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Stem Cell Niche (0):
Recent article
Stem Cell Niche
Abstract
We transitioned the technique to a mouse model, allowing investigation of the processes involved during TESI formation through the transgenic tools available in this species. This is a necessary step toward applying the technique to human therapy. Multicellular organoid units were derived from small...
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PMID: 21395443
PDF is available here.
PDF is available here.
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Abstract
We found that Sonic hedgehog (Shh) from neurons signals to a population of cells in the telogen bulge marked by the Hedgehog response gene Gli1. Gli1-expressing bulge cells function as multipotent stem cells in their native environment and repeatedly regenerate the anagen follicle. Shh-responding pe...
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PMID: 21549329
PDF is available here.
PDF is available here.
Abstract
We show that continuous depletion of the neural stem cell pool, as a consequence of their division, may contribute to the age-related decrease in hippocampal neurogenesis. Our results indicate that adult hippocampal stem cells, upon exiting their quiescent state, rapidly undergo a series of asymmetr...
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PMID: 21549330
PDF is available here.
PDF is available here.
Abstract
Abstract
We sought to determine if somatic stem-cell niches more broadly are immune-privileged sites by examining the haematopoietic stem/progenitor cell (HSPC) niche in the bone marrow, a site where immune reactivity exists. We observed persistence of HSPCs from allogeneic donor mice (allo-HSPCs) in non-irr...
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PMID: 21654805
PDF is available here.
PDF is available here.
Abstract
Systemic available circulating cells play a role in cardiac maintenance and ameliorate cardiac recovery and repair after myocardial infarction. However, only a small number of cells will be incorporated during cardiac damage. Cell mobilization, homing to the ischemic myocardium and e...
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PMID: 20528755
PDF is available here.
PDF is available here.
Abstract
We will emphasize the major factors that are involved in the regulation of lodgment of transplanted HSCs. Specifically, we will first introduce early observations on the spatial distribution of hematopoietic progenitors within the BM, then we will discuss the soluble factors, chemokines, cell-cell i...
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PMID: 20682000
PDF is available here.
PDF is available here.
Macromolecular Bioscience (10)11 2010
Abstract
We review work highlighting the growing complexity of stem cell-ECM interactions and their impact on the fields of biomaterials research and regenerative medicine....
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PMID: 20715131
PDF is available here.
PDF is available here.
Abstract
Abstract
Mesenchymal stem cells are multipotent adult stem cell populations that have broad differentiation plasticity and immunosuppressive potential that render them of great importance in cell-based therapies. They are identified by in vitro characteristics based on their differentiation potential for cli...
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PMID: 20836622
PDF is available here.
PDF is available here.
Abstract
Our results showed that stromal cells with the immunophenotypical (vimentin, CD34) and ultrastructural features of telocytes were present in the mouse heart since early embryonic to adult life, as well as in primary cultures of neonatal mouse cardiac cells. These cells formed an extended network of...
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PMID: 20977627
PDF is available here.
PDF is available here.
Human Reproduction (25)9 2010
Abstract
We studied GDNF production in isolated peritubular cells from men with normal spermatogenesis (HTPCs) and impaired spermatogenesis and testicular fibrosis (HTPC-Fs). Human testicular biopsies and peritubular cells in culture were evaluated using immunohistochemistry, laser microdissection (LMD), RT-...
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PMID: 20601681
PDF is available here.
PDF is available here.
Abstract
We have previously demonstrated that environment-derived signals control the fate choice of adult NSCs. More recently we have provided evidence that in the adult hippocampal dentate gyrus - one of the two neurogenic regions of the adult CNS - specialized astrocytes provide signals that instruct NSCs...
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PMID: 20881448
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to develop a 3D culture system with similarities to the human heart, which was suitable for studies of adult cardiac stem or progenitor cells.
Dissociated cells from human cardiac biopsies were placed in high-density pellet cultures and cultured for up to 6 weeks. Gene and...
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PMID: 20868328
PDF is available here.
PDF is available here.
Abstract
We focus on the adult stem/progenitor cells that were initially isolated from bone marrow and first referred to as colony forming units-fibroblastic, then as marrow stromal cells and subsequently as either mesenchymal stem cells or multipotent mesenchymal stromal cells (MSCs). The current interest i...
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PMID: 20716123
PDF is available here.
PDF is available here.
Nature Cell Biology (12)8 2010
Abstract
We show here that the principal signalling pathway implicated in this niche, chemokine activation of STAT, does not primarily regulate self-renewal of germline stem cells (GSCs), but rather governs GSC adhesion to hub cells. In fact, GSC renewal does not require hub cell contact, as GSCs can be rene...
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PMID: 20622868
PDF is available here.
PDF is available here.
Abstract
We examined the hippocampal neural stem cell niche in a transgenic rat model of Huntington disease. In this model, progressive cognitive deficits develop at the age of 9 months, suggesting possible hippocampal dysfunction. We found a disease-associated progressive decline in hippocampal progenitor c...
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PMID: 20535034
PDF is available here.
PDF is available here.
Abstract
We investigated the use of hyaluronic acid (HA) hydrogels as an artificial SC niche and examined regenerative capabilities of encapsulated embryonic endothelial progenitor cells (eEPC) in three different in vivo models. Hydrogel-encapsulated eEPC demonstrated improved resistance to toxic insult (adr...
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PMID: 20410213
PDF is available here.
PDF is available here.
Abstract
Abstract
Recent studies have identified new cellular and molecular components of the HSC niche and highlighted reciprocal interactions between the hematopoietic cells and their niches. These studies indicate that the HSC niche is not constituted by a single cell type but rather should be considered as a mult...
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PMID: 20473160
PDF is available here.
PDF is available here.
Pediatric Research (68)1 2010
Abstract
We examined whether regenerated bone marrow (BM) with BM-derived stromal cells (BMSCs) on hydroxyapatite (HA) scaffolds can reconstitute the functional niche. Ly5.2 BMSCs on HA scaffolds were implanted s.c. onto the backs of Ly5.2 recipient mice. Lineage negative Ly5.1 BM cells expressing luciferase...
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PMID: 20389261
PDF is available here.
PDF is available here.
Abstract
Abstract
We show that the MaSC pool increases 14-fold during maximal progesterone levels at the luteal dioestrus phase of the mouse. Stem-cell-enriched CD49fhi cells amplify at dioestrus, or with exogenous progesterone, demonstrating a key role for progesterone in propelling this expansion. In aged mice, CD4...
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PMID: 20445538
PDF is available here.
PDF is available here.
Neurological Research (32)5 2010
Abstract
TMP protected brain from damage by reducing volume of infarction, neuronal loss and water content. TMP not only increased the number of BrdU positive cell in SVZ, but also stimulated the cell differentiation after ischemia. The nNOS expression in cortex and dentate gyrus was reduced by treatment of...
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PMID: 20501058
PDF is available here.
PDF is available here.
Abstract
Cardiovascular disease is the number one cause of death and disability in the US. Understanding the biological activity of stem and progenitor cells, and their ability to contribute to the repair, regeneration and remodeling of the heart and blood vessels affected by pathological processes is an ess...
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PMID: 20453170
PDF is available here.
PDF is available here.
Abstract
In each major theory of the origin of cancer-field theory, chemical carcinogenesis, infection, mutation, or epigenetic change-the tissue stem cell is involved in the generation of cancer. Although the cancer type is identified by the more highly differentiated cells in the cancer cell lineage or hie...
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PMID: 20431026
PDF is available here.
PDF is available here.
Abstract
Stem cell biology has increasingly gained scientific and public interest in recent years. In particular, the use of stem cells for treatment of heart disease has been strongly pursued within the scientific and medical communities. Significant effort has gone into the use of adult tis...
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PMID: 19941452
PDF is available here.
PDF is available here.
Abstract
In addition to being a protective shield, the cornea represents two thirds of the eye's refractive power. Corneal pathology can affect one or all of the corneal layers, producing corneal opacity. Although full corneal thickness keratoplasty has been the standard procedure, the ideal...
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PMID: 19941445
PDF is available here.
PDF is available here.
Abstract
Periodontal disease leads to destruction of the periodontium such as alveolar bone, cementum, the periodontal ligament, and gingiva. Effective treatment for periodontal tissue regeneration is important, because periodontal disease is related to several systemic diseases. However, var...
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PMID: 19941449
PDF is available here.
PDF is available here.
Abstract
We examine the evidence indicating that ASC can stimulate nerve regeneration by both undergoing neural differentiation and through the release of a range of growth factors. We also discuss some of the issues that need to be addressed before ASC can be developed as an effective cellular therapy for t...
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PMID: 19941451
PDF is available here.
PDF is available here.
Abstract
In the face of mounting clinical demand, and armed with reconstructive techniques that are technically challenging and frequently result in suboptimal patient outcomes, increasing focus is being placed on tissue engineering and regenerative medicine as a potential source of novel ske...
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PMID: 19941457
PDF is available here.
PDF is available here.
Abstract
We need more information regarding optimal culture conditions and methods to promote chondrogenic lineages of stem cells. The necessary information includes necessary differentiation factors, cell scaffolds, and cell culture conditions. We reviewed the methodology for manufacturing cell constructs u...
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PMID: 19941456
PDF is available here.
PDF is available here.
Abstract
Severe hepatic dysfunctions including hepatic cirrhosis and hepatocarcinoma are life-threatening conditions for which effective medical treatments are needed. With the only effective treatment to date being orthotropic liver transplantation, alternative approaches are needed because...
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PMID: 19941447
PDF is available here.
PDF is available here.
Brain Research Reviews (63)1-2 2010
Abstract
We propose that neurotransmitters are master regulators of the different stages of neurogenesis. In favor of this idea, a description of selective neurotransmitter signaling and their functions in the largest neurogenic zone, the subventricular zone (SVZ), is provided. In particular, we emphasize th...
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PMID: 20188124
PDF is available here.
PDF is available here.
Microvascular Research (79)3 2010
Abstract
Embryonic stem (ES) cells are pluripotent cells capable of differentiating in all the cell types present in a living organism. They derive from the inner cell mass of blastocysts of different species including humans. Given their unlimited potential, ES cells represent an invaluable resource of diff...
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PMID: 20053368
PDF is available here.
PDF is available here.
Microvascular Research (79)3 2010
Abstract
Bone-marrow-derived endothelial progenitor cells (EPCs) contribute to angiogenesis-mediated pathological neovascularization, and recent studies have begun to recognize the biological significance of this contribution. This review will discuss the ability of EPCs to contribute to neovascularization i...
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PMID: 20188747
PDF is available here.
PDF is available here.
Abstract
We evaluated this model with the use of lineage analysis and live imaging, and found that this putative stem cell population is not homogeneous. Instead, the stem cell pool that supports steady-state spermatogenesis is contained within a subpopulation of single spermatogonia. We also found that cyst...
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PMID: 20299552
PDF is available here.
PDF is available here.
Abstract
We found a fundamental difference between cultures of primary, adult PSCs grown as monolayers compared to those grown as spheres. The first supported the expansion and maintenance of PSCs from single cells while the latter did not. In an attempt to determine the mechanisms governing stem cell contro...
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PMID: 20102283
PDF is available here.
PDF is available here.
Neuroreport (21)5 2010
Abstract
We therefore sought to investigate in functional MHC class I knockout mice, transporter associated with antigen processing 1 (TAP1) KO, whether there are alterations in adult neurogenesis. We found no significant differences in cell proliferation or neurogenesis in either the dentate gyrus or subven...
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PMID: 20147861
PDF is available here.
PDF is available here.
Abstract
We find that the intravenous injection of BM progenitors into nonconditioned zeta-chain-associated protein kinase 70 (ZAP-70)-deficient mice with SCID supports short- but not long-term thymopoiesis. Remarkably, we now show that the IT administration of these progenitors produces a significant level...
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PMID: 20040762
PDF is available here.
PDF is available here.
Abstract
We implemented a new transplantation unit with HEPA filtration. We retrospectively evaluated its efficacy for hospitalized transplantation unit subjects whose sera were tested for aspergillus galactomannan antigen between April 2004 and March 2007. Subjects numbered 265 (973 samples) categorized as...
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PMID: 20420162
PDF is available here.
PDF is available here.
Abstract
We discuss the possibility of a continuous genetic modulation of stem cells by a MV-mediated transfer of information between cells....
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PMID: 20054810
PDF is available here.
PDF is available here.
Abstract
We examined the effects of intrafemoral injection of MSCs on HSC self-renewal in rigorous competitive repopulating unit (CRU) assays using congenic transplantation models in which stromal progenitors (CFU-F) were ablated by irradiation. Interestingly, naïve MSCs injected into femur contributed to t...
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PMID: 20054234
PDF is available here.
PDF is available here.
Abstract
We deal with is that hESCs undergoing differentiation, sequentially generate trophectoderm and endoderm lineages and thereafter influence further events through the production of growth factors. These factors control the fate of hESCs either by promoting or retarding the recruitment of new cells in...
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PMID: 19951253
PDF is available here.
PDF is available here.
Cell Stem Cell (6)2 2010
Abstract
Stem cell niches are dynamic microenvironments that balance stem cell activity to maintain tissue homeostasis and repair throughout the lifetime of an organism. The development of strategies to monitor and perturb niche components has provided insight into the responsive nature of th...
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PMID: 20144784
PDF is available here.
PDF is available here.
Abstract
We demonstrate that the binding of PCa to annexin II induces the expression of the growth arrest-specific 6 (GAS6) receptors AXL, Sky, and Mer, which, in the hematopoietic system, induce dormancy. In addition, GAS6 produced by osteoblasts prevents PCa proliferation and protects PCa from chemotherapy...
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PMID: 20126470
PDF is available here.
PDF is available here.
Abstract
The vertebrate intestine is a complex and highly specialized organ comprising tissues derived from all three germ layers. While a description of the morphological events underlying the consolidation and organization of the endoderm, mesoderm, and ectoderm-derived cells into a multi-layered, continuo...
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PMID: 20691849
PDF is available here.
PDF is available here.
Cellular Immunology (264)1 2010
Abstract
We overview common processes in the naturally occurring examples of: pregnancy, cancer, oral tolerance and anterior chamber associated immune deviation. The case is made that an easily accessible byproduct of plastic surgery, the adipose stromal vascular fraction, contains elements directly capable...
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PMID: 20537320
PDF is available here.
PDF is available here.
Abstract
The mechanism of stem cell-induced kidney repair remains controversial. Engraftment of bone marrow-derived stem cells is considered a rare event and several studies point to paracrine/endocrine processes. This review focuses on microvesicle-mediated transfer of genetic information be...
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PMID: 19823086
PDF is available here.
PDF is available here.
Abstract
The mechanism of stem cell-induced kidney repair remains controversial. Engraftment of bone marrow-derived stem cells is considered a rare event and several studies point to paracrine/endocrine processes. This review focuses on microvesicle-mediated transfer of genetic information be...
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PMID: 19823086
PDF is available here.
PDF is available here.
Current Drug Targets (11)1 2010
Abstract
We will discuss the rationale for these LSCs-targeted strategies and highlight recent advances that may ultimately help pave the way towards selective LSCs-elimination....
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PMID: 20017722
PDF is available here.
PDF is available here.
Abstract
Abstract
Proper tissue function and regeneration rely on robust spatial and temporal control of biophysical and biochemical microenvironmental cues through mechanisms that remain poorly understood. Biomaterials are rapidly being developed to display and deliver stem-cell-regulatory signals in a precise and n...
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PMID: 19940913
PDF is available here.
PDF is available here.
Abstract
We now know that micro- and nanoscale manipulation of scaffold composition, mechanical properties, and three-dimensional architecture have profound influences on SC fate and will likely prove important in developing the next generation of "transplantable SC niches" for regeneration of heart and othe...
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PMID: 19552604
PDF is available here.
PDF is available here.
Abstract
We review the current literature examining several aspect of medical therapy such as the applicability of experimental models to clinical practice....
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PMID: 19500064
PDF is available here.
PDF is available here.
Abstract
We utilized a tissue-specific stem cell, synovium-derived stem cell (SDSC), as a model to reconstruct an in vitro three-dimensional stem cell niche. After seeding on SDSC-derived extracellular matrix, the initially wide and flat SDSCs became thin and spindle shaped and were arranged in a three-dimen...
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PMID: 19545204
PDF is available here.
PDF is available here.
Abstract
Injuries to articular cartilage are one of the most challenging issues of musculoskeletal medicine due to the poor intrinsic ability of this tissue for repair. Despite progress in orthopaedic surgery, the lack of efficient modalities of treatment for large chondral defects has prompt...
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PMID: 19804369
PDF is available here.
PDF is available here.
Journal of Biophotonics (2)11 2009
Abstract
We provide a description of the basic concepts and paradigms currently constituting the foundations of adult stem cell biology, and discuss the role that live imaging techniques have in the development of the field. We focus on live imaging of hematopoietic stem cells (HSCs) as the basic biology and...
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PMID: 19847800
PDF is available here.
PDF is available here.
Abstract
We have developed a method for locating individual transplanted cells and simultaneously identifying and analyzing the molecules and cellular phenotypes surrounding them in situ using transmission electron microscopy. This innovative method involves triple immunogold labeling combined with serial ul...
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PMID: 19754979
PDF is available here.
PDF is available here.
Neuroreport (20)14 2009
Abstract
We investigated whether long-term depression (LTD) induction also affects adult neurogenesis. We induced LTD in the dentate gyrus in one hemisphere and compared the amount of progenitor proliferation with that in the other hemisphere. Unlike LTP induction, LTD induction per se did not affect progeni...
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PMID: 19633582
PDF is available here.
PDF is available here.