Marcella Visentini,
Serena Ludovisi,
Antonio Petrarca,
Federica Pulvirenti,
Marco Zaramella,
Monica Monti,
Valentina Conti,
Jessica Ranieri,
Stefania Colantuono,
Elisa Fognani,
Alessia Piluso,
Carmine Tinelli,
Anna Linda Zignego,
Mario U Mondelli,
Massimo Fiorilli and
Milvia Casato
Abstract
We designed a phase II single-arm two-stage study (EUDRACT n. 2008-000086-38) to evaluate the efficacy of a lower dosage of rituximab, 250mg/m(2) given twice, for refractory mixed cryoglobulinemia. We present here the preliminary results in the first 27 patients enrolled. The overall response rate i...
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PMID: 21570494
PDF is available here.
Abstract
We designed a lentiviral vector expressing a chimeric antigen receptor with specificity for the B-cell antigen CD19, coupled with CD137 (a costimulatory receptor in T cells [4-1BB]) and CD3-zeta (a signal-transduction component of the T-cell antigen receptor) signaling domains. A low dose (approxima...
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PMID: 21830940
PDF is available here.
Abstract
The objective of this study is to assess cost-effectiveness of different biologic strategies in patients with moderate-to-severe active RA after an insufficient response to anti-TNF agents within the context of the Italian healthcare system.
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PMID: 21813056
PDF is available here.
Abstract
Although oligoarticular juvenile idiopathic arthritis (oJIA) is considered to carry the best prognosis among the JIA subtypes, many children evolve to a chronic course. A few studies have identified clinical risk factors for disease extension, and recent studies have evaluated synovial fluid markers....
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PMID: 21813070
PDF is available here.
Abstract
Non-response, loss of response, or intolerance to anti-tumour necrosis factor alpha (anti-TNFα) therapy is well recognised in Crohn's disease (CD) patients. Data concerning outcomes following the use of a second anti-TNFα therapy, particularly in patients who do not respond to a fi...
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PMID: 21683302
PDF is available here.
Abstract
The patient, a 58-year-old woman, underwent a partial excision of the right breast and an axillary lymph node dissection in October 2004. The histopathological findings were: solid tubular carcinoma with metastasis to 17 axillary lymph nodes; triple negative-type breast cancer. As ad...
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PMID: 21829078
PDF is available here.
Abstract
RTX could be an alternative in the therapy of patients with IS-dependent MCD, leading to successful cessation of other IS treatment....
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PMID: 21762648
PDF is available here.
Abstract
five of seven had a complete remission of the nephrotic syndrome and two of seven had a partial response. After a mean 24-month follow-up, only one patient experienced relapse of the nephropathy. Conclusions GN with monoclonal Ig deposits can be associated with MPGN or MN, which are correlated with...
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PMID: 21700823
PDF is available here.
Priya P Wickramaratne,
Marc J MJ Gameroff,
Daniel J DJ Pilowsky,
Carroll W CW Hughes,
Judy J Garber,
Erin E Malloy,
Cheryl C King,
Gabrielle G Cerda,
A Bela AB Sood,
Jonathan E JE Alpert,
Madhukar H MH Trivedi,
Maurizio M Fava,
A John AJ Rush,
Stephen S Wisniewski and
Myrna M MM Weissman
Abstract
Maternal major depressive disorder is an established risk factor for child psychopathology. The authors previously reported that 1 year after initiation of treatment for maternal depression, children of mothers whose depression remitted had significantly improved functioning and psychiatric symptoms....
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PMID: 21406462
PDF is available here.
Abstract
To examine the association between beta-blocker (BB) intake, pathologic complete response (pCR) rates, and survival outcomes in patients with breast cancer treated with neoadjuvant chemotherapy.
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PMID: 21632501
PDF is available here.
Abstract
We report our experience using a combination of corticosteroid, cyclosporine A (CsA), and mycophenolate mofetil (MMF) to treat 10 refractory NS patients....
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PMID: 21612754
PDF is available here.
Yasuo Y Hamamoto,
Tomomi T Komaki,
Junko J Miyamoto,
Noriyuki N Akutsu,
Etsuko E Warita,
Yasuhiro Y Yamanaka,
Yoshinori Y Kuroki,
Hirofumi H Shirakawa,
Heita H Ozawa,
Morihiro M Tomikawa,
Shoichi S Hishinuma,
Sayuri S Hoshi,
Seiji S Igarashi,
Tomoe T Ozasa,
Yasuyoshi Y Sugano and
Kenjiro K Kotake
Abstract
We experienced a case in which an initially unresectable mCRC liver metastases converted into a resectable one after cetuximab monotherapy as third-line treatment. The sample from hepatectomy was a pathologically complete response; no remnants were detected. The management of liver metastases contri...
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PMID: 21677499
PDF is available here.
Abstract
We elucidated whether additional paraurethral fixation of a tape to prevent displacement during tensioning could improve the transobturator sling outcome....
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PMID: 21575972
PDF is available here.
Abstract
Aim: While the best treatment of nephrosis-inducing idiopathic membranous nephropathy (IMN) is controversial, some trials have suggested positive outcomes following treatment with oral cyclophosphamide used in combination with steroids. However, data on i.v. cyclophosphamide plus steroids in treat...
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PMID: 21091923
PDF is available here.
Abstract
Systemic mastocytosis is a heterogeneous group of hematological disorders characterized by accumulation of mast cells in different organs.
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PMID: 21739912
PDF is available here.
Abstract
We presented a patient with HE who developed a complete recovery after the IVIG therapy followed by a long-lasting remission....
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PMID: 21739914
PDF is available here.
Abstract
These results suggest that drug dose plays an important role in determining the mechanism of tumor cell death and effectiveness of PDT....
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PMID: 21550293
PDF is available here.
Abstract
Rituximab has been proven to be an important part of the treatment of newly diagnosed and relapsed or refractory follicular lymphoma both alone and in combination with chemotherapy. Given its tolerability, rituximab has now been investigated in the maintenance setting in an effort to...
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PMID: 21550969
PDF is available here.
Abstract
Multicentric histiocytosis (MH) is a rare form of histiocytosis of unknown aetiology and is associated with a malignant neoplasm in 25% of cases. Herein, we report the case of a female patient in whom HM enabled us to diagnose gastric carcinoma.
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PMID: 21570566
PDF is available here.
Abstract
ABCG2 protein overexpression and FLT3 internal tandem duplication (ITD) correlate with higher relapse rate and shorter disease-free survival (DFS) in acute myeloid leukemia (AML), but no data are available on the possible effect of concomitant presence of these 2 factors.
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PMID: 21523728
PDF is available here.
Abstract
The duration of use of azathioprine (Aza) and 6-mercaptopurine (6-MP) for maintaining remission for Crohn's disease is debatable.
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PMID: 21476031
PDF is available here.
Abstract
Outstanding progress regarding the pathophysiology of Crohn's disease (CD) has led to the development of innovative therapeutic concepts. Numerous controlled trials have been performed in CD. This review concentrates on the results of randomized, placebo-controlled trials, and meta-analyses when avai...
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PMID: 21528051
PDF is available here.
Abstract
Short-term data on the immunogenicity of monoclonal antibodies showed associations between the development of antidrug antibodies and diminished serum drug levels, and a diminished treatment response. Little is known about the clinical relevance of antidrug antibodies against these d...
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PMID: 21486979
PDF is available here.
Abstract
We encountered a rare case of CML showing marked lymph node swelling, which represented extramedullary involvement composed of cells at different stages of maturation but not showing blast crisis. In 1996, a 60-year-old Japanese male was diagnosed with CML in the chronic phase, and imatinib mesylate...
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PMID: 21618900
PDF is available here.
Abstract
We have utilized two cellular models of EOC, where transfer of normal chromosome 18 material into the EOC cell lines TOV-112D and TOV-21G induced in vitro and in vivo suppression of their tumourigenic phenotype. A combination of quantitative two-dimensional difference gel electrophoresis (2D-DIGE) a...
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PMID: 21237297
PDF is available here.
Abstract
To determine the effectiveness and safety of short-term treatment of infliximab (IFX) in a group of Chinese patients with active Crohn's disease (CD).
Patients with established diagnosis of active CD were treated with IFX intravenously with a dose of 5 mg/kg at week 0...
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PMID: 21401895
PDF is available here.
Abstract
We reduced this therapy, extended the interval, and discontinued it after 24 courses due to adverse reactions, such as leucopenia(grade 3)and general fatigue(grade 2). Afterward, he had no recurrence for over 5 years....
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PMID: 21498998
PDF is available here.
Abstract
We diagnosed a stricture due to a duodenal ulcer and laparotomy was performed. By means of biopsy of No.14d lymph node in the operation, adenocarcinoma of the duodenum was pointed out and we performed a pancreatoduodenectomy. Although adjuvant chemotherapy with S-1/paclitaxel (S-1 80 mg/body, po, da...
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PMID: 21499002
PDF is available here.
Abstract
A 59-year-old man visited our hospital. After examination he was diagnosed with advanced gastric cancer with multiple liver metastases. At first, chemotherapy of S-1/CDDP was administered. After two weeks, he had severe diarrhea and anorexia, so the therapy was discontinued. Weekly paclitaxel was sel...
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PMID: 21498997
PDF is available here.
Abstract
We performed distal gastrectomy(noncurative resection)because anemia had progressed. After operation, we administered S-1/CDDP combination chemotherapy. Although he received two courses of S-1/CDDP, renal dysfunction was found. Afterwards a rise in tumor marker(CEA)occurred, so we changed to chemoth...
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PMID: 21498999
PDF is available here.
Abstract
We found an FDG accumulation in her pelvic lesion by PET examination. To identify the FDG accumulated lesion in her pelvis, an operation was performed. Histopathological examination of the right ovary demonstrated the presence of an adenocarcinoma. Postoperatively, we administered 2 courses of pacli...
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PMID: 21499006
PDF is available here.
Abstract
Secondary acute myeloid leukemia (AML) from an antecedent myelodysplastic syndrome (MDS)/myeloproliferative neoplasm is associated with a poor prognosis. The authors evaluated predictive factors in patients with secondary AML treated with anthracycline-based induction therapy.
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PMID: 21425147
PDF is available here.
Bob Löwenberg,
Thomas Pabst,
Edo Vellenga,
Wim van Putten,
Harry C Schouten,
Carlos Graux,
Augustin Ferrant,
Pieter Sonneveld,
Bart J Biemond,
Alois Gratwohl,
Georgine E de Greef,
Leo F Verdonck,
Martijn R Schaafsma,
Michael Gregor,
Matthias Theobald,
Urs Schanz,
Johan Maertens,
Gert J Ossenkoppele and
Dutch-Belgian Cooperative Trial Group for Hemato-Oncology (HOVON) and Swiss Group for Clinical Cancer Research (SAKK) Collaborative Group
Abstract
We compared two induction regimens in patients 18 to 60 years of age (median, 49) who had newly diagnosed AML. The intermediate-dose group, totaling 431 patients, received cytarabine at a dose of 200 mg per square meter given by continuous intravenous infusion for 24 hours during cycle 1 of inductio...
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PMID: 21410371
PDF is available here.
Abstract
Treatment options for patients with relapsed myeloma have benefited from the development of new targeted agents. The use of bortezomib, thalidomide, and lenalidomide have dramatically changed outcomes for patients with relapsed myeloma. New agents are also in development, on the basis of preclinical...
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PMID: 21411442
PDF is available here.
Abstract
Endogenous opioid peptides have been shown to play a role in the development and/or perpetuation of inflammation. We hypothesize that the endogenous opioid system is involved in inflammatory bowel disease, and antagonism of the opioid-opioid receptor will lead to reversal of inflammation.
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PMID: 21380937
PDF is available here.
Abstract
Granulocyte-colony-stimulating factor (G-CSF) is effective in accelerating neutrophil recovery after intensive chemotherapy for acute myeloid leukemia (AML). However, the optimal G-CSF dosage for patients with AML has not been determined. To the authors' knowledge, G-CSF dosages have not been compare...
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PMID: 21381017
PDF is available here.
Abstract
Interferon α therapy has been reported to result in a variety of autoimmune side effects and to increase the risk of thyroid dysfunction. Autoimmune polyglandular syndromes are rarely described conditions characterized by the combination of at least 2 autoimmune endocrinopathies and...
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PMID: 21412133
PDF is available here.
Abstract
Peripheral T-cell lymphomas (PTCL) are infrequent subtypes of non-Hodgkin's lymphomas. The clinical course is aggressive and the median survival is about 2-3 years. An optimal first-line chemotherapy protocol has not been established and the role of high-dose therapy with autologous stem cell transpl...
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PMID: 21475380
PDF is available here.
Abstract
Pathogenesis acute lymphoblastic leukaemia ( ALL ) in adults is not well understood, as it is more common in children. We examined the immunological status and the activity of certain enzymes in blood lymphocytes in adult patients of ALL at different stages.
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PMID: 21441681
PDF is available here.
Abstract
We firstly analyzed the effect of clearance of leukemic cells during induction of remission therapy on relapse-free survival (RFS). Four indexes were used to assess the clearance of leukemic cells including prednisone response on day 8 (d8-PR), percentage of lymphoblast in bone marrow on day 22 (d22...
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PMID: 21575363
PDF is available here.
Abstract
Our data suggest the superiority of SCT for early relapse patients. For late relapses a better outcome is achieved with chemotherapy only using the rotational chemotherapy scheme. The most important factor for survival was interval between first CR and occurrence of the first relapse. Pediatr Blood...
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PMID: 21337680
PDF is available here.
Abstract
To assess the outcome of giant cell hepatitis combined with autoimmune hemolytic anemia in early childhood.
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PMID: 21349541
PDF is available here.
Abstract
We therefore evaluated the efficacy, toxicity, and prognostic factors for achieving CR following treatment with fludarabine and cytarabine in 25 newly diagnosed AML patients who did not respond to initial therapy with idarubicin and cytarabine followed by mitoxantrone and etoposide. CR was achieved...
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PMID: 21315448
PDF is available here.
Abstract
We explored whether remission from depression was associated with better survival and aimed to characterize participants who remitted during the trial. Based on depression response during the 12-week treatment phase, SADHART-CHF participants were divided into 2 groups: (1) remission, defined as part...
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PMID: 21295172
PDF is available here.