Abstract
These results suggest that repeated inhalation exposure to brevetoxin may delay virus particle clearance and recovery from influenza A infection in the rat lung....
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PMID: 21240731
PDF is available here.
Abstract
ENDORSEMENT: South African Thoracic Society, South African Society of Paediatric Infectious Diseases, United South African Neonatal Association. OBJECTIVE: To develop and publish a guideline for doctors managing acute viral bronchiolitis, because this condition is extremely common in South Africa, i...
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PMID: 20460028
PDF is available here.
Abstract
We present the case of a 15-week-old infant boy who was brought to a private physician with symptoms of a common cold and was sent home. Three days later, his parents brought him to the hospital emergency department stating he was congested and crying a lot. He was again discharged. Another 2 days p...
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PMID: 20463428
PDF is available here.
Abstract
We analyze the expression of inflammatory markers (C-reactive protein, erythrocyte sedimentation rate, and neutrophil count) underlying inflammatory processes in children: 482 children (241 girls and 241 boys) hospitalized for pneumonia (n = 384), pyelonephritis (n = 39), or bronchiolitis (n = 59) m...
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PMID: 19543152
PDF is available here.
Abstract
This study was designed to evaluate the effect of once-daily montelukast therapy on the clinical progress and the cytokine profile of patients with acute viral bronchiolitis. A randomized, double-blind, placebo-controlled trial included 85 patients (mean age, 3.5 +/- 2.35 months), clinically diagnos...
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PMID: 20406596
PDF is available here.
Ariel Pereda,
Javier Cappuccio,
Maria A Quiroga,
Elsa Baumeister,
Lucas Insarralde,
Mariela Ibar,
Ramon Sanguinetti,
Maria L Cannilla,
Debora Franzese,
Oscar E Escobar Cabrera,
Maria I Craig,
Agustina Rimondi,
Mariana Machuca,
Rosa T Debenedetti,
Carlos Zenobi,
Leonardo Barral,
Rodrigo Balzano,
Santiago Capalbo,
Adriana Risso and
Carlos J Perfumo
Abstract
In June-July 2009, an outbreak of pandemic (H1N1) 2009 infection occurred on a pig farm in Argentina. Molecular analysis indicated that the virus was genetically related to the pandemic (H1N1) 2009 influenza virus strain. The outbreak presumably resulted from direct human-to-pig transmission.
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PMID: 20113566
PDF is available here.
Abstract
In this mouse model of paramyxoviral bronchiolitis, azithromycin attenuated acute and chronic airway inflammation. These findings demonstrate anti-inflammatory effects of azithromycin that are not related to anti-viral activity. Our findings support the rationale for future prospective randomized cl...
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PMID: 20591166
PDF is available here.
Abstract
The proportion of CD4+ CD25+ Treg and the Foxp3 mRNA expression in the control, non-atopic, and atopic groups reached (10.5 +/- 1.6)% and 0.34 +/- 0.11, (8.8 +/- 2.2)% and 0.26 +/- 0.08, (7.6 +/- 1.8)% and 0.21 +/- 0.09, respectively. There were significant differences among these groups (all P < 0....
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PMID: 19953886
PDF is available here.
Abstract
We also analyzed various reports on childhood morbidity and mortality of Director General of Health Services (DGHS), Bangladesh. ARI/pneumonia was found to be leading cause of under five morbidity and mortality. Most of the pneumonia deaths occurred under two years of age and it accounted for 77.5%...
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PMID: 19377432
PDF is available here.
Abstract
Viruses were detected in 168 (93%) of the 180 children with bronchiolitis. A single virus was identified in 127 (71%) children and multiple viruses in 41 (23%). Respiratory syncytial virus (RSV) was the most common virus detected (77%), followed by adenovirus (15%), human metapneumovirus (11%), coro...
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PMID: 18785966
PDF is available here.
Abstract
Timing of birth in relationship to winter virus season confers a differential and definable risk of developing early childhood asthma, establishing winter virus seasonality as a causal factor in asthma development. Delay of exposure or prevention of winter viral infection during early infancy could...
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PMID: 18776151
PDF is available here.
Abstract
Similar statistically significant bronchodilation occurred after all three bronchodilators as indicated by a decrease in peak inspiratory pressure and respiratory system resistance, but these changes were small and probably clinically insignificant. However, side effects of bronchodilators, such as...
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PMID: 18838938
PDF is available here.
Abstract
There was a significant difference between the AVB/AD (23.4 +/- 14.3 ppb, n=15) vs the AVB without AD group (13.5 +/- 10. 1 ppb, n=13) or the AD without AVB group (11.0 +/- 8.3 ppb, n=14). Maternal feeding for more than 2 months decreased FeNO by 50%. CONCLUSION: Atopic children below 2 years with A...
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PMID: 19106904
PDF is available here.
Abstract
Of the children, 48% (n = 97) developed asthma (physician-diagnosed), and 48% (n = 97) had eczema by age 6 years; 32% (n = 48 of 150) developed allergic sensitization by 3 years of age. Children with asthma had lower IL-13 expression at 6 years of age than those without (P = .001). IFN-gamma, IL-2,...
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PMID: 18760461
PDF is available here.
Abstract
Respiratory syncytial virus (RSV) bronchiolitis, an important respiratory disease in infancy, is thought to be caused by severe inflammation of the small peripheral airways and has been associated with the development of recurrent wheeze, childhood asthma, and early allergen sensitization. Both inna...
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PMID: 18820586
PDF is available here.
Abstract
Home administration of palivizumab was associated with a significantly higher rate of compliance and lower hospitalization rate for RSV illness in high-risk infants....
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PMID: 18776822
PDF is available here.
Abstract
Viral respiratory infections are closely associated with wheezing illnesses and exacerbations of asthma throughout childhood, and yet there are a number of remaining questions pertaining to the specific nature of this relationship. Infection with an expanding list of respiratory viruses is an import...
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PMID: 18820588
PDF is available here.
Abstract
We compared cytokines and chemokines in secretions of infants surviving various forms of respiratory illness caused by RSV or influenza viruses, to determine which mediators were associated with more severe illness. We analyzed lung tissue from fatal cases of RSV and influenza LRTI to determine the...
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PMID: 18820587
PDF is available here.
Abstract
Pattern of lung disease, ventilatory settings, blood gases, infant's vital parameters, sedation and analgesia during the periods of conventional mechanical ventilation (CMV, 6 infants), after initiation of HFOV (HFOVi, 9 infants), in the middle of its course (HFOVm), at the end (HFOVe) and after ext...
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PMID: 18500423
PDF is available here.
Abstract
Bronchiolitis is the commonest reason for hospital admission in infancy and the most frequent cause of acute respiratory failure in children admitted to paediatric intensive care units in the UK and North America. The respiratory syncytial virus accounts for most cases of bronchiolitis, however, new...
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PMID: 18539685
PDF is available here.
Abstract
We tested the following hypotheses: (1) Secondhand smoke (SHS) exposure increases uLTE4 in well infants and in those hospitalized for RSV bronchiolitis; (2) Length of hospital stay for those with RSV bronchiolitis correlates with uLTE4; and (3) Infants with parent(s) with asthma will have higher uLT...
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PMID: 18615667
PDF is available here.
Abstract
HBoV was the fourth most frequent single virus after RSV, rhinovirus, and adenovirus in children hospitalized because of respiratory infection. It was associated with recurrent wheezing and bronchiolitis showing a different clinical course from other virus in terms of diagnosis, fever, and age....
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PMID: 18574440
PDF is available here.
Abstract
Infants hospitalized for bronchiolitis associated with respiratory syncytial virus are isolated for the duration of their hospitalization. This article reviews whether a negative rapid antigenic test could be used to shorten the duration of isolation measures. Rapid respiratory syncytial virus tests...
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PMID: 18509148
PDF is available here.
Abstract
Nasal continuous positive airway pressure improves the clinical score and the CO(2) elimination of infants with refractory bronchiolitis. These positive effects are significantly enhanced when nasal continuous positive airway pressure is combined with heliox instead of air oxygen. Both techniques ar...
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PMID: 18411235
PDF is available here.
Abstract
Both groups (16 infants each) had comparable characteristics at study entry. Mean (+/-SD) age was 72 +/- 43 days, and 29/32 infants were RSV positive. Oxygen requirement (FiO(2)) decreased significantly at 30 min post-inhalation (30 +/- 9.2% to 26 +/- 7.1%, P < 0.05) only in the IF group. RACSs and...
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PMID: 18214942
PDF is available here.
Abstract
In PICU, respiratory viral infections were associated with significant morbidity and life-threatening conditions.
(c) 2008 Wiley-Liss, Inc....
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PMID: 18219695
PDF is available here.
Abstract
We investigated a cohort of children hospitalized with RSV bronchiolitis from when they were under 2 yr old until they reached a mean age of 6.2 yr. In total, we enrolled 175 children in this study. Both the group treated with ribavirin and the group not treated with ribavirin included high-risk you...
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PMID: 18257904
PDF is available here.
Abstract
Acute bronchiolitis is the main cause of emergency visits and hospitalizations in infants. Recent data suggest that neutrophil- and eosinophil-mediated inflammations were part of bronchiolitis pathophysiology. Apart from the defined risk factors, few was known on the underlying pathophysiology, whic...
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PMID: 18093085
PDF is available here.
Alma-Martina Cepika,
Alenka Gagro,
Ana Bace,
Dorian Tjesic-Drinkovic,
Jadranka Kelecic,
Tamara Baricic-Voskresensky,
Mladen Matic,
Vladimir Drazenovic,
Igor Marinic,
Gordana Mlinaric-Galinovic,
Duska Tjesic-Drinkovic,
Zvonimir Vrtar and
Sabina Rabatic
Abstract
Respiratory syncytial virus (RSV) glycoprotein G mimics fractalkine, a CX(3)C chemokine, which mediates chemotaxis of leukocytes expressing its receptor, CX(3)CR1. The aim of this study was to examine the relationship between RSV infection and expression of perforin and IFN-gamma in CX(3)CR1-express...
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PMID: 18257903
PDF is available here.
Abstract
Oxygen supplementation is the prime determinant of the length of hospitalization for infants with bronchiolitis. Infants remaining in the hospital for oxygen supplementation once feeding difficulties had resolved did not experience deterioration to the extent of needing PICU support....
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PMID: 18310194
PDF is available here.
Abstract
In this multicenter study, RSV was the most frequent cause of bronchiolitis (64%). RV was present in 16%, and these children have a distinct profile in terms of demographics, medical history, and ED treatment....
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PMID: 18275439
PDF is available here.
Abstract
No benefits were found in either LOS or clinical score in infants and young children treated with systemic glucocorticoids as compared to placebo. There were no differences in these outcomes between treatment groups; either in the pooled analysis or in any of the sub analyses. Among the three studie...
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PMID: 18254063
PDF is available here.
Abstract
Current evidence suggests nebulized 3% saline may significantly reduce the length of hospital stay and improve the clinical severity score in infants with acute viral bronchiolitis....
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PMID: 18843717
PDF is available here.
Abstract
We present the process of illness of an 10 month old baby with GBS. The report discusses RSV as possible triggers. For children with ARDS, a nitric oxide ventilation could represent a lifesaving option....
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PMID: 18256980
PDF is available here.
Abstract
Respiratory syncytial virus (RSV) bronchiolitis is a serious and distressing illness, which occurs almost exclusively in infants under one year of age. Although the majority of all children will have experienced an infection with RSV by the time they reach their second birthday, only a minority deve...
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PMID: 18075829
PDF is available here.
Abstract
During 1997 through 2004, the average annual incidence rates for bronchiolitis, RSV, and pneumonia were 3.8, 2.7, and 6.8 per 1000 children younger than 5 years, respectively. The incidence of each condition was higher for infants younger than 1 year (15.1, 9.8, and 15.9 per 1000 infants, respective...
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PMID: 18043442
PDF is available here.
Abstract
We present a case of a 5-month-old infant with a presentation of spontaneous pneumothorax 7 days after hospitalization for acute bronchiolitis. The characteristics of this particular manifestation are discussed....
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PMID: 18091598
PDF is available here.
Abstract
The majority of hRSV and hMPV in nasal secretions is not associated with cells. Removal of the cellular component of NPA does not interfere with quantification of hRSV and hMPV....
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PMID: 17920332
PDF is available here.
Abstract
Respiratory Syncytial Virus (RSV) is the leading cause of hospitalization for lower respiratory tract infections (LRTI) in young children worldwide. RSV is an important cause of LRTI in infants and a variety of factors, such as gender, age at admission, gestational age, birth weight, and exposure to...
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PMID: 18073171
PDF is available here.
Abstract
This is the first study, to our knowledge, to demonstrate that Down syndrome is a novel independent risk factor for severe respiratory syncytial virus lower respiratory tract infections. These findings should prompt studies to investigate possible mechanisms that underlie severe respiratory syncytia...
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PMID: 17908728
PDF is available here.
Riny R Janssen,
Louis L Bont,
Christine L E CL Siezen,
Hennie M HM Hodemaekers,
Marieke J MJ Ermers,
Gerda G Doornbos,
Ruben R van 't Slot,
Ciska C Wijmenga,
Jelle J JJ Goeman,
Jan L L JL Kimpen,
Hans C HC van Houwelingen,
Tjeerd G TG Kimman and
Barbara B Hoebee
Abstract
SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. Apart from association at the allele level, these 4 SNPs also demonstrated association at the genot...
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PMID: 17703412
PDF is available here.
Abstract
We examined whether human milk immunomodulatory factors (cells, cytokines) change in response to clinically diagnosed, severe bronchiolitis in the recipient breast-fed infant. We examined milk from 36 breast feeding mothers of infants hospitalized with bronchiolitis and compared them with milk from...
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PMID: 17680907
PDF is available here.
Abstract
The use of nebulized 3% HS is a safe, inexpensive, and effective treatment for infants hospitalized with moderately severe viral bronchiolitis....
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PMID: 17719935
PDF is available here.
Abstract
Most patients admitted for severe bronchiolitis to the PICU are healthy infants whose principal risk factor is young age. The main predictors of severe clinical course during PICU stay are the association of two or more risk factors, the presence of apnea, and pulmonary consolidation on admission ch...
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PMID: 17692256
PDF is available here.
Abstract
The LLMIs in the acute stage were significantly higher than those in the remission stage (p < 0.05). The neutrophil percentage of the laryngeal lavage correlated significantly with the LLMI (r = 0.707, p < 0.0001) during the acute stage of bronchiolitis. When patients were divided into pHm-positive...
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PMID: 17498191
PDF is available here.