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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Salvage Therapy (0):
Recent article
Salvage Therapy
Abstract
We provide the first report outlining toxicities and survival outcomes in a series of 19 patients. Our experience suggests that initial surgery provides durable local control rates in two-thirds of patients, with low risk for significant permanent deficits. Salvage therapy with surgery and/or radiat...
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PMID: 21824889
PDF is available here.
PDF is available here.
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Abstract
Tegafur/uracil (UFT) is suitable for metronomic chemotherapy because of its underlying antiangiogenesis mechanism. This study aimed to assess the efficacy of adding daily oral UFT to gefitinib treatment in patients with pulmonary adenocarcinoma who had failed previous chemotherapy....
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PMID: 21415778
PDF is available here.
PDF is available here.
Abstract
Pantalar arthrodesis is an important salvage option for stabilizing the hindfoot and salvaging the limb following trauma or collapse. This report evaluates the healing rates and complications which occur in diabetics and post-traumatic patients.
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PMID: 21733419
PDF is available here.
PDF is available here.
Abstract
Erlotinib and gefitinib are quinazoline derivatives that selectively and reversibly inhibit the tyrosine kinase activity of the EGFR. Activating mutations in the EGFR confer hypersensitivity to the tyrosine kinase inhibitors gefitinib and erlotinib in patients with advanced non-small-cell lung cancer...
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PMID: 21677478
PDF is available here.
PDF is available here.
Abstract
Anti-EGFR antibodies show benefits for some K-ras wild-type patients. Addinganti -VEGF monoclonal antibodies to stateof- the-art adjuvant chemotherapy for stage II or III colon cancer does not improve disease-free survival. Bevacizumab shows an additive effect for FOLFOX/FOLFIRI therapy as a first-li...
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PMID: 21677479
PDF is available here.
PDF is available here.
Abstract
We reviewed results of patients who underwent salvage ureteral reimplantation following failed dextranomer/hyaluronic acid injection....
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PMID: 21575977
PDF is available here.
PDF is available here.
Abstract
We report two cases of subacute cutaneous lupus erythematosus occurring in patients treated for metastatic breast adenocarcinoma....
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PMID: 21570567
PDF is available here.
PDF is available here.
Abstract
Although treatment for multiple myeloma (MM) has considerably improved in the past decade, MM continues to be an incurable hematological malignancy that causes most patients to eventually relapse and die from their illness. Thus, the identification of effective salvage strategies remains a priority....
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PMID: 21509765
PDF is available here.
PDF is available here.
Abstract
Abstract
The aim of this study was to assess the concomitant perioperative procedures, the causes of nasolacrimal duct obstruction, the success rate, and the complications associated with endonasal dacryocystorhinostomy (ENDCR).
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PMID: 21585152
PDF is available here.
PDF is available here.
Abstract
Motexafin gadolinium (MGd) disrupts redox-dependent pathways by inhibiting oxidative stress-related proteins leading to apoptosis. MGd selectively targets tumor cells, disrupting energy metabolism and repair mechanisms, rendering cells more prone to apoptosis. Preclinical studies wit...
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PMID: 21289521
PDF is available here.
PDF is available here.
Abstract
We conducted a multicenter phase II study in previously treated patients with NSCLC to evaluate the efficacy of single-agent S-1 in a predominantly non-Asian population.
Patients with advanced NSCLC and previously treated with only one line of chemotherapy received oral S-1 at 30 mg/...
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PMID: 21325974
PDF is available here.
PDF is available here.
Abstract
We reduced this therapy, extended the interval, and discontinued it after 24 courses due to adverse reactions, such as leucopenia(grade 3)and general fatigue(grade 2). Afterward, he had no recurrence for over 5 years....
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PMID: 21498998
PDF is available here.
PDF is available here.
Abstract
Currently, no standard therapy exists for patients with relapsed and/or refractory non-Hodgkin lymphoma (NHL) who are ineligible for transplantation or who have failed after bone marrow transplantation. The authors of this report investigated the safety and efficacy of clofarabine (CLO) in these pati...
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PMID: 21425150
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)9 2011
Abstract
We aimed to evaluate the effect of pretreatment serum metabolic profiles generated by (1)H NMR spectroscopy on toxicity in patients with inoperable colorectal cancer receiving single agent capecitabine....
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PMID: 21415219
PDF is available here.
PDF is available here.
Abstract
Intracranial schwannomas presenting with cyst formation following gamma knife radiosurgery (GKRS) were investigated to clarify their clinicopathological characteristics.
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PMID: 21369949
PDF is available here.
PDF is available here.
Abstract
Abstract
Acta clinica Belgica (66)4 2011
Abstract
Our study suggests that long-term survival can be obtained by means of HDCT for metastatic germ cell tumours, even in patients with bad prognostic features at diagnosis. The question of whether to use 1 or 2 cycles of HDCT still remains unanswered....
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PMID: 21938979
PDF is available here.
PDF is available here.
Abstract
To evaluate the efficacy and toxicity of etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine (EMA-CO) chemotherapy for the treatment of high-risk gestational trophoblastic neoplasia (GTN).
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PMID: 21682117
PDF is available here.
PDF is available here.
Abstract
We reviewed our bariatric database to identify patients who had undergone LAGB from 2004 to 2007 and had undergone either revision of their original band or conversion to Roux-en-Y gastric bypass.
Of the 66 patients who met our inclusion criteria, 47 (71.2%) had undergone revision an...
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PMID: 21130704
PDF is available here.
PDF is available here.
Abstract
Standard second-line chemotherapies for non-small cell lung cancer (NSCLC) have been established but have limited clinical relevance. S-1 is a recently developed agent with potential activity against NSCLC.
Patients with confirmed NSCLC recurrence after previous singl...
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PMID: 21107293
PDF is available here.
PDF is available here.
Abstract
It is recognized that radiation therapy can eradicate microscopic tumor disease, even in postoperative prostate cancer patients, when extracapsular extension, positive surgical margins or increased prostate-specific antigen is found in surgical specimens. This review of recent literature analyzes and...
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PMID: 21528655
PDF is available here.
PDF is available here.
Abstract
We describe a case of a treatment-experienced patient with important limitations in therapeutic options dictated by the presence of HIV-2 infection, severe HIV nephropathy (requiring haemodialysis), intolerance to PIs and clinical contraindications to the use of some nucleoside analogues (anaemia, p...
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PMID: 21344955
PDF is available here.
PDF is available here.
Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society (100)1 2011
Abstract
Biliary atresia (BA) is a progressive fibro-obliterative cholangiopathy of unclear etiology affecting varying degrees of both extra- and intrahepatic biliary tree resulting in obstructive bile flow and cholestasis in neonates. The diagnostic work-up is designed to diagnose or rule out BA without any...
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PMID: 21482505
PDF is available here.
PDF is available here.
Abstract
We present a case of a previously healthy 40-year-old obese man who succumbed to H1N1-associated ARDS. In this focused review, we discuss the pathophysiologic peculiarities and management of acute lung injury/ARDS related to H1N1 infection....
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PMID: 21119333
PDF is available here.
PDF is available here.
Medicina Clínica (135 Suppl 3) 2010
Abstract
The European Cubicin(®) Outcome Registry and Experience (EU-CORE) is a retrospective, non-interventional, multicenter database of daptomycin use in several European countries. This database provides information on the routine use of this antibiotic to treat various infections caused by Gram-positive...
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PMID: 21477701
PDF is available here.
PDF is available here.
Abstract
This study evaluated whether progression-free interval (PFI) following primary chemotherapy (PCT) was predictive of overall survival (OS) after second-line chemotherapy in advanced/recurrent endometrial cancer (EC).
This is a pooled analysis of patients who recurred a...
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PMID: 20737572
PDF is available here.
PDF is available here.
Abstract
A phase II study was carried out to assess the efficacy and toxicity of combination chemotherapy with irinotecan, 5-fluorouracil (5-FU), and leucovorin (FOLFIRI) for the treatment of patients with metastatic or recurring gastric cancer previously treated with fluoropyrimidine-based chemotherapy.
Eli...
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PMID: 20042971
PDF is available here.
PDF is available here.
Abstract
This study was performed to determine the feasibility and safety of salvage chemotherapy, using docetaxel and cisplatin in 5-fluorouracil (5-FU) and cisplatin-pretreated esophageal cancer.
Patients with metastatic or recurrent esophageal squamous cell carcinoma that had previously been treated with...
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PMID: 20142726
PDF is available here.
PDF is available here.
Abstract
Compared with AVF that mature without interventions, AVF that require interventions have decreased cumulative survival and require more interventions to maintain their patency for hemodialysis....
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PMID: 21088288
PDF is available here.
PDF is available here.
Abstract
Therapeutic agents directed against the epidermal growth factor receptor (EGFR) signaling pathway have been effective in the treatment of non-small cell lung cancer (NSCLC). Cetuximab is a monoclonal antibody against the EGFR receptor with antitumor activity in NSCLC. This study eval...
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PMID: 20975380
PDF is available here.
PDF is available here.
Cancer Treatment Reviews (36 Suppl 3) 2010
Abstract
Metastatic colorectal cancer (mCRC) patients carrying KRAS mutated tumors do not benefit from epidermal growth factor receptor (EGFR)-targeted cetuximab- or panitumumab-based therapies. Indeed, the mutational status of KRAS is currently a validated predictive biomarker employed to select mCRC patien...
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PMID: 21129603
PDF is available here.
PDF is available here.
Anti-Cancer Drugs (21)10 2010
Abstract
I trial was carried out to determine the recommended duration of oral etoposide in combination with a fixed dose of carboplatin. Nineteen patients with varied solid tumors, who were not candidates for standard chemotherapy, were administered an escalating duration (6, 9 or 12 consecutive days) of or...
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PMID: 20856105
PDF is available here.
PDF is available here.
Journal of wound care (19)11 2010
Abstract
The risk of amputation is dramatically increased in diabetic patients with osteomyelitis of the foot complicated by Charcot neuroarthropathy. Antibiotic-impregnated cement beads have been widely reported in the treatment of deep soft tissue and bone infections. This case report demonstrates that thi...
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PMID: 21135796
PDF is available here.
PDF is available here.
Abstract
We retrospectively determined the efficacy and safety of CRT for patients with esophageal cancer.
The study population comprised patients with esophageal cancer who had been treated with CRT between April 2004 and October 2009 in our institute. Acute and late toxicity was assessed with NCI-CTC and R...
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PMID: 21084810
PDF is available here.
PDF is available here.
Abstract
Higher-risk myelodysplastic syndromes (MDS) are similar pathobiologically to acute myeloid leukemia (AML), particularly in older adults. AML therapies thus may have activity in MDS. In the current study, phase 2 study data of arsenic trioxide (ATO) and gemtuzumab ozogamicin (GO) in CD33-positive pati...
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PMID: 20960521
PDF is available here.
PDF is available here.
Abstract
Acute myeloid leukemia (AML) in first relapse is associated with a poor outcome even when treated with intermediate- to high-dose cytarabine (IHDAraC). Gemtuzumab ozogamycin (GO) used as a single agent has clinical activity in relapsed and refractory AML. Various combination regimens of GO have been...
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PMID: 20957721
PDF is available here.
PDF is available here.
Abstract
We report the proportion of patients demonstrating CR-IM at 5-year follow-up.
Prospective, multicenter US trial (NCT00489268). After endoscopic RFA of NDBE up to 6 cm, patients with CR-IM at 2.5 years were eligible for longer-term follow-up. At 5 years, we obtained four-quadrant biopsies from ever...
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PMID: 20857372
PDF is available here.
PDF is available here.
Abstract
Our aim was to evaluate the cost-effectiveness of docetaxel versus weekly paclitaxel regimen in patients with metastatic breast cancer previously treated with anthracycline from the Spanish National Health Service (NHS) perspective.
A Markov model with a 21-day cycle duration was developed to estima...
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PMID: 20947484
PDF is available here.
PDF is available here.
Journal of Infection (61)4 2010
Abstract
We identified HIV-1 infected patients from a large treatment cohort who experienced virological failure (HIV-1 RNA >1000 copies/mL) with evidence of resistance mutations including the K65R, but without thymidine analogue mutations (TAMs) in genotypic resistance assay. Phenotype was performed from pr...
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PMID: 20600301
PDF is available here.
PDF is available here.
Abstract
AZD6244 (ARRY-142886) is a potent, selective MEK inhibitor. This study aimed to evaluate the efficacy and safety of AZD6244 versus pemetrexed as second- or third-line treatment in patients with advanced non-small cell lung cancer (NSCLC).
In this randomized phase II s...
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PMID: 20802351
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
Increased knowledge about the treatment of pancreatic cancer has influenced the management of locally advanced and metastatic disease. Nonetheless, prognosis remains dismal (24%, 1-year survival). The impact on overall survival (OS) of second-line therapy has not been clarified and the use of platin...
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PMID: 21036754
PDF is available here.
PDF is available here.
Abstract
These results suggest that RPA classification should determine whether or not WBRT is added to SRS. WBRT may be recommended to be added to SRS for patients in whom long-term survival is expected on the basis of RPA classification.
2010 Elsevier Inc. All rights reserved....
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PMID: 20097485
PDF is available here.
PDF is available here.
Abstract
Between 1997 and 2007, 43 patients with single brainstem metastases were treated with SRS. The median age at treatment was 59 years, the median Karnofsky performance status was 80, and the median follow-up was 5.3 months. The median dose was 15 Gy (range, 9.6-24), and the median conformality and het...
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PMID: 20133072
PDF is available here.
PDF is available here.
Abstract
We conducted a randomized phase II study to evaluate the efficacy and safety of the combination of docetaxel and S-1 in the second-line setting.
Patients with relapse of NSCLC after first-line platinum-based chemotherapy were randomly assigned to docetaxel alone (60 mg/m, day 1, q3 w...
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PMID: 20651615
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
Between 2007-2009, 14 patients enrolled, 12 were evaluable. Nine patients were on study at 12 weeks. Objective responses (by RECIST and/or CA125) occurred in 4 patients. There were no grade 4, and only four grade 3 toxic events: diarrhea, edema and 2 cases of neutropenia. Early study closure was due...
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PMID: 20944093
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
We describe therapeutic results from a series of 13 patients autografted in second molecular remission (MR) by a molecular negative apheresis product. In all patients, the disease was confirmed at the molecular level and all had received the GIMEMA/AIDA protocol, achieving molecular remission at the...
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PMID: 20944181
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
The overall response rate was 27.8%. The median survival was 19.2 months, and the median time to disease progression was 6.2 months. The most common treatment-related adverse events (all grades) were hand-foot syndrome (15%), nausea (15%), vomiting (7.5%), disorder of taste (7.5%), and diarrhea (5%)...
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PMID: 20944178
PDF is available here.
PDF is available here.
Abstract
We describe a multicenter experience of 11 pediatric patients diagnosed with acute or chronic GVHD (aGVHD, cGVHD) treated for compassionate use with GMP-grade unrelated HLA-disparate donors' bone marrow-derived MSCs, expanded in platelet-lysate (PL)-containing medium. Eleven patients (aged 4-15 year...
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PMID: 20350611
PDF is available here.
PDF is available here.
Abstract
Recurrent disease is one of the main reasons for the persistently poor prognosis of squamous cell carcinoma of the head and neck (HNSCC; European 5-year survival, 42%). The main treatment option for primary and secondary malignancy as well as recurrent disease is surgical therapy. If R0 resection (r...
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PMID: 20628714
PDF is available here.
PDF is available here.
Abstract
We evaluated the safety and efficacy of cediranib, a potent small molecule inhibitor of the vascular endothelial growth factor receptor, in patients with refractory or recurrent small cell lung cancer (SCLC).
Patients with SCLC with progression after prior platinum-based chemotherapy only; performan...
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PMID: 20559150
PDF is available here.
PDF is available here.
Abstract
I trials have fuelled efforts to characterize more clearly the application of this approach to unmet clinical needs such as metastatic carcinoma. To examine this approach in breast cancer, a Phase I trial was conducted in which zoledronate, a Vgamma9Vdelta2 T cell agonist, plus low-dose interleukin...
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PMID: 20491785
PDF is available here.
PDF is available here.
Abstract
Abstract
The efficacy and toxicity of high-dose chemotherapy and autologous stem cell transplantation (HDCT/ASCT) were investigated for improving the outcomes of patients with relapsed medulloblastoma. A total of 15 patients with relapsed medulloblastoma were enrolled in the KSPNO-S-053 study from May 2005 t...
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PMID: 20676326
PDF is available here.
PDF is available here.
Abstract
Clinical trials may be feasible in second- or third-line salvage chemotherapy for gastric cancer. Future clinical trials in these settings should take into account the low response rate, short progression-free survival, and the prognostic factors for optimal trial design....
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PMID: 20221831
PDF is available here.
PDF is available here.
Auris Nasus Larynx (37)4 2010
Abstract
Many patients with recurrent glottic carcinoma after primary radiotherapy can be cured by single or repeated TLM as an organ-preserving procedure. However, in case of failure after TLM for the first recurrence, salvage laryngectomy should be considered early as local control by further laser surgery...
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PMID: 20031355
PDF is available here.
PDF is available here.
Abstract
The rates of overall survival, HPC-specific survival, HPC recurrence-free survival, and local control with laryngeal voice preservation for the 77 patients at 5 years were 47%, 74%, 57%, and 70%, respectively. The survival rates were not affected by the patient characteristics or treatment factors,...
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PMID: 19910141
PDF is available here.
PDF is available here.
Gastroenterology (139)1 2010
Abstract
Autoimmune hepatitis (AIH) is characterized by chronic inflammation of the liver, interface hepatitis (based on histologic examination), hypergammaglobulinemia, and production of autoantibodies. Many clinical and basic science studies have provided important insights into the pathogenesis and treatm...
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PMID: 20451521
PDF is available here.
PDF is available here.
Abstract
BI 2536 monotherapy has modest efficacy and favorable safety in relapsed non-small cell lung cancer. The findings support the further development of polo-like kinase-1 inhibitors within this indication....
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PMID: 20526206
PDF is available here.
PDF is available here.