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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Self Administration (0):
Recent article
Self Administration
Abstract
Previous studies have indicated a role of serotonin (5-HT)2 receptors in modulation of the behavioral effects of cocaine. In the present study, the efficacy of SR 46349B (a 5-HT(2A) receptor antagonist) or SDZ SER-082 (a 5-HT(2C) receptor antagonist) in altering cocaine seeking behavior was examined...
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PMID: 15849375
PDF is available here.
PDF is available here.
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Academic Pediatrics (12)1 2012
Abstract
We coded transcripts using an inductive approach. Thematic saturation was reached after the seventh focus group.
Adolescents assumed increased responsibility for managing medication as they matured and developed insight into the functional impact of ADHD and medication on their lives...
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PMID: 22133501
PDF is available here.
PDF is available here.
Abstract
We trained male Long-Evans rats to self-administer 10% ethanol plus 10% sucrose, using a protocol in which the concentration of ethanol was kept constant throughout the study. The animals were required to press the lever four times to gain continuous access to the drinking solution for 20 minutes, a...
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PMID: 21827930
PDF is available here.
PDF is available here.
Abstract
Previous studies demonstrated the effectiveness of selective σ-receptor (σR) agonists [1,3-di-o-tolylguanidine (DTG), PRE-084] as reinforcers in rats trained to self-administer cocaine. Similar to cocaine, these drugs increased nucleus accumbens shell dopamine levels, and effects of DTG, but not PR...
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PMID: 21808192
PDF is available here.
PDF is available here.
Abstract
A number of articles have addressed differences in productivity between male and female dentists, but little is known about differences between the sexes in practice patterns regarding caries management.
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PMID: 21454850
PDF is available here.
PDF is available here.
Abstract
Studies have suggested that the N-methyl-D-aspartate antagonist dextromethorphan may be useful in the treatment of opioid dependence.
This double-blinded, placebo-controlled inpatient study evaluated the effects of 0, 30, and 60 mg of dextromethorphan and quinidine (D...
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PMID: 22320027
PDF is available here.
PDF is available here.
HIV Clinical Trials (12)5 2011
Abstract
The VAS, AACTG, and qualitative single-item measures correlated significantly with MEMS and pharmacy data. Our data support self-administration of the VAS, even in Span-ish speakers....
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PMID: 22180522
PDF is available here.
PDF is available here.
Abstract
Beginning January 1, 2006, the Medicare Part D prescription drug benefit shifted drug coverage from Medicaid to the new Medicare Part D program for patients who were eligible for both Medicare and Medicaid benefits ("dual-eligibles"). These patients were randomly assigned to a private Part D plan an...
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PMID: 21190639
PDF is available here.
PDF is available here.
Neuroscience (170)2 2010
Abstract
In this study, the expression patterns of zif268 and activity-regulated cytoskeleton-associated gene (arc) were investigated in the basolateral amygdala (BLA) and dorsal hippocampal (dHPC) subregions during context-induced drug-seeking following 22 h or 15 d abstinence from cocaine self-administrati...
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PMID: 20654701
PDF is available here.
PDF is available here.
Abstract
Modafinil is a central nervous system stimulant used to promote wakefulness, and it is being evaluated clinically as an agonist medication for treating stimulant abuse. This is the first report of the effects of modafinil on the abuse-related effects of cocaine in nonhuman primates. The behavioral e...
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PMID: 20939643
PDF is available here.
PDF is available here.
Behavioural Pharmacology (21)5-6 2010
Abstract
Studies using targeted gene deletion in mice have revealed distinct roles for individual isozymes of the protein kinase C (PKC) family of enzymes in regulating sensitivity to various drugs of abuse. These changes in drug sensitivity are associated with altered patterns of drug self-administration. T...
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PMID: 20671547
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of chronic intermittent ethanol vapor exposure on behaviors in the forced swim test (FST) and neuropeptide Y (NPY) and corticotropin-releasing factor (CRF) levels in specific brain regions. Adult male Wistar rats were subjected to intermittent ethanol vapor (14 h on/10 h...
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PMID: 20705420
PDF is available here.
PDF is available here.
Southern Medical Journal (103)9 2010
Abstract
Psychopharmacology (211)4 2010
Abstract
The dorsal raphé nucleus (DRN), the origin for serotonin (5-HT) in forebrain areas, has been implicated in the neural control of escalated aggression. Gamma aminobutyric acid type-A (GABA(A)) and type-B (GABA(B)) receptors are expressed in the DRN and modulate 5-HT neuronal activity, and both play...
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PMID: 20589493
PDF is available here.
PDF is available here.
Southern Medical Journal (103)9 2010
Abstract
Home SCIG therapy was safe and led to improved perceptions of general health, higher serum IgG levels, and very low rates of infections and days missed from work/school....
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PMID: 20689467
PDF is available here.
PDF is available here.
Abstract
Prior analyses of the Wisconsin Inventory of Smoking Dependence Motives (Piper et al., 2004) implicated 4 subscales as primary dependence motives (PDM) indexing the core features of tobacco dependence, with the remaining subscales reflecting secondary dependence motives (SDM; Piper et al., 2008). Th...
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PMID: 20677840
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)2 2010
Abstract
These results show that nicotine has an area-specific effect on receptor subtypes, regardless of its administration route, but the effect is quantitatively greater in the case of MP administration....
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PMID: 20439469
PDF is available here.
PDF is available here.
Behavioral Neuroscience (124)4 2010
Abstract
Cocaine use is associated with high levels of impulsive choice (preference for immediate over delayed rewards), but it is not clear whether cocaine use causes elevated impulsive choice, or whether elevated impulsive choice is solely a predisposing factor for cocaine use. This study examined the effe...
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PMID: 20695646
PDF is available here.
PDF is available here.
Psychopharmacology (211)2 2010
Abstract
Manipulations of nicotinic cholinergic receptors have been shown to influence both alcohol and nicotine intake. Sazetidine-A [6-(5(((S)-azetidine-2-yl)methoxy)pyridine-3-yl)hex-5-yn-1-ol] is a novel compound that potently and selectively desensitizes alpha4beta2 nicotinic receptors w...
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PMID: 20535453
PDF is available here.
PDF is available here.
European Journal of Pharmacology (644)1-3 2010
Abstract
Cocaine dependence continues to be a worldwide public health concern. Although the majority of individuals reporting cocaine use do so via the intranasal route, relatively few laboratory experiments have examined the reinforcing effects of cocaine administered intranasally. The purpo...
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PMID: 20638380
PDF is available here.
PDF is available here.
The Lancet (376)9736 2010
Abstract
527 participants were randomly assigned to self-management (n=263) or control (n=264), of whom 480 (91%; self-management, n=234; control, n=246) were included in the primary analysis. Mean systolic blood pressure decreased by 12.9 mm Hg (95% CI 10.4-15.5) from baseline to 6 months in the self-manage...
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PMID: 20619448
PDF is available here.
PDF is available here.
Addiction Biology (15)3 2010
Abstract
We investigated whether the dopamine D3 partial agonist CJB090 (1-10 mg/kg, i.v) and the D3 antagonist PG01037 (8-32 mg/kg, s.c.) modified methamphetamine (0.05 mg/kg/injection) intravenous self-administration under fixed- (FR) and progressive- (PR) ratio schedules in rats allowed limited (short acc...
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PMID: 20456290
PDF is available here.
PDF is available here.
Abstract
The purpose of this study is to evaluate patients' perspective about beta-cell replacement therapies. 105 Japanese type 1 diabetic patients answered questionnaire on current treatments, transplantation and necessity of psychosomatic therapy. The motivation of receiving transplantation seems to becom...
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PMID: 20444516
PDF is available here.
PDF is available here.
Behavioural Pharmacology (21)4 2010
Abstract
A symposium held at the 50th annual meeting of the Behavioral Pharmacology Society in May 2007 reviewed progress in the human behavioral pharmacology of drug abuse. Studies on drug self-administration in humans are reviewed that assessed reinforcing and subjective effects of drugs of abuse. The clos...
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PMID: 20664330
PDF is available here.
PDF is available here.
Abstract
Little is known about who chooses medication abortion with misoprostol and why. Women seeking early abortion in 5 public hospitals in Maputo, Mozambique were recruited in 2005 and 2006 to explore decision-making strategies, method preferences and experiences with misoprostol and vacuum aspiration fo...
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PMID: 20452107
PDF is available here.
PDF is available here.
Abstract
We found that animals that progressively develop the behavioral hallmarks of addiction have permanently impaired LTD, whereas LTD is progressively recovered in nonaddicted rats maintaining a controlled drug intake. By making drug seeking consistently resistant to modulation by environmental continge...
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PMID: 20576893
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that chronic alcohol intake causes an up-regulation of cardiac beta(3)-AR, which exacerbates myocyte dysfunction and impairs calcium regulation, thereby directly contributing to the progression of ACM....
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PMID: 20477780
PDF is available here.
PDF is available here.
Abstract
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Insulin pens are developed to address specific needs of diabetes patients for their pens, such as ease of use, portability, and discreetness. Like many consumer-based products, the development of insulin pens can pose significant challenges to the development team in that they must b...
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PMID: 20513318
PDF is available here.
PDF is available here.
Abstract
Insulin pens are developed to address specific needs of diabetes patients for their pens, such as ease of use, portability, and discreetness. Like many consumer-based products, the development of insulin pens can pose significant challenges to the development team in that they must b...
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PMID: 20513318
PDF is available here.
PDF is available here.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit (16)5 2010
Abstract
We conducted a cross-sectional study of 430 randomly selected adult residents of Kalamoon in the Syrian Arab Republic using a questionnaire. A high proportion (85%) had taken antibiotics in the past 4 weeks and 34% were not aware of the dangers of antibiotics. Of 365 participants, only 43% were pres...
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PMID: 20799551
PDF is available here.
PDF is available here.
Abstract
Clinical evidence often points to stress as a cause or an antecedent to the development of drinking problems. Yet, animal models of alcohol drinking have yielded inconsistent evidence for a direct contribution of stress, and many studies have shown that stress suppresses alcohol consumption. The aim...
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PMID: 20682194
PDF is available here.
PDF is available here.
Abstract
Several studies indicated the involvement of serotonin-3 ([5-hydroxy tryptamine] 5-HT(3)) receptors in regulating alcohol-drinking behavior. The objective of this study was to determine the involvement of 5-HT(3) receptors within the ventral tegmental area (VTA) in regulating ethanol self-administra...
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PMID: 20682192
PDF is available here.
PDF is available here.
Postgraduate Medicine (122)3 2010
Abstract
Optimization of glycemic control is a fundamental aspect of diabetes management, and rates of diabetes-related microvascular complications are significantly decreased when glycemic control is improved. Currently, > 5 million Americans require insulin therapy to manage their diabetes, and this number...
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PMID: 20463417
PDF is available here.
PDF is available here.
Psychopharmacology (209)4 2010
Abstract
The necessity of a self-administration session in the presence of d-amphetamine suggests that the protracted decrease in cocaine self-administration may be a manifestation of behavioral tolerance. Regarding treatment of cocaine dependence, data suggest that prolonged d-amphetamine treatment may be n...
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PMID: 20217052
PDF is available here.
PDF is available here.
Abstract
A study was carried out in 2008-2009 on the practices of patients with diabetes with regard to insulin self-injection techniques. The results highlight in particular the importance of patient education.
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PMID: 20509483
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)15 2010
Abstract
We verified whether alpha6* receptors mediate the systemic effects of nicotine on the mesolimbic DA pathway by perfusing the selective antagonists alpha-conotoxin MII (CntxMII) (alpha3/alpha6beta2* selective) or alpha-conotoxin PIA (CntxPIA) (alpha6beta2* selective) into ventral tegmental area (VTA)...
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PMID: 20392953
PDF is available here.
PDF is available here.
Abstract
We assessed several behavioral responses to define behaviors which might predict SAP and RAP. B6 x FVB exhibited less severe ethanol-induced conditioned taste aversion and were less sensitive to ethanol-induced loss of righting reflex than B6 x NZB. Both hybrids demonstrated ethanol-induced place pr...
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PMID: 20364436
PDF is available here.
PDF is available here.
Abstract
Operant self-administration procedures are used to assess the neural basis of ethanol-seeking behavior under a wide range of experimental conditions. In general, rats do not spontaneously self-administer ethanol in pharmacologically meaningful amounts. This unit provides a step-by-step guide for tra...
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PMID: 20373508
PDF is available here.
PDF is available here.
Brain Research Bulletin (81)6 2010
Abstract
We investigated the effect of acupuncture on morphine self-administration and potential roles of GABA receptors in the mechanisms behind acupuncture. Male Sprague-Dawley rats were trained to self-administer morphine (0.1 mg/kg per infusion) during daily 1-h session under fixed-ratio 1 schedule. Foll...
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PMID: 20043979
PDF is available here.
PDF is available here.
Abstract
Self-adjusted dosage of mometasone furoate nasal spray gives reasonable control of allergic rhinitis (albeit with some 'breakthrough' symptoms). Patients should learn how to control these symptoms with the least number of steroid doses....
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PMID: 19930776
PDF is available here.
PDF is available here.
Child Health Alert (28) 2010
Abstract
Psychopharmacology (209)2 2010
Abstract
These data confirm a previous report (Hollander et al., Proc Natl Acad Sci U S A 105:19480-19485, 2008) that the hypocretin receptor hcrtR1 is activated in nicotine reinforcement and in addition show that both the arcuate nucleus and lateral hypothalamus are sites at which hcrt receptor mechanisms m...
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PMID: 20177882
PDF is available here.
PDF is available here.
Brain research (1318) 2010
Abstract
The effects of chronic ethanol self-administration on glutamate receptor ionotropic NMDA (GRIN), as well as GRIN1 splice variant mRNA expression was studied in the orbitofrontal cortex (OFC; Area 13), dorsolateral prefrontal cortex (DLPFC; Area 46) and anterior cingulate cortex (ACC; Area 24) of mal...
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PMID: 20043891
PDF is available here.
PDF is available here.
Abstract
We investigated the sensitivity of adult hippocampal neurogenesis to alcohol and the cannabinoid receptor agonist WIN 55,212-2 (WIN). Specifically, we analysed the potential link between alcohol relapse, cannabinoid receptor activation, and adult neurogenesis. Adult rats were exposed to subchronic a...
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PMID: 20047713
PDF is available here.
PDF is available here.
Abstract
The dopamine D3 receptor (DRD3) has been suggested to be involved in the mechanisms underlying stimulus-controlled drug-seeking behaviour. Ligands acting as DRD3 antagonists (SB 277011-A) or DRD3 partial agonists (BP 897) have shown some promise for reducing the influence of drug-associated cues on...
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PMID: 19995481
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of various doses of intravenous GHB in maintaining self-administration (from 0.001 to 10 mg/kg per infusion), and its ability to induce conditioned place preference (CPP) in rats when given orally (175-350 mg/kg) or injected directly either in the VTA or NAc (from 10 to 3...
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PMID: 19573264
PDF is available here.
PDF is available here.
The Nurse Practitioner (35)3 2010
Abstract
Abstract
The goal of this series of experiments was to develop an operant choice procedure to examine rapidly the punishing effects of intravenous drugs in rats. First, the cardiovascular effects of experimenter-administered intravenous histamine, a known aversive drug, were assessed to determine a biologica...
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PMID: 20885811
PDF is available here.
PDF is available here.
Behavioural Pharmacology (21)2 2010
Abstract
These results indicate that activation of dopaminergic D1 and D2 receptors may play a role in mediating the conditioned motivational effects of nicotine-associated cues as measured in the response-reinstatement procedure. These findings suggest that manipulation of dopaminergic neurotransmission at...
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PMID: 20168211
PDF is available here.
PDF is available here.
Behavioural Pharmacology (21)2 2010
Abstract
This study tested the effects of the nicotine addiction treatment varenicline on cocaine self administration (SA) and reinstatement. In one SA experiment, rats were trained to self-administer cocaine (0.75 mg/kg/infusion). Thereafter, daily SA sessions continued as before except that every fourth se...
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PMID: 20093928
PDF is available here.
PDF is available here.
Behavioural Pharmacology (21)2 2010
Abstract
The effects of the acute administration of nicotine [through nicotine inhalers (NI) and placebo inhalers (PI)], nicotine-containing tobacco (NT), and denicotinized tobacco (DT), on smokers' subjective responses and motivation to smoke were examined in 22 smokers (12 male, 10 female; 11 low dependent...
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PMID: 20168213
PDF is available here.
PDF is available here.