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Muscles (3):
Recent article
Muscles
Xenobiotica (41)5 2011
Abstract
Studies described in the recent literature support the idea that gene therapy can lead to genuine clinical benefits when mediated by plasmid delivery in conjunction with electroporation. Plasmid-mediated muscle-targeted gene transfer offers the potential of a cost-effective pharmaceutical-grade ther...
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PMID: 18370221
PDF is available here.
PDF is available here.
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Abstract
The clinical applicability of high-intensity focused ultrasound (HIFU) for noninvasive therapy is today hampered by the lack of robust and real-time monitoring of tissue damage during treatment. The goal of this study is to show that the estimation of local tissue elasticity from she...
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PMID: 21342822
PDF is available here.
PDF is available here.
Abstract
We show that the extracellular matrix protein biglycan regulates utrophin expression in immature muscle and that recombinant human biglycan (rhBGN) increases utrophin expression in cultured myotubes. Systemically delivered rhBGN up-regulates utrophin at the sarcolemma and reduces muscle pathology in...
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PMID: 21187385
PDF is available here.
PDF is available here.
Abstract
To investigate the mechanisms underpinning modifications in glucose homeostasis and insulin sensitivity 24 h after a bout of resistance exercise (RE) with or without protein ingestion.
Twenty-four healthy males were assigned to a control (CON; n = 8), exercise (EX...
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PMID: 21701685
PDF is available here.
PDF is available here.
Abstract
We describe an in situ formed hydrogel based on a water-soluble derivative of chitosan, hydroxypropyl chitosan (HPCTS), and sodium alginate dialdehyde (SAD). Periodate oxidized alginate rapidly cross-links HPCTS due to Schiff's base formation between the available aldehyde and amino groups. Hydrogel...
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PMID: 20832263
PDF is available here.
PDF is available here.
Abstract
We demonstrate that transgenic mice expressing EGFP transcripts with long CAG repeats in the 3' untranslated region develop pathogenic features. Expression of the transgene was directed to the muscle in order to compare the resulting phenotype to that caused by the CUG expansion, as occurs in myoton...
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PMID: 21283659
PDF is available here.
PDF is available here.
Abstract
These results suggest that cells from different tissues have different potentials for differentiation. Furthermore, cells derived from rabbits with craniosynostosis were different from cells from wild-type rabbits. Interestingly, cells derived from the craniosynostotic rabbits were not uniformly mor...
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PMID: 20871482
PDF is available here.
PDF is available here.
Abstract
Abstract
This study is focused on the analysis of an accumulation of inorganic elements in muscles, liver and gonad of seven fish species from São Francisco River located in the Paraná state of Brazil. Concentrations of the elements were determined using the SR-TXRF technique. In the muscles of fish specie...
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PMID: 20828660
PDF is available here.
PDF is available here.
Acta Biomaterialia (6)11 2010
Abstract
The implantation of biomaterials may elicit a host response to this foreign body, and the magnitude of that reaction depends on the host and on the implanted material. The aim of this study was to compare the inflammatory response induced by the implantation of starch-based (SPCL) sc...
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PMID: 20601228
PDF is available here.
PDF is available here.
Abstract
Glucocorticoid (GC) action depends on GC plasma concentration, cellular GC receptor expression, and the pre-receptor hormone metabolism catalyzed by 11β-hydroxysteroid dehydrogenase (11β-HSD). 11β-Hydroxysteroid dehydrogenase exists in 2 isoforms; 11β-HSD1 converts inactive cortisone to cortisol...
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PMID: 20688460
PDF is available here.
PDF is available here.
Biotechnology Letters (32)11 2010
Abstract
We isolated MDSCs from GFP-transgenic mice and transferred them to chondrogenic, neurogenic or myogenic media. Multilineage differentiation was examined by morphological observation, histological staining, immunocytochemical staining, real-time RT-PCR and Western blot. Both differentiated cells and...
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PMID: 20632072
PDF is available here.
PDF is available here.
Abstract
We conclude that a controlled resistance exercise program without weight loss increases strength and lean body mass, improves hepatic insulin sensitivity, and decreases GPR without affecting total fat mass or visceral, hepatic, and intramyocellular fat contents....
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PMID: 20351587
PDF is available here.
PDF is available here.
Abstract
Trace elements concentrations (As, Cd, Cu, Pb and Hg) were determined in the liver, kidney and muscle of 28 red fox (Vulpes vulpes) and 16 stone marten (Martes foina) from suburban and rural habitats from Croatia. Rural and suburban habitats affected Cd and Hg levels in the muscle, liver and kidney...
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PMID: 21069280
PDF is available here.
PDF is available here.
Abstract
Since July 2005, recurrent outbreaks of vibriosis have occurred in shrimp farms in northwestern Mexico. Moribund Litopenaeus vannamei associated with mass mortalities were lethargic and displayed red discoloration spots on their abdomen, and hence were called 'bright-reds' by farmers. Shrimp submitt...
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PMID: 21166310
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)43 2010
Abstract
The intracellular fatty acid-binding proteins (FABPs) are abundantly expressed in almost all tissues. They exhibit high affinity binding of a single long-chain fatty acid, with the exception of liver FABP, which binds two fatty acids or other hydrophobic molecules. FABPs have highly similar tertiary...
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PMID: 20716527
PDF is available here.
PDF is available here.
Abstract
We aimed to investigate various aspects related with glucose homeostasis analyzing: blood glucose and insulin levels, intraperitoneal glucose and insulin tolerance tests (ipGTT and ipITT), glucose-stimulated insulin secretion (2.8, 5.6 or 8.3 mmol/L glucose) in pancreas fragments, cellular distribut...
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PMID: 20566319
PDF is available here.
PDF is available here.
Abstract
We present results on the morphology of poly(L-lactide-co-epsilon-caprolactone) copolymer micromachined by femtosecond laser and demonstrate the attachment and alignment of C2C12 myoblast cells in the microchannels. C2C12 cells exhibited favorable attachment in the channels after 1 day of seeding....
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PMID: 20050808
PDF is available here.
PDF is available here.
Abstract
Infectious myonecrosis virus (IMNV) has been causing a progressive disease in farm-reared shrimps in Brazil and Indonesia. Immunodiagnostic methods for IMNV detection, although reliable, are not employed currently because monoclonal antibodies (MAbs) against this virus are not available. In this stu...
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PMID: 20678523
PDF is available here.
PDF is available here.
Abstract
We performed purification before renaturation in the prokaryotic expression system instead of using the traditional renaturation-before-purification approach. rhBMP-2 was separated on a Sephacryl S-300 HR column and eluted from a DEAE-Sepharose Fast Flow column. The collected protein was refolded by...
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PMID: 19823948
PDF is available here.
PDF is available here.
Kidney International (78)10 2010
Abstract
Kidney International (78)10 2010
Abstract
Kidney International (78)10 2010
Abstract
Kidney International (78)10 2010
Abstract
Chemico-Biological Interactions (187)1-3 2010
Abstract
We have compared the RNA expression profiles of the muscles of AChE knockout mice with those of the wild-type siblings. Total RNA from the leg muscle of the mice of the wild-type and the AChE nullizygous mice were subjected to microarray analyses with Affymetrix GeneChip((R)) Mouse Gene 1.0 ST Array...
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PMID: 20381477
PDF is available here.
PDF is available here.
Abstract
Recently, it has been suggested that insulin resistance is a better predictor of metabolic syndrome than obesity. Numerous studies have been conducted to identify insulin resistance susceptibility genes in various model systems. This review focuses on recent findings in microarray analyses, which ha...
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PMID: 20669253
PDF is available here.
PDF is available here.
Abstract
The Drosophila larval neuromuscular junction (NMJ) shares many structural and functional similarities to synapses in other animals, including humans. These include the basic feature of synaptic transmission, as well as the molecular mechanisms regulating the synaptic vesicle cycle. Because of its la...
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PMID: 20810634
PDF is available here.
PDF is available here.
Abstract
We report on expression quantitative trait loci (eQTL) that were estimated from the quantitative real-time RT-PCR data of 276 F(2) animals and compared with eQTL identified using 74 microarrays. In total, 13 genes were selected that showed trait-dependent expression in microarray experiments and exh...
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PMID: 20145673
PDF is available here.
PDF is available here.
Developmental Biology (344)2 2010
Abstract
We identified zipper (zip), encoding a Drosophila non-muscle myosin II (myosin II) heavy chain, as a gene required for LR asymmetric development of the embryonic anterior midgut (AMG). Myosin II is known to directly generate mechanical force in various types of cells during morphogenesis and cell mi...
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PMID: 20553709
PDF is available here.
PDF is available here.
Abstract
We studied their expression in a conditional Dicer knockdown cell line, DT40. We found that FXR1P, but not FMRP, is significantly increased upon Dicer knockdown and the consequent reduction of miRNAs, suggesting that FXR1P is regulated by miRNAs while FMRP is not in DT40 cells. Expression of a lucif...
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PMID: 20519410
PDF is available here.
PDF is available here.
Abstract
We investigated systemic gene delivery in 4-day-old GRMD dogs given a single intravenous injection of an AAV9 vector (1.5 x 10(14) vector genomes/kg) carrying a human codon-optimized human mini-dystrophin gene under control of the cytomegalovirus (CMV) promoter. One of the three treated dogs was eut...
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PMID: 20517298
PDF is available here.
PDF is available here.
Abstract
INTRODUCTION: The giant fiber system (GFS) of Drosophila is a well-characterized neuronal circuit that mediates the escape response in the fly. It is one of the few adult neural circuits from which electrophysiological recordings can be made routinely. This protocol describes a simple procedure for...
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PMID: 20647357
PDF is available here.
PDF is available here.
Abstract
We succeeded in forcing the physical system to behave in the same way as the muscle model with acceptable margin of error. An implementation in the knees of a simulated biped robot is realized. Simulation compares articular trajectories with and without the muscle emulator and shows that with muscle...
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PMID: 20726042
PDF is available here.
PDF is available here.
Abstract
Catalysis by rabbit muscle pyruvate kinase involves domain movements and conformational changes induced by activating cations and its substrates. Fluorescence acrylamide quenching analyses reveal that interactions with Mg(2+) and K(+) lead to a more exposed active site of PK while interactions with...
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PMID: 20435056
PDF is available here.
PDF is available here.
Abstract
We found that heart progenitor cells of the simple chordate Ciona intestinalis also generate precursors of the atrial siphon muscles (ASMs). These precursors express Islet and Tbx1/10, evocative of the splanchnic mesoderm that produces the lower jaw muscles and SHF of vertebrates. Evidence is presen...
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PMID: 20671188
PDF is available here.
PDF is available here.
Abstract
An acidic protein with phospholipase A(2) activity was purified to homogeneity from the venom of the Northeast Argentinian viperid Bothrops alternatus by two chromatographic steps: a conventional gel filtration on Sephadex G-75 and reversed phase on C18 HPLC column. A molecular mass of 14185.48 Da w...
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PMID: 20331996
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We used the same molecular tools to explore whether the Ca(2+) mechanism of excitation-contraction coupling also relies on STIM1 and STIM2. Live cell imaging of early differentiating myoblasts revealed a characteristic clustering of activated STIM1 and STIM2 during the first few hours of differentia...
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PMID: 20436167
PDF is available here.
PDF is available here.
Journal of Cell Science (123)Pt 14 2010
Abstract
We report Drosophila Waharan (Wah), a 170-kD predominantly nuclear protein with two potential human homologues, as a newly identified regulator of endosomal trafficking. Wah is required for neuromuscular-junction development and muscle integrity. In muscles, knockdown of Wah caused novel accumulatio...
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PMID: 20551180
PDF is available here.
PDF is available here.
Parasitology Research (107)2 2010
Abstract
Natural infection with Trichinella has been described in more than 150 mammalian species. However, few reports of Trichinella infection in wild animals have come from Argentina. In this study, muscle tissue was obtained from wild animals in Argentina with the aim of evaluating the presence of Trichi...
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PMID: 20424859
PDF is available here.
PDF is available here.
Abstract
We stably transfected an Oct4 promoter driven luciferase reporter (Oct4-1.9k-Luc) into P19 embryonic carcinoma (EC) cells and C2C12 myoblasts and examined their response to VPA. We found that VPA could both activate Oct4 promoter and rescue its inhibition by retinoic acid (RA). In C2C12 myoblasts, V...
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PMID: 20564199
PDF is available here.
PDF is available here.
Abstract
Previous research has suggested a relationship between low-frequency power of heart rate variability (HRV; LF in normalized units, LFnu) and muscle sympathetic nerve activity (MSNA). However, investigations have not systematically controlled for breathing, which can modulate both HRV and MSNA. Accor...
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PMID: 20410469
PDF is available here.
PDF is available here.
Abstract
It was investigated whether skeletal muscle K(+) release is linked to the degree of anaerobic energy production. Six subjects performed an incremental bicycle exercise test in normoxic and hypoxic conditions prior to and after 2 and 8 wk of acclimatization to 4,100 m. The highest workload completed...
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PMID: 20410475
PDF is available here.
PDF is available here.
Abstract
We sought to determine the molecular basis of elevations in aerobic metabolic capacity in the oxidative muscle and liver of Gasterosteus aculeatus in response to cold acclimation. Fishes were cold- or warm-acclimated for 9 wk and harvested on days 1, 2, and 3 and weeks 1, 4, and 9 of cold acclimatio...
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PMID: 20427717
PDF is available here.
PDF is available here.
Abstract
We show that HPSE2 is expressed in the fetal and adult central nervous system, where it might be implicated in controlling facial expression and urinary voiding, and also in bladder smooth muscle, consistent with a role in renal tract morphology and function. Our findings have broader implications f...
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PMID: 20560210
PDF is available here.
PDF is available here.
Abstract
We recommend to the lobster industry that if a reduction in depth and hauling rate is not economically feasible, fishermen should take particular care in handling lobsters and provide them with a recovery period in recirculating seawater prior to land transport. The ecological role of P. indicum is...
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PMID: 20662372
PDF is available here.
PDF is available here.
Abstract
We provide the first report of infections in treeshrews, describe the morphology of encysted parasites using light and transmission electron microscopy, and place this agent within a phylogenetic context by sequencing and comparing its 18S ribosomal DNA to that of related parasites. Muscle infection...
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PMID: 20026242
PDF is available here.
PDF is available here.
Akt2-mediated phosphorylation of Pitx2 controls Ccnd1 mRNA decay during muscle cell differentiation.
Abstract
We show that Pitx2 is phosphorylated by the protein kinase Akt2 and is necessary to ensure proper C2C12 myoblast proliferation and differentiation. Pitx2 associates with a ribonucleoprotein complex that includes the mRNA stabilizing factor HuR and sustains Ccnd1 (also known as Cyclin D1) expression,...
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PMID: 20019746
PDF is available here.
PDF is available here.
Abstract
Desire, pain and total female sexual index scores were significantly higher in the 7th month compared to 4th month in both groups (p < 0.05). However, sexual arousal, lubrication, orgasm, and satisfaction scores were improved in the 7th month in the training group (paired t-test, p < 0.001), but not...
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PMID: 20397759
PDF is available here.
PDF is available here.
Abstract
We hypothesized that insulin resistance develops when dysregulation of Pck1 occurs in the triglyceride/fatty acid cycle, which regulates lipid synthesis and transport between adipose tissue and the liver. We examined this by analyzing mice with a deletion of the PPARgamma binding site in the promote...
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PMID: 20124556
PDF is available here.
PDF is available here.
Health Physics (98)6 2010
Abstract
Treatment of severe radiation burns remains a difficult medical challenge. The response of the skin to ionizing radiation results in a range of clinical manifestations. The most severe manifestations are highly invalidating. Although several therapeutic strategies (excision, skin grafting, skin or m...
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PMID: 20445393
PDF is available here.
PDF is available here.
Abstract
We describe a novel set of single particle based procedures for the structural analysis of electron microscope images of muscle thin filaments and other partially decorated actin based filaments. The thin filament comprises actin and the regulatory proteins tropomyosin and troponin in a 7:1:1M ratio...
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PMID: 20025974
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)5 2010
Abstract
Adult inflammatory myopathies are rare conditions. Amongst them, inclusion body myositis (IBM) is considered to be the most common acquired myopathy in adults above 50 years of age, follows a slowly progressive course, and ultimately leads to severe disability. The case of a 57-year-old patient with...
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PMID: 20108015
PDF is available here.
PDF is available here.
médecine/sciences (26)5 2010
Abstract
The dermomyotome is a transient epithelial sheet that forms from the dorsal aspect of the somite. The dermomyotome gives rise to a variety of tissues, most importantly myotomal muscle and dermis. Despite the central importance of the dermomyotome in the development of amniotes, the question of its e...
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PMID: 20510149
PDF is available here.
PDF is available here.
Veterinary Pathology (47)3 2010
Abstract
A striped skunk with neurological signs was euthanized and examined via necropsy. Histologically, protozoa were found in multiple tissues. Protozoal schizonts measured 15 to 25 mum in diameter and contained 4 to 6 mum crescent-shaped merozoites. Protozoa were associated with necrosis and inflammatio...
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PMID: 20375428
PDF is available here.
PDF is available here.
Journal of Fish Biology (76)7 2010
Abstract
The effect of temperature and mass on specific growth rate (G) was examined in spotted wolffish Anarhichas minor of different size classes (ranging from 60 to 1500 g) acclimated at different temperatures (4, 8 and 12 degrees C). The relationship between G and 20S proteasome activity in heart ventric...
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PMID: 20557616
PDF is available here.
PDF is available here.
Journal of Experimental Biology (213)Pt 10 2010
Abstract
During their annual breeding migration the Christmas Island land crab Gecarcoidea natalis sustains locomotion aerobically for up to 12 h per day compared with just 10 min during the dry season when their muscles quickly become anaerobic. A seasonal transition to an endurance-muscle phenotype would t...
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PMID: 20435825
PDF is available here.
PDF is available here.
Journal of Experimental Biology (213)Pt 9 2010
Abstract
We identified muscle groups possibly involved in hooding based on their attachments on the specialized ribs of the neck. We then used a combination of morphology, kinematic analysis, morphometrics, electromyography and muscle stimulation to test hypotheses about the functional basis of hooding. We c...
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PMID: 20400637
PDF is available here.
PDF is available here.
Journal of Experimental Biology (213)Pt 9 2010
Abstract
We found that to counter-regulate the insulin-induced hypoglycaemia, trout metabolism is strongly modified. This short-term, efficient response to hypoglycaemia includes a rapid, coordinated response involving the reorganization of muscle and liver metabolism. During chronic insulin treatment some o...
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PMID: 20400628
PDF is available here.
PDF is available here.