Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Drug Administration Routes (11):
Recent article
Drug Administration Routes
Avian Diseases (55)3 2011
Abstract
Spray application is a commonly used, time- and labor-efficient means to deliver live Mycoplasma gallisepticum (MG) vaccine to laying hens in commercial production facilities. The dosage of vaccine received by spray-vaccinated birds can vary due to variation in the spray plume and th...
|
PMID: 22017053
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Journal of Neuroscience (31)31 2011
Abstract
We examine the effect of endotoxin-induced inflammation on Ox neuron biology and LMA in rats. Our results demonstrate a vital role for diminished Ox signaling in mediating inflammation-induced lethargy. This work defines a specific population of inflammation-sensitive, arousal-associated Ox neurons...
|
PMID: 21813697
PDF is available here.
PDF is available here.
Abstract
We investigated the role of the neurokinin-1, dopamine D1 and D2 receptors on the METH-induced cytogenesis. To that end, male mice were given a single injection (30mg/kg, ip) or a binge of METH (10mg/kg, 4× at two-hour intervals, ip). BrdU (100mg/kg, ip) was given 36h after the last injection of ME...
|
PMID: 21652034
PDF is available here.
PDF is available here.
Abstract
Many older adults with type 2 diabetes require insulin to supplement or replace oral hypoglycemic control. Overtime, the addition of this more intensive therapy is needed to preserve beta cell function or prevent macrovascular sequelae. This is the result of the natural progression of diabetes and no...
|
PMID: 21539006
PDF is available here.
PDF is available here.
Journal of Immunotherapy (34)3 2011
Abstract
We showed that the route of administration is critical to the antitumor activity of CpG. Although intravenous (i.v.) injection of CpG was capable of inducing the activation and expansion of tumor antigen-specific T cells, most of these activated T cells failed to migrate to tumor sites. By contrast,...
|
PMID: 21389870
PDF is available here.
PDF is available here.
Abstract
We studied the effects of dosing route and tracer concentration on the mass isotopomer distribution profile as well as the action of selective inhibitors of microsomal tri-glyceride transfer protein (MTP) in mice and diacylglycerol acyltransferase 1 (DGAT1) in nonhuman primates, using a stable-isoto...
|
PMID: 21415123
PDF is available here.
PDF is available here.
Avian Diseases (55)1 2011
Abstract
We evaluated protection conferred by mucosal vaccination with replication-competent adenovirus-free recombinant adenovirus expressing a codon-optimized avian influenza (AI) H5 gene from A/turkey/WI/68 (AdTW68.H5ck). Commercial, layer-type chicken groups were either singly vaccinated ocularly at 5 day...
|
PMID: 21500634
PDF is available here.
PDF is available here.
Abstract
Abstract
Our results confirm that the use of continuous infusions remains rare, despite increased interest in continuous infusions for time-dependent antibiotics....
|
PMID: 21485671
PDF is available here.
PDF is available here.
Abstract
We tested the hepatoprotective profiles of SIL and silibinin in assays that measure antiviral and anti-inflammatory functions. Both mixtures inhibited fusion of HCV pseudoparticles (HCVpp) with fluorescent liposomes in a dose-dependent fashion. SIL inhibited 5 clinical genotype 1b isolates of NS5B R...
|
PMID: 21297992
PDF is available here.
PDF is available here.
Abstract
Evaluation of in vitro-in vivo correlation (IVIVC) plays important role in securing therapeutic effect if a dosage form undergoes technological modifications. Similarity (closeness) of dissolution profiles of the original and modified dosage forms has been traditionally considered to be sufficient fo...
|
PMID: 21648197
PDF is available here.
PDF is available here.
Acta clinica Belgica (66)2 2011
Abstract
Vitamin K deficiency bleeding (VKDB) in infants still occurs despite worldwide use of prophylaxis. Clinical manifestations can be dramatic with over 50% of patients presenting with intracranial haemorrhage and a mortality rate of 20% in late vitamin K deficiency bleeding. Special attention should be...
|
PMID: 21630615
PDF is available here.
PDF is available here.
Abstract
Nebulisation is an important and common method of administering medication to patients with respiratory disease. Although the routine use of nebulisers is contentious, they are helpful when the patient is unable to use other devices, perhaps because of illness or poor dexterity, and are recommended i...
|
PMID: 21560711
PDF is available here.
PDF is available here.
Kardiologiia (51)5 2011
Abstract
We consider in this review traditional and novel approaches to drug prevention of pulmonary embolism (PE) which in predominant number of cases is related to deep vein thrombosis of lower extremities. Risk of PE development is especially high in patients after orthopedic hip or knee surgery. Modern r...
|
PMID: 21649596
PDF is available here.
PDF is available here.
Nursing Times (107)24 2011
Abstract
The Care Homes' Use of Medicines Study (Alldred et al, 2009) found medication administration errors occur during drug rounds in care homes.
|
PMID: 21780721
PDF is available here.
PDF is available here.
AIDS Alert (25)12 2010
Abstract
Abstract
Cerebral palsy is the most common motor disability in childhood. Orthopedic care depends on the appreciation and the identification of muscle tone abnormalities and how they affect growth and development of the child. Abnormal muscle tone is a common diagnostic feature of cerebral palsy and can incl...
|
PMID: 20868881
PDF is available here.
PDF is available here.
Abstract
Ventricular tachycardia (VT) may be monomorphic or polymorphic. Although commonly related to organic heart disease, a significant percentage of VTs are idiopathic (occurring in patients with otherwise normal hearts). Correctly identifying the substrate and mechanism of the tachycardia is essential f...
|
PMID: 20887902
PDF is available here.
PDF is available here.
Abstract
The morbidity and mortality resulting from alcohol-related diseases globally impose a substantive cost to society. To minimize the financial burden on society and improve the quality of life for individuals suffering from the ill effects of alcohol abuse, substantial research in the alcohol field is...
|
PMID: 20586763
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)9 2010
Abstract
Selection of the antimicrobial agent and maintenance of adequate drug concentrations at the site of infection are the most relevant problems in mastitis antibiotic therapy. Intramammary drug efficacy can be maximized by keeping drug concentrations at the site of infection above the minimum inhibitor...
|
PMID: 20723685
PDF is available here.
PDF is available here.
Interventional neuroradiology : journal of peritherapeuticneuroradiology, surgical procedures and related neurosciences (16)3 2010
Abstract
Our study demonstrated an optimal infusion rate at 4,000U/min, suggesting relatively low levels of infusion are better able to improve brain reperfusion and reduce brain injury after stroke....
|
PMID: 20977863
PDF is available here.
PDF is available here.
Medicina Clínica (135)6 2010
Abstract
Revista de Neurologia (51)1 2010
Abstract
In the advanced stages of Parkinson's disease (PD), the conventional orally-administered pharmacological treatment can prove to be insufficient to control the motor complications associated with the disease. One of the causes involved in the genesis of the motor fluctuations that are observed in PD...
|
PMID: 20568067
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)24 2010
Abstract
We report the results of in situ hybridization and immunohistochemistry experiments in rats and mice, which show that systemic injections of OEA (5-10 mg kg(-1), intraperitoneal) enhance expression of the neuropeptide oxytocin in magnocellular neurons of the paraventricular nucleus (PVN) and supraop...
|
PMID: 20554860
PDF is available here.
PDF is available here.
Abstract
IV and oral NAC are generally mild adverse drug reactions....
|
PMID: 20524832
PDF is available here.
PDF is available here.
Abstract
Type 2 diabetes poses a major health challenge among African Americans. Older therapies are associated with shortcomings such as hypoglycemia and/or weight gain. In recent years the "incretin system" has become understood as offering great promise for drug development. Two drug classes-namely, the i...
|
PMID: 20575217
PDF is available here.
PDF is available here.
Abstract
To analyze naringin, naringenin and its metabolites in rat plasma after intragastric administration of exocarpium Citri grandis alcohol extract.
Rat blood samples were collected 1.0 hour after oral administration of 50 g x kg(-1) exocarpium Citri grandis alcohol extract and analyzed by UPLC-Q-TOF wi...
|
PMID: 20815212
PDF is available here.
PDF is available here.
Abstract
There is no integrated pharmacokinetic/pharmacodynamic analysis that can supply parameter estimates to be programmed into pumps for either plasma or effect-site concentration determination over the broad paediatric age range. The six pharmacokinetic parameter sets available for children out of infan...
|
PMID: 20386438
PDF is available here.
PDF is available here.
Abstract
We investigated conjugation of PEG to FGF2 and compared its distribution relative to unmodified FGF2 in injured spinal cord tissue when delivered intrathecally from HAMC. Importantly, PEG conjugation nearly doubled the concentration of FGF2 in the injured spinal cord when delivered locally and, cont...
|
PMID: 20114065
PDF is available here.
PDF is available here.
Abstract
As long as no effective malaria vaccine is available, chemotherapy belongs to the most important weapons fighting malaria. One of the most promising new drug developments is the sesquiterpene artemisinin (ARS) and its derivatives, e.g., artemether, arteether, and sodium artesunate. Large clinical st...
|
PMID: 20158370
PDF is available here.
PDF is available here.
Abstract
The results showed that post-training administration of different doses of histamine (5, 10, and 20 microg/mouse, i.c.v.) decreased the step-down latency on the test day. Repeated pretreatment of histamine (10 and 20 microg/mouse) for three days followed by five days of no drug treatment prevented a...
|
PMID: 20433225
PDF is available here.
PDF is available here.
Abstract
Breakthrough pain is defined as transitory flares of pain. Breakthrough pain is caused by cancer, cancer complications, treatment or comorbidities. The usual onset to maximum breakthrough pain intensity time is 3 min and duration is 30 min; therefore, the assessment for response needs to be at short...
|
PMID: 20420495
PDF is available here.
PDF is available here.
Abstract
We report the clinical course of a patient with bitemporal epilepsy who ingested 12 g of lacosamide, 56 g of gabapentin, 2g of topiramate, and 2.8 g of zonisamide during a suicide attempt. The patient was found comatose and experienced repeated generalized tonic-clonic seizures, aspiration with subs...
|
PMID: 20171144
PDF is available here.
PDF is available here.
Human Gene Therapy (21)4 2010
Abstract
We will be proposing a cautious approach to dose escalation in a phase I clinical trial among patients with HCC....
|
PMID: 19911974
PDF is available here.
PDF is available here.
Pediatric Emergency Care (26)4 2010
Abstract
Abstract
This study aims to investigate the therapeutic effect of paclitaxel temperature-responsive gel (PTRG) for interstitial chemotherapy on breast cancer, and to explore a new minimally invasive treatment for breast cancer.
Breast cancer models were induced in rats using s...
|
PMID: 19777257
PDF is available here.
PDF is available here.
Abstract
Ten patients from the IVT group and 9 patients from the STI group completed the 24-week study visit. Mean baseline best-corrected visual acuity (logarithm of the minimum angle of resolution) was 20/259 and 20/222 in the IVT and STI groups, respectively (t = 0.41; P = 0.3407). A significant improveme...
|
PMID: 20182403
PDF is available here.
PDF is available here.
Abstract
After receiving one to three injections, all three patients had subretinal fluid completely reabsorbed. All patients had one session of subsequent ablative procedures for diseased vessels and supplementary intravitreal bevacizumab injection. No patients had recurrent subretinal fluid. Improved visua...
|
PMID: 19996822
PDF is available here.
PDF is available here.
Abstract
An intravenous solution is a dosage forms intended for administration into the bloodstream. This route is the most rapid and the most bioavailable method of getting drugs into systemic circulation, and therefore it is also the most liable to cause adverse effects. In order to reduce the possibility...
|
PMID: 20182828
PDF is available here.
PDF is available here.
Neurosurgery (66)3 2010
Abstract
In the 9L rodent glioma model, groups treated with the combination of local TMZ, local BCNU, and radiation therapy (XRT) had 75% long-term survivors (defined as animals alive 120 days after tumor implantation), which was superior to the combination of local TMZ and local BCNU (median survival, 95 da...
|
PMID: 20173548
PDF is available here.
PDF is available here.
Abstract
All the flaps survived, and the knee function recovered. One patient had epidermis necrosis at the distal end of the flap of lateral side of the knee. CONCLUSION: The early combination of Chinese and Western medicine for anti-inflammation is a simple, easy to promote, and no special microsurgical in...
|
PMID: 20415069
PDF is available here.
PDF is available here.
Abstract
Olopatadine is a tricyclic compound with antihistaminic, mast cell-stabilizing, and anti-inflammatory properties. In the United States olopatadine is approved as a b.i.d. ophthalmic solution, Patanol (Alcon Laboratories, Inc., Fort Worth, TX) to treat all signs and symptoms of allergic conjunctiviti...
|
PMID: 20406593
PDF is available here.
PDF is available here.
Abstract
Aldehydes such as acrolein are ubiquitous pollutants present in automobile exhaust, cigarette, wood, and coal smoke. Such aldehydes are also constituents of several food substances and are present in drinking water, irrigation canals, and effluents from manufacturing plants. Oral intake represents t...
|
PMID: 20034506
PDF is available here.
PDF is available here.
Abstract
Cutaneous T-cell lymphomas (CTCLs) are a rare group of mature T-cell lymphomas presenting primarily in the skin. The most common subtypes of CTCL are mycosis fungoides and its leukaemic variant Sézary's syndrome. Patients with early-stage disease frequently have an indolent clinical course; however...
|
PMID: 20166766
PDF is available here.
PDF is available here.
Journal of Neuroimmunology (220)1-2 2010
Abstract
We investigated the effect of rapamycin administration to SJL/j mice affected by PLP(139-151)-induced relapsing-remitting experimental autoimmune encephalomyelitis (RR-EAE). We found that oral or intraperitoneal treatment at the peak of disease or at the end of the first clinical attack, dramaticall...
|
PMID: 20149931
PDF is available here.
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: Despite the fact that Parkinson's disease (PD) was discovered almost 200 years ago, its treatment and management remain immense challenges because progressive loss of dopaminergic nigral neurons, motor complications experienced by the patients as the disease progresses and d...
|
PMID: 20095943
PDF is available here.
PDF is available here.
Current Eye Research (35)2 2010
Abstract
Bevacizumab injections partially inhibit the growth of corneal neovascularization induced by acute chemical injury in a mouse model. The intraocular routes of injection were found to be the most effective, and the subconjunctival route of injection yielded the earliest peak response....
|
PMID: 20136420
PDF is available here.
PDF is available here.
Abstract
Despite significant advances in surgical and pharmacological techniques, myocardial infarction (MI) remains the main cause of morbidity in the developed world because no remedy has been found for the regeneration of infarcted myocardium. Once the blood supply to the area in question is interrupted,...
|
PMID: 20063367
PDF is available here.
PDF is available here.
Abstract
We reviewed clinical trials on different otorhinolaryngological procedures, assessing choice of antibiotic, length of treatment and administration route. There are no clinical trials for laryngo-pharyngeal laser surgery. Nor are there clinical trials on implant cochlear surgery or neurosurgical clea...
|
PMID: 20061205
PDF is available here.
PDF is available here.
Abstract
Infections of the reproductive tract, complications after childbirth, and reproductive problems continue to be a major health challenge worldwide. An impressive number of plant species is traditionally used to remedy such afflictions, and some have been investigated for their efficacy with positive...
|
PMID: 21040536
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To provide pharmacists with a current, comprehensive review of medication adherence challenges and solutions. DATA SOURCES: A computerized search of the PubMed and Medline databases (through July 2008) identified English language review articles on medication adherence using the MeSH term...
|
PMID: 20452915
PDF is available here.
PDF is available here.
Missouri medicine (107)5 2010
Abstract
Treatment of acute ischemic stroke is time dependent and technically challenging. Sixty-four percent of hospitals in the U.S. have never given intravenous (IV) tissue plasminogen activator (tPA) for stroke and 40% of the U.S. population lives in a county without a hospital that routinely treats elig...
|
PMID: 21207786
PDF is available here.
PDF is available here.
Abstract
Most nurses working in an acute hospital setting will encounter patients with chest drains and underwater seal drainage at some point in their careers. This article is primarily written for the non-specialist nurse who requires a good working knowledge of chest drain insertion and underwater seal dr...
|
PMID: 20196325
PDF is available here.
PDF is available here.
Ophthalmic Research (43)3 2010
Abstract
After a single injection, effective drug levels were achieved in corneas in group A, maintained for 7 days, exceeding the minimum inhibitory concentration at which 90% of isolates are inhibited (MIC(90)) for a wide spectrum of fungi and molds. There were significant differences (p < 0.001) compared...
|
PMID: 19887881
PDF is available here.
PDF is available here.
European Neurology (63)4 2010
Abstract
Internal carotid artery (ICA) dissection with tandem internal carotid and middle cerebral artery occlusion may carry a poor prognosis even if intravenous recombinant-tissular plasminogen activator is administered. A better outcome may be expected with the combination of intravenous thrombolysis and...
|
PMID: 20215752
PDF is available here.
PDF is available here.
Abstract
Three of the 45 children (11%) presented with white matter changes upon MRI examination. All children with MRI abnormalities received CRT. In 13 (31%) children, changes in (1)H-MRS metabolite ratios were seen. We observed decreased NAA/Cr and Cho/Cr ratios. MR spectroscopy showed a significant reduc...
|
PMID: 19812948
PDF is available here.
PDF is available here.
Abstract
We tested whether salsolinol, a dopamine derivative (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), participates in the regulatory process of GH secretion in lactating sheep. A series of intracerebroventricular (i.c.v.) infusions of salsolinol, in two doses, was performed in nursing sheep,...
|
PMID: 20407483
PDF is available here.
PDF is available here.
Reumatismo (62)3 2010
Abstract
Ketoprofen is a drug belonging to the family of non-steroidal anti-inflammatory drugs (NSAIDs). The present review examines the main available clinical evidence of ketoprofen in the treatment of acute and chronic pain, of both rheumatic and traumatic origin, as well as postoperative pain. Ketoprofen...
|
PMID: 21052564
PDF is available here.
PDF is available here.
Drug Delivery (17)7 2010
Abstract
This study focused on preparation and evaluation of a thermosensitive and mucoadhesive in situ gelling ophthalmic system of azithromycin (ATM). Poloxamer 407 (P407) and poloxamer 188 (P188) were used as gelling agents. Addition of Carbopol 974P (CP 974P) to the gelling systems could increase the sol...
|
PMID: 20500130
PDF is available here.
PDF is available here.