Abstract
We found that MNV infection can accelerate bacteria-induced inflammatory bowel disease (IBD) progression in Mdr1a(-/-) mice. The studies presented here examined whether MNV infection also affects the phenotype of a bacterially driven mouse model of inflammation-associated colon cancer in genetically...
|
PMID: 21819691
PDF is available here.
Abstract
We analysed epidemiological and laboratory data collected using standardized methods from long-term care facilities (LTCFs) during 2003-2006. Faecal specimens were tested for NoV by real-time reverse transcriptase-polymerase chain reaction. NoV strains were genotyped by sequencing. Of the 234 acute...
|
PMID: 20412611
PDF is available here.
Abstract
We analysed the characteristics of four norovirus outbreaks which occurred during a 3-year period in an in-patient psychiatric care unit. A total of 184 patients were affected which included 172 hospitalized patients, seven healthcare workers (HCWs) and five psychiatric nursing-home residents. The m...
|
PMID: 20334730
PDF is available here.
Abstract
SUMMARYIn December 2006, an outbreak of gastroenteritis occurred involving 372 guests and 72 employees at a hotel after a guest vomited in corridors on the third (F3) and 25th (F25) floors. Norovirus with identical genotype was confirmed by real-time reverse transcription-polymerase chain reaction i...
|
PMID: 20429969
PDF is available here.
Abstract
We report a 2-year-old girl who demonstrated "benign convulsions with gastroenteritis (CwG)" with transient splenial lesions twice during the winter. The first episode was associated with noro-virus and the second with rota-virus. During each episode, seizures occurred in clusters without clinical s...
|
PMID: 21077356
PDF is available here.
Abstract
Our study aimed at providing an assessment of their significance in hospitalized children and adolescents with acute gastroenteritis using ELISA test at the time of their introduction.
A prospective hospital based study of the etiology of acute gastroenteritis was undertaken in a total of 618 patien...
|
PMID: 21110484
PDF is available here.
Abstract
We investigated 163 children ≤5 years of age, without a recent history of diarrhea (≤10 days).
Asymptomatic norovirus infections were observed in 11.7% (19/163), with children ≤6 months of age being most frequently infected (16%). Of the 19 norovirus-positive children, 4 (21%) and 10 (53%) wer...
|
PMID: 20657344
PDF is available here.
Abstract
We describe the prevalence, seasonality and characteristics of asymptomatic norovirus infection in England. Healthy individuals were recruited at random from the general population during the Study of Infectious Intestinal Disease (1993-1996). Norovirus was identified using real-time RT-PCR. The age...
|
PMID: 20196905
PDF is available here.
Miguel L O'Ryan,
Alfredo Peña,
Rodrigo Vergara,
Janepsy Díaz,
Nora Mamani,
Hector Cortés,
Yalda Lucero,
Roberto Vidal,
Gonzalo Osorio,
María Elena Santolaya,
Germán Hermosilla and
Valeria J Prado
Abstract
Rotavirus and more recently noroviruses are recognized as main causes of moderate to severe acute diarrhea episodes (ADE) in children < or =5 years of age. Comparing epidemiologic and clinical features of norovirus to rotavirus ADE will aid in the decision-making process required to develop noroviru...
|
PMID: 20581736
PDF is available here.
Abstract
We use Monte Carlo maximum likelihood via data augmentation for obtaining estimates of the transmission rate and infectious period from household outbreaks with the 3 above features.
We apply this parameter estimation technique to 153 infection sequences within households from a norovirus outbreak i...
|
PMID: 20508526
PDF is available here.
Abstract
We developed a new trivalent inactivated vaccine, Kyoto Biken Feline-CPR, consisting of three FCV strains; one was the production strain of our previous vaccine, and the others were screened from 60 field isolates obtained between 1998 and 2000 based on cross-neutralization tests. In this report, th...
|
PMID: 20453450
PDF is available here.
Kazushi Motomura,
Masaru Yokoyama,
Hirotaka Ode,
Hiromi Nakamura,
Hiromi Mori,
Tadahito Kanda,
Tomoichiro Oka,
Kazuhiko Katayama,
Mamoru Noda,
Tomoyuki Tanaka,
Naokazu Takeda,
Hironori Sato and
Norovirus Surveillance Group of Japan
Abstract
We examined here how the GII/4 virus evolves to generate and sustain new epidemics in humans, using 199 near-full-length GII/4 genome sequences and 11 genome segment clones from human stool specimens collected at 19 sites in Japan between May 2006 and February 2009. Phylogenetic studies demonstrated...
|
PMID: 20534859
PDF is available here.
Abstract
We conducted an investigation to identify the source and described the extent of the outbreak. We performed a retrospective cohort study among students, teachers and food handlers exposed to canteen food in the elementary school. Using self-administered questionnaires we collected information on sym...
|
PMID: 20676321
PDF is available here.
Abstract
The relationship between the incidence of norovirus-associated gastroenteritis outbreaks (NAGOs) in Victoria, Australia for the period 2002-2007 and rainfall was examined. Statistical analysis involving the correlation between time series indicated that there was a statistically significant (p < 0.0...
|
PMID: 20717541
PDF is available here.
Abstract
We previously reported the detection and partial characterization of a wide range of variable and novel SaV strains of uncertain taxonomic status in Canadian swine. We now report on further genomic characterization of two novel strains to clarify their taxonomic relationship to other swine and human...
|
PMID: 20352267
PDF is available here.
Abstract
We tested fecal samples by using reverse transcription-PCR. We found canine norovirus in 40% and 9% of dogs with and without diarrhea, respectively. The virus was genetically unrelated to other noroviruses and constitutes a tentative new genogroup....
|
PMID: 20507751
PDF is available here.
Abstract
Health care-associated infections (HAI) remain a major cause of patient morbidity and mortality. Although the main source of nosocomial pathogens is likely the patient's endogenous flora, an estimated 20% to 40% of HAI have been attributed to cross infection via the hands of health care personnel, w...
|
PMID: 20569853
PDF is available here.
Abstract
We examined the prevalence and importance of NoV infection in three international traveler cohorts with diarrhea acquired in three developing regions of the world, Mexico, Guatemala, and India. We also characterized the demographics and symptoms associated with NoV diarrhea in these travelers. Stool...
|
PMID: 20305012
PDF is available here.
Abstract
From January to December 2007, 973 stool specimens were prospectively collected from children hospitalized for gastroenteritis signs or from neonates and premature cases who were born in two French hospital settings in the north of France. They were tested by rapid enzyme immunoassay (EIA) analyses...
|
PMID: 20305010
PDF is available here.
Abstract
Members of the public are always somewhat aware of foodborne and other zoonotic pathogens; however, recent illnesses traced to produce and the emergence of pandemic H1N1 influenza virus have increased the scrutiny on all areas of food production. The Council for Agricultural Science and Technology h...
|
PMID: 20348375
PDF is available here.
Abstract
The European rabbit was brought to Australia as a companion animal by early settlers. It sometimes escaped, but failed to survive in the Australian bush. In 1879 wild rabbits were deliberately sent to Victoria to provide game for wealthy settlers to shoot. They soon spread all over Australia, except...
|
PMID: 20617651
PDF is available here.
Abstract
Although noroviruses were the first viral agents to be linked to gastrointestinal disease, they were long considered a secondary cause far behind rotaviruses. Development of molecular-based diagnostic techniques has provided clearer insight into the epidemiological impact of noroviruses that are now...
|
PMID: 20486340
PDF is available here.
Abstract
I (G I). The sequence analysis showed that all 10 G II strains selected randomly belonged to genotype G II4, while 3 GI strains were classified into three different genotypes: G I2, G I4 and G I8.
The study showed that norovirus was an important etiologic agent of sporadic gastroenteritis among adul...
|
PMID: 20575264
PDF is available here.
Abstract
Over 400 office workers from the same unit of a manufacturing company in Stockholm County, Sweden, fell ill with gastroenteritis. A retrospective cohort study of office workers in the affected unit demonstrated that canteen visitors on one day had an increased risk of illness [risk ratio (RR) 27.1,...
|
PMID: 19765351
PDF is available here.
Abstract
We report the prevalence of rotavirus and calicivirus infections, along with their respective association with diarrhoea in the porcine population of the region of northern Spain. A total of 221 samples were collected at random from different farms in the region and from the main slaughterhouse faci...
|
PMID: 19781118
PDF is available here.
Abstract
Frequently cited statistics indicate that the burden of foodborne disease is a serious public health problem, particularly for vulnerable populations such as children. The purpose of the descriptive retrospective study discussed in this article was to analyze data collected within the Electronic Foo...
|
PMID: 20235403
PDF is available here.
Abstract
The objective of this study was to determine the prevalence of anti-norovirus (NoV), -sapovirus (SaV) and -Tulane virus (TV) antibodies in rhesus macaques of the Tulane National Primate Research Center and to evaluate the antigenic relationship between these viruses. A high prevalence of NoV-binding...
|
PMID: 19889933
PDF is available here.
Abstract
A quantitative microbial risk analysis-Monte Carlo method was used to estimate norovirus infection risks to consumers of wastewater-irrigated lettuce. Using the same assumptions as used in the 2006 WHO guidelines for the safe use of wastewater in agriculture, a norovirus reduction of 6 log units was...
|
PMID: 20009246
PDF is available here.
Abstract
We built structural models and recombinant virus-like particles (VLPs) of five GI strains: GI.1-1968, GI.1-2001, GI.2-1999, GI.3-1999, and GI.4-2000. Structural models of four GI genotype capsid P domain dimers suggested that intragenotype structural variation is limited, that the GI binding pocket...
|
PMID: 20007270
PDF is available here.
Abstract
Norovirus is the principal agent of bivalve shellfish-associated gastroenteric illness worldwide. Numerous studies using PCR have demonstrated norovirus contamination in a significant proportion of both oyster and other bivalve shellfish production areas and ready-to-eat products. By comparison, the...
|
PMID: 20132676
PDF is available here.
Abstract
Recently, many cases related to viral gastroenteritis outbreaks have been reported all over the world. Noroviruses are found to be leading as the major cause of outbreaks of acute gastroenteritis. Patients with the acute gastroenteritis normally found to be positive with norovirus when stools and vo...
|
PMID: 20208424
PDF is available here.
Gábor Reuter,
Janet Zimsek-Mijovski,
Mateja Poljsak-Prijatelj,
Ilaria Di Bartolo,
Franco Maria Ruggeri,
Tuija Kantala,
Leena Maunula,
István Kiss,
Sándor Kecskeméti,
Nabil Halaihel,
Javier Buesa,
Christina Johnsen,
Charlotte K Hjulsager,
Lars E Larsen,
Marion Koopmans and
Blenda Böttiger
Abstract
We report on the incidence, genetic diversity, and molecular epidemiology of sapoviruses detected in domestic pigs in a comprehensive study conducted in six European countries (Denmark, Finland, Hungary, Italy, Slovenia, and Spain) between 2004 and 2007. A total of 1,050 swine fecal samples from 88...
|
PMID: 19940055
PDF is available here.
Abstract
Despite its common occurrence, the aetiology of chronic gingivostomatitis in cats remains uncertain. Aetiology is likely multifactorial, and several infectious agents may be associated with chronic gingivostomatitis. The purpose of this study was to investigate the prevalence of feline calicivirus (...
|
PMID: 21038808
PDF is available here.
Abstract
This winter's extreme weather conditions, coupled with an outbreak of norovirus, put the NHS under strain. Many nurses proved their dedication by their willingness to work extra hours.
|
PMID: 20222241
PDF is available here.
Abstract
A 68-year-old man, immunocompromised due to non-Hodgkin lymphoma and chemotherapy, was admitted for a community-acquired norovirus infection. He developed chronic intermittent diarrhoea and cachexia. A video-capsule examination showed severe mucosal atrophy in the jejunum. The patient died eight mon...
|
PMID: 20456762
PDF is available here.
Abstract
Noroviruses (NoVs) resembling human NoV genotype GIV (Alphatron-like) have recently been detected in carnivores. By using an enzyme-linked immunosorbent assay based on baculovirus-expressed capsid protein VP1 of lion strain GGIV.2/Pistoia/387/06/ITA, NoV-specific antibodies were detected in cats (16...
|
PMID: 19923574
PDF is available here.
Abstract
Our analysis were based on data from routine surveillance system on foodborne and waterborne outbreaks in Poland. A total number of 154 norovirus outbreaks were registered from 2004 to 2008. The outbreaks showed seasonal peak in winter months. Those outbreaks mainly occurred in hospitals and residen...
|
PMID: 20499656
PDF is available here.
Abstract
Noroviruses belong to the Caliciviridae family. They are a major cause of sporadic cases and outbreaks of gastroenteritis in all age groups, and are responsible for a considerable disease burden in industrialized countries. Noroviruses are single-stranded RNA viruses, and show great genetic diversit...
|
PMID: 20132778
PDF is available here.
Abstract
The molecular and epidemiological features of noroviruses associated with community-based NASGIs and community-based NAGOs are similar but are different from those found for institutional NAGOs.
2010 S. Karger AG, Basel....
|
PMID: 20130414
PDF is available here.
Abstract
This paper reports on several simultaneous outbreaks of norovirus infection linked to the consumption of raw oysters. Since January 2010, 334 cases in 65 clusters were reported from five European countries: the United Kingdom, Norway, France, Sweden and Denmark. The article describes the available e...
|
PMID: 20350499
PDF is available here.
Abstract
We detected > or =1 virus in 120 (53%) of HA-AGE cases; rotavirus (31%), norovirus (16%), and adenovirus 40/41 (15%) were the predominant viruses identified. Molecular evidence indicated rotaviruses and noroviruses were frequently introduced into the hospital from the community. Rotavirus vaccines c...
|
PMID: 20031043
PDF is available here.
Abstract
We report a foodborne outbreak of GI.3 NoV gastroenteritis that affected 33/83 (40%) persons. Symptomatic disease was as likely to develop in nonsecretors as in secretors (odds ratio [OR] 1.41, 95% confidence interval [CI] 0.46-4.36 vs. OR 0.71, 95% CI 0.23-2.18, p = 0.57). Moreover, no statistical...
|
PMID: 20031047
PDF is available here.
Abstract
Management of fulminant hepatic failure (FHF) continues to be one challenging problem, and experimental animal models resembling its clinical conditions are still needed. Rabbit hemorrhagic disease (RHD) fullfils many requirements of an animal model of FHF. This work investigated changes in MAPK, NF...
|
PMID: 19726019
PDF is available here.
Abstract
The present paper refers to the cytometric analysis of lymphocytes T (with receptor CD5+), Th (with receptor CD4+), Tc/Ts (with receptor CD8+), lymphocytes CD25+ and lymphocytes B with receptor CD19+ in rabbits experimentally infected with strains of RHD virus--Rainham, Frankfurt and Asturias, not h...
|
PMID: 21077445
PDF is available here.
Abstract
In our cohort, NV infection was shown to be frequent among returning travelers especially in those with diarrhea, with over 1/5 of diarrhea patients tested positive for NV within the first four days after their return to Germany. Due to this prevalence, routine testing for NV infection and hygienic...
|
PMID: 20500860
PDF is available here.
Abstract
We analyzed 773 NoV outbreaks reported to the CDC from 1994 to 2006. Of these NoV outbreaks, 629 (81.4%) were caused by GII viruses and 342 (44.2%) were caused by GII.4 strains. The proportion of GII.4 outbreaks increased from 5% in 1994 to 85% in 2006, but distinct annual differences were noted, in...
|
PMID: 19864482
PDF is available here.
Abstract
Noroviruses (NoVs) are a major etiological agent of sporadic acute gastroenteritis worldwide.
To detect, quantify and characterize genogroups and genotypes of NoVs in children with and without gastrointestinal symptoms.
NoVs were investigated by RT-PCR...
|
PMID: 20004146
PDF is available here.
Abstract
We report a disease outbreak in a Michigan rabbitry of a rabbit calicivirus distinct from the foreign animal disease agent, rabbit hemorrhagic disease virus (RHDV). The novel virus has been designated Michigan rabbit calicivirus (MRCV). Caliciviruses of the Lagovirus genus other than RHDV have not b...
|
PMID: 19961675
PDF is available here.
Abstract
We demonstrated that low-concentration ClO2 gas (mean 0.08 ppm, 0.22 microg/I) could inactivate FCV in the wet state with 0.5% fetal bovine serum (FBS) within 6 h in 45 to 55% relative humidity (RH) (> 3 log10 reductions) and FCV in the dry state with 2% FBS (percentage of FBS in the viral suspensio...
|
PMID: 20055219
PDF is available here.
I H M Friesema,
H Vennema,
J C M Heijne,
C M de Jager,
G Morroy,
J H T C van den Kerkhof,
E J M de Coster,
B A Wolters,
H L G ter Waarbeek,
E B Fanoy,
P F M Teunis,
R van der Linde and
Y T H P van Duynhoven
Abstract
Effective infection control measures during norovirus outbreaks are urgently needed in places where vulnerable individuals gather. In the present study, the effect of a number of measures was investigated in daily practice. Forty-nine Dutch nursing homes were monitored prospectively for norovirus ou...
|
PMID: 19426572
PDF is available here.
D Werber,
D LauseviÄ,
B Mugosa,
Z Vratnica,
L IvanoviÄ-NikoliÄ,
L ZiziÄ,
A Alexandre-Bird,
L Fiore,
F M Ruggeri,
I Di Bartolo,
A Battistone,
B Gassilloud,
S Perelle,
D Nitzan Kaluski,
M Kivi,
R Andraghetti and
K G J Pollock
Abstract
We estimated the total size of the outbreak to be 10 000-15 000 corresponding to an attack rate of approximately 10%. We conducted an age- and neighbourhood-matched case-control study, microbiologically analysed faecal and municipal water samples and assessed the water distribution system. All cases...
|
PMID: 19534843
PDF is available here.
Abstract
Noroviruses are the most common cause of outbreaks of acute gastroenteritis worldwide. Norovirus outbreaks affect persons of all ages and occur in a wide variety of settings (e.g., nursing homes, hospitals, restaurants, communities, schools, day care centers, military barracks, and cruise ships). Du...
|
PMID: 19816397
PDF is available here.
Abstract
We evaluated the norovirus (NoV) detection reagent kit, which uses immunochromatography (IC), against outbreaks of food-borne acute viral gastroenteritis having occurred in Osaka Prefecture between November 2008 and March 2009. A total of 33 outbreaks, RT-PCR identified 27 NoV-positive cases, wherea...
|
PMID: 19928492
PDF is available here.
Abstract
To determine the burden of norovirus infections in children stools from a longitudinal community cohort were evaluated using reverse transcription polymerase chain reaction. Norovirus was detected in 21.3% of diarrheal and 8.0% of nondiarrheal stools (P < 0.01). Norovirus diarrhea was highly associa...
|
PMID: 19636281
PDF is available here.