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Articles on Viruses
Viruses and type 1 diabetes: ignorance acquires a better vocabulary.
The hypothesis that a virus might in some way be involved in the causation of type 1 diabetes has a long history, but decades of research have failed to resolve the issue beyond reasonable doubt. Viruses could potentially play a primary role in the pathogenesis of type 1 diabetes by...
Principles of virus structural organization.
We review principles underlying capsid formation in a variety of viruses, emphasizing the recent developments along with some historical perspective....
Viral polymerases play a central role in viral genome replication and transcription. Based on the genome type and the specific needs of particular virus, RNA-dependent RNA polymerase, RNA-dependent DNA polymerase, DNA-dependent RNA polymerase, and DNA-dependent RNA polymerases are fo...
Viruses: sophisticated biological machines.
Virus infection involves coordination of a series of molecular machines, including entry machines, replication machines, assembly machines, and genome packaging machines, leading to the production of infectious virions. This chapter provides an introduction to various viral molecular...
Reconstructing virus structures from nanometer to near-atomic resolutions with cryo-electron microscopy and tomography.
We present the common techniques used to acquire and process cryo-EM and cryo-ET data and discuss their implications for structural virology both now and in the future....
A promising tool for biomolecular nanotechnology - bionanoparticles
Bionanoparticles are naturally produced entities that are of nanometre dimension. Viruses like cowpea mosaic virus (CPMV), cowpea chlorotic mottle virus (CCMV), turnip yellow mosaic virus (TYMV), tobacco mosaic virus (TMV), adenovirus, ferritin, and enzyme complexes exemplify these systems, with thei...
Lipid-containing viruses: bacteriophage PRD1 assembly.
We will also discuss the major challenges still to be addressed in PRD1 assembly....
Chaperonin-mediated folding of viral proteins.
I and group II chaperonins are discussed. Furthermore, the general mechanism of chaperonin-mediated protein folding is addressed in addition to illustrating how viral phages such as Lambda, T4, and RB49 exploit the host machinery for the proper folding of viral gene products. Lastly, the phiEL chape...
PEG-b-PPS-b-PEI micelles and PEG-b-PPS/PEG-b-PPS-b-PEI mixed micelles as non-viral vectors for plasmid DNA: tumor immunotoxicity in B16F10 m...
Cationic micelles formed from poly(ethylene glycol)-bl-poly(propylene sulfide)-bl-poly(ethylene imine) (PEG-b-PPS-b-PEI) and from mixtures of poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-b-PPS) with PEG-b-PPS-b-PEI were explored as non-viral vectors for plasmid DNA (pDNA) tr...
How appropriate are cerebrospinal fluid polymerase chain reaction requests for suspected central nervous system infections?
Cerebrospinal fluid (CSF) polymerase chain reaction (PCR) assays have become the main diagnostic tests for central nervous system viral infections in recent years. Previous studies have suggested algorithms based on CSF leukocyte count and total protein levels to determine when CSF P...