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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Drug Therapy, Computer-Assisted (0):
Recent article
Drug Therapy, Computer-Assisted
Abstract
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Tropical Doctor (40)3 2010
Abstract
We share our experience of using computer software (Microsoft Office Excel) to improve the planning of patient care. This technology is now widely available and we suggest that it is feasible and, indeed, particularly valuable in a resource-poor setting. We focus on the steps taken to minimize the c...
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PMID: 20223798
PDF is available here.
PDF is available here.
Abstract
We have designed, manufactured, and characterized a novel dynamically programmable e-pill dispensing system. Our system is initially programmed remotely through a cell phone. After programming, the system may be reconfigured in order to adapt pill dispensation to new conditions. In this paper we des...
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PMID: 20503621
PDF is available here.
PDF is available here.
Abstract
Although significantly more patients in the intensive strategy group experienced MTX-related AEs than in the conventional strategy group, all recorded AEs were relatively mild. A higher body mass index (BMI) was significantly associated with withdrawal due to MTX-related AEs in the multiple regressi...
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PMID: 19581281
PDF is available here.
PDF is available here.
Abstract
Thirty percent of alerts were handled incorrectly, because the action itself and/or the reason for the handling were incorrect. Sixty-three percent of the errors were categorized as rule based and residents in surgery used incorrect justifications twice as often as residents in internal medicine. Th...
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PMID: 20171929
PDF is available here.
PDF is available here.
Abstract
At a 450 bed teaching hospital, the number of medication orders which triggered alerts during all 2-month study periods was 1011. For all the alerts, the likelihood of a valid alert (an alert that occurred in patients with one of the predefined diagnoses) was 96+/-1%. The alert yield, defined as occ...
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PMID: 18599342
PDF is available here.
PDF is available here.
Lakartidningen (107)3 2010
Abstract
Lakartidningen (107)3 2010
Abstract
Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society (99)2 2010
Abstract
Abstract
The purpose of this contribution is to review new technologies and make an educated prediction as to how they will impact veterinary pharmacology over the coming decades. By examining past developments, it becomes evident that change is incremental and predictable unless either a transforming discov...
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PMID: 20204588
PDF is available here.
PDF is available here.
Abstract
We conducted a systematic review to explore the barriers to, and facilitators of, CDSS uptake by physicians to guide prescribing decisions. We identified 58 studies by searching electronic databases (1990-2007). Factors impacting on CDSS use included: the availability of hardware, technical support...
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PMID: 20064798
PDF is available here.
PDF is available here.
Abstract
We investigated whether use of an automated clinical management system in our liver transplant program would improve clinical outcomes in managing transplant recipients' immunosuppressive medications.
We performed a retrospective cohort study of two patient groups receiving liver transplants at our...
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PMID: 20595306
PDF is available here.
PDF is available here.
Abstract
A 64-run, 2-level partial factorial experimental analysis was conducted on a 2D axisymmetric finite-element model of the convection-enhanced drug delivery to the parenchyma of the brain. The purpose of this ANOVA analysis was to determine the relative importance of eight factors and their interactio...
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PMID: 17945650
PDF is available here.
PDF is available here.
Abstract
Modern insulin pump therapy for type 1 diabetes mellitus offers the freedom to program several basal profiles that may accommodate diurnal ariability in insulin sensitivity and activity level. However, these basal profiles do not change even if a pending hypoglycemic or hyperglycemic...
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PMID: 20144423
PDF is available here.
PDF is available here.
Abstract
The technological advancements in subcutaneous continuous glucose monitoring and insulin pump delivery systems have paved the way to clinical testing of artificial pancreas devices. The experience derived by clinical trials poses technological challenges to the automatic control expe...
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PMID: 20144422
PDF is available here.
PDF is available here.
Abstract
The average age of the patients was 74, two-thirds were female, and just over half were African American. Decision support was provided 114 times to intervention physicians, who accepted 49 (43%) of the recommendations. Intervention physicians prescribed one or more inappropriate medications during...
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PMID: 19549022
PDF is available here.
PDF is available here.
Abstract
Abstract
We performed a prospective, observational study in 81 critically ill children categorized into two levels of sedation (moderate and deep) and three age groups (<1, 1-6, and >6 months). The parameters of the bispectral index and middle latency auditory-evoked potentials studied were the signal qualit...
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PMID: 19417687
PDF is available here.
PDF is available here.
Der Internist (50)6 2009
Abstract
Patients in internal medicine frequently experience adverse drug events. Many of those events, however, are avoidable because they are caused by medication errors, which are particularly frequent in drug prescribing. Therefore, practical concepts are needed to make the rapidly growing knowledge on d...
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PMID: 19430754
PDF is available here.
PDF is available here.
Abstract
Abstract
This study demonstrates a significant increase in BG following discontinuation of an IIP. Higher insulin requirements during the last 12 hours of an IIP were identified as an independent risk factor for poor glycemic control following the IIP. A standardized insulin transition protocol may help bett...
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PMID: 19140192
PDF is available here.
PDF is available here.
Abstract
This multifaceted intervention, which was easy to implement and required minimal resources, was associated with improvements in both insulin ordering practices and glycemic control among non-ICU medical patients....
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PMID: 19140191
PDF is available here.
PDF is available here.
Abstract
We compared the local anaesthetic consumption by parturients using either CIPCEA or patient-controlled epidural analgesia with a moderate basal infusion (PCEABI) of 5 ml/hour. We recruited 60 parturients after receiving ethics committee approval. Group CIPCEA (n = 30) received a similar patient-cont...
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PMID: 19157345
PDF is available here.
PDF is available here.
Abstract
Of 4534 citations returned by the search, 41 met the inclusion criteria. Of these, 37 reported successful system implementations, 25 reported success at changing health care provider behaviour, and 5 noted improvements in patient outcomes. A mean of 17 features per study were mentioned. The statisti...
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PMID: 19210782
PDF is available here.
PDF is available here.
Abstract
GPs who use the DSS daily prescribe more according to the advice given in the DSS than GPs who do not use the DSS. Contradictory to our expectation there was no significant difference between the HHIs for both groups: variation in prescription was comparable. CONCLUSION: We studied the use of a DSS...
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PMID: 19183464
PDF is available here.
PDF is available here.
Abstract
We studied clinical alerts currently in place to support antibiotic prescribing in a neonatal intensive care unit in order to ensure that appropriate information is being provided in a way that is consistent with current recommendations. Data were obtained from our alerts tracking database. Alerts w...
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PMID: 19592898
PDF is available here.
PDF is available here.
Abstract
For specific surgical interventions, such as aortic stent implantation, it might be temporarily necessary to decrease mean arterial pressure to rather low levels (around 40 mm Hg). Such hypotensive pressure levels are necessary to avoid intra- and postoperative intricacies. Traditionally, the drug N...
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PMID: 19807293
PDF is available here.
PDF is available here.
Development of computerized alerts with management strategies for 25 serious drug-drug interactions.
Abstract
PURPOSE: The development of computerized alerts with management strategies for 25 drug-drug interactions (DDIs) is described. SUMMARY: To ensure that clinicians, when confronted with any of 25 serious DDIs in the ambulatory care setting, can avoid these DDIs while treating patients with appropriate...
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PMID: 19106343
PDF is available here.
PDF is available here.
Abstract
Statistics in Medicine (27)27 2008
Abstract
We derived a sample size formula for continuous outcomes that takes into account both the intraclass correlation coefficient (representing the clustering effect) and the interperiod correlation (induced by the cross-over design).
Copyright (c) 2008 John Wiley & Sons, Ltd....
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PMID: 18646266
PDF is available here.
PDF is available here.
Nursing Management (Suppl) 2008
Abstract
Nursing Management (Suppl) 2008
Abstract
Abstract
Our research hypothesis was that single lung ventilation during thoracic surgery in the lateral position increases the blood concentration of propofol during target-controlled infusion. Thirty adult patients in two tertiary referral hospitals undergoing open-chest surgery were studied. Anaesthesia w...
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PMID: 19115647
PDF is available here.
PDF is available here.
Pediatrics (122)4 2008
Abstract
The 840 patient visits (420 before intervention and 420 after intervention) generated 724 medication orders, which contained 156 medication prescribing errors (21%). The groups did not differ with respect to urgency level, physician training level, or patient age. There were significant decreases in...
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PMID: 18829802
PDF is available here.
PDF is available here.
Abstract
PURPOSE: The development and implementation of a program to assess medical patients' need for venous thromboembolism (VTE) prophylaxis are described. SUMMARY: The pharmacy services, medicine, and information services departments at Hartford Hospital collaborated to institute a program to improve VTE...
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PMID: 18769004
PDF is available here.
PDF is available here.
Abstract
This paper presents the application of predictive control to drug dosing during anesthesia in patients undergoing surgery. The performance of a generic predictive control strategy in drug dosing control, with a previously reported anesthesia-specific control algorithm, has been evaluated. The robust...
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PMID: 18713685
PDF is available here.
PDF is available here.
Abstract
Several treatment modalities for neurodegenerative diseases or tumors of the central nervous system involve invasive delivery of large molecular weight drugs to the brain. Despite the ample record of experimental studies, accurate drug targeting for the human brain remains a challenge. This paper pr...
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PMID: 18713700
PDF is available here.
PDF is available here.
Abstract
Using CAPS, the endoscopist/nurse teams precisely controlled the administration of propofol achieving minimal to moderate sedation in subjects undergoing colonoscopy and EGD procedures. Mean propofol dosage was low and post-procedure recovery times were rapid. The device performed well when operated...
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PMID: 18511048
PDF is available here.
PDF is available here.
Intensive Care Medicine (34)8 2008
Abstract
Our computer-assisted glucose control protocol provides safe and efficient glucose regulation in routine intensive care practice. A low rate of hypoglycemic episodes was achieved with a considerably lower number of glucose measurements than used in most other schemes....
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PMID: 18389221
PDF is available here.
PDF is available here.
Cephalalgia (28)8 2008
Abstract
We show that attack and interictal periods can be described by a random probability distribution. Based on a gamma distribution, the mean interval between attacks was estimated to be 24 (17-34) days for placebo, 23 (18-29) days for naratriptan 2.5 mg and 22 (17-28) for sumatriptan 100 mg. These find...
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PMID: 18540870
PDF is available here.
PDF is available here.
Bioinformatics (24)15 2008
Abstract
We show that by an appropriate use of a different optimization algorithm, the simulated annealing, we have been able to downsize the computational effort by a factor 10(2). The new algorithm requires computational effort that can be achieved by current generation personal computers. AVAILABILITY: So...
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PMID: 18535084
PDF is available here.
PDF is available here.
Abstract
Although one third to one half of refractory schizophrenic patients responds to clozapine, however, there are few evidences currently that could predict clozapine response before the use of the medication. The present study aimed to train and validate artificial neural networks (ANN), using clinical...
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PMID: 18508152
PDF is available here.
PDF is available here.
Abstract
We provide a set of criteria for patients who might choose such a device and clinicians who may recommend these kinds of devices. More work is needed in the design and deployment of these devices if they are to be part of a successful medication adherence plan....
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PMID: 18649820
PDF is available here.
PDF is available here.
Abstract
We capture their reasons for declining as part of ongoing, iterative protocol validation and refinement processes. Even though our protocol was well-accepted by clinicians overall, noncompliance patterns revealed potential protocol improvement targets, and suggested ways to reduce barriers impeding...
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PMID: 18499528
PDF is available here.
PDF is available here.
Abstract
The safety and effectiveness of computer-assisted dosage has been demonstrated using two different marketed programs in comparison with experienced medical staff dosage at the centers with established interest in anticoagulation. Significant prevention of clinical events in patients with deep vein t...
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PMID: 18489430
PDF is available here.
PDF is available here.
Critical Care Medicine (36)6 2008
Abstract
The 91% to 98% clinician compliance indicates eProtocol-insulin is an exportable instrument that can establish a replicable experimental method for clinical trials of blood glucose management in critically ill adults. Control of blood glucose was better with eProtocol-insulin than with a simple clin...
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PMID: 18520641
PDF is available here.
PDF is available here.
Abstract
The computer-guided glucose management system achieved tighter blood glucose control than a standard paper-based protocol in diabetic patients undergoing cardiac surgery. However, the low proportion of blood glucose recordings within the desired range in both groups during the intraoperative period...
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PMID: 18503924
PDF is available here.
PDF is available here.
Abstract
PURPOSE: The development of a computerized system for protocol management, dispensing, inventory accountability, and billing by the investigational drug service (IDS) of a university health system is described. SUMMARY: After an unsuccessful search for a commercial system that would accommodate the...
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PMID: 18463347
PDF is available here.
PDF is available here.
Abstract
During treatment all patients had marked improvement in terms of reduction of pain measured with a visual analog scale. Twelve (15%) of the subjects were pain free after one to three treatments, nine of the 12 achieving relief with the initial instillation. At 6-month follow-up evaluation, 52 patien...
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PMID: 18430842
PDF is available here.
PDF is available here.
Abstract
Despite initial enthusiasm, the use of pharmacogenetics has remained limited to investigation in only a few clinical fields such as oncology and psychiatry. The main reason is the paucity of scientific evidence to show that pharmacogenetic testing leads to improved clinical outcomes. Moreover, for m...
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PMID: 18253145
PDF is available here.
PDF is available here.
Abstract
We re-explored this mathematically in an attempt to reveal hitherto undiscovered insights or limitations. In this study, we examined the square root of time model (viewed as a power function) and compared it with multi-compartment models. Further, we explored the stability of this relationship to sy...
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PMID: 18460768
PDF is available here.
PDF is available here.
Abstract
In the past decade, the introduction of electronic monitoring systems for monitoring medication adherence has contributed to the dialog about what works and what does not work in monitoring adherence. The purpose of this article is to describe the use of the Medication Event Monitoring System (MEMS)...
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PMID: 18387881
PDF is available here.
PDF is available here.
Abstract
Primary care prescribers recognize the patient safety value of drug prescribing alerts embedded within electronic prescribing software. Improvements to increase specificity and reduce alert overload are needed....
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PMID: 18373142
PDF is available here.
PDF is available here.
Abstract
A steady-state brain concentration was rapidly achieved corresponding to a whole-brain concentration of 118+/-6 ng/ml. As the infusion rate decreased to lower the exposure by a factor of 2, the brain concentration decreased to 56+/-4 ng/ml. A third increased steady-state level of anesthesia correspo...
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PMID: 18355685
PDF is available here.
PDF is available here.
Abstract
There are multiple publications and electronic programs available to aid clinicians in the management of drug-drug interactions; however, clinicians should understand the advantages and limitations of these programs before using them in clinical practice. Because time constraints can make evaluation...
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PMID: 18285786
PDF is available here.
PDF is available here.
Pediatrics (121)3 2008
Abstract
The rate of nonintercepted serious medication errors in this pediatric population was reduced by 7% after the introduction of a commercial computerized physician order entry system, much less than previously reported for adults, and there was no change in the rate of injuries as a result of error. S...
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PMID: 18310162
PDF is available here.
PDF is available here.
Abstract
We dissected out or held constant as many parameters of the model as possible to investigate the effect of the remaining parameters on the behavior of the system as a whole. Empirical correlations between immunotoxin binding affinity and the target binding site density were obtained for several reco...
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PMID: 18183487
PDF is available here.
PDF is available here.
Drug Discovery Today (13)5-6 2008
Abstract
Dental drug delivery systems have been used for a long time, in particular for the local therapy of diseases affecting the oral cavity. Research today concentrates on the design of formulations to increase their retention time. Even today, however, prosthetic devices incorporating drug delivery are...
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PMID: 18342801
PDF is available here.
PDF is available here.
Abstract
This paper presents the first microneedle-based transdermal patch with integrated active dispensing functionality. The electrically controlled system consists of a low-cost dosing and actuation unit capable of controlled release of liquid in the microliter range at low flow-rates and minimally invas...
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PMID: 18334398
PDF is available here.
PDF is available here.