Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Drug Delivery Systems (4):
Recent article
Drug Delivery Systems
Anaesthesia (67)2 2012
Abstract
This study evaluated the effect of limiting maximal infusion-pump flow rate on suppression of remifentanil-induced cough during target-controlled infusion. Two hundred and ten patients were randomly assigned to receive remifentanil at an effect-site concentration of 4.0 ng.ml(-1) wit...
|
PMID: 22251106
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We have performed structural and kinetic investigations of the nicotinamidase from Saccharomyces cerevisiae (Pnc1). Steady-state product inhibitor analysis revealed an irreversible reaction in which ammonia is the first product released, followed by nicotinic acid. A series of nicotinamide analogues...
|
PMID: 22229411
PDF is available here.
PDF is available here.
Abstract
We used a series of reactive cyclostreptin analogues, 6-chloroacetyl-cyclostreptin, 8-chloroacetyl-cyclostreptin, and [(14)C-acetyl]-8-acetyl-cyclostreptin, to characterize the cellular target of the compound and to map the binding site. The three analogues were cytotoxic and stabilized microtubules...
|
PMID: 22148836
PDF is available here.
PDF is available here.
Journal of Chromatography B (880)1 2012
Abstract
A simple, sensitive and specific high-performance liquid chromatography (HPLC) assay for the quantification of camptothecin (CPT), a potent anticancer candidate, incorporated into solid lipid nanoparticles (SLN) in several rat organs (brain, heart, kidneys liver, lung, spleen) and se...
|
PMID: 22153332
PDF is available here.
PDF is available here.
Brain research (1426) 2011
Abstract
Active efflux transport processes at the blood-brain barrier (BBB), such as P-glycoprotein (P-gp)-mediated efflux, can limit brain uptake of therapeutics. Accurate determination of the consequent impact on brain uptake is assumed to require sampling post-attainment of brain-to-blood...
|
PMID: 22036081
PDF is available here.
PDF is available here.
Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine (225)12 2011
Abstract
This paper presents a concept for an implantable micro-pump based on hydrogen-generating gas cells. The gas-generating cell is separated from the drug reservoir by an expandable latex membrane. The system offers linear drug delivery with flowrates ranging from 8 nl/s to 2 microl/s an...
|
PMID: 22320059
PDF is available here.
PDF is available here.
Molecular Oncology (5)6 2011
Abstract
Chemotherapy represents a mainstay and powerful adjuvant therapy in the treatment of cancer. The field has evolved from drugs possessing all-encompassing cell-killing effects to those with highly targeted, specific mechanisms of action; a direct byproduct of enhanced understanding of...
|
PMID: 22071376
PDF is available here.
PDF is available here.
Abstract
Fibromyalgia is a debilitating, chronic pain disorder typically present with allodynia and hyperalgesia. Estimates from the USA suggest that fibromyalgia affects about 5% of women, and is the third most common rheumatic disorder after lower back pain and osteoarthritis. Recent research advances high...
|
PMID: 21905964
PDF is available here.
PDF is available here.
Abstract
Because a significant percentage of patients who require high-dose statin therapy for dyslipidemia experience treatment-related muscle symptoms and an inconsistent clinical response, alternative or adjunctive approaches to the management of dyslipidemia are needed. One alternative ap...
|
PMID: 22108147
PDF is available here.
PDF is available here.
Abstract
An effective transdermal delivery system for local anaesthetic was developed with lidocaine hydrochloride (LID) as model drug. Chitosan coated elastic liposome (CCEL) were proposed and its in vitro/in vivo skin permeation properties were evaluated. Elastic liposome composed of soya l...
|
PMID: 22195489
PDF is available here.
PDF is available here.
Abstract
The chitosan nanoparticles (CSNPs) loading with low molecular weight heparin (LMWH) was prepared by ionic gelatin process of chitosan (CS) and sodium tripolyphosphate (TPP) and the preparation process was optimized by a central composite design (CCD). Encapsulation efficiency (96.98%...
|
PMID: 22195488
PDF is available here.
PDF is available here.
Abstract
In vivo tumor targeting and drug delivery properties of small polymerized polydiacetylene (PDA) micelles (∼10 nm) is investigated in a murine MDA-MB-231 xenograft model of breast cancer. Three micelles with different surface coatings are synthesized and tested for their ability to...
|
PMID: 21837631
PDF is available here.
PDF is available here.
Abstract
Interest in use of the polysaccharide chitosan as a pharmaceutical excipient by different dose routes and for a number of applications is not new but it still does not appear to be present in any marketed drugs. Also a novel excipient in a new formulation requires a lot of safety consideration. Publi...
|
PMID: 21928704
PDF is available here.
PDF is available here.
Biomacromolecules (12)9 2011
Abstract
We investigated the properties of micellar siRNA delivery vehicles prepared with poly(ethylene glycol)-block-poly(l-lysine) (PEG-b-PLL) comprising lysine amines modified to contain amidine and thiol functionality. Lysine modification was achieved using 2-iminothiolane (2-IT) [yielding PEG-b-PLL(N2IM...
|
PMID: 21863796
PDF is available here.
PDF is available here.
Abstract
Delta opioid receptors represent a promising target for the development of novel analgesics. A number of tools have been developed recently that have significantly improved our knowledge of δ receptor function in pain control. These include several novel δ agonists with potent analgesic properties,...
|
PMID: 21836459
PDF is available here.
PDF is available here.
Abstract
Topical delivery of drugs to the sinuses is challenging and requires also particular administration manoeuvres from the patient. This study was conducted to investigate 1) the delivery efficiency of a pulsating aerosol (Vibrent prototype device) to the sinuses and the nose, 2) the ae...
|
PMID: 21858257
PDF is available here.
PDF is available here.
Abstract
We sought to develop an appropriate method to examine large sets of GPCR ligand information for both screening collection enhancement and hit expansion. To this end, we have implemented a modified version of BDACCS that removes highly correlated descriptors (rBDACCS). To test the hypothesis that a s...
|
PMID: 21761904
PDF is available here.
PDF is available here.
Abstract
We showed previously that the PI3 kinase-Akt pathway downstream of BDNF/TrkB signaling stimulates synaptic delivery of PSD-95 via vesicular transport. However, vesicular transport requires PSD-95 palmitoylation to attach it to a lipid membrane. Also, PSD-95 insertion at synapses is known to require...
|
PMID: 21849550
PDF is available here.
PDF is available here.
Abstract
We discovered that curcuminoids were mainly present as glucuronides in plasma, whereas in free form in tumor tissue. A validated LC/MS/MS method was established to determine the three free curcuminoids in tumor homogenate. Samples were separated on a Zorbax SB-C(18) column, eluted with acetonitrile-...
|
PMID: 21856253
PDF is available here.
PDF is available here.
Abstract
We evaluated the efficacy of 2-stage revision in TKAs infected with resistant organisms and compared the clinical outcomes with articulating and conventional static spacers, in terms of both infection control and function. Methods In a prospective manner, from June 2003 to January 2007 selected pati...
|
PMID: 21883049
PDF is available here.
PDF is available here.
Nature Medicine (17)8 2011
Abstract
Abstract
Abstract
Multifunctional lipid nanoemulsions have shown to combine several advantages e.g. tissue targeting, cell targeting, imaging analysis, barrier permeability enhancement, and therapeutic purposes. Depending on the choice of lipid composition, surfactants and additional surface modifiers...
|
PMID: 21812320
PDF is available here.
PDF is available here.
Abstract
A 5-day workshop on adjuvant for vaccines was held in Trinidad, Cuba, on the 16-21 May 2010. Organized by the Latin American Association for Immunology and the Cuban Society for Immunology, the workshop attracted more than 60 scientists from different parts of the world. The meeting...
|
PMID: 21806395
PDF is available here.
PDF is available here.
Abstract
Our results suggest that the amphiphilic nanoparticles with core-shell structures are potentially useful to develop novel drug carriers....
|
PMID: 22121594
PDF is available here.
PDF is available here.
Abstract
In this study, poly(D,L lactic-co-glycolic acid) (PLGA) was used as a drug carrier to generate two types of stents loaded with different concentrations of sirolimus. These stents were prepared by ultrasonic atomizing spray coating. Ultrasonic atomizing spray nozzle uses a low-pressur...
|
PMID: 22121592
PDF is available here.
PDF is available here.
Abstract
The incidence of life-threatening viral and microbial infections has dramatically increased over recent decades. Despite significant developments in anti-infective chemotherapy, many issues have increasingly narrowed the therapeutic options, making it imperative to discover new effec...
|
PMID: 21806382
PDF is available here.
PDF is available here.
Abstract
Vascular endothelial growth factor (VEGF)-targeted agents have rapidly been adopted into standard-of-care treatment for renal cell carcinoma (RCC). However, a substantial proportion of patients fail to respond to these agents or experience considerable toxicity. This article reviews the benefits and...
|
PMID: 21711062
PDF is available here.
PDF is available here.
Biomacromolecules (12)6 2011
Abstract
Currently, biomedical engineering is rapidly expanding, especially in the areas of drug delivery, gene transfer, tissue engineering, and regenerative medicine. A prerequisite for further development is the design and synthesis of novel multifunctional biomaterials that are biocompati...
|
PMID: 21469742
PDF is available here.
PDF is available here.
Biomacromolecules (12)6 2011
Abstract
This Review is focused on the growing interest brought to phosphorus-containing organic materials for applications in the biomedical field, mainly because of their properties such as biocompatibility, hemocompatibility, and protein adsorption resistance. It mainly describes relevant...
|
PMID: 21553908
PDF is available here.
PDF is available here.
Abstract
The aim of the present investigation is to encapsulate rofecoxib in niosomes and incorporate the prepared niosomes into dermal gel base for sustained therapeutic action. Niosomes were prepared by lipid film hydration technique and were analyzed for size, entrapment efficiency and drug retention capac...
|
PMID: 21702223
PDF is available here.
PDF is available here.
Abstract
We report the demonstration of a multilayered particle-based delivery system for inducing bone formation in vivo. This new strategy is an alternative approach for in vivo bone formation....
|
PMID: 21830494
PDF is available here.
PDF is available here.
Abstract
We used the new HRMAS-NMR DOSY technique to study the diffusive motions of sodium fluorescein, a drug mimetic small chromophoric molecule, loaded in a promising hydrogel developed for tissue engineering. While fluorescein behavior in water was as expected, also showing aggregation from mid concentra...
|
PMID: 21830493
PDF is available here.
PDF is available here.
Abstract
We performed fluorescence correlation spectroscopy measurements to assess the long-time self diffusion of a variety of spherical tracer particles in periodic porous nanostructures. Inverse opal structures with variable cavity sizes and openings in the nanometer domain were employed as model system....
|
PMID: 21548605
PDF is available here.
PDF is available here.
Abstract
We show that oligonucleotide-oligospermine conjugates (Zip nucleic acids or ZNAs) can help overcome these shortcomings by serving as effective antisense and antigene agents. Conjugates containing DNA and locked nucleic acid (LNA) oligonucleotides are active, and oligospermine conjugation facilitates...
|
PMID: 21539318
PDF is available here.
PDF is available here.
Abstract
The oral route is considered the most patient-convenient means of drug administration. In recent years there has been a tendency to employ smart carrier systems that enable controlled or timed release of a bioactive material, thereby providing a better dosing pattern and minimizing side effects. Nano...
|
PMID: 21699064
PDF is available here.
PDF is available here.
Abstract
We performed an agglutination assay. Agglutination in DL treated H. pylori suspension suggested selectivity of DL towards the PE surface receptor of H. pylori. Monotherapy is generally not recommended for treatment of a H. pylori infection due to the danger of development of resistance and unaccepta...
|
PMID: 21699071
PDF is available here.
PDF is available here.
Abstract
Melittin liposomes surface modified with poloxamer 188 were developed, and the effect of poloxamer 188 was investigated with regard to anti-cancer effect and vascular stimulation. Melittin liposomes surface modified with poloxamer 188 at different concentrations (0%, 2%, and 5%) were prepared using t...
|
PMID: 21699070
PDF is available here.
PDF is available here.
Abstract
The aim of this study is to determine whether baicalin can be transferred along the olfactory pathway to the brain after nasal administration of baicalin phospholipid (BP) complex to rats, thereby circumventing the blood brain barrier. The concentration of baicalin in plasma and different brain tissu...
|
PMID: 21699072
PDF is available here.
PDF is available here.
Abstract
Abstract
We would like to review recent patents and the relationship between triple negative and basal-like breast cancers, as well as BRCA1-linked breast carcinomas. Specifically, potential treatment modalities and current innovations that are designed for the predictive and prognostic values of triple nega...
|
PMID: 21247402
PDF is available here.
PDF is available here.
Abstract
The objective of this study is to investigate the anticancer efficacy of a drug delivery system comprised of gelatin hydrogel (jelly) containing cisplatin (CDDP)-loaded gelatin/poly(acrylic acid) nanoparticles by peritumoral implantation, and to compare the treatment response between...
|
PMID: 21428432
PDF is available here.
PDF is available here.
Abstract
A dimeric neomycin-neomycin conjugate 3 with a flexible linker, 2,2'-(ethylenedioxy)bis(ethylamine), has been synthesized and characterized. Dimer 3 can selectively bind to AT-rich DNA duplexes with high affinity. Biophysical studies have been performed between 3 and different nucleic acids with vary...
|
PMID: 21524066
PDF is available here.
PDF is available here.
Abstract
Recently adipose tissue has been implicated in the regulation of vascular function in humans. This regulatory function is mediated via the release of vasoactive cytokines called adipokines. Adiponectin is an adipokine with powerful anti-inflammatory and antioxidant properties and fou...
|
PMID: 21453253
PDF is available here.
PDF is available here.
Abstract
: To examine the efficacy and safety of an intravitreal cell-based production of glucagon-like peptide-1 (GLP-1) by intravitreally implanted and encapsulated cells.
|
PMID: 21836406
PDF is available here.
PDF is available here.
Abstract
The objective of the present investigation was to prepare mucoadhesive microspheres of ketorolac for nasal administration by means of a solvent evaporation technique using carbopol (CP), polycarbophil (PL) and chitosan (CS) as mucoadhesive polymers. The prepared microspheres were cha...
|
PMID: 21612151
PDF is available here.
PDF is available here.
Abstract
The objective of the present study was to determine the intestinal absorption of sulpiride incorporated into SMEDDS by means of single-pass intestinal perfusion method (SPIP) in rat and to compare the effective permeability coefficient obtained with that of drug solution and micellar...
|
PMID: 21454158
PDF is available here.
PDF is available here.
Abstract
A bio-nanofilm consisting of a tetrad nanomaterial (nanotubes, nanoparticles, DNA, polymer) was fabricated utilizing in situ reduction and noncovalent interactions and it displayed effective antibacterial activity and biocompatibility. This bio-nanofilm was composed of homogenous sil...
|
PMID: 21336791
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)6 2011
Abstract
Multiple myeloma (MM) is an example of rapid bench-to-bedside translation in new drug development. Bortezomib and lenalidamide target the tumor cell in the bone marrow microenvironment to overcome drug resistance in laboratory and animal models; each is effective to treat relapsed and/or refractory,...
|
PMID: 21411438
PDF is available here.
PDF is available here.
Abstract
We demonstrate the technique in dye infusion experiments that provide cylindrical and spherical distributions when infusing with porous membrane and conventional single-port catheters, respectively. This optical method incorporates important parameters, such as optimum camera exposure, captured came...
|
PMID: 21342811
PDF is available here.
PDF is available here.
Abstract
The transdermal therapeutic system (TTS) with buprenorphine is currently being used 'off-label' to treat chronic pediatric pain. We compiled available pharmacokinetic (PK), pharmacodynamic (PD), and clinical pediatric data on buprenorphine to rationalize treatment regimens.
|
PMID: 21091589
PDF is available here.
PDF is available here.
Abstract
Intravitreal administration has been widely used since 20 years and has been shown to improve the treatment of diseases of the posterior segment of the eye with infectious origin or in edematous maculopathies. This route of administration allows to achieve high concentration of drug in the vitreous a...
|
PMID: 21440102
PDF is available here.
PDF is available here.
Abstract
Due to the eye's specific anatomical and physiological conformation, the treatment of eye diseases is a real challenge for pharmaceutical therapy. The presence of efficient protective barriers (i.e., the conjunctival and corneal membranes) and protective mechanisms (i.e., blinking and nasolachrymal d...
|
PMID: 21440104
PDF is available here.
PDF is available here.
La Presse Médicale (40)4 Pt 1 2011
Abstract
Clinical Cancer Research (17)9 2011
Abstract
We sought to determine whether PN represents a target-mediated adverse drug reaction (ADR)....
|
PMID: 21364033
PDF is available here.
PDF is available here.
Abstract
We demonstrate that mechanism-based PK/PD binding models are useful for predicting human response to biologics compounds. Especially, such models have the ability to integrate preclinical and clinical, in vitro and in vivo information and facilitate rational decision making during various stages of...
|
PMID: 21336535
PDF is available here.
PDF is available here.
La Presse Médicale (40)4 Pt 1 2011
Abstract
Standard treatment of advanced non-small cell lung cancer is based on several lines of therapy separated by treatment-free intervals in which each new line is started when tumour progression is detected. The maintenance strategy consists of pursuing an appropriate, well-tolerated treatment after the...
|
PMID: 21349683
PDF is available here.
PDF is available here.
Abstract
The development of clinically applicable scaffolds is important for the application of cell transplantation in various human diseases. The aims of this study are to evaluate fibrin glue in a novel protein replacement therapy using proliferative adipocytes and to develop a mouse model system to monito...
|
PMID: 21339696
PDF is available here.
PDF is available here.