Abstract
Antipsychotic polypharmacy refers to the co-prescription of more than one antipsychotic drug for an individual patient. Surveys of prescribing in psychiatric services internationally have identified the relatively frequent and consistent use of combined antipsychotics, usually for people with establi...
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PMID: 21476610
PDF is available here.
Abstract
At V1 patients in Cohort 1 had 5 (median, range 3 - 15) and at V3 6 (3 - 17) medications. No differences could be observed between cohorts regarding number and pattern of medications. At V1, 30/102 patients of Cohort 1 had creatinine measured within the last 6 months, 13/30 patients had an eGFR...
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PMID: 21329619
PDF is available here.
Abstract
The term polypharmacy, meaning the concomitant use of multiple medications by one individual, has been widely reported in institutionalized or elderly patients. It can, however, occur in patients with chronic diseases, such as rheumatoid arthritis (RA).
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PMID: 21412604
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Abstract
Elderly patients are at an increased risk of developing adverse drug events due to polypharmacy, co-morbidity and changes in physiology. Often, pharmacotherapy in frail elderly patients is initiated based on randomized trials from which this population has been excluded. In such cases, the question w...
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PMID: 21914235
PDF is available here.
Abstract
To establish whether type 2 diabetes (T2D) is associated with changes in the bone mineral density (BMD) of femoral neck, total hip and lumbar spine.
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PMID: 21717722
PDF is available here.
Abstract
Prescription with more than one drug increases the risk of drug-drug interaction (D-DI), therapeutic failure, high pharmacological effect, or adverse events. The objectives of this study were to estimate the frequency of potential drug-drug interactions in prescriptions for hospitalized patients, and...
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PMID: 21717723
PDF is available here.
Abstract
Medication errors (MEs) are important in terms of their magnitude and severity, and there are numerous systems in place to reduce their occurrence. However, the ideal system has not yet been identified. The authors' institution uses three different medication prescription-dispensation systems which o...
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PMID: 21938969
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Abstract
This article reports on a few ethical considerations associated with prescribing for the elderly. A large number of elderly people are on several medications for the treatment of various chronic conditions that develop with age. Most of these treatments involve symptom management and prevention of sy...
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PMID: 21616016
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Abstract
Anemia is a frequent side effect of imatinib in patients with chronic myeloid leukemia (CML). Erythropoietic-stimulating agents have been used for treatment of imatinib-induced anemia. There are no data on long-term safety of erythropoietic-stimulating agents in CML patients.
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PMID: 20960502
PDF is available here.
Abstract
Multiple medication use is common in older adults and may ameliorate symptoms, improve and extend quality of life, and occasionally cure disease. Unfortunately, multiple medication use is also a major risk factor for prescribing and adherence problems, adverse drug events, and other adverse health o...
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PMID: 20940385
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Abstract
The theriac of Andromachus was the symbol of polypharmacy and the theriac Diatessaron was a product of oligopharmacy. The four substances that entered in its composition were gentian roots, aritolochia roots, sweet bays and myrrh. The excipient, honey, was sometimes replaced by peppermint syrup. It w...
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PMID: 21560364
PDF is available here.
Abstract
Multiple and inappropriate medications are often the cause for poor health status in the elderly. Medication reviews can improve prescribing. This study aimed to determine if a ten minute medication review by a general practitioner could reduce polypharmacy and inappropriate prescribing in elderly p...
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PMID: 21046863
PDF is available here.
Abstract
We conducted a population-based case-control study to investigate whether polypharmacy increases the risk for hip fracture in the elderly. We used insurance claims data from the Taiwan Bureau of National Health Insurance, a universal insurance program with a coverage rate of more than 98% of the pop...
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PMID: 20827106
PDF is available here.
Abstract
The simultaneous use of beta adrenergic receptor blockers (beta-blockers) and trimethoprim-sulfamethoxazole (TMP-SMX) may confer a high risk of hyperkalemia.
Two nested case-control studies were conducted to examine the association between hospitalization for hyperkal...
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PMID: 20595693
PDF is available here.
Abstract
Diabetic retinopathy remains a leading cause of visual loss worldwide. Patients with diabetes mellitus commonly have multiple comorbidities treated with a wide variety of medications. Systemic medications that target glycemic control and coexisting conditions may have beneficial or d...
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PMID: 20664533
PDF is available here.
Abstract
Medication management is a major part of nursing practice. Ensuring safety in medication management is all the more important in the community, where patients are not under constant observation of a health-care professional. One of the prime factors in maintaining safety with medication is establish...
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PMID: 20852525
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Abstract
The objective was to evaluate the use of medicines in the elderly population living in a city in the South of Santa Catarina state. It was carried out a transverse study where 104 patients distributed in five Family Health Program covering area were interviewed. 68.3% of the interviewed people were...
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PMID: 20922298
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Abstract
Altogether 433 residents were on PPIs. The factors associated with regular PPI use in univariate analyses included poor functional status, higher number of comorbidities, higher number of medications and lactose intolerance. The users had suffered from a prior ventricular or duodenal ulcer, cancer a...
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PMID: 20586539
PDF is available here.
Abstract
A 73-year-old male patient with delusional disorder, somatic type (DDST) who had a delusion of skin infestation with insects was presented. He was taking multiple medications to treat concomitant physical diseases. Milnacipran was selected as the treatment drug because of its low drug-interaction pr...
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PMID: 20386103
PDF is available here.
Abstract
Pharmacotherapy in the elderly is a challenge as the real risk-benefit ratio of many drugs and treatment strategies often remains unknown in these patients. Furthermore there are some special adverse drug reactions such as falls and delirium not only occurring more often but also causing an increase...
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PMID: 20424813
PDF is available here.
Abstract
1 in 20 Spanish citizens is currently undergoing a potential drug interaction, including a high rate of clinically relevant ones that should be avoided. These results confirm the existence of a serious safety issue that should be approached and where all parties involved (physicians, health services...
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PMID: 20504263
PDF is available here.
Abstract
Patients with metastatic cancer continue to take drugs for prevention of co-morbidities which are associated with side effects and inconvenience. The benefits of these drugs are likely to be minimal, and medication reviews should be undertaken to address their appropriateness....
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PMID: 20140686
PDF is available here.
Abstract
We identified community mental health outpatients who had been treated with the same pharmacologic regimen for at least 90 days. Apart from antipsychotics, data collection included anticholinergics, antidepressants, mood stabilizers, benzodiazepines, lipid-lowering agents, and antidiabetic agents. D...
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PMID: 20361903
PDF is available here.
Abstract
This paper is the start of a series on general medicine and surgery for dental practitioners. It follows on from a previous series, published in the British Dental Journal in 2003. The proportion of older people in the UK population has been on the increase for several years. Dental practitioners wh...
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PMID: 20418828
PDF is available here.
Abstract
To describe the pattern and factors associated with daily medication use in nursing home (NH) residents with advanced dementia.
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PMID: 20406320
PDF is available here.
Abstract
The prescription pattern of psychotropic drugs changes considerably over time, even in the same clinical setting. Mental health professionals need to keep up with changes in the prescription patterns of psychotropic drugs in order to serve their patients at the best possible level. The socio-economi...
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PMID: 20353748
PDF is available here.
Abstract
During the course of the Alzheimer's disease (AD), many patients need to be hospitalized either due to the direct consequences of the disease itself, or due to associated diseases or life event. The objective of the present study was to determine predictive factors for hospitalisation in AD patients...
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PMID: 20305996
PDF is available here.
Abstract
The objectives of this study were: to characterize the polipharmacy in subjects with type 2 diabetes mellitus (DM2) and to verify the correlation between polipharmacy and number of medications for DM2 complications with depression indicators (Beck Depression inventory (BDI) and urinary cortisol (COR...
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PMID: 20394217
PDF is available here.
Abstract
We proposed to identify nursing diagnoses, according to NANDA's taxonomy II, in a group of elderly people who use five or more drugs. Sixty-seven elderly people were selected using the Wide Geriatric Evaluation (WGE), out of 301 elderly residents from a Family Health Program (PSF) unit. All of the 6...
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PMID: 20394218
PDF is available here.
Abstract
OBJECTIVES: To review the literature on sleep disturbances in nursing home settings. Although 50% of older adults complain of sleep difficulties, increased reports of sleep disturbances are generally associated with poor health. After controlling for comorbidities that often contribute to poor sleep...
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PMID: 20191255
PDF is available here.
F Lattanzio,
C Mussi,
E Scafato,
C Ruggiero,
G Dell'Aquila,
C Pedone,
F Mammarella,
L Galluzzo,
G Salvioli,
U Senin,
P U Carbonin,
R Bernabei,
A Cherubini and
U.L.I.S.S.E. Study Group
Abstract
Health care services for older people in Italy are currently inadequate to manage the complexity of the older patients. An important effort should be undertaken to create a more integrated health care system....
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PMID: 20191260
PDF is available here.
Abstract
These results indicate that strategies to reduce dispensing errors should address polypharmacy and focus on high-risk units. This should, however, be substantiated by a future trial....
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PMID: 19912167
PDF is available here.
Abstract
Albeit great efforts in reducing the burden of cardiovascular diseases (CVD), their prevalence continues to grow worldwide. Among the causes for this rising burden, the upcoming pandemic of obesity and diabetes further enhances the estimates of CV mortality and healthcare costs over...
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PMID: 19817871
PDF is available here.
Abstract
The increasing proportions of older persons accounting for global populations, and the implications for increasing rates of chronic diseases such as type 2 diabetes mellitus, continue to be a cause of concern for clinicians. Considering that older persons are a very heterogeneous group of individual...
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PMID: 20518191
PDF is available here.
Abstract
Betablockers still represent widely prescribed drugs as they cover a wide spectrum of cardiovascular indications. Obviously, it is not trivial which betablocker to choose as they differ both with regard to their pharmacodynamic (e. g. selective vs. nonselective, beta vs. beta + alpha blocking activi...
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PMID: 20329652
PDF is available here.
Abstract
OBJECTIVE: To provide pharmacists with a current, comprehensive review of medication adherence challenges and solutions. DATA SOURCES: A computerized search of the PubMed and Medline databases (through July 2008) identified English language review articles on medication adherence using the MeSH term...
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PMID: 20452915
PDF is available here.
Abstract
The article has for objective to reflect on the polypharmacy of the aged with emphasis in the adverse drug reactions and the drug-drug interactions. The vulnerability of the elderly to the problems related from the use as of drugs is pretty upswing, the one to in case that must the complexity of the...
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PMID: 20339769
PDF is available here.
Abstract
Diabetic neuropathy is the third most common complication of diabetes mellitus. When this neuropathy is accompanied by pain, it requires a specific treatment. In the elderly patient, the pain has an enormous impact on quality of life, as it is associated with anxiety, depression and sleep disorders,...
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PMID: 21222317
PDF is available here.