Abstract
A tremendous increase in the number of female athletes of all ages and abilities has occurred in the past 35 years. In general, sports and athletic competition produce healthier and happier women. However, explosion in participation has revealed clear gender-specific injuries and medical conditions u...
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PMID: 21570034
PDF is available here.
Abstract
We described two patients that developed premature ovarian failure without previous diagnosis and therefore just were treated pharmacologically with estrogen-progestagen to induce menstrual bleeding. In blood of both patients was found low levels (< or = 4 ng/mL) of anti-müllerian hormone, and by m...
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PMID: 21966820
PDF is available here.
Abstract
We exposed isolated neonatal cardiomyocytes to H(2)O(2) and found that L-T3 rescued mitochondrial biogenesis and function and protected against cell death via a mitoKATP dependent pathway. Early and sustained physiological restoration of circulating L-T3 levels after MI halves infarct scar size and...
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PMID: 20100314
PDF is available here.
Abstract
Adrenal insufficiency is rarely associated with adrenal haemorrhage. In this report, a case of polycythaemia vera with adrenal haemorrhage and insufficiency has been presented.
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PMID: 21630611
PDF is available here.
Abstract
We have studied 154 men (mean age 61,4+/-4,1 years) with the first hemispheric ischemic stroke. Clinical and laboratory studies have revealed the androgenic deficit in 66,3%, with its frequency higher in patients with diabetes mellitus type II (50 and 26,3%, respectively). Forty-two men with diabete...
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PMID: 22224240
PDF is available here.
Abstract
We describe a case of a young girl who had Turner's syndrome with concomitant chronic lymphocytic thyroiditis, growth hormone deficiency, and hypothyroidism with cardiopericarditis. CASE: An 11-year-old girl was referred to the outpatient clinic because of short stature, ochriasis, and cardiopalmus....
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PMID: 21648302
PDF is available here.
Abstract
We report a case of Cushing syndrome due to isolated non-familial PPNAD. The child presented with typical clinical characteristics, growth retardation and obesity. Liddle's test was positive but micronodular appearance was not evident on CT scan and MRI; selective venous sampling revealed higher cor...
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PMID: 21648292
PDF is available here.
Abstract
Disturbances in some endocrine hormones have been implicated in the pathophysiology of depression. Some of these hormones (and drugs that affect hormone function) have been used as therapeutic agents for the treatment of depression, especially adrenal, thyroid, and gonadal axis hormones. Open-label...
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PMID: 21117521
PDF is available here.
Sharon J Pitteri,
Lynn M Amon,
Tina Busald Buson,
Yuzheng Zhang,
Melissa M Johnson,
Alice Chin,
Jacob Kennedy,
Chee-Hong Wong,
Qing Zhang,
Hong Wang,
Paul D Lampe,
Ross L Prentice,
Martin W McIntosh,
Samir M Hanash and
Christopher I Li
Abstract
We conducted 14 independent quantitative proteomics experiments comparing pooled plasma samples collected from 420 estrogen receptor-positive (ER(+)) breast cancer patients ≤17 months before their diagnosis and matched controls. Based on the more than 3.4 million tandem mass spectra collected in t...
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PMID: 20959476
PDF is available here.
Abstract
Our comprehensive database of 2175 consecutive patients with invasive breast cancer diagnosed during the period 1992-2009 served for the analysis. Several potential factors associated with lobular carcinoma as compared with ductal carcinoma were evaluated.
During this period, a 2.4-f...
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PMID: 21243872
PDF is available here.
Abstract
Sex steroids play a key role in maintaining skeletal integrity lifelong, through a complex variety of endocrine, but also paracrine and possibly autocrine actions. The current knowledge that androgens may act as pro-hormones for estrogens has seriously challenged many traditional views, so that, at...
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PMID: 20627086
PDF is available here.
Rowan T Chlebowski,
Garnet L Anderson,
Margery Gass,
Dorothy S Lane,
Aaron K Aragaki,
Lewis H Kuller,
JoAnn E Manson,
Marcia L Stefanick,
Judith Ockene,
Gloria E Sarto,
Karen C Johnson,
Jean Wactawski-Wende,
Peter M Ravdin,
Robert Schenken,
Susan L Hendrix,
Aleksandar Rajkovic,
Thomas E Rohan,
Shagufta Yasmeen,
Ross L Prentice and
WHI Investigators
Abstract
Estrogen plus progestin was associated with greater breast cancer incidence, and the cancers are more commonly node-positive. Breast cancer mortality also appears to be increased with combined use of estrogen plus progestin. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00000611....
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PMID: 20959578
PDF is available here.
Abstract
We studied 20 well controlled hypertensive postmenopausal women who received 6 months of HRT and 6 months of placebo on top of antihypertensive treatment. Two-dimensional M-mode, office blood pressure, 24-h ambulatory blood pressure (ABPM), S-estradiol and S-ACE activity were investigated at baselin...
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PMID: 20486868
PDF is available here.
Abstract
We studied effects of growth hormone replacement (GHRT) on fasting and postprandial metabolic parameters as well as on insulin sensitivity in patients with adult-onset GHD.
Using a standardized mixed meal, we studied insulin, glucose, non-esterified free fatty acid (NEFA) and triglycerides (TG) conc...
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PMID: 20146168
PDF is available here.
Abstract
I AIT) or by destructive thyroiditis (type II AIT). If the medical condition allows it, discontinuation of the drug is recommended in type I AIT. Otherwise, large doses of thioamides are required. Type II AIT is treated with corticosteroids. Mixed cases require a combination of both drugs. Potassium...
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PMID: 20689491
PDF is available here.
Abstract
We herein report an adolescent boy with primary adrenal insufficiency that developed glucocorticoid deficiency after added phenytoin treatment. The patient had an increased requirement for hydrocortisone replacement, and two episodes of vomiting, hyponatremia and mild hypoglycemia. His ACTH levels w...
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PMID: 21175098
PDF is available here.
Abstract
Given the known increased risk of venous thromboembolism (VTE) associated with both oral contraceptive (OC) use and hormone replacement therapy (HRT), it is important to address questions about the prevention and management of hormone-associated VTE. Specifically, the objectives of this article are...
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PMID: 20659653
PDF is available here.
Abstract
The life expectancy of Mexican women has increased to 80 years and thus the possibility of disease. This requires health professionals to remain current in the skills needed to provide optimal service. He has spent more than a century since released the first report of effective treatment to reduce o...
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PMID: 20939251
PDF is available here.
Abstract
We evaluated the changes of lipidic and coagulative pattern during menopause and the influence of hormone replacement therapy (HRT) on these parameters.
We considered 158 patients divided into 2 groups: Group I consisted of 127 women in physiological/surgical menopause and Group II of 31 women with...
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PMID: 20671654
PDF is available here.
Abstract
LOMH is frequently observed in primary care, with an increasing prevalence in older men. The diagnosis is based on a combination of mostly nonspecific signs and symptoms and measurement of testosterone and other hormones. Various testosterone formulations are available to individualize therapy to re...
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PMID: 20625573
PDF is available here.
Abstract
ISSUE: Hypoactive sexual desire disorder (HSDD) is hypothesized to be a disorder of the brain's reward circuitry. Neurotransmitters in reward circuits are thus therapeutic targets for improving sexual desire. Novel treatment strategies are to enhance dopamine (DA) actions, reduce serotonin (5-HT) ac...
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PMID: 20667289
PDF is available here.
Abstract
Adjuvant endocrine treatment is an essential component in therapy for hormone receptor-positive breast cancer. Among postmenopausal patients, options include tamoxifen, aromatase inhibitors, or a sequence of these agents. Tamoxifen and aromatase inhibitors have distinctive side-effect profiles. Amon...
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PMID: 20620932
PDF is available here.
Abstract
The effect of change in reproductive hormones and menopause on incident obesity (body mass index > or =30 kg/m(2)) and severe obesity (body mass index > or =35 kg/m(2)) was evaluated over 9 years in 3,260 US women recruited in the multiethnic Study of Women's Health Across the Nation in 1996-1997. Af...
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PMID: 20427327
PDF is available here.
C Noel Bairey Merz,
Marian B Olson,
Candace McClure,
Yu-Ching Yang,
James Symons,
George Sopko,
Sheryl F Kelsey,
Eileen Handberg,
B Delia Johnson,
Rhonda M Cooper-DeHoff,
Barry Sharaf,
William J Rogers and
Carl J Pepine
Abstract
These data suggest that low-dose hormone therapy improved chest pain symptoms, menopausal symptoms, and quality of life, but did not improve ischemia or endothelial dysfunction. Given that it was not possible to enroll the prespecified sample size, these results should not be considered definitive....
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PMID: 20569710
PDF is available here.
Abstract
Mean predose serum calcium levels were maintained at, or just below, the normal range, and urine calcium levels remained in the normal range throughout the 3-yr study, with no significant differences between treatment groups. Creatinine clearance, corrected for body surface area, did not differ betw...
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PMID: 20392870
PDF is available here.
Abstract
Twenty-six percent of subjects displayed atypical responses to GnRH: 1) 10 remained hypogonadotropic and hypogonadal, demonstrating pituitary and testicular defects; 2) eight achieved spermatogenesis and normal T but only with hypergonadotropism, indicating impaired testicular responsiveness to gona...
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PMID: 20382682
PDF is available here.
Abstract
Traditionally, it has been assumed that intellectual development in children with growth hormone deficiency (GHD) is distributed between ranges of a normal population based on the observation that it does not differ substantially from that of children of the same age. Nevertheless, f...
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PMID: 20684123
PDF is available here.
Abstract
We propose that GH-IGFI axis defects form a continuum of clinical and biochemical effects ranging from GH deficiency to GH resistance. The pathophysiology of GH resistance is described followed by a scheme for investigation of the child with severe short stature and normal GH secretion. We criticall...
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PMID: 20679995
PDF is available here.
Abstract
The discovery of ERbeta in the middle of the 1990s represents a paradigm shift in our understanding of estrogen signaling. It has turned out that estrogen action is not mediated by one receptor, ERalpha, but by two balancing factors, ERalpha and ERbeta, which are often antagonistic to one another. E...
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PMID: 20494112
PDF is available here.
Abstract
Tamoxifen and raloxifene uterosacrals expressed differing collagen I/III receptor density ratios, but both selective estrogen receptor modulators showed decreased tensile stiffness compared to ethinyl estradiol and controls. CONCLUSION: These findings support a possible effect of selective estrogen...
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PMID: 20452495
PDF is available here.
Abstract
In the developing frog brain, the majority of mast cells (MC) are distributed in the pia mater, and some immature MC are located adjacent to the blood capillaries in and around the neuropil. In the adult brain, MC are more numerous than in pre- and pro-metamorphic tadpoles; they are mainly located w...
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PMID: 20435827
PDF is available here.
Abstract
We have to pay attention to background diseases and life style of the patients....
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PMID: 20445286
PDF is available here.
Abstract
Prevalence of use of HRT was 5,2% in this study. The most frequently used agents were tibolone and combined estrogens plus progestin.
Copyright 2009 Elsevier España, S.L. All rights reserved....
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PMID: 20045126
PDF is available here.
Abstract
We discuss the most promising agents in CRC chemoprevention, together with their potential mechanisms of action in tumor inhibition....
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PMID: 20496537
PDF is available here.
Abstract
The health profile of Israeli women gynecologists is chracterized by a high performance of screening tests for cancer and low rate of smoking. Our study also demonstrates that the impact of the results of the WHI trial is still well manifested and most Israeli women gynecologists do not routinely re...
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PMID: 20357729
PDF is available here.