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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Ischemic Preconditioning (1):
Recent article
Ischemic Preconditioning
Abstract
The present review is focused on the dual role played by platelet-activating factor (PAF) in ischemia and reperfusion (I/R) injury of the heart. Although the involvement of PAF in the pathogenesis of myocardial reperfusion injury is well established, in the last few years it has emer...
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PMID: 21378031
PDF is available here.
PDF is available here.
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Abstract
We used three independent experimental approaches to determine the role of ADK as a molecular target for predicting the brain's susceptibility to ischemic stroke. First, when subjected to a middle cerebral artery occlusion model of focal cerebral ischemia, transgenic fb-Adk-def mice, which have incr...
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PMID: 21427729
PDF is available here.
PDF is available here.
Abstract
Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive measures, no currently available therapy can effectively treat or prevent ischemic AKI. This paper discusses recent developments in the understan...
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PMID: 21288330
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1813)7 2011
Abstract
We speculate that this permits sorting of highly functional components into one end of a mitochondrion, while damaged components are segregated at the other end, to be jettisoned by asymmetric fission followed by selective mitophagy. Ischemic preconditioning requires autophagy/mitophagy, resulting i...
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PMID: 21147177
PDF is available here.
PDF is available here.
Abstract
We have previously shown that remote ischemic preconditioning (rIPC) by transient limb ischemia leads to the release of a circulating factor(s) that induces potent myocardial protection. Intra-arterial injection of adenosine into a limb also leads to cardioprotection, but the mechanism of its signal...
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PMID: 20802131
PDF is available here.
PDF is available here.
Abstract
We summarize available literature regarding the protective signaling pathways activated by (hypothermic) ischemia and preconditioning and how they can be activated pharmacologically. Optimizing the graft quality before transplantation improves long-term graft survival. The major factor influencing o...
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PMID: 20571465
PDF is available here.
PDF is available here.
Surgery Today (40)9 2010
Abstract
Carnosol is a phenolic diterpene that has potent antioxidant and anti-inflammatory activities. The purpose of this study was to investigate the preconditioning effects of carnosol on lung injury induced by intestinal ischemia/reperfusion (II/R).
Rats were divided into control, II/R, and carnosol gro...
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PMID: 20740350
PDF is available here.
PDF is available here.
Abstract
We aimed to evaluate the role of a synthetic somatostatin analogue in delay procedure of experimental skin flaps. Thirty-six rats were randomly divided into 2 groups of 18 each to compare the possible local ischemic effect of octreotide with that of surgical delay in the dorsal random pattern skin f...
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PMID: 20585235
PDF is available here.
PDF is available here.
Abstract
We aimed to determine whether remote ischemic preconditioning (IP) reduces renal damage following elective open infrarenal abdominal aortic aneurysm (AAA) repair. Sequential common iliac clamping was used to induce remote IP in randomized patients. Urinary retinol binding protein (RBP) and albumin-c...
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PMID: 20484066
PDF is available here.
PDF is available here.
Abstract
PURPOSE. Retinal ischemia/reperfusion (I/R) injury damages retinal neurons. Carbon monoxide (CO) recently attracted attention as cytoprotective because of its anti-inflammatory and antiapoptotic effects. Rapid preconditioning of retinal neurons by inhaled CO before I/R injury may reduce inflammation...
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PMID: 20181836
PDF is available here.
PDF is available here.
Abstract
Akt-mediated eNOS upregulation in neurons and vascular endothelial cells is required for LPS-induced tolerance against HI in the neonatal rat brain....
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PMID: 20508195
PDF is available here.
PDF is available here.
Anesthesiology (113)1 2010
Abstract
Perinatal hypoxic-ischemic encephalopathy can be a devastating complication of childbirth. Herein, the authors review the pathophysiology of hypoxic-ischemic encephalopathy and the current status of neuroprotective strategies to ameliorate the injury centering on four themes: (1) monitoring in the p...
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PMID: 20526192
PDF is available here.
PDF is available here.
Abstract
Abstract
Our data imply that remote ischemic preconditioning improves the recovery from HCA. It provides a faster recovery of cortical neuronal activity and protection against potential oxygen radical-mediated ischemia damage during and after HCA. In addition, it seems to protect from a late phase lactate an...
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PMID: 20609771
PDF is available here.
PDF is available here.
Abstract
We will focus on how PHD/HIF signaling is pathogenetically implicated in metabolic and vessel alterations in these diseases and how manipulation of this pathway might offer novel treatment opportunities....
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PMID: 20582529
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (90)23 2010
Abstract
To investigate the effects of ketamine pretreatment on cerebral edema following brain ischemia reperfusion injury in rats and assess the involvement of Aquaporin 4 (AQP4) expression.
Sixty-two healthy male Sprague-Dawley rats weighing 220 -250 g were randomly divided into 3 groups: sham operation gr...
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PMID: 20979759
PDF is available here.
PDF is available here.
Kidney International (77)9 2010
Abstract
We exposed the kidney to a nonlethal period of ischemia, rendering it refractory to future ischemia-induced dysfunction. This ischemic preconditioning is partially mediated by Treg lymphocytes that suppress immune responses. We found that this maneuver significantly inhibited the accumulation of neu...
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PMID: 20164824
PDF is available here.
PDF is available here.
Circulation (121)16 2010
Abstract
Abstract
Occlusion times of 33 +/- 12 min (mean +/- SD) and 34 +/- 14 min and the extent of resected liver tissue (2.7 segments) were similar in both groups. In controls (PM), on reperfusion of liver remnants for 15 min, portal perfusion markedly decreased by 29% while there was a slight increase of 8% in th...
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PMID: 20397265
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)15 2010
Abstract
We previously observed that signal transduction systems typically associated with neurodegeneration such as caspase activation are requisite events for the expression of tolerance and induction of HSP70. In this work, we sought to determine the extent and duration of oxidative and energetic dysfunct...
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PMID: 20392947
PDF is available here.
PDF is available here.
Abstract
Recent demographic developments challenge anaesthesiologists with an increasing number of elderly patients with cardiovascular comorbidities undergoing major surgery. Interventions that are capable to increase tissue tolerance against ischemia are of paramount importance. In this context, conditioni...
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PMID: 20387183
PDF is available here.
PDF is available here.
Journal of Neurotrauma (27)4 2010
Abstract
We tested the hypothesis that hyperbaric oxygen preconditioning (HBO-PC) reduces retinal neuronal death due to optic nerve crush (ONC). Adult male Sprague-Dawley rats were subjected to ONC accompanied by a contralateral sham operation. HBO-PC was conducted four times by giving 100% oxygen at 2.5 atm...
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PMID: 20070171
PDF is available here.
PDF is available here.
Abstract
We will review many of these articles, focusing on those that address intracranial hemorrhage, intracranial procedures, carotid endarterectomy, spine surgery, and the determinants of outcome in patients with evolving or new-onset neurologic disease. Additionally, we will review articles addressing n...
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PMID: 20308816
PDF is available here.
PDF is available here.
Abstract
Lipopolysaccharide pre-treatment reduced lung injury and inflammatory mediator production after subsequent exposure to ischemia-reperfusion. Understanding the clinical significance of lipopolysaccharide in donor lungs has the potential to expand and clarify donor inclusion criteria....
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PMID: 20044277
PDF is available here.
PDF is available here.
Abstract
These results validate immunotargeting by anti-ACE mAb conjugated with catalase as a prospective and specific strategy to augment anti-oxidative defence of the pulmonary endothelium during lung transplantation. Vascular immunotargeting of anti-oxidative enzymes could limit reactive oxygen species me...
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PMID: 19948411
PDF is available here.
PDF is available here.
Abstract
The harsh ischemic and cytokine-rich microenvironment in the infarcted myocardium, infiltrated by the inflammatory and immune cells, offers a significant challenge to the transplanted donor stem cells. Massive cell death occurs during transplantation as well as following engraftment...
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PMID: 20560023
PDF is available here.
PDF is available here.
Abstract
Abstract Ischemic stroke is a major cause of death worldwide, and current therapeutic options are very limited. Preconditioning with an ischemic or hypoxic insult is beneficial in experimental models of ischemic stroke. Ischemia/hypoxia results in activation of numerous transcription...
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PMID: 19737089
PDF is available here.
PDF is available here.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation (8)1 2010
Abstract
Interruption of blood flow and subsequent organ reperfusion lead to significant tissue damage. This well-studied phenomenon is recognized as ischemia/reperfusion injury. Ischemic preconditioning refers to a mechanism in which a prior, short, ischemic period induces some protection against a subseque...
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PMID: 20199363
PDF is available here.
PDF is available here.
Annals of Surgery (251)2 2010
Abstract
Brief hindlimb occlusion prevents liver I/R injury. This effect appears to be related to release of HMG-B1 and is dependent on the presence of a functional TLR4. Remote ischemia preconditioning represents a novel approach to preventing distant organ injury....
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PMID: 19858701
PDF is available here.
PDF is available here.
Abstract
Matrix metalloproteinase-9 (MMP-9) plays a deleterious role in cell death after global cerebral ischemia. Preconditioning with hyperbaric oxygen (HBO-PC) reduces neuronal damage in the post-ischemic brain; however, its effect on ischemia-induced increase in MMP-9 activity and expression remains unex...
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PMID: 19812919
PDF is available here.
PDF is available here.
Abstract
Neuroimaging demonstrated a reduction in ischemic lesion volume in the MCAO + Rad group compared with MCAO alone. Neurological deficits did not differ between ischemia groups. Interestingly, there was a 34% decrease in the number of TUNEL-positive cells in MCAO + Rad brains compared to MCAO alone. C...
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PMID: 19812920
PDF is available here.
PDF is available here.
Abstract
We find that the expression of Bcl-2 in centrolobular and peliotic areas colocalizes with the autophagy protein Beclin 1 in IP livers. Increased expression of phosphorylated Bcl-2 in preconditioned livers is associated with decreased immunoprecipitation of Beclin 1 and increased expression of LC3-II...
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PMID: 20009565
PDF is available here.
PDF is available here.
Abstract
HMGB1 is a ubiquitous, highly conserved DNA-binding protein with well-established functions in the maintenance of nuclear homeostasis. Much of the recent work about its signaling functions in the brain has focused on its proinflammatory properties and relationship to known inflammatory receptors suc...
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PMID: 20515842
PDF is available here.
PDF is available here.
Abstract
We investigated whether the cardioprotective effect of ischemic postconditioning (postC) against ischemia/reperfusion (I/R)-induced cardiac dysfunction is associated with the negative control of I/R-enhanced norepinephrine (NE) overflow, an aggravating factor of I/R injury, in comparison with the ef...
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PMID: 19786893
PDF is available here.
PDF is available here.
Abstract
The findings of this study suggest that IPC of the lower limb in total knee arthroplasty patients induces a protective genomic response, which results in increased expression of immediate early response genes, oxidative stress defence genes and pro-survival genes. These findings indicate that ischae...
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PMID: 20459731
PDF is available here.
PDF is available here.
Abstract
The complex molecular cascades of ischemic tolerance in brain cells remain unclear. Recently, sphingolipid-related metabolite ceramide has been implicated as a second messenger in many biological functions, including neuronal survival and death. The present study, therefore, examined the roles of ce...
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PMID: 20045928
PDF is available here.
PDF is available here.
Abstract
The present study has been designed to investigate the modulatory role of dichlorobenzamil a Na(+)/Ca(2+) exchanger inhibitor in ischemic post-conditioning-induced neuroprotection in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant rise in cerebral infarct siz...
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PMID: 20410590
PDF is available here.
PDF is available here.
Abstract
Our results for markers of neuronal ischemic injury and rate of recovery suggest that a clinical trial with sufficient statistical power to detect an effect of RIPC on the incidence of neurologic complications (paresis, palsy, etc) due to spinal cord ischemia-reperfusion injury after spine surgery i...
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PMID: 19996767
PDF is available here.
PDF is available here.
Abstract
We applied in vivo EPR oximetry and redoximetry technique and implemented its physiological/pathophysiological applications, along with the use of biocompatible lithium pthalocyanine (liPc) and nitroxide redox sensitive probes, on in vivo tissue oxygenation and redox profile of the ischemic and repe...
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PMID: 20072911
PDF is available here.
PDF is available here.
Abstract
We investigated the osteogenic differentiation potential of hMSCs under 2% O(2) (hypoxia) in comparison to a standard tissue culture oxygen atmosphere of 21% (normoxia). We assessed the osteogenic differentiation of hMSCs following hypoxic preconditioning to address whether this pretreatment is bene...
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PMID: 19642854
PDF is available here.
PDF is available here.
Abstract
Analysis of published data indicates that erythropoietin plays an important role in regulation of brain tolerance to impact of ischemia-reperfusion. This cytokine is involved in ischemic preconditioning of the brain and can mimic the phenomenon of preconditioning and postconditioning. However, it is...
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PMID: 20297690
PDF is available here.
PDF is available here.
Abstract
Compared to the I/R group, NF-kappaB activity decreased significantly in the IPC group. Supershift assays were then performed to examine the NF-kappaB subunits in the binding complexes. In both the I/R and IPC groups, the composition of NF-kappaB contained p65 and p50. The densities of these two sup...
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PMID: 19851061
PDF is available here.
PDF is available here.
Abstract
Compared with controls, LI rabbits showed more subendocardial (103+/-14 vs. 113+/-13 capillaries/mm2, respectively; p=0.01) and intramyocardial blood vessels (102+/-12 vs. 114+/-16 capillaries/mm(2), respectively; p=0.009). LI rabbits had significantly smaller infarct size compared with the SHO anim...
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PMID: 20363986
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (89)46 2009
Abstract
The level of serum ALT [(65 +/- 28) U/L], AST [(187 +/- 43) U/L] in CoPP and ALT [(75 +/- 16) U/L], AST [(185 +/- 42) U/L] in MC group was significantly lower than that ALT [(346 +/- 45) U/L], AST [(474 +/- 90) U/L] in control group and ALT [(578 +/- 75) U/L], AST [(1084 +/- 128) U/L] in ZnPP group...
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PMID: 20193372
PDF is available here.
PDF is available here.
Abstract
Ischemic postconditioning and ischemic preconditioning reduce hepatic ischemia-reperfusion injury, but in clinical practice the former is a more appropriate choice....
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PMID: 20007074
PDF is available here.
PDF is available here.
Abstract
MicroRNAs play important regulatory roles in many physiological processes. This study investigated potential involvement of microRNAs in hepatic ischemia/reperfusion injury and ischemic preconditioning in mice. MicroRNAs with significant changes in expression in the livers upon ische...
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PMID: 19780683
PDF is available here.
PDF is available here.
Abstract
Abstract
Journal of Physiology and Pharmacology (60 Suppl 7) 2009
Abstract
We investigated whether glucocorticoid hormones participate in a realization of gastroprotective effect of ischemic preconditioning. Rats were exposed to prolonged gastric ischemia-reperfusion (30 min occlusion of celiac artery followed by 3 h of reperfusion) alone or with brief preliminary ischemic...
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PMID: 20388959
PDF is available here.
PDF is available here.
The Chinese journal of physiology (52)5 Suppl 2009
Abstract
We tested whether tolerance induced by ischemic preconditioning (IPC) in kidneys was related to renal nerves. Experimental acute renal failure (ARF) in a rat model was induced for 45 min of left renal arterial occlusion (RAO), followed by 6 or 24 h of reperfusion (ischemic reperfusion (I/R) group)....
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PMID: 20359127
PDF is available here.
PDF is available here.
Abstract
Renal ischemia-reperfusion injury (IRI) is an invariable consequence of transplantation. The tubuloepithelial expression of CD44 is markedly enhanced in autoimmune renal injuries. The aim of this experimental study was to evaluate the effect of IRI on the expression of CD44 in rat kidney. Thirty mal...
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PMID: 19283506
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (89)41 2009
Abstract
Sevoflurane pretreatment can protect neuron on ischemia-reperfusion injury by attenuating neuronal apoptosis in rats....
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PMID: 20137656
PDF is available here.
PDF is available here.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (20)6 2009
Abstract
Our aim in this study was to evaluate the protective effect of brief liver ischemia on the pancreas against severe ischemia-reperfusion-induced pancreatitis. This study was performed on 30 male Wistar rats. Ischemic pre-conditioning of liver was performed by first clamping of the hepatic pedicle for...
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PMID: 19861862
PDF is available here.
PDF is available here.
Abstract
Image analysis revealed that averages of 1404+/-20 and 1338+/-20 were detected in II/R and IPC groups. A total of 10 spots yielded good spectra, and 8 spots matched with known proteins after database searching. These proteins were mainly involved in anti-oxidation, inhibiting apoptosis and energy me...
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PMID: 19921573
PDF is available here.
PDF is available here.
Abstract
Ischemic preconditioning (IPC), a strategy used to attenuate ischemia-reperfusion injury, consists of brief ischemic periods, each followed by reperfusion, prior to a sustained ischemic insult. The purpose of the present study was to evaluate the local and systemic anti-inflammatory effects of hind...
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PMID: 19738981
PDF is available here.
PDF is available here.
Turkish Neurosurgery (19)4 2009
Abstract
Elucidation of the endogenous cell survival pathways involved in ischemic tolerance (preconditioning) and postconditioning has significant clinical implications for preventing neuronal damage in susceptible patients. Ischemic tolerance is a phenomenon in which the brain protects itself against futur...
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PMID: 19847763
PDF is available here.
PDF is available here.
Abstract
Abstract
We examined the effects of ischemia preconditioning and ketamine, an NMDA receptor antagonist, on the activation and its nucleus translocation of ERK5 in hippocampal CA1 region. Our results showed ERK5 was not activated in rat hippocampus CA1 region. But in cytosol extracts preconditioned with 3 min...
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PMID: 19519168
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that partial hindlimb occlusion during coronary artery occlusion increases the ventricular arrhythmia threshold (VAT) induced by coronary artery occlusion. Rats (n = 7) were instrumented with a radio-telemetry device for recording arterial pressure, electrocardiogram (ECG),...
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PMID: 19721132
PDF is available here.
PDF is available here.
Abstract
Improving the ability of the kidney to tolerate injury through preconditioning is likely to have important clinical implications. Although a number of preconditioning strategies have been studied, ischemic preconditioning (IP) has been studied the most experimentally. The information gathered has he...
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PMID: 19773719
PDF is available here.
PDF is available here.