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Drug Therapy, Combination (2):
Recent article
Drug Therapy, Combination
Presse Medicale (40)11 2011
Abstract
In chronic kidney disease patients, inexorable renal function decline is reduced by renin-angiotensin system (RAS) blockers. ACE inhibitors and angiotensin receptor blockers decrease blood pressure and proteinuria. Guidelines recommend a reduction of blood pressure to less than 130/8...
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PMID: 21889290
PDF is available here.
PDF is available here.
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Abstract
The omega-3 (n-3) fatty acids docosahexaenoic acid and eicosapentaenoic acid, along with γ-linolenic acid and antioxidants, may modulate systemic inflammatory response and improve oxygenation and outcomes in patients with acute lung injury.
To determine if dietary su...
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PMID: 21976613
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (153)41 2011
Abstract
Abstract
We would like to report our experience of using rituximab in cyclophosphamide refractory, rapidly progressive interstitial lung disease (ILD) in a patient with limited scleroderma. A 40-year-old man presented with 10-week history of inflammatory polyarthritis, which responded to a short course of or...
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PMID: 21593063
PDF is available here.
PDF is available here.
Presse Medicale (40)11 2011
Abstract
Clinical studies of the last 15years have shown the benefit of pharmacological interventions on the progression of chronic kidney disease, confirming the concept of nephroprotection. Pharmacological blockade of the renin angiotensin system remains the cornerstone of the nephroprotect...
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PMID: 21981881
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)13 2011
Abstract
We enrolled 3493 infants receiving antibiotics for suspected or proven serious infection and randomly assigned them to receive two infusions of either polyvalent IgG immune globulin (at a dose of 500 mg per kilogram of body weight) or matching placebo 48 hours apart. The primary outcome was death or...
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PMID: 21962214
PDF is available here.
PDF is available here.
Abstract
Curcumin is the active ingredient of commonly used spice Curuma longa Linn. In the present study, the antidepressant like activity of curcumin and its combination with fluoxetine and imipramine was studied in acute model (three doses 24, 5 and 1 h before test) of forced swimming test (FST) in glass j...
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PMID: 21928724
PDF is available here.
PDF is available here.
Abstract
Metoprolol, the most commonly used beta-receptor antagonist in Norway, is eliminated mainly via the enzyme cytochrome P450 (CYP) 2D6. This enzyme is inhibited to a varying extent by antidepressants. The aim of this article is to provide an overview of the interactions between metoprolol and antidepre...
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PMID: 21946596
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)11 2011
Abstract
We designed a noninferiority trial (noninferiority margin, -10.5%) to compare rates of sustained virologic response among patients receiving two treatment durations.
We enrolled patients with chronic infection with HCV genotype 1 who had not previously received treatment. All patient...
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PMID: 21916639
PDF is available here.
PDF is available here.
Missouri medicine (108)4 2011
Abstract
We now are at the cusp of yet another such overhaul with the protease inhibitors about to be introduced into the market....
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PMID: 21905441
PDF is available here.
PDF is available here.
Orvosi Hetilap (152)37 2011
Abstract
Nearly 90% of the diabetic patients are suffering of type 2 diabetes while approximately 60-65% of patients with type 2 diabetes are treated with oral antidiabetic drugs. In the last couple of years a new treatment option, namely incretin-based therapy, became available. The dipeptid...
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PMID: 21893477
PDF is available here.
PDF is available here.
Abstract
Background. Among human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) taking combination antiretroviral therapy (cART), the impact of rectal sexually transmitted infections (STIs) on rectal HIV-1 shedding is unknown. Methods. Human immunodeficiency virus type 1 (HIV-1) RNA...
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PMID: 21844302
PDF is available here.
PDF is available here.
Abstract
We conclude that IV zanamivir as late add-on therapy has limited effectiveness. The effect of an immediate start with IV zanamivir monotherapy or in combination with other drugs need to be evaluated....
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PMID: 21844304
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (42 Online)5 2011
Abstract
Retinopathy associated with pegylated interferon and ribavirin is a known complication of this therapy, and is typically bilateral and asymptomatic. Few patients complain of visual disturbance, and only rarely is there permanent visual impairment after the retinopathy resolves. A 65-...
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PMID: 21899250
PDF is available here.
PDF is available here.
Abstract
African American ethnicity is a well-described negative predictor of treatment outcome for chronic hepatitis C (CHC); however, less is known about the influence of Hispanic and Asian ethnicity. The aim of this subanalysis of the Weight-based Dosing of PegINterferon α-2b and Ribavirin (WIN-R) study w...
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PMID: 21836471
PDF is available here.
PDF is available here.
Abstract
Thalidomide provided significant protection against tri nitro benzene sulfonic acid induced colitis. Combination therapy also reduced colonic inflammation and all the biochemical parameters (myeloperoxidase assay, malondialdehyde assay and tumor necrosis factor-alpha, estimation) wer...
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PMID: 21941940
PDF is available here.
PDF is available here.
Abstract
B-cell-directed therapy-the use of agents that eliminate B cells or block cytokines important for B-cell function-is emerging as a promising approach to the treatment of rheumatic disease. Target diseases, including systemic lupus erythematosus (SLE), display diverse patterns of auto...
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PMID: 21808289
PDF is available here.
PDF is available here.
Abstract
We conducted a randomized trial involving 150 kidney transplant recipients to compare tacrolimus/sirolimus, tacrolimus/mycophenolate mofetil (MMF), and cyclosporine/sirolimus. All patients received daclizumab induction and maintenance corticosteroids. Median follow-up was 8 yr post-transplant. Acute...
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PMID: 21807891
PDF is available here.
PDF is available here.
Abstract
We describe the different treatment options available. About the association peginterferon plus ribavirin, we analyze thirteen non-randomized studies and one trial, found in recent literature. These studies are not directly compared because of differences in age, type of infection (vertical or not),...
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PMID: 22013729
PDF is available here.
PDF is available here.
Prescrire international (20)119 2011
Abstract
Management of episodes of herpes labialis (cold sores) in otherwise healthy individuals is mainly based on hygiene measures intended to avoid transmitting the virus. At best, topical treatment with aciclovir, an antiviral drug, simply reduces the duration of the episode. A cream cont...
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PMID: 21954513
PDF is available here.
PDF is available here.
Sexual Health (8)3 2011
Abstract
We investigated the degree to which several risk factors could explain this rise in notifications and the younger age profile....
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PMID: 21851769
PDF is available here.
PDF is available here.
Abstract
Observational studies from Asia suggest that maxingshigan-yinqiaosan may be effective in the treatment of acute H1N1 influenza.
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PMID: 21844547
PDF is available here.
PDF is available here.
Orvosi Hetilap (152)33 2011
Abstract
Osteoporosis affects approximately 9% of the population in Hungary resulting in about 100 000 osteoporotic fractures annually. Thirty-five percent of patients with hip fractures due to osteoporosis will die within 1 year. Direct costs of osteoporosis exceed 25 billion forints per year. Apparently, co...
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PMID: 21824859
PDF is available here.
PDF is available here.
Abstract
Abstract
To investigate the expression of the soluble form of the resident macrophage marker CD163 (sCD163) and its association with core parameters for disease activity, including radiographic progression in early rheumatoid arthritis (RA).
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PMID: 21813065
PDF is available here.
PDF is available here.
Abstract
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure recommends that clinicians consider the use of multidrug therapy to increase likelihood of achieving blood pressure goal. Little is known about recent patterns of combination...
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PMID: 21835296
PDF is available here.
PDF is available here.
Abstract
To investigate new strategies to intensify chemosensitivity in head and neck squamous cell carcinoma.
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PMID: 21844414
PDF is available here.
PDF is available here.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... (55)4 2011
Abstract
Bone metastases are responsible for most of the morbidity and mortality associated with solid malignant tumors, occurring in about 65-70% of the patients with advanced breast or prostate cancer. The pathophysiology of skeletal metastasis is a complex process that involves several bio...
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PMID: 21738116
PDF is available here.
PDF is available here.
Abstract
Hepatitis C virus (HCV), a major cause of liver disease throughout the world, is difficult to treat with interferon (IFN) (and various formulations and combinations thereof) being the only approved molecule available. It has been investigated recently that proinflammatory chemokine i...
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PMID: 21554996
PDF is available here.
PDF is available here.
Harvard Heart Letter (21)12 2011
Abstract
Harvard Heart Letter (21)12 2011
Abstract
Therapeutische Umschau (68)8 2011
Abstract
For drug therapy a differentiation of acute and chronic pain is essential. In emergency situations of acute abdominal pain a fast diagnosis is mandatory. Analgesia should be provided as soon as possible. The different groups of analgesics should be used according to their known effects, side effects...
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PMID: 21796593
PDF is available here.
PDF is available here.
Abstract
Azelaic acid (AzA) gel 15% is approved by the US Food and Drug Administration (FDA) for the treatment of papulopustular rosacea (PPR). Its efficacy and safety as monotherapy have been demonstrated. Release of active drug from the gel formulation is superior to the cream. The combination of AzA gel 15...
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PMID: 21916272
PDF is available here.
PDF is available here.
Abstract
Abstract
Coronary artery disease is a leading cause of death in the United States. Angina is encountered frequently in clinical practice. Effective management of patients with coronary artery disease and stable angina should consist of therapy aimed at symptom control and reduction of adverse clinical outcome...
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PMID: 21787900
PDF is available here.
PDF is available here.
Abstract
The mechanism of osteoporosis with fracture secondary to mastocytosis is little known, and its treatment is poorly codified.
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PMID: 21787907
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (153)29-31 2011
Abstract
MMW Fortschritte der Medizin (153)29-31 2011
Abstract
Abstract
We describe the combined use of rhBMP-2 and the bisphosphonate zoledronic acid in a mouse model of NF1-deficient fracture repair. Fractures were generated in the distal tibiae of neurofibromatosis type 1-deficient (Nf1(+/-)) mice and control mice. Fractures were open and featured periosteal strippin...
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PMID: 21768643
PDF is available here.
PDF is available here.
Abstract
The objective of the study was to determine the prevalence of high on-treatment platelet reactivity (HPR) in coronary artery disease patients enrolled in the ONSET/OFFSET and RESPOND studies.
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PMID: 21742103
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
To evaluate treatment outcomes in patients with carbapenem-resistant Acinetobacter baumannii (CRAB) nosocomial infections treated with antimicrobial agent either alone or in combination.
Clinical data were retrospectively evaluated in patients with CRAB nosocomial inf...
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PMID: 21774295
PDF is available here.
PDF is available here.
Abstract
We build up A-TOP (Adequate Treatment of Osteoporosis) research group and why we perform JOINT (Japanese Osteoporosis Intervention Trial) protocol to obtain the evidences, which are required by the clinicians. The two protocols were aimed to investigate whether concurrent treatment with bisphosphona...
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PMID: 21774372
PDF is available here.
PDF is available here.
Therapeutische Umschau (68)7 2011
Abstract
Tuberculosis (TB) is currently a rare disease in Switzerland (2.8 per 100'000 native Swiss), but is still more prevalent in some population groups especially among migrants. After more than a century on the decrease, from 2007 to 2009 the TB cases have increased from 478 to 556 for unknown reasons. T...
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PMID: 21728153
PDF is available here.
PDF is available here.
Therapeutische Umschau (68)7 2011
Abstract
Tuberculosis is the second most common cause of death from an infectious disease after HIV/AIDS and the leading cause of death from an infectious disease in HIV-co-infected patients. Currently, drug susceptible TB is treated with a four drug regimen given over a period of two months followed by two d...
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PMID: 21728158
PDF is available here.
PDF is available here.
Therapeutische Umschau (68)7 2011
Abstract
We recommend depending on severity and susceptibility testing a three to four drug treatment with a macrolide, rifampicin and ethambutol and for M. kansasii a treatment with Isoniazid, rifampicin and ethambutol. Surgical management only plays a role in rare and special cases. Treatment should be con...
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PMID: 21728159
PDF is available here.
PDF is available here.
Therapeutische Umschau (68)7 2011
Abstract
The different modalities in the treatment of tuberculosis (TB) changed within the last century. With the beginning of the era of effective antibiotic treatment, indication for surgical methods became rare. The combination of different classes of antibiotics to treat TB is most often effective but sev...
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PMID: 21728160
PDF is available here.
PDF is available here.
Delaware medical journal (83)7 2011
Abstract
Abstract
We present a case series of 10 patients with hyperhidrosis and a history of partial response to botulinum toxin type A monotherapy. With the addition of AC 15% in a salicylic acid 2% gel base, 5 patients achieved 75% to 100% reduction in sweating and 5 patients achieved 100% reduction in sweating. A...
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PMID: 21877507
PDF is available here.
PDF is available here.
Abstract
We used a rabbit model of pulmonary TB to evaluate the impact of adjunctive immune modulation, using a phosphodiesterase-4 inhibitor that dampens the innate immune response, on the outcome of treatment with the antibiotic isoniazid. Our data show that cotreatment of M. tuberculosis infected rabbits...
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PMID: 21703411
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)26 2011
Abstract
New England Journal of Medicine (364)25 2011
Abstract
We assigned 1088 patients with HCV genotype 1 infection who had not received previous treatment for the infection to one of three groups: a group receiving telaprevir combined with peginterferon alfa-2a and ribavirin for 12 weeks (T12PR group), followed by peginterferon-ribavirin alone for 12 weeks...
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PMID: 21696307
PDF is available here.
PDF is available here.
Abstract
To describe immune ring (IR) formation as a manifestation of cytomegalovirus (CMV) endotheliitis.
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PMID: 21676373
PDF is available here.
PDF is available here.
Presse Medicale (40)11 2011
Abstract
Presse Medicale (40)11 2011
Abstract
MMW Fortschritte der Medizin (153)23 2011
Abstract
MMW Fortschritte der Medizin (153)23 2011
Abstract
Abstract
Twenty years ago, ribavirin was first used in the treatment for chronic hepatitis C. After few years, ribavirin, in combination with interferon-alpha, showed a dramatic synergistic efficacy against hepatitis C virus infection, leading to viral clearance in about 50% of patients. Recent discovery of p...
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PMID: 21093391
PDF is available here.
PDF is available here.