Abstract
The trained group scheduled fewer restorations for replacement (6.00±3.01 and 9.71±3.15; p=0.034), in a shorter time (27.86±3.45 mins and 36.71±3.74 mins; p=0.003) and showed greater agreement with the study's gold standard for restoration replacement (0.85±0.27 and 0.79±0.06; p=0.002). Conclu...
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PMID: 21702675
PDF is available here.
Abstract
The aim of this paper was to review the current teaching of repairs to direct composite restorations in dental schools in Germany, last surveyed ten years ago. Based on an 83% response rate, the findings indicate that most, but not all, dental schools included teaching of repair techniques; however m...
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PMID: 21780727
PDF is available here.
Abstract
Recent evidence suggests a role for gut bacteria and antibiotics in the pathophysiology and treatment of irritable bowel syndrome (IBS), respectively. While the benefits of the antibiotic rifaximin have demonstrated efficacy and durable improvement in symptoms over 3 months, the long-term need for r...
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PMID: 21559740
PDF is available here.
Abstract
We compared 179 patients whose persistent AF was always terminated in <1 week by cardioversion/drugs to 244 whose AF actually lasted >1 week to 1 year. Patients with AF termination in <1 week by cardioversion/drugs had smaller left atrial (LA) size (4.1 ± 0.6 vs 4.5 ± 0.7 cm, p <0.0001), a longer...
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PMID: 21600534
PDF is available here.
Abstract
Data demonstrating the superiority of nilotinib over imatinib in the frontline treatment of chronic myeloid leukemia (CML) and ongoing studies with dasatinib and bosutinib are rapidly changing the treatment landscape for CML. In this review, the authors discuss currently available therapies for CML,...
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PMID: 21509757
PDF is available here.
Abstract
Treatment with intravitreal bevacizumab may be effective, as measured by visual and anatomic criteria, in patients who are unresponsive to treatment with intravitreal ranibizumab....
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PMID: 21708088
PDF is available here.
Abstract
In this review, the authors examine whether there is any decisive evidence to support the revision of root fillings that have been exposed to the oral environment for more than three months, undertaken solely because of suspicions of microleakage. Researchers in numerous endodontic studies have addre...
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PMID: 21454844
PDF is available here.
Abstract
Thirty-day mortality was <1% in both primary and recurrent treatment groups, but morbidity was doubled in the reintervention group (4% versus 8%; p<0.05). While the incidence of systemic complications was low in both groups, the drivers for increased morbidity in the recurrent group were lesion-spec...
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PMID: 21521057
PDF is available here.
Abstract
Hypnosis has been used in the treatment of bulimia nervosa from the early 1980s. Dissociation theory identified a certain subgroup of eating disordered patients with dissociative signs and symptoms. These patients react well to hypnotherapy. Simultaneous hypnosis ("tandem hypnosis") in the treatment...
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PMID: 21598841
PDF is available here.
Bruce R Bacon,
Stuart C Gordon,
Eric Lawitz,
Patrick Marcellin,
John M Vierling,
Stefan Zeuzem,
Fred Poordad,
Zachary D Goodman,
Heather L Sings,
Navdeep Boparai,
Margaret Burroughs,
Clifford A Brass,
Janice K Albrecht,
Rafael Esteban and
HCV RESPOND-2 Investigators
Abstract
We randomly assigned patients (in a 1:2:2 ratio) to one of three groups. In all three groups, peginterferon alfa-2b and ribavirin were administered for 4 weeks (the lead-in period). Subsequently, group 1 (control group) received placebo plus peginterferon-ribavirin for 44 weeks; group 2 received boc...
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PMID: 21449784
PDF is available here.
Abstract
Small bowel adenocarcinoma (SBA) is a rare tumor with poor prognosis. First-line platinum-based chemotherapy is active in patients with advanced SBA, but data regarding second-line chemotherapy are lacking. The aim of this study was to evaluate the efficacy and tolerability of fluorouracil, leucovori...
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PMID: 21425142
PDF is available here.
Abstract
Currently, no standard therapy exists for patients with relapsed and/or refractory non-Hodgkin lymphoma (NHL) who are ineligible for transplantation or who have failed after bone marrow transplantation. The authors of this report investigated the safety and efficacy of clofarabine (CLO) in these pati...
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PMID: 21425150
PDF is available here.
Abstract
Tyrosine kinase inhibitors (TKIs) of the epidermal growth factor receptor (EGFR) have activity in solid tumors. The authors evaluated an oral EGFR TKI, erlotinib, in patients with previously treated esophageal cancer.
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PMID: 21425140
PDF is available here.
Abstract
We intend to appraise the latest evolution in treatment strategies in IBD and to suggest an evidence-based approach and risk stratification while coping with cases of non-responders or loss of response to biological therapies....
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PMID: 21427713
PDF is available here.
Abstract
In a controlled prospective split-mouth study, clinical behavior of two different resin composites in extended Class II cavities was observed over six years.
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PMID: 21397316
PDF is available here.
Abstract
Information relating the outcome of percutaneous coronary intervention to diabetes mellitus or hypertension is limited. The study objective was to describe the outcome in patients undergoing percutaneous coronary intervention in relation to diabetes and hypertension.
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PMID: 21396511
PDF is available here.
Abstract
Dual-action antidepressants serotonin-norepinephrine reuptake inhibitors (SRNIs) are widely used to treat depression. Owing to its efficiency and safety, venlafaxine holds a prominent place in this group of depressants. Abrupt venlafaxine discontinuation involves a high risk of withd...
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PMID: 21448114
PDF is available here.
Abstract
To evaluate the effectiveness and safety of covered stents for the management of iatrogenic arterial injury.
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PMID: 21318936
PDF is available here.
Abstract
We review the literature on the incidence, contributing factors and clinical impact of stent fracture....
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PMID: 21553613
PDF is available here.
Abstract
We evaluated 866 patients with PAD in the National Heart, Lung, and Blood Institute (NHLBI) Dynamic Registry undergoing PCI according to treatment eras: the early bare metal stent (BMS) era (wave 1, 1997 to 1998, n = 180), the BMS era (waves 2 and 3, 1999 and 2001 to 2002, n = 339), and the drug-elu...
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PMID: 21256469
PDF is available here.
Abstract
Concurrent inhibition of epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) is an active and well tolerated regimen in recurrent head and neck cancer (HNC). In the current phase 1 trial, the authors sought to determine the maximum tolerated dose (MTD) and efficacy of concurrent erlo...
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PMID: 21246519
PDF is available here.
Abstract
We assess the feasibility and effectiveness of intra/extra-aneurysmal stent-assisted coil embolization in the treatment of those complex intracranial aneurysms....
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PMID: 21225295
PDF is available here.
Abstract
There are several variables which must be considered before initiating endodontic treatment, including assessing the feasibility of endodontic treatment, addressing past, present and future periodontal concerns, determining the restorability of the tooth, and detecting root fractures. If these parame...
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PMID: 21905362
PDF is available here.
Abstract
In 2009, nearly half (289,756) of global re-treatment TB notifications are from India; no nationally-representative data on the source of previous treatment was available to inform strategies for improvement of initial TB treatment outcome.
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PMID: 21814566
PDF is available here.
Abstract
A technique for restoration of decayed and fractured teeth with composite inlays or onlays is presented. This approach conserves the tooth structure, requires less preprosthetic periodontal surgical intervention, and provides excellent functional results, while minimizing the incidence of post-therap...
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PMID: 21491010
PDF is available here.
Abstract
Dysregulation of phosphatase and tensin homolog (PTEN) and the gene that encodes the p110α catalytic subunit of phosphatidylinositol-3-kinase (PI3K), PIK3CA, are the most common mutations in endometrial carcinoma (EC). Loss of PTEN or activation of PIK3CA results in constitutive act...
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PMID: 20681032
PDF is available here.
Abstract
To evaluate treatment outcomes after intramedullary nailing using Ender nails for diaphyseal forearm fractures.
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PMID: 21187545
PDF is available here.
Abstract
To evaluate best-corrected visual acuity (BCVA) and foveal thickness (FT) changes in occult subfoveal choroidal neovascularization (CNV) from age-related macular degeneration (AMD) after intravitreal bevacizumab (IVB, 1.25 mg/0.05 ml), pegaptanib (IVP, 0.3 mg/0.09 ml) and triamcinolo...
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PMID: 20946332
PDF is available here.
Abstract
Hepatitis C infection has evolved in the past quarter century from a newly recognized entity without a known pathogen (non-A, non-B hepatitis) to one of the world's most prevalent causes of liver disease, an important source for hepatocellular carcinoma, and the major indication for liver transplant...
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PMID: 20960375
PDF is available here.
Abstract
This narrative review explores treatment planning options in restorative dentistry. The growth of dental implants, as an accessible and predictable treatment option, gives practitioners a useful tool for managing the missing tooth or teeth with a hopeless prognosis. Traditionally, endodontics and fi...
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PMID: 21179928
PDF is available here.
Abstract
Detrusor injection of botulinum toxin (BTX) has shown great promise in the treatment of neurogenic detrusor overactivity (NDO) refractory to conservative therapy. Despite a paucity of prospective evidence, there exists a growing consensus that BTX injection therapy is a well-tolerated, low-risk ther...
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PMID: 20955908
PDF is available here.
Abstract
SRS was delivered to a median marginal dose of 20 Gy (range, 10-30 Gy) in 1-5 fractions (median, 2), targeting a median tumor volume of 10.3 cm(3) (range, 0.2-128.6 cm(3)). Converting the SRS regimens with the linear quadratic model (α/β = 3), the median spinal cord maximum single-session equivale...
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PMID: 20133079
PDF is available here.
Abstract
A rapid access service model for palliative RT facilitated access to RT. Travel distance and other factors remained substantial barriers to use of palliative RT services. The pattern of practice suggests an unmet need for symptom control in patients with bone metastases.
2010 Elsevier Inc. All right...
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PMID: 19910133
PDF is available here.
Abstract
The purpose of this article is to provide the dental health professional with sound science related to sealants so that he/she can provide the best care to his/her patients. This article will synthesize the recommendations made by the American Academy of Pediatric Dentistry and the American Dental A...
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PMID: 21162347
PDF is available here.
Abstract
No cost-effectiveness evaluation of pit and fissure sealants has ever been carried out in Quebec. The objective of this study was to simulate a publicly funded program of pit and fissure administration, either in the public or private sectors, and compare these hypothetical situations with the curren...
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PMID: 20880047
PDF is available here.
Abstract
Epigenetic dysregulation is a hallmark of cancer, including multiple myeloma. Inhibitors of histone deacetylases (HDACs) induce DNA hyperacetylation by inhibiting removal of acetyl groups from amino tails on histone proteins, thereby uncoiling condensed chromatin favoring transcription of silenced ge...
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PMID: 20862746
PDF is available here.
Abstract
Each episode of hemoptysis was acutely terminated with BAE. In the majority of cases, patients had multiple aberrant bronchial arteries embolized, and an average of 2.3 arteries was embolized per session (1-4 embolized arteries). Each BAE was performed utilizing polyvinyl alcohol particles, ranging...
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PMID: 20689485
PDF is available here.
Abstract
Long-term follow-up studies after endovascular treatment for intracranial aneurysm are still rare and inconclusive. The aim of this study was to assess the long-term clinical and angiographic outcome of patients with endovascularly treated aneurysms. The clinical outcome of all 185 patients with end...
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PMID: 20977853
PDF is available here.
Abstract
Ensuring the longevity of crown restorations is an important objective for the clinician. Veneering porcelain fracture needs to be addressed when considering restoration longevity. This clinical report presents the use of a CAD/CAM-aided design to produce a zirconia substructure with a collar that w...
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PMID: 20654763
PDF is available here.
Jonathan Shamash,
Justin Stebbing,
Chris Sweeney,
Guru Sonpavde,
Steve Harland,
Guy Dawkins,
Cathryn Brock,
Walter Abelman,
Peter Wilson,
Adam Sanitt,
Tim Oliver and
Thomas Powles
Abstract
The easy-to-use prognostic index that the authors developed was able to identify a subgroup of patients with CRPC who had prolonged survival only 1 month after starting DS therapy.
Copyright (c) 2010 American Cancer Society....
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PMID: 20564115
PDF is available here.
Abstract
Pulsed Reduced Dose Rate (PRDR) is a method of irradiation designed to minimize radiation-related toxicities in patients undergoing reirradiation for loco-regional reoccurrence of glioblastoma. PRDR delivers a standard 2 Gy fraction delivered on a conventional medical linear accelerator using conven...
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PMID: 20626205
PDF is available here.
Abstract
Transurethral resection of the prostate (TURP) has been the gold standard of the treatment of benign prostatic hyperplasia (BPH). In recent years there has been a significant shift in the treatment of BPH and guidelines emphasize minimally invasive surgery as a new treatment option. Minimal invasive...
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PMID: 20735902
PDF is available here.
Abstract
We found that including the postoperative radiation boost after preoperative radiation and a margin-positive excision did not provide an advantage in preventing LR for patients treated with external beam radiotherapy. Given that higher radiation doses placed patients at greater risk for late complic...
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PMID: 20056340
PDF is available here.
Abstract
The main aim of this meta-analysis was to compare the efficacy and safety of clarithromycin and second-generation fluoroquinolone-based triple therapy vs. bismuth-based quadruple therapy for the treatment of persistent Helicobacter pylori infection.
A systematic literature search was conducted for a...
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PMID: 20628905
PDF is available here.
Abstract
The duration of follow-up was a mean of 8 months (range, 3 to 22). Of the 60 patients, 22 were treated once and 38 were treated 2 to 18 times (mean 2.6 times/patient). The mean total volume of ethanol in 60 patients was 11.2 mL (range, 0.5 to 230 mL). Of the 60 patients, 56 had complete volume reduc...
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PMID: 19962811
PDF is available here.
Abstract
Eighty-two of 676 patients underwent more than one CE study. Group 1 (incomplete study) included 22 patients (27%) and yielded 10 positive findings (45%). Group 2 (screening) comprised four patients (5%) and yielded two positive findings (50%). Group 3 (ongoing symptoms despite previous negative stu...
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PMID: 20652160
PDF is available here.
Abstract
We present the case of a 6-year-old child with malignant posterior temporal glioma treated with surgery, radiotherapy, local chemotherapy with carmustine wafers, and oral therapy with temozolomide, both at initial diagnosis and at relapse 18 months later. After 6 years, the patient seems healthy wit...
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PMID: 20523247
PDF is available here.
Vicente Bodí,
Oliver Husser,
Juan Sanchis,
Julio Núñez,
María P López-Lereu,
José V Monmeneu,
Luis Mainar,
Fabian Chaustre,
Günter A J Riegger,
María J Bosch,
Francisco J Chorro and
Angel Llácer
Abstract
During follow-up (median, 613 days; range, 312-1243 days), 18 MACEs (five cardiac deaths, six myocardial infarctions, seven readmissions for heart failure) occurred. MACEs were associated with a lower EF(D) (43% +/- 12 [standard deviation] vs 49% +/- 10, P = .02) and a larger ETN (seven segments +/-...
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PMID: 20392984
PDF is available here.
Abstract
We describe a 45-year-old male patient with recurrent retroperitoneal fibrosis (RPF), in whom a pseudocyst in the peri-aortic fibrotic mantle was diagnosed. Without any intervention other than oral treatment with tamoxifen, the pseudocyst showed significant regression. Although rare, pseudocyst form...
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PMID: 20505023
PDF is available here.
Abstract
Results of this study do not support the hypothesis that monthly ranibizumab injections reduce the rate of CNV development in untreated fellow eyes.
Copyright 2010 Elsevier Inc. All rights reserved....
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PMID: 20378094
PDF is available here.
Abstract
Barely visible 10-millisecond Pascal laser seems to produce an effect at the level of the inner and outer photoreceptor segments and apical retinal pigment epithelium, with minimal axial and lateral spread of burns. FD OCT confirmed spatial localization of AF signal changes that correlated with lase...
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PMID: 20510687
PDF is available here.