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RNA Virus Infections (17):
- Togaviridae Infections
- Orthomyxoviridae Infections
- Caliciviridae Infections
- Hemorrhagic Fevers, Viral
- Reoviridae Infections
- Mononegavirales Infections
- Encephalitis, Arbovirus
- Bunyaviridae Infections
- Arenaviridae Infections
- Retroviridae Infections
- Nidovirales Infections
- Hepatitis E
- Hepatitis D
- Birnaviridae Infections
- Astroviridae Infections
- Picornaviridae Infections
- Flaviviridae Infections
Recent article
RNA Virus Infections
Cell Host & Microbe (8)6 2010
Abstract
We generated Riplet-deficient mice. Fibroblasts, macrophages, and conventional dendritic cells from Riplet-deficient animals were defective for the production of IFN and other cytokines in response to infection with several RNA viruses. However, Riplet was dispensable for the production of IFN in re...
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PMID: 21147464
PDF is available here.
PDF is available here.
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Abstract
Abstract
Respiratory viruses contribute to the seasonal pattern of invasive pneumococcal disease (IPD), but the impact of viral coinfections on the clinical characteristics and outcomes of patients with IPD have not been well defined.
This study was designed to describe and compare the clinical presentations...
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PMID: 20051928
PDF is available here.
PDF is available here.
Abstract
Our data show that sequence-independent amplification of partially purified viral RNA is an efficient procedure for identification of known and highly divergent new RNA viruses in clinical diarrhea samples....
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PMID: 20335418
PDF is available here.
PDF is available here.
Abstract
I interferon (IFN) response with the expression of Mx gene. However, little of the defense mechanism in fish cells against NNV infection is understood. In this study, the anti-NNV mechanism of barramundi Mx protein (BMx) was elucidated in cBB cells which were derived from BB cell line after serial t...
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PMID: 20034570
PDF is available here.
PDF is available here.
Abstract
Nervous necrosis virus (NNV) has caused mass mortality in many species of cultured fish at larval stage. Strong evidence of vertical transmission of NNV has been reported in the carrier broodstock of striped jack and sea bass. An effective immunization program was developed and monitored in adult gr...
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PMID: 19954763
PDF is available here.
PDF is available here.
Abstract
We tested ten medaka cell lines for susceptibilities to redspotted grouper nervous necrosis virus (RGNNV). Although the viral coat protein was detected in all the cell lines inoculated, the levels of cytopathic effect development and viral propagation were quite different among the cell lines. Those...
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PMID: 20624282
PDF is available here.
PDF is available here.
Pneumonologia i alergologia polska : organ Polskiego Towarzystwa Ftyzjopneumonologicznego, Polskiego Towarzystwa Alergologicznego, i Instytutu Gruzlicy i Chorob Pluc (78)1 2010
Abstract
Viral infections are the most common infectious diseases of the respiratory tract characterized by the considerable mortality (especially among children and elderly people) and considered as the significant economic burden. It has been demonstrated that implementation of rapid diagnostic methods ena...
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PMID: 20162518
PDF is available here.
PDF is available here.
PLoS Pathogens (5)11 2009
Abstract
We demonstrate that Triad3A negatively regulates the RIG-I RNA sensing pathway through Lys48-linked, ubiquitin-mediated degradation of the tumor necrosis factor receptor-associated factor 3 (TRAF3) adapter. Triad3A was induced following dsRNA exposure or virus infection and decreased TRAF3 levels in...
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PMID: 19893624
PDF is available here.
PDF is available here.
Abstract
Standard and real-time reverse transcription-PCR (rRT-PCR) procedures were used to monitor cultured and wild bivalve molluscs from the RÃa de Vigo (NW Spain) for the main human enteric RNA viruses, specifically, norovirus (NoV), hepatitis A virus (HAV), astrovirus (AsV), rotavirus (RT), enterovir...
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PMID: 19784920
PDF is available here.
PDF is available here.
Abstract
Abstract
I is recognized as G instead of A, A-to-I editing by ADAR1 can lead to genetic recoding and altered RNA structures. The importance of PKR and ADAR1 in innate antiviral immunity is illustrated by a number of viruses that encode either RNA or protein viral gene products that antagonize PKR and ADAR1 e...
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PMID: 19715457
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (101)6 2009
Abstract
Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine (15)3 Suppl 4 2009
Abstract
Abstract
Betanodavirus infects both larvae and juvenile fish and can cause the disease viral encephalopathy and retinopathy (VER). During an acute outbreak of VER, infected individuals display several clinical signs of infection, i.e. abnormal swimming pattern and loss of appetite. Betanodaviruses can also c...
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PMID: 19326790
PDF is available here.
PDF is available here.
Abstract
We report a unique vaccination method in sevenband grouper Epinephelus septemfasciatus using a synthetic double-stranded RNA polyinosinic polycytidylic acid (Poly(I:C)), an interferon inducer, followed by challenge with a live fish nodavirus. Fish injected with Poly(I:C) at 200 microg fish(-1) were...
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PMID: 19326792
PDF is available here.
PDF is available here.
Journal of Fish Diseases (32)2 2009
Abstract
These results indicate that combined inoculation with iRGNNV and ABV conferred both rapid non-specific and delayed specific protection against VNN....
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PMID: 19261047
PDF is available here.
PDF is available here.
Archives of Virology (154)2 2009
Abstract
Diseased wild redspotted grouper Epinephelus akaara were collected from Seto Inland Sea, Ehime Prefecture, in August 2002. Fish showed erratic swimming behavior and inflation of the swim bladder. The fish brains were positive for nodavirus in both RT-PCR and nested PCR. The sequence of the nested PC...
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PMID: 19130166
PDF is available here.
PDF is available here.
Abstract
We examined the effect of 17-beta-estradiol (E2) on the maturational response triggered by virus in human DCs and its influence on their ability to activate naive T cells. We developed an in vitro system to measure the response of DCs to virus infection with Newcastle disease virus (NDV) after a 24-...
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PMID: 18802009
PDF is available here.
PDF is available here.
La Revue du praticien (58)17 2008
Abstract
Abstract
Penaeus monodon shrimp collected from across the Indo-Pacific region during 1997-2004 were screened for the presence of yellow head-related viruses. Phylogenetic analyses of amplified ORF1b gene segments identified at least six distinct genetic lineages (genotypes). Genotype 1 (YHV) was detected onl...
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PMID: 18768192
PDF is available here.
PDF is available here.
Abstract
We show that replication of FHV positive-strand RNA genome produces an approximately 400 bp dsRNA from its 5' terminus that serves as the major Dicer-2 substrate. ViRNAs thus generated are loaded in Argonaute-2 and methylated at their 3' ends. Notably, FHV-encoded RNAi suppressor B2 protein interact...
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PMID: 18854242
PDF is available here.
PDF is available here.
Abstract
We investigate what role MAVS may play in apoptosis. Induction of cell death led to the rapid cleavage of MAVS, resulting in its release from the outer mitochondrial membrane. This cleavage is blocked in cells incubated with proteasome or caspase inhibitors. Transfection of synthetic viral dsRNA and...
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PMID: 18692023
PDF is available here.
PDF is available here.
Acta Microbiologica Sinica (48)10 2008
Abstract
We present our current understanding of RLR signaling in RNA virus recognition and antiviral innate immunity....
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PMID: 19160829
PDF is available here.
PDF is available here.
Biological Chemistry (389)10 2008
Abstract
The Raf/MEK/ERK signal transduction cascade belongs to the mitogen-activated protein kinase (MAPK) cascades. Raf/MEK/ERK signaling leads to stimulus-specific changes in gene expression, alterations in cell metabolism or induction of programmed cell death (apoptosis), and thus controls cell different...
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PMID: 18713014
PDF is available here.
PDF is available here.
Abstract
We have quantified statistically significant differences in the rates of expansion and spatial dynamics of colony growth between the two strains and concluded that fractal dimension is affected by the presence of the hypovirus. Therefore, fractal dimension measurement is an effective quantitative to...
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PMID: 18759224
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
We also developed and validated a multiplex RT-PCR assay for the simultaneous detection of ABPV, BQCV, and DWV in Brazil....
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PMID: 18471826
PDF is available here.
PDF is available here.
Abstract
DNA virus score (DNAVS) point, which incorporates quantitative analysis of CD64 on neutrophils and total and differential count of leukocytes, varied between 0 and 8, and displayed 95% sensitivity and 100% specificity in distinguishing between dsDNA and ssRNA virus infections [average (S.D.); DNAVS...
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PMID: 18499515
PDF is available here.
PDF is available here.
Abstract
Foremost among the newly described antiviral agents that may be developed into drugs are, for the treatment of human papilloma virus (HPV) infections, cPrPMEDAP; for the treatment of herpes simplex virus (HSV) infections, BAY 57-1293; for the treatment of varicella-zoster virus (VZV) infections, FV-...
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PMID: 18764719
PDF is available here.
PDF is available here.
Abstract
Although often encoding fewer than a dozen genes, RNA viruses can overcome host antiviral responses and wreak havoc on the cells they infect. Some manage to evade host antiviral defences, whereas others elicit an aberrant or disproportional immune response. Both scenarios can result in the disruptio...
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PMID: 18654572
PDF is available here.
PDF is available here.
Abstract
Respiratory viruses are important human pathogens, affecting both healthy individuals and immunocompromised patients. In the past decade several new human respiratory viruses have been described, some of which have the potential to start an epidemic. At the same time, influenza A viruses continue to...
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PMID: 18666032
PDF is available here.
PDF is available here.
Abstract
Betanodaviruses, a member of the family Nodaviridae, have small positive-stranded bipartite RNA genomes and are the causal agent of viral nervous necrosis in marine-farmed fish. To facilitate the study of betanodavirus, infectious cDNA clones of its two genomic RNAs were generated. The full-length c...
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PMID: 18508134
PDF is available here.
PDF is available here.
Abstract
I than to the other porcine PBV described so far. Analysis by RT-PCR and polyacrylamide gel electrophoresis of fecal samples collected in Venezuela and Argentina showed that PBV circulate at high frequencies in piglets....
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PMID: 18508933
PDF is available here.
PDF is available here.
Journal of Fish Diseases (31)7 2008
Abstract
Our results demonstrated that IPNV binds to around 88% of cells either in single or dual infections, whereas IHNV attachment always decreased in the presence of any of the other viruses. VHSV binding was not affected by IPNV, but coinfection with IHNV reduced the percentage of virus-binding cells, w...
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PMID: 18482382
PDF is available here.
PDF is available here.
Journal of Fish Diseases (31)6 2008
Abstract
We inoculated brain extract prepared from kuchijirosho-affected fugu onto an established fugu cell line, fugu eye, and observed that cytopathic effect appeared 7 days after inoculation. Injection of the culture medium of infected fugu eye cells into fugu resulted in the onset of kuchijirosho, indica...
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PMID: 18471100
PDF is available here.
PDF is available here.
Abstract
We have previously shown that Eo/B progenitor phenotypes are altered in cord blood (CB) in infants at high risk of atopy/asthma, and respond to maternal dietary intervention during pregnancy. As respiratory tract viral infections have been shown to induce wheeze in infancy, we investigated the relat...
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PMID: 18397408
PDF is available here.
PDF is available here.
Current Microbiology (56)5 2008
Abstract
Betanodaviruses causing viral nervous necrosis (VNN) have been detected and isolated from several species of cultured marine fish worldwide. In Korea, VNN was identified in several species of cultured marine fish. This study presents data on the amplified nested PCR product (420 bp) of 11 nodavirus...
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PMID: 18293033
PDF is available here.
PDF is available here.
Journal of Infection (56)5 2008
Abstract
The findings obtained in the present report support strong evidence that large genome profile PBV can be considered more an occasional viral agent rather than an etiological agent associated with diarrheal illness....
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PMID: 18403022
PDF is available here.
PDF is available here.
Abstract
We will summarize the so far limited number of studies that have demonstrated that double-membrane vesicles resembling autophagosomes are the sites of nidovirus replication. In addition, we will discuss how the formation of these large vesicles might be induced....
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PMID: 18032917
PDF is available here.
PDF is available here.
Abstract
We describe the new multiparameter RespiFinder assay, which is based on the multiplex ligation-dependent probe amplification (MLPA) technology. This assay detects 15 respiratory viruses in one reaction. The MLPA reaction is preceded by a preamplification step which ensures the detection of both RNA...
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PMID: 18256230
PDF is available here.
PDF is available here.
Antiviral Research (78)1 2008
Abstract
We provide a brief summary of the current status of animal models used to study highly pathogenic encephalitic RNA viruses for the development of antiviral therapeutics and vaccines....
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PMID: 18031836
PDF is available here.
PDF is available here.
Antiviral Research (78)1 2008
Abstract
A number of RNA viruses can cause severe disease when transmitted to humans from an animal reservoir. One of them, the recently emerged H5N1 subtype of influenza A virus, has caused several hundred cases of severe disease when transferred directly from domestic poultry. This or another avian subtype...
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PMID: 18243346
PDF is available here.
PDF is available here.
Antiviral Research (78)1 2008
Abstract
RNA viruses are a significant source of morbidity and mortality in humans every year. Additionally, the potential use of these viruses in acts of bioterrorism poses a threat to national security. Given the paucity of vaccines or postexposure therapeutics for many highly pathogenic RNA viruses, novel...
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PMID: 18258313
PDF is available here.
PDF is available here.
Antiviral Research (78)1 2008
Abstract
We here provide a non-exhaustive review of potential experimental strategies, using small molecules, to inhibit the replication of several RNA viruses. Other approaches, such as the use of interferon or other host-response modifiers, immune serum or neutralizing antibodies, are not addressed in this...
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PMID: 18313769
PDF is available here.
PDF is available here.
Antiviral Research (78)1 2008
Abstract
With intensification of trade, livestock are increasingly exposed to severe animal diseases caused by a range of RNA viruses. Recent prime examples include outbreaks of foot-and-mouth disease (FMD), peste des petits ruminants, Rift Valley fever and bluetongue. To minimise their impact, controlling t...
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PMID: 18035428
PDF is available here.
PDF is available here.
Abstract
A biological terrorism event could have a large impact on the general population and health care system. The impact of an infectious disaster will most likely be great to emergency departments, and the collaboration between emergency and infectious disease specialists will be critical in developing...
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PMID: 18295687
PDF is available here.
PDF is available here.
Abstract
These results indicate that nodavirus is present from wild marine invertebrates in the southern coastal areas of Korean Peninsula. These subclinically infected marine invertebrates may constitute an inoculum source for betanodavirus infection and cause mortality in cultured fishes in Korea....
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PMID: 18076900
PDF is available here.
PDF is available here.
Abstract
The suitability of nested reverse transcription polymerase chain reaction (nRT-PCR) to detect betanodavirus in blood samples from naturally infected Senegalese sole (Solea senegalensis) was evaluated in comparison with other diagnostic methods. Results indicated that histologic examination of brain...
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PMID: 18319436
PDF is available here.
PDF is available here.
Journal of General Virology (89)Pt 2 2008
Abstract
We describe the molecular analysis of porcine PBVs identified in the intestinal content of dead pigs. Six of 13 positive samples were cloned and then subjected to single-strand conformation polymorphism analysis and nucleotide sequencing. All clones belonged to genogroup I PBVs and almost all clones...
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PMID: 18198385
PDF is available here.
PDF is available here.
Molecular Immunology (45)4 2008
Abstract
We have attempted to successfully establish NNV infection in zebrafish (Danio rerio) showing typical NNV symptoms and which could potentially serve as an in vivo model for studying virus pathogenesis. Zebrafish being already a powerful research tool in developmental biology and having its genome com...
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PMID: 17727953
PDF is available here.
PDF is available here.
Abstract
An integrated system capable of sample pretreatment using antibody-conjugated magnetic beads and one-step reverse transcriptase-polymerase chain reaction (RT-PCR) on a microfluidic system was developed to accelerate the detection of RNA viruses such as dengue virus or enterovirus 71. The targeted vi...
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PMID: 17911000
PDF is available here.
PDF is available here.
Abstract
We describe the paradoxical role of TLR3 in innate immunity against different viruses and in viral pathogenesis but also the evidence for TLR3 as a "danger" receptor in nonviral diseases. We also discuss the structure and cellular localization of TLR3, as well as the complex signaling and regulatory...
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PMID: 18202435
PDF is available here.
PDF is available here.
Abstract
RNA virus infections cause immense human disease burdens globally, and few effective antiviral drugs are available for their treatment. Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMO) are nuclease resistant and water-soluble single-stranded-DNA-analogues that can enter cells readil...
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PMID: 18991679
PDF is available here.
PDF is available here.
Archives of Virology (153)3 2008
Abstract
We have not detected any betanodavirus-positive wild cod in northern Norway. The presence of significant amounts of betanodaviruses in wild cod represents a serious challenge for the management of viral nervous necrosis in farmed cod in Norway. Betanodavirus-positive farmed cod were present both in...
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PMID: 18175044
PDF is available here.
PDF is available here.
Archives of Virology (153)1 2008
Abstract
We examined the possibility that a betanodavirus, redspotted grouper nervous necrosis virus (RGNNV), can infect human cell lines and showed that this virus can attach to the cells but cannot penetrate them, although human cells can support the replication of the betanodavirus when viral RNAs are tra...
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PMID: 17906832
PDF is available here.
PDF is available here.
Abstract
These results indicate that betanodaviruses occur in large populations of wild marine fish in the southern part of the Korean peninsula, suggesting the importance of these subclinically infected fish as an inoculum source of betanodavirus that is horizontally transmitted to susceptible cultured fish...
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PMID: 18182506
PDF is available here.
PDF is available here.
Abstract
We define the role of plasmacytoid dendritic cells (PDC) and PDC-derived interferon alpha (IFNalpha) during viral infections. Specifically, we address the mechanisms of IFNalpha induction and the cooperation between PDC, PDC-derived IFNalpha and T cells, B cells, NK, iNKT, and myeloid dendric cells...
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PMID: 18298384
PDF is available here.
PDF is available here.
Molecular Immunology (45)1 2008
Abstract
We analyzed the expression of the same genes on a susceptible species, such as sea bass (Dicentrarchus labrax) and, although the same pattern of expression was observed both in brain and kidney, the magnitude was different mainly in the case of brain, the key organ of the infection, where higher exp...
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PMID: 17543386
PDF is available here.
PDF is available here.