Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Drug Dosage Calculations (0):
Recent article
Drug Dosage Calculations
Abstract
We compared the clinical efficacy of long-term monotherapy with suplatast tosilate with a low dose of inhaled steroids in patients with mild atopic asthma.
A total of 32 patients with mild atopic asthma were randomly assigned to receive suplatast (n=15) or fluticasone (n=17). In the...
|
PMID: 21980828
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
Pharmacokinetics and pharmacodynamics of pegfilgrastim. LID - 10.2165/11586040-000000000-00000 [doi]
Abstract
Pegfilgrastim is a sustained-duration form of filgrastim, a recombinant methionyl form of human granulocyte colony-stimulating factor (G-CSF), to which a 20 kDa polyethylene glycol molecule is covalently bound to the N-terminal methionine residue. Similar to filgrastim, pegfilgrastim increases the...
|
PMID: 21456630
PDF is available here.
PDF is available here.
Abstract
Abstract The recent campaign for standardization of creatinine measurements has been promoted to allow the widespread use of formulas for estimating the glomerular filtration rate (GFR). However, studies on trueness verification and measurement interferences still show disappointing...
|
PMID: 21428858
PDF is available here.
PDF is available here.
Abstract
We designed a dose-finding trial of oral misoprostol administered for labor augmentation.
|
PMID: 21514556
PDF is available here.
PDF is available here.
Abstract
The present analysis suggests that screening for TPMT mutations using either genotype or enzymatic laboratory tests prior to the administration of 6-MP in pediatric ALL patients is not cost-effective. Pediatr Blood Cancer © 2011 Wiley-Liss, Inc.
Copyright © 2011 Wiley-Liss, Inc....
|
PMID: 21344614
PDF is available here.
PDF is available here.
Connecticut medicine (75)2 2011
Abstract
A retrospective cohort study of 2,218 patients with deep vein thrombosis or pulmonary embolism during a 25-year period from 1966-1990 in Minnesota showed an annual incidence of venous thromboembolism of 117 per 100,000 (deep vein thrombosis, 48 per 100,000; pulmonary embolism, 69 per 100,000). Higher...
|
PMID: 21476378
PDF is available here.
PDF is available here.
Kardiologiia (51)7 2011
Abstract
These results indicates that variations of GP IIb/IIIa content affect platelet aggregating activity within first hours of ACS upon ASA treatment. However after saturation with clopidogrel this factor has no significant influence on platelet aggregation, at least on aggregation induced by ADP which r...
|
PMID: 21878077
PDF is available here.
PDF is available here.
Acta clinica Belgica (66)2 2011
Abstract
In March 2008 and June 2009, an ad hoc working group of nephrologists discussed the status of anaemia therapy with erythropoiesis-stimulating agents [ESA] in patients on chronic haemodialysis, the phenomenon of fluctuations of haemoglobinaemia, and the need for individualisation of ESA treatment. The...
|
PMID: 21630609
PDF is available here.
PDF is available here.
Abstract
Hospitalized patients with type 2 diabetes may benefit from tighter glycemic control to prevent hyperglycemia and its complications. The glycemic control of two groups of inpatients with diabetes receiving subcutaneous insulin via a basal-bolus approach or sliding scale was compared.
|
PMID: 21941930
PDF is available here.
PDF is available here.
Abstract
Abstract
To evaluate prevalence of dose escalation among RA patients in normal clinical practice treated with etanercept, adalimumab or infliximab and to estimate its economic impact.
|
PMID: 21345289
PDF is available here.
PDF is available here.
Abstract
Influenza is a contagious airborne viral illness characterized by abrupt onset of symptoms. Fever, myalgia, headache, rhinitis, sore throat, and cough are commonly reported symptoms. The diagnosis should be made clinically, and the decision to begin antiviral therapy should not be delayed for labora...
|
PMID: 21121554
PDF is available here.
PDF is available here.
Irish medical journal (103)8 2010
Abstract
Abstract
We aimed to evaluate an assay using endogenous thrombin potential (ETP) to investigate the procoagulant properties of a range of Australian whole venoms in human plasma and compared this to traditional clotting and prothrombinase activity studies. We developed a novel modification of ETP using proco...
|
PMID: 20338189
PDF is available here.
PDF is available here.
Abstract
FAHF-2 appeared to be safe and well tolerated in patients with food allergy....
|
PMID: 20642207
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)1 2010
Abstract
We have, in the current study, assessed dose-dependent effects of FK506 on atherosclerotic lesion formation as well as on inflammatory parameters relevant to atherosclerosis. Unlike low-dose FK506, high-dose FK506 did not protect against atherosclerosis in ApoE-/- mice. The high-dose induced hyperch...
|
PMID: 20458432
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)1 2010
Abstract
We hypothesised that the prothrombotic state is reflected by elevated thrombin generation and can be mitigated by increasing the low-molecular-weight heparin (LMWH) dose. Non-surgical cancer patients were randomised to enoxaparin 40 or 80 mg. D-dimer, prothrombin fragment F1+2 (F1+2) and peak thromb...
|
PMID: 20458441
PDF is available here.
PDF is available here.
Abstract
Diabetic Medicine (27)6 2010
Abstract
Thrombosis and Haemostasis (103)5 2010
Abstract
Previous studies investigating continuous unfractionated heparin (UFH) therapy report age-related differences in UFH response in children, as measured by APTT and anti-Xa assay. This study determined the age-related response following administration of a single UFH bolus of 75-100 IU/kg in children....
|
PMID: 20174762
PDF is available here.
PDF is available here.
Abstract
The dose conversion ratio of 1:200 was unsuitable and led to a rapid increase of hemoglobin. A conversion ratio of 1:250 to 1:300 should be employed when switching from epoetin alpha to darbepoetin alpha in Japanese patients....
|
PMID: 20593349
PDF is available here.
PDF is available here.
Clinical Biochemistry (43)6 2010
Abstract
An optimal prediction model was identified for each PK parameter of each beta-lactam. The best predictor of each model was one of the AMK PK parameters estimated from TDM. Other variables included colloid solution, renal and hepatic biomarkers, age and body weight. CONCLUSION: PK of the four beta-la...
|
PMID: 20036226
PDF is available here.
PDF is available here.
Child Health Alert (28) 2010
Abstract
Abstract
Our data suggest that older patients are prescribed lower antipsychotic dosages primarily when using SGAs. This finding emphasizes the need for dose-finding studies assessing both the efficacy and the safety of antipsychotics in older patients with a psychotic or mood disorder....
|
PMID: 20416148
PDF is available here.
PDF is available here.
Abstract
Abstract
It remains unclear whether unipolar psychotic depression should be treated with an antidepressant and an antipsychotic or with an antidepressant alone.
In a multi-center RCT, 122 patients (18-65 years) with DSM-IV-TR psychotic major depression and HAM-D-17 > or = 18 w...
|
PMID: 19694628
PDF is available here.
PDF is available here.
Pharmacotherapy (30)3 2010
Abstract
We describe a 388-kg man who was started on an intravenous infusion of heparin according to hospital protocol for suspected pulmonary embolism. The patient was given a 5000-unit heparin bolus followed by an initial heparin infusion rate of 1500 units/hour, the maximum initial rate specified in the p...
|
PMID: 20180615
PDF is available here.
PDF is available here.
Abstract
Invasive fungal infections in children appear to have increased over the past few decades. Substantial differences compared with adult patients in risk factors, pathogen epidemiology, pathophysiology and, most notably, pharmacokinetics of antifungal agents require age-adapted management and treatmen...
|
PMID: 20109043
PDF is available here.
PDF is available here.
Abstract
Although many of the data regarding this approach are positive, not all the studies have demonstrated efficacy. It is hoped that future non-pharmaceutical company-sponsored research will clarify this issue and, should efficacy be confirmed, shed light on the mechanism of action....
|
PMID: 20306813
PDF is available here.
PDF is available here.
Abstract
We had applied methods of stratified sampling and simple random sampling and collected 1704 questionnaires in 21 various hospitals, 18 provinces, then analyzed them. The conclusion showed that 78.4 percent experts presumed that the dosage rang of some traditional Chinese medicine should be revised....
|
PMID: 20450062
PDF is available here.
PDF is available here.
Child Health Alert (28) 2010
Abstract
Abstract
Abstract
Sustained virological response was obtained in 83 (47.2%) of the patients and we derived formulae to predict sustained virological response at pretreatment and weeks 4, 12 and 24. The likelihood of sustained virological response could be predicted effectively by the formulae at weeks 4, 12 and 24 (t...
|
PMID: 20039454
PDF is available here.
PDF is available here.
Casopis lekaru ceskych (149)10 2010
Abstract
Therapeutic drug monitoring is a specific method of clinical pharmacology for monitoring of the therapy using measurement of drug serum concentrations followed by interpretation and good cooperation with clinician. It significantly helps to personalize and rationalize the treatment, to set individua...
|
PMID: 21121139
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
The Dutch 'euthanasia and assisted suicide' practice guideline advises using 2000 mg thiopental to induce coma, followed by a muscle relaxant to cause death by respiratory paralysis. However, when a doctor administers such a high dose of thiopental as a bolus injection to a cachectic patient, there...
|
PMID: 21083948
PDF is available here.
PDF is available here.
Abstract
Abstract
The ability to perform calculations competently is a basic requirement for all nurses. Calculations are used in everyday tasks such as working out drug doses, body mass index and fluid balance charts. Healthcare staff may have problems with numeracy and this can lead to drug errors, which can have a...
|
PMID: 20373629
PDF is available here.
PDF is available here.
Abstract
Hypertension is the number one diagnosis made by primary care physicians, placing them in a unique position to prescribe the antihypertensive agent best suited to the individual patient. In individuals with diabetes mellitus, blood pressure (BP) levels>130/80 mmHg confer an even higher risk for card...
|
PMID: 20539838
PDF is available here.
PDF is available here.
Abstract
Children are particularly a challenging group of patients when trying to ensure the safe use of medicines. Their variable weight, body surface area and organ system maturity affect their ability to metabolize and excrete medications. In addition, there are few standardized dosing regimens for childr...
|
PMID: 20578656
PDF is available here.
PDF is available here.
Abstract
Abstract
Epinephrine (adrenaline) is universally recommended as the initial drug of choice for the treatment of anaphylaxis. No other medication has similar life-saving pharmacologic effects in multiple organ systems, including prevention and relief of both upper and lower airway obstruction, and of shock. F...
|
PMID: 20519893
PDF is available here.
PDF is available here.
Abstract
Current guidelines for the management of type 2 diabetes call for the use of basal insulin when glycemic targets are not achieved. Previous studies have demonstrated noninferiority of insulin detemir, dosed once or twice daily, and insulin glargine, dosed once daily. In this issue of Journal of Diab...
|
PMID: 20167180
PDF is available here.
PDF is available here.
Seminars in Oncology (36) 2009
Abstract
Temsirolimus, a highly specific inhibitor of mammalian target of rapamycin (mTOR), is a novel anticancer targeted therapy with a new mechanism of action. The prototype mTOR inhibitor, oral rapamycin, is poorly soluble and undergoes extensive first-pass metabolism, leading to low and potentially vari...
|
PMID: 19963096
PDF is available here.
PDF is available here.
Abstract
Despite the study limitations of retrospectivity and its cross-sectional nature, the reported observations that Hb fluctuations outside target ranges occur frequently in patients on HD receiving ESAs are clearly confirmed and were strikingly similar in the two different geographical locations....
|
PMID: 19842997
PDF is available here.
PDF is available here.
Abstract
The insulin lispro pen had significantly lower median GF and GFV compared with insulin aspart pen when tested at two dose sizes and two dosing speeds. Median dose error was similar between the device types at the 10 U/s dosing speed, but median dose error was significantly lower for the insulin lisp...
|
PMID: 19916727
PDF is available here.
PDF is available here.
Nursing Times (105)46 2009
Abstract
Medicines administration is one of the high risk areas for nursing practice and a matter of considerable concern for practitioners, policymakers and the public. Drug errors can lead to devastating consequences for patients and for nurses' careers. It is an integral part of nurses' role, underpinned...
|
PMID: 20041614
PDF is available here.
PDF is available here.
Clinical Pharmacokinetics (48)11 2009
Abstract
Fifty-two percent of the observed AUC(12) values (three periods) in the 40 patients receiving a fixed dose of mycophenolate mofetil 750 mg twice daily were outside the recommended therapeutic range (30-60 microg x h/mL). The failure of the standard dose to yield an AUC(12) value within the therapeut...
|
PMID: 19817503
PDF is available here.
PDF is available here.
Abstract
The pharmacokinetics and the effects of pyridostigmine on red blood cell AChE activity were described using a mixed effects model. For Chinese males, the dosing interval may have been shorter than that recommended for the Caucasian population. Additional studies are needed to confirm these findings....
|
PMID: 19703368
PDF is available here.
PDF is available here.
Psychiatria Danubina (21)3 2009
Abstract
The hypothesis of each individual being special and different leading to heterogenity of diseases sets the ground for the concept of personalized medicine. Personalized psychiatry follows the principles of personalized medicine. A constituent part of an individually adapted approach towards the psyc...
|
PMID: 19794353
PDF is available here.
PDF is available here.
Critical Care Medicine (37)8 2009
Abstract
Journal of Family Practice (58)8 Suppl 2009
Abstract
Journal of Family Practice (58)8 Suppl 2009
Abstract
Journal of Family Practice (58)8 Suppl 2009
Abstract
Obesity Surgery (19)8 2009
Abstract
Low-molecular-weight heparins are effective as initial therapy for pulmonary embolism (PE) in a weight-based dosing regimen up to known body weights of 160 kg. The present case reports an extremely obese man of 252 kg (body mass index (BMI) 74 kg/m2) with PE who was treated with tinzaparin, dosed on...
|
PMID: 19506978
PDF is available here.
PDF is available here.
Abstract
A therapeutic concentration of fluconazole in premature infants with invasive candidiasis requires dosing substantially greater than commonly recommended in most reference texts. To prevent invasive candidiasis, twice weekly prophylaxis regimens can provide adequate exposure when unit specific MICs...
|
PMID: 19593252
PDF is available here.
PDF is available here.
Pediatric Annals (38)7 2009
Abstract
Abstract