tissue factor-activated plasmas from patients with coagulation deficiency, we measured time curves of thrombin generatio...
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PMID: 20024495
PDF is available here.
PDF is available here.
Abstract
Critical Care (14)2 2010
Abstract
Restoring fibrinogen with 70 or 200 mg kg-1 after severe dilutional coagulopathy safely improved coagulation and attenuated blood loss after experimental blunt liver trauma. The higher dosage of fibrinogen was not associated with a further reduction in blood loss....
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PMID: 20398253
PDF is available here.
PDF is available here.
ASAIO Journal (56)4 2010
Abstract
We have used a novel technique based on the closed cardiopulmonary bypass system without cardiotomy suction (minimal cardiopulmonary bypass [mini-CPB]) for aortic valve replacement (AVR). In this study, we investigated the clinical advantages of this approach. We prospectively studied 32 patients wh...
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PMID: 20559134
PDF is available here.
PDF is available here.
Blood Purification (30)1 2010
Abstract
There is still no consensus on the optimal infusion flow (Qi) in mid-dilution hemodiafiltration. The aim of this study was to compare mid-dilution with varying Qi.
Prospective study in 25 patients who underwent seven hemodialysis sessions with a Qi of 0, 50, 100, 150, 200, 250 and 300 ml/min.
All se...
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PMID: 20588009
PDF is available here.
PDF is available here.
Abstract
Normovolemic hemodilution produces conflicting results on hemostasis, since works differ according to the fluids used, degree of hemodilution, method used to evaluate hemostasis, and the way used to produce hemodilution. The effects of hemodilution on hemostasis can depend on how it is done and whet...
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PMID: 20659608
PDF is available here.
PDF is available here.
Bratislavske lekarske listy (111)9 2010
Abstract
We monitored the patient's hemocoagulation profile. ANH is one of the possibilities for practical and pragmatic hemotherapy. It is a safe and effective method when facing massive blood loss or when it is necessary to temporarily replace or substitute the blood with a fluid during the operation (thro...
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PMID: 21180269
PDF is available here.
PDF is available here.
Experimental Lung Research (35)10 2009
Abstract
Acute normovolemic hemodilution (ANH) can be used in acute lung injury (ALI) patients who refuse blood transfusions. To investigate the effects of hemodilution on the acute inflammatory response in lung injury, the authors studied the effects of ANH in a rat model of bleomycin-induced lung injury. B...
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PMID: 19995278
PDF is available here.
PDF is available here.
Abstract
A total of 62 patients, from 68 enrolled, completed the study: 27 in group A and 35 in group H. Both groups had similar prolongation of prothrombin time and partial thromboplastin time, decreased platelets count and changes in postoperative thromboelastographic variables. There were no differences b...
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PMID: 19528806
PDF is available here.
PDF is available here.
Abstract
We hereby present a case in which ANH was used successfully. A 22 year old male patient with known homozygous sickle cell disease undergoing orthopedic surgery, underwent Acute Normovolemic Hemodilution (ANH) because of the absence of blood and suitable blood donors and high hemoglobin level. Just b...
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PMID: 19950747
PDF is available here.
PDF is available here.
Abstract
Minimal ANH is safe and cost effective and its routine use in eligible patients is therefore justified. Intraoperative autologous blood donation in CABG surgery decreased perioperative allogeneic blood requirement. However, the removal and reinfusion of about one unit autologous blood had no effect...
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PMID: 19950738
PDF is available here.
PDF is available here.
Abstract
This review examines the science and methodology of blood conservation in modern anaesthetic and surgical practice. Blood transfusion is associated with increased morbidity and mortality in all surgical patients, and the reduction or even elimination of transfusion has been and continues to be the s...
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PMID: 19448549
PDF is available here.
PDF is available here.
A potential role for inducible nitric oxide synthase in the cerebral response to acute hemodilution.
Abstract
Cerebral cortical iNOS and nNOS protein levels were both increased in anemic rats. The nNOS response was predominant. This suggests that NOS-derived NO may be an important signalling pathway which is activated in the brain during anemia. These cellular responses could maintain cerebral homeostasis,...
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PMID: 19412649
PDF is available here.
PDF is available here.
Sao Paulo Medical Journal (127)2 2009
Abstract
Fluid resuscitation is intended to eliminate microcirculatory disorders and restore adequate tissue oxygenation. The safety limits for a restrictive transfusion policy are given by patients' individual tolerance of acute normovolemic anemia. Artificial oxygen carriers based on perfluorocarbon or hem...
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PMID: 19597685
PDF is available here.
PDF is available here.
Abstract
The authors present a rare case of anti-Vel antibodies in a patient who underwent a shoulder replacement with a custom designed procedure which involved combination of autologous blood pre-deposit, pre-operative haemodilution and resurfacing arthroplasty.
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PMID: 19409169
PDF is available here.
PDF is available here.
Abstract
We compared haemodilution acid-base effects of 4% albumin, 3.5% polygeline, 4% succinylated gelatin (all weak acid colloids, strong ion difference 12 mEq/l, 17.6 mEq/l and 34 mEq/l respectively), 6% hetastarch (non-weak acid colloid, strong ion difference zero) and 0.9% saline (crystalloid, strong i...
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PMID: 19499860
PDF is available here.
PDF is available here.
Abstract
Use of viscous plasma expanders in experimental models of extreme hemodilution, hemorrhagic shock and endotoxemia shows that the limiting factor in anemia is not oxygen-carrying capacity but the decline of microvascular function due to the lowering of functional capillary density. In support of this...
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PMID: 19307891
PDF is available here.
PDF is available here.
Abstract
Trauma-induced coagulopathy primarily results from blood loss, hypovolemia-induced activation of the protein C system and consequent increase of the fibrinolytic potential, whereas hemodilution, localized consumption of clotting factors and platelets, hypothermia, acidosis, anemia and hypocalcemia f...
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PMID: 19390253
PDF is available here.
PDF is available here.
Abstract
With recent improvements in prehospital care, trauma specialists face more challenging cases than ever before. Hemostatic transfusion strategies, with early and more aggressive use of plasma, platelets, cryoprecipitate and coagulation factor isolates, decrease blood loss in trauma patients. Combined...
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PMID: 19300245
PDF is available here.
PDF is available here.
Abstract
Following the publication of a review on circulatory volume expansion in the Cochrane Registry database in 2004 and a meta-analysis in 2003, there are no new randomized trials of triple-H therapy to prevent or treat cerebral vasospasm. However, physiological studies have been reported that contribut...
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PMID: 19276798
PDF is available here.
PDF is available here.
Abstract
Of all groups, MP4 showed the smallest area of no perfusion (in percentage of the ear +/- SEM: 16.3% +/- 2.4), the control group the largest (22.4% +/- 3.5). Leukocytes showed a significant increase in the MP4 and dextran group (from 8.7 to 13.6 respectively 15.4*109/l). On histology no changes of t...
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PMID: 19380283
PDF is available here.
PDF is available here.
Abstract
The combination of fibrinogen and rFVIIa displays an additive effect and improves overall in vitro whole blood clot formation in a model of in vitro crystalloid-induced haemodilution....
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PMID: 19243319
PDF is available here.
PDF is available here.
Abstract
There is a considerable amount of literature published on the detrimental effects of banked blood exposure in cardiac surgery. Likewise, in an effort to minimize blood exposure, many of these articles involve modifications to the heart-lung machine or its components to reduce priming volumes, theref...
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PMID: 19361029
PDF is available here.
PDF is available here.
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue (21)3 2009
Abstract
(1)MAP declined gradually and HR tended to accelerate during the course of the experiment in group E, but no significant differences were found in both group C and group AHH. (2)After AHH, the Hb and Hct decreased by 20% in group AHH. In group E, arterial oxygen saturation (SaO(2)), arterial partial...
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PMID: 19278582
PDF is available here.
PDF is available here.
Anaesthesia (64)3 2009
Abstract
We investigated the effects of acute isovolaemic haemodilution during volatile inhalational anaesthesia. Forty patients undergoing coronary surgery were randomly assigned to two groups according to the rate of atrioventricular pacing (Group 70 at 70.min(-1) and Group 90 at 90.min(-1)). While paced a...
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PMID: 19302634
PDF is available here.
PDF is available here.
Abstract
ANH may be effective in reducing the necessity of allogenic blood transfusion during radical cystectomy with a relatively large surgical blood loss....
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PMID: 19227167
PDF is available here.
PDF is available here.
Journal of Urology (181)2 2009
Abstract
In this cohort of healthy men hemodilution from increased plasma volume may be responsible for the observed decreased tumor marker concentration in men with a higher body mass index. In addition, an increase in body mass index may predict a lower tumor marker concentration in an individual....
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PMID: 19084848
PDF is available here.
PDF is available here.
Abstract
Hemodilutional autologous blood transfusion has been experienced by 13 cases in urological surgery and has been able to save on blood, 276.6 ml in mean volume, so that this blood transfusion is thought to be valuable. And medical technologists played an important role of this method as a specialist...
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PMID: 19317215
PDF is available here.
PDF is available here.
Abstract
The development of Cardiopulmonary Bypass (CPB) catopulted the field of cardiothoracic surgery into a new dimension--one that changed the lives of individuals with congenital and acquired heart disease worldwide. Despite its contributions, CPB has clear limitations and creates unique challenges for...
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PMID: 18214639
PDF is available here.
PDF is available here.
Abstract
The mean relative viscosity of Ringer's lactate was 4.19 (+/- 0.49), that of Ringer's lactate with 1.3% albumin was 4.30 (+/- 0.31), and of 20% albumin was 7.32 (+/- 0.71). The relative viscosity of Ringer's lactate and Ringer's lactate with 1.3% albumin were statistically similar, but that of 20% a...
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PMID: 19575079
PDF is available here.
PDF is available here.
Acta Chirurgica Belgica (109)1 2009
Abstract
Abstract
We hypothesised that restriction of parenteral fluids in comparison to a liberal fluid administration policy leads to less use of packed red cells in CABG operations supported by cell salvage. After consent and approval, 130 patients operated under equal conditions were assigned prospectively and ra...
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PMID: 20187484
PDF is available here.
PDF is available here.
Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukrainy, Naukove tovarystvo khirurhiv Ukrainy ()7-8 2009
Abstract
ASAIO Journal (55)1 2009
Abstract
Although blood transfusion is essential in pediatric surgery, it is associated with increased morbidity. The goal of this study is to assess the efficiency of downsized bypass circuits and vacuum-assisted venous return in decreasing the need for blood transfusion. This study was performed on 150 pat...
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PMID: 19092654
PDF is available here.
PDF is available here.
Abstract
Besides crystalloids, colloids are used for the treatment of hypovolemia and shock. They are high-molecular-weight proteins of bovine origin with properties of more rapid replacement of circulating blood volume. Iso-oncotic character provides the volume effect (approximately equal to 100%) close to...
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PMID: 19223709
PDF is available here.
PDF is available here.
Terapevticheskii arkhiv (81)1 2009
Abstract
For both groups spatial clot growth rate 2 hours after hemodilution was high. Then it fell and reached baseline level 48 hours after PRS infusion. Endogenic thrombin potential and thromboelastography data (for group 2) changed by the same pattern. A hypercoagulation effect of gelofusin on parameters...
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PMID: 19253712
PDF is available here.
PDF is available here.
Abstract
Forty-five patients with dilated cardiomyopathy, NYHA Functional Classes III-IV chronic heart failure with left ventricular ejection fraction 26.98+/-7%, who had undergone surgical left ventricular remodeling using an extracardiac conduit in combination with mitral or tricuspid valve correction and...
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PMID: 19938711
PDF is available here.
PDF is available here.
Abstract
The results of using three infusion solutions, such as 6% hydroxyexyethyl starch (HES) 200/0.5 (HaesSteril), HES 130/0.4 (Voluven), and 4% modified gelatin solution (Gelofusin), were compared in 33 patients with neurosurgical diseases of the brain (supratentorial meningovascular tumors) and predicta...
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PMID: 20491145
PDF is available here.
PDF is available here.
Vnitrni lekarstvi (55)1 2009
Abstract
Hemostasis is an important intricately regulated homeostatic process. During the hospitalization a critically ill patient is often subjected to various external and internal stimuli which have abilities to influence the hemostasis. Administration of substitute solutions could be related to such an a...
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PMID: 19227953
PDF is available here.
PDF is available here.
Abstract
Anesthesia & Analgesia (108)1 2009
Abstract
The relatively slow whole-body distribution of lactated Ringer's solution, which boosts the plasma volume expansion during and for up to 30 min after an infusion, is probably governed by a joint effect of capillary permeability and differences in tissue perfusion between body regions....
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PMID: 19095840
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (88)41 2008
Abstract
There was no significant difference in intra-operative blood loss between these 2 groups. The Hb one day after operation of the AHH group was (89 +/- 12) g/L, significantly lower than that immediately after operation [(98 +/- 10) g/L, P < 0.05]. The Hb one day after operation of the CNT group was (9...
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PMID: 19080095
PDF is available here.
PDF is available here.
Abstract
We focus to avoid any transfusion (allogeneic and autologous blood). Therefore the most important techniques used are pharmacological: erythropoietin before surgery with a number of injections related to baseline Hb, and tranexamic acid during and after surgery. Cell saving is used only if bleeding...
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PMID: 18930421
PDF is available here.
PDF is available here.