Philip P Haaf,
Cathrin C Balmelli,
Tobias T Reichlin,
Raphael R Twerenbold,
Miriam M Reiter,
Julia J Meissner,
Nora N Schaub,
Claudia C Stelzig,
Michael M Freese,
Patricia P Paniz,
Christophe C Meune,
Beatrice B Drexler,
Heike H Freidank,
Katrin K Winkler,
Willibald W Hochholzer and
Christian C Mueller
Abstract
We hypothesized that NT-proBNP might be useful in the early diagnosis and risk stratification of patients with suspected acute myocardial infarction....
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PMID: 21787902
PDF is available here.
Abstract
We assessed the effect of the baseline characteristics and management on 30-day mortality. Consecutive patients were included from January 2006 to December 2007. Two propensity scores (for being male) were calculated, 1 from the baseline characteristics and 1 from both the baseline characteristics a...
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PMID: 21741026
PDF is available here.
Abstract
We still need the newly more effective neuroprotective drugs which can be applied to many ischemic stroke patients. Therefore, we review and describe the future neuroprotective strategies in the post-thrombolysis era....
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PMID: 21706826
PDF is available here.
Abstract
Besides the reduction of the delay for the myocardium reperfusion, the revascularization must be optimized by tools and techniques of percutaneous intervention. These are pharmacological, mechanical and procedural. The appeal to antiGP2b3a can be useful in the cathlab. Its intracoronary administratio...
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PMID: 21498034
PDF is available here.
Abstract
An early reperfusion of the culprit artery in patients with myocardial infarction leads to a reduction of the infarct size and mortality. The benefit of reperfusion (primary angioplasty or fibrinolysis) is well established in the first 12 hours following the symptom onset, remains discussed between 1...
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PMID: 21489745
PDF is available here.
Abstract
Acute PE is a cardiovascular emergency and early risk stratification is important in the management of these patients. Pre-test clinical prediction models together with D-dimer assays help select those who require imaging. Each hospital should develop a strategy for investigating patients with suspec...
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PMID: 21526699
PDF is available here.
Abstract
SP bound to the B region and promoted the activation of plasminogen by t-PA, and then induced effective thrombolysis.
Copyright © 2011 International Society on Thrombosis and Haemostasis....
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PMID: 21392255
PDF is available here.
Abstract
Open-label administration of perispinal etanercept resulted in rapid neurological improvement in three consecutive patients with chronic neurological dysfunction due to strokes occurring 13-36 months earlier. These results suggest that stroke may result in chronic TNF-mediated pathophysiology that m...
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PMID: 21254790
PDF is available here.
Abstract
We designed and synthesized several APCE inhibitors and assessed each versus plasma dipeptidyl peptidase IV (DPPIV) and prolyl oligopeptidase (POP), which have amino acid sequence similarity with APCE. Acetyl-Arg-(8-amino-3,6-dioxaoctanoic acid)-D-Ala-L-boroPro selectively inhibited APCE versus DP...
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PMID: 21251197
PDF is available here.
Abstract
We compiled demographics, data to calculate the PESI and a composite outcome. Patients were considered to have a negative PESI if they were in category I or II (≤85 points). Patients were considered to have the composite outcome if, within five days of diagnosis, they: A) had recurrent PE; B) deve...
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PMID: 21225095
PDF is available here.
Sergio S Fasullo,
Sebastiano S Scalzo,
Giorgio G Maringhini,
Filippo F Ganci,
Sergio S Cannizzaro,
Ivana I Basile,
Debora D Cangemi,
Gabriella G Terrazzino,
Gaspare G Parrinello,
Filippo M FM Sarullo,
Roberto R Baglini,
Salvatore S Paterna and
Pietro P Di Pasquale
Abstract
Our data suggest that, in hemodynamically stable patients with SPE, thrombolysis shows an earliest reduction of RVD and a more favorable trend in clinical outcome, so, it could merit consideration in SPE....
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PMID: 20890176
PDF is available here.
Abstract
The authors report a case of a 77 years old male patient with mild stenosis of the carotid artery caused by an exulcerated plaque in the carotid bifurcation. The patient presented with recurrent ipsilateral strokes which were treated with intravenous thrombolysis. A brief review of the literature rel...
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PMID: 21560450
PDF is available here.
Abstract
We report the case of a 51-year-old woman who underwent pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension. On postoperative day 1 she developed bilateral pulmonary thrombosis due to preoperatively undiagnosed heparin-induced thrombocytopenia. Systemic thrombolytic therapy wi...
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PMID: 21095367
PDF is available here.
Abstract
The value of assessing coronary artery calcium (CAC) with regard to characterizing unstable coronary artery disease remains controversial.
To evaluate the amount of CAC in patients with an acute marker-positive coronary syndrome in segments containing the culprit lesion compared with the remote coro...
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PMID: 20849316
PDF is available here.
Abstract
In patients with acute basilar artery occlusion, no significant gender differences for outcome and recanalization were observed, regardless of treatment modality....
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PMID: 20947845
PDF is available here.
Abstract
In this nonrandomized comparison, outcomes after thrombolysis were significantly better than in untreated comparators across baseline NIHSS 5 to 24. The significant association was lost only at extremes of baseline NIHSS when sample sizes were small and confidence limits were wide....
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PMID: 20947852
PDF is available here.
Abstract
The introduction of intravenous thrombolytic therapy started the new era of reperfusion therapy in ST elevation myocardial infarction. The addition of aspirin almost halved mortality in patients with ST elevation infarction. Primary coronary intervention (PCI) often in combination with stent implant...
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PMID: 21082532
PDF is available here.
Marion A Simpson,
Helen M Dewey,
Leonid Churilov,
Niaz Ahmed,
Christopher F Bladin,
David Schultz,
Romesh Markus,
Jonathan W Sturm,
Christopher R Levi,
David J Blacker,
Jim Jannes,
Richard I Lindley and
Mark W Parsons
Abstract
To report Australian outcomes from the Safe Implementation of Thrombolysis in Stroke International Stroke Thrombolysis Register (SITS-ISTR).
Observational study using data collected prospectively from December 2002 to December 2008.
Centres administering thrombolysis for acute stroke in Australia a...
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PMID: 20955119
PDF is available here.
Abstract
Kawasaki disease is an acute, systemic vasculitis of unknown cause affecting mainly neonates (infants) and young children. Despite treatment during the acute phase with intravenous immunoglobulin and aspirin, up to 5% of those affected will develop coronary aneurysms, predisposing them to thrombotic...
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PMID: 20717006
PDF is available here.
Abstract
Our study demonstrated an optimal infusion rate at 4,000U/min, suggesting relatively low levels of infusion are better able to improve brain reperfusion and reduce brain injury after stroke....
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PMID: 20977863
PDF is available here.
Abstract
Reperfusion therapy for myocardial infarction is limited by significant re-occlusion rates and less-than-optimal myocardial tissue perfusion. It was the objective of this study to assess and compare the effect of ticagrelor, the first reversibly binding oral P2Y12 receptor antagonist, with that of c...
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PMID: 20694285
PDF is available here.
Abstract
To study retrospectively the prognostic factors for acute basilar artery occlusion treated with intraarterial thrombolysis and stent placement.
Within 3-48 hours of disease onset, 52 patients with basilar artery occlusion were treated with emergency intraarterial thrombolysis with recombinant tissue...
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PMID: 20688533
PDF is available here.
Abstract
Strong proof-of-concept evidence suggests that catheter-directed thrombolysis (CDT) may enable prevention of the post-thrombotic syndrome (PTS) in patients with deep vein thrombosis (DVT). The goal of this review is to summarize recent publications and thereby improve physicians' ability to make sou...
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PMID: 20613507
PDF is available here.
Abstract
Invasive treatment significantly improves in-hospital and long-term survival in older patients with STEMI. Lack of mortality reduction was related to worse clinical presentation of the currently hospitalised older patient....
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PMID: 20730715
PDF is available here.
Abstract
We report a young man with CVST as a complication of nephrotic syndrome, who was diagnosed with MRV and treated with local thrombolysis. We also reviewed 10 reported cases of CVST in adult nephrotic syndrome in the literature together with our current case. CVST in nephrotic syndrome appears to occu...
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PMID: 20630135
PDF is available here.
Abstract
The aim of this paper was to prospectively monitor the performance of an isolated pharmacomechanical thrombolysis (IPMT) device, the Trellis(R) Peripheral Infusion System, through a company-sponsored registry.
Demographic, thrombus characterization, and procedural data were collected on the treatmen...
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PMID: 20671648
PDF is available here.
Abstract
Patients with acute iliofemoral venous thrombosis treated with anticoagulation only are at high risk of developing postthrombotic syndrome. Immediate removal of the thrombus by catheter-directed thrombolysis (CDT) may increase patency, prevent damage of the venous valves, and prevent reflux and PTS....
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PMID: 20671646
PDF is available here.
Abstract
We share the outcomes of 3 pregnant women complicated with PVT and treated with recombinant tissue-type plasminogen activator....
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PMID: 19825917
PDF is available here.
Abstract
We hypothesized that SCIs are related to HMCAS at baseline, which subsequently disappears (HMCAS-D) on follow-up CT in stroke patients treated with intravenous rtPA.
Baseline and 24-hour follow-up CTs were evaluated for HMCAS in acute ischemic stroke patients treated with intravenous rtPA and follow...
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PMID: 20664262
PDF is available here.
Abstract
We aimed to compare the efficacy and safety of different doses of tPA in Chinese stroke patients. We included all acute ischemic stroke patients treated with tPA within 4.5 hours of onset. Patients were treated with three dose regimens of tPA (0.6-0.7mg/kg, 0.8mg/kg, 0.9mg/kg). The following data we...
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PMID: 20510615
PDF is available here.
Abstract
Venous thromboembolism (VTE) has been treated with a glycosaminoglycan, followed by a vitamin K antagonist during the past 60 years. During the past two decades the glycosaminoglycans have undergone refinement, allowing for simplification of care for these patients, but parenteral ad...
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PMID: 20497295
PDF is available here.
Tomonori Itoh,
Ken'ichi Fukami,
Tomomi Suzuki,
Takumi Kimura,
Yoshinori Kanaya,
Makoto Orii,
Iwao Goto,
Hiroki Matsui,
Shoma Sugawara,
Satoshi Nakajima,
Tetsuya Fusazaki,
Motoyuki Nakamura and
IMPORTANT investigators
Abstract
Acute efficacy and long-term prognostic differences between ST-elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (primary PCI) and those treated with pre-intervention thrombolysis combined with back-up of facilitated PCI has not been evaluated i...
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PMID: 20571249
PDF is available here.
Abstract
Intravenous thrombolysis (IVT) is considered an effective treatment for acute ischemic stroke (IS). However, not all treated patients may achieve good outcome. The aim was to evaluate whether the initial NIHSS and DWI infarct volume could be the predictors for good outcome after IVT.
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PMID: 20597864
PDF is available here.
Abstract
We report the case of a man who presented a jugular vein thrombosis responsible for severe intracranial hypertension. Because of clinical worsening despite intravenous heparin and symptomatic treatment, endovascular procedure including the placement of five venous stents, thrombolysis and balloon an...
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PMID: 19782403
PDF is available here.
Abstract
Cerebral venous sinus (sinovenous) thrombosis (CSVT) in childhood is a rare, but underrecognized, disorder, typically of multifactorial etiology, with neurologic sequelae apparent in up to 40% of survivors and mortality approaching 10%. There is an expanding spectrum of perinatal brain injury associ...
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PMID: 20561500
PDF is available here.
Abstract
This paper reports a 43-year-old patient who had a large, mobile, worm-like thrombus in the left main coronary artery after receiving a chemotherapy regimen containing cisplatin, bleomycin and etoposide for a nonseminomatous testes tumor. The patient was successfully treated with thrombolytic therap...
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PMID: 20595825
PDF is available here.
Abstract
At Get With the Guidelines-Stroke hospital Emergency Departments, more than one quarter of patients with documented onset time and at least one eighth of all ischemic stroke patients arrived within 1 hour of onset, where they received thrombolytic therapy more frequently but more slowly than late ar...
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PMID: 20522809
PDF is available here.
Atte Meretoja,
Jukka Putaala,
Turgut Tatlisumak,
Sari Atula,
Ville Artto,
Sami Curtze,
Olli Häppölä,
Perttu J Lindsberg,
Satu Mustanoja,
Katja Piironen,
Janne Pitkäniemi,
Kirsi Rantanen,
Tiina Sairanen,
Oili Salonen,
Heli Silvennoinen,
Lauri Soinne,
Daniel Strbian,
Marjaana Tiainen and
Markku Kaste
Abstract
Off-license thrombolysis was not associated with poorer clinical outcome, except for age >80 years, nor with increased rates of symptomatic intracerebral hemorrhage. The current extensive list of contraindications should be re-evaluated when data from ongoing randomized trials and observational stud...
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PMID: 20538701
PDF is available here.
Abstract
The term cerebral small vessel disease refers to a group of pathological processes with various aetiologies that affect the small arteries, arterioles, venules, and capillaries of the brain. Age-related and hypertension-related small vessel diseases and cerebral amyloid angiopathy are the most commo...
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PMID: 20610345
PDF is available here.
Abstract
Reperfusion therapy for acute myocardial infarction has dramatically reduced mortality. Coronary angioplasty and thrombolysis are the most effective reperfusion techniques. The controversy about which of the two methods is best has been superseded by a search for the most rapid and effective way of...
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PMID: 20540897
PDF is available here.
Abstract
Timely fibrinolytic therapy was associated with lower risk of a composite outcome of shock, death, or stroke, yet DTN times of < or =30 minutes were achieved in less than half of the patients studied. Thus, efforts to optimize regional systems of STEMI care should focus on shortening reperfusion tim...
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PMID: 20569712
PDF is available here.
R John Simes,
Rachel L O'Connell,
Philip E Aylward,
Sergei Varshavsky,
Rafael Diaz,
Robert G Wilcox,
Paul W Armstrong,
Christopher B Granger,
John K French,
Frans Van de Werf,
Ian C Marschner,
Rob Califf,
Harvey D White and
HERO-2 Investigators
Abstract
The variation in mortality and other clinical outcomes across geographic regions was not adequately explained by risk factors, patterns of care, or national health statistics. Nevertheless, large international trials are a better way to assess potential new treatments across many countries than the...
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PMID: 20569711
PDF is available here.
Abstract
Baseline TnT and 90-minute STRes are independent predictors of 30-day CV death in patients with STEMI. Use of these 2 simple, readily available tools can aid clinicians in early risk stratification.
Copyright 2010 Mosby, Inc. All rights reserved....
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PMID: 20569707
PDF is available here.