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DNA Viruses (27):
- Guttaviridae
- Circoviridae
- Nanoviridae
- Iridoviridae
- Adenoviridae
- Phycodnaviridae
- Inoviridae
- Baculoviridae
- Anellovirus
- Tectiviridae
- Herpesviridae
- Fuselloviridae
- Ascoviridae
- Polydnaviridae
- Parvoviridae
- Asfarviridae
- Papillomaviridae
- Nimaviridae
- Poxviridae
- Microviridae
- Caudovirales
- Caulimoviridae
- Rudiviridae
- Polyomaviridae
- Lipothrixviridae
- Hepadnaviridae
- Geminiviridae
Recent article
DNA Viruses
Cell Host & Microbe (8)6 2010
Abstract
We generated Riplet-deficient mice. Fibroblasts, macrophages, and conventional dendritic cells from Riplet-deficient animals were defective for the production of IFN and other cytokines in response to infection with several RNA viruses. However, Riplet was dispensable for the production of IFN in re...
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PMID: 21147464
PDF is available here.
PDF is available here.
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Abstract
We review the etiology, clinical features, pathology, epidemiology, and diagnosis of these DNA viruses....
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PMID: 20424393
PDF is available here.
PDF is available here.
Journal of Virology (84)13 2010
Abstract
We sequentially measured the TTV loads in the plasma of four TTV-positive leukemia patients who were strongly myelosuppressed and then transplanted with haploidentical hematopoietic stem cells. The findings provide clear quantitative evidence for an extremely important role of hematopoietic cells in...
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PMID: 20410268
PDF is available here.
PDF is available here.
Abstract
We identify a central role for AIM2 in regulating caspase-1-dependent maturation of IL-1beta and IL-18, as well as pyroptosis, in response to synthetic double-stranded DNA. AIM2 was essential for inflammasome activation in response to Francisella tularensis, vaccinia virus and mouse cytomegalovirus...
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PMID: 20351692
PDF is available here.
PDF is available here.
Abstract
A retrospective serosurvey of multi-host feline and canine viruses among carnivore species in southern Africa (n=1018) identified widespread pathogen exposure even in remote protected areas. In contrast to mortality experienced in East African predators, canine distemper virus (CDV) infection among...
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PMID: 19038454
PDF is available here.
PDF is available here.
Abstract
Quantitative multiplex real-time RT-PCR assays utilizing fluorescence resonance energy transfer (FRET) hybridization probes were developed for the detection of 13 respiratory viruses, including well recognized viral causes (respiratory syncytial virus, influenza viruses A and B, parainfluenza viruse...
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PMID: 20153377
PDF is available here.
PDF is available here.
Abstract
Seventy-six 2-phenylbenzimidazole derivatives were synthesized and evaluated in cell-based assays for cytotoxicity and antiviral activity against a panel of 10 RNA and DNA viruses. The most commonly affected viruses were, in decreasing order, CVB-2, BVDV, Sb-1, HSV-1, and YFV, while HIV-1 and VSV we...
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PMID: 20359898
PDF is available here.
PDF is available here.
Abstract
The use of whole genome amplification and analysis of viruses is of increasing importance, as data generated using these methods are currently used for clinical diagnostics, epidemiological studies, phylogenetic analyses, and studies of genome organization and evolution. The best known amplification...
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PMID: 20360369
PDF is available here.
PDF is available here.
Abstract
We derive the complete set of rules for constructing an icosahedral structure from these symmetrons when the T lattice symmetry is odd and show that there are three classes of solutions, each of which follows from a different relationship between the size of the pentasymmetron and the values of the...
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PMID: 19963064
PDF is available here.
PDF is available here.
Abstract
Our knowledge of the interaction between viruses and host RNA silencing machineries, and how this influences the course of infection, is becoming increasingly complex. This chapter aims to summarize our current knowledge about viral miRNAs/ncRNAs and their targets, as well as cellular miRNAs that ar...
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PMID: 20217543
PDF is available here.
PDF is available here.
Abstract
The present method provides a new way for recovering the phylogeny of large dsDNA viruses and parvoviruses, and also some insights on the affiliation of a number of unclassified viruses. In comparison, some alignment-free methods such as the CV Tree method can be used for recovering the phylogeny of...
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PMID: 20565983
PDF is available here.
PDF is available here.
Abstract
Chronic intestinal pseudo-obstruction (CIPO), one of the most severe gastrointestinal motility disorders, is a condition characterized by a clinical picture mimicking small bowel occlusion with related symptoms and signs in the absence of demonstrable mechanical obstruction. Analysis of full-thickne...
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PMID: 20172270
PDF is available here.
PDF is available here.
Journal of Virology (84)2 2010
Abstract
We demonstrate that the extrachromosomal histone H2B mediates innate antiviral immune responses in human cells. H2B physically interacts with IPS-1 through the association with a newly identified adaptor, CIAO (COOH-terminal importin 9-related adaptor organizing histone H2B and IPS-1), to transmit t...
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PMID: 19906922
PDF is available here.
PDF is available here.
Journal of General Virology (91)Pt 1 2010
Abstract
We named them chimpanzee stool-associated circular viruses (ChiSCV). Further metagenomic studies of animal samples will greatly increase our knowledge of viral diversity and evolution....
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PMID: 19759238
PDF is available here.
PDF is available here.
Journal of Virology (84)2 2010
Abstract
We used controlled virion dissociation to reveal the structural organization of Halorubrum pleomorphic virus 1 (HRPV-1) infecting an extremely halophilic archaeal host. The single-stranded DNA genome is enclosed in a pleomorphic membrane vesicle without detected nucleoproteins. VP4, the larger major...
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PMID: 19864380
PDF is available here.
PDF is available here.
Journal of Virology (84)2 2010
Abstract
We have cloned and characterized one of the HzNV-1 early genes, hhi1, which maps to the HindIII-I fragment of the viral genome. During the productive viral infection, a 6.2-kb hhi1 transcript was detectable as early as 0.5 h postinfection (hpi). The level of transcript reached a maximum at 2 hpi and...
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PMID: 19889784
PDF is available here.
PDF is available here.
Abstract
The citrus disease Huanglongbing (HLB) is highly destructive in many citrus-growing regions of the world. The putative causal agent of this disease, 'Candidatus Liberibacter asiaticus', is difficult to culture, and Koch's postulates have not yet been fulfilled. As a result, efforts have focused on o...
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PMID: 19888827
PDF is available here.
PDF is available here.
Abstract
Twelve aminoarylazocompounds (A-C) and 46 aryltriazene 7 derivatives (D-G) have been synthesized and evaluated in cell-based assays for cytotoxicity and antiviral activity against a panel of 10 RNA and DNA viruses. Eight aminoazocompounds and 27 aryltriazene derivatives exhibited ant...
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PMID: 19482481
PDF is available here.
PDF is available here.
Abstract
Currently, the origin of autoimmune diseases is considered to be multifactorial. Genetic predisposition, immune system malfunction or even backfire, hormonal regulation, and environmental factors, i.e. infections, all play important roles in the pathogenesis of autoimmune diseases such as the antiph...
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PMID: 19089659
PDF is available here.
PDF is available here.
Virus/Uirusu (59)1 2009
Abstract
At present, more than 40 protist-infecting viruses have been isolated and characterized. From the viewpoints of molecular ecology, taxomony and molecular evolution, several new discoveries were made within the last five years. In this minireview, three topics of interest on protist-infecting viruses...
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PMID: 19927986
PDF is available here.
PDF is available here.
Abstract
We discuss the similarities and differences in how specific viruses tether episomal genomes to host cell chromosomes during mitosis to ensure long-term persistence....
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PMID: 19203914
PDF is available here.
PDF is available here.
New Microbiologica (32)2 2009
Abstract
Our data support the usefulness of mPCR as a rapid molecular method for the simultaneous detection of major viral pathogens and T. gondii in aseptic meningitis also to allow the earlier application of specific antiviral therapy....
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PMID: 19579690
PDF is available here.
PDF is available here.
Nature Protocols (4)4 2009
Abstract
We have successfully used to: (i) concentrate viral particles from various types of samples, (ii) eliminate contaminating cells and free nucleic acids and (iii) extract, amplify and purify viral nucleic acids. Overall, a sample can be processed to isolate viral nucleic acids suitable for high-throug...
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PMID: 19300441
PDF is available here.
PDF is available here.
Journal of Molecular Biology (385)4 2009
Abstract
These results are consistent with the observations for other large, icosahedral dsDNA viruses that also utilize minor capsid proteins for stabilization and for determining their assembly....
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PMID: 19027752
PDF is available here.
PDF is available here.
Abstract
The host innate immune response, including the production of type-I IFN, represents the primary line of defense against invading viral pathogens. Of the hundreds of IFN-stimulated genes (ISGs) discovered to date, ISG15 was one of the first identified and shown to encode a ubiquitin-l...
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PMID: 19680460
PDF is available here.
PDF is available here.
Abstract
Given the high rates of cervical cancer in minority women, access to cervical cancer screening and diagnostic follow-up must be ensured. It may also be beneficial to ensure affordable access to technologies such HPV DNA testing that increases the sensitivity of disease detection and to on-site colpo...
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PMID: 19098602
PDF is available here.
PDF is available here.
Critical Care Medicine (37)1 2009
Abstract
Matching criteria were: 1) the same main diagnosis on ICU admission, 2) the same age (+/- 10 yrs), 3) the same Simplified Acute Physiology II score (+/-10 points), 4) the same McCabe and Jackson comorbidity score, 5) admission within 1 year, and 6) diagnosis of at least one bacterial VAP during the...
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PMID: 19050618
PDF is available here.
PDF is available here.
Virus/Uirusu (59)2 2009
Abstract
We introduce the generation mechanisms and functions of novel non-coding RNAs generated from both animal and plant RNA viruses, after a brief review of non-coding RNAs of DNA viruses....
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PMID: 20218326
PDF is available here.
PDF is available here.
Abstract
Two methods are presented that provide independent evidence with which to test virus-phylogeny roots. The methods may be applied to phages and other viruses in which at least one horizontal transfer between hosts is inferred across the virus phylogeny. The methods are based upon the inference that v...
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PMID: 18793737
PDF is available here.
PDF is available here.
Molecular Microbiology (70)5 2008
Abstract
We show that purified viral DNAs can transfect host cells. Intact terminal proteins were essential for this process. Despite the narrow host ranges of these viruses, at least under laboratory conditions, their DNAs were able to transfect a wide range of haloarchaeal species, demonstrating that the c...
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PMID: 19006816
PDF is available here.
PDF is available here.
Virus/Uirusu (58)2 2008
Abstract
New England Journal of Medicine (359)17 2008
Abstract
Abstract
We isolated viruses by centrifugation and sequential filtration before performing a metagenomic investigation. We adopted multiple-displacement amplification (MDA), an isothermal whole-genome amplification method with phi29 polymerase and random hexamers, to amplify viral DNA and construct clone lib...
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PMID: 18708511
PDF is available here.
PDF is available here.
Abstract
Eighty-five arylazoenamines, characterized by different types of aryl and basic moieties, have been synthesized and evaluated in cell-based assays for cytotoxicity and antiviral activity against a panel of ten RNA and DNA viruses. The most commonly affected viruses were, in decreasing order, CVB-2,...
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PMID: 18760610
PDF is available here.
PDF is available here.
Abstract
The acyclic azanucleosides with 2-, 3-, or 4-aminobenzenesulfonyl function at the nitrogen atom of the sugar mimic were prepared by coupling of 2-, 3-, or 4-nitro-N-(2-pivaloyloxyethyl)-N-(pivaloyloxymethyl)benzenesulfonamide with the silylated pyrimidine nucleobases followed by the reduction of the...
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PMID: 18778942
PDF is available here.
PDF is available here.
Abstract
Abstract
We describe an icosahedral small virus, Sputnik, 50 nm in size, found associated with a new strain of APMV. Sputnik cannot multiply in Acanthamoeba castellanii but grows rapidly, after an eclipse phase, in the giant virus factory found in amoebae co-infected with APMV4. Sputnik growth is deleterious...
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PMID: 18690211
PDF is available here.
PDF is available here.
Abstract
Abstract
Many viruses introduce DNA into the host-cell nucleus, where they must either embrace or confront chromatin factors as a support or obstacle to completion of their life cycle. Compared to the eukaryotic cell, viruses have compact and rapidly evolving genomes. Despite their smaller size, viruses have...
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PMID: 18314879
PDF is available here.
PDF is available here.
Abstract
The genome of the virus that causes salivary gland hypertrophy in Musca domestica (MdSGHV) was sequenced. This non-classified, enveloped, double stranded, circular DNA virus had a 124,279bp genome. The G + C content was 43.5% with 108 putative methionine-initiated open reading frames (ORFs). Thirty...
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PMID: 18495197
PDF is available here.
PDF is available here.
Abstract
The NucliSens easyMAG and BioRot 9604 automated nucleic acid extraction systems were evaluated and compared with the manual QIAamp (Qiagen) extraction method for their abilities to extract nucleic acid from nasopharyngeal aspirate samples for the detection of RNA and DNA respiratory viruses. The nuc...
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PMID: 18463206
PDF is available here.
PDF is available here.
Research in Microbiology (159)5 2008
Abstract
We have taken advantage of the availability of the genome sequences of a collection of large and giant viruses infecting bacteria (T4 family) and eukaryotes (NCLDV group) to assess some of the evolutionary forces which might have shaped their genomes. Despite having apparently different ancestors, t...
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PMID: 18572389
PDF is available here.
PDF is available here.
Research in Microbiology (159)5 2008
Abstract
Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral s...
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PMID: 18541415
PDF is available here.
PDF is available here.
Abstract
In the present study, multiplex reverse transcription-polymerase chain reaction (mRT-PCR) was developed for simultaneously detection of six major shrimp viruses including yellow-head virus (YHV), white spot syndrome virus (WSSV), Taura syndrome virus (TSV), hepatopancreatic parvovirus (HPV), infecti...
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PMID: 18406570
PDF is available here.
PDF is available here.
Abstract
We present an exception to this paradigm by demonstrating that genome delivery and packaging in the virus Acanthamoeba polyphaga mimivirus occur through two distinct portals. By using high-resolution techniques, including electron tomography and cryo-scanning electron microscopy, we show that Mimivi...
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PMID: 18479185
PDF is available here.
PDF is available here.
Abstract
Recent discoveries have uncovered considerable genetic diversity among aquatic viruses and raised questions about the variability of this diversity within and between environments. Studies of the temporal and spatial dynamics of aquatic viral assemblages have been hindered by the lack of a common ge...
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PMID: 18344351
PDF is available here.
PDF is available here.
Abstract
Nucleic Acids Research (36)9 2008
Abstract
We briefly introduce cytosine methylation before reviewing what is currently known about CpG methylation in DNA viruses....
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PMID: 18367473
PDF is available here.
PDF is available here.
Journal of Virology (82)9 2008
Abstract
We sequenced and analyzed its genome. The GpSGHV genome is a double-stranded circular DNA molecule of 190,032 bp containing 160 nonoverlapping open reading frames (ORFs), which are distributed equally on both strands with a gene density of one per 1.2 kb. It has a high A+T content of 72%. About 3% o...
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PMID: 18272583
PDF is available here.
PDF is available here.
Journal of Molecular Biology (378)1 2008
Abstract
We have characterized the first virally encoded cyclophilin (mimicyp) derived from the largest virus discovered to date (the Mimivirus) that is also a causative agent of pneumonia in humans. Mimicyp adopts a typical cyclophilin-fold, yet it also forms trimers unlike any previously characterized homo...
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PMID: 18342330
PDF is available here.
PDF is available here.
Abstract
We propose to divide biological entities into two groups of organisms: ribosome-encoding organisms, which include eukaryotic, archaeal and bacterial organisms, and capsid-encoding organisms, which include viruses. Other replicons (for example, plasmids and viroids) can be termed 'orphan replicons'....
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PMID: 18311164
PDF is available here.
PDF is available here.
Abstract
The successful replication of mammalian DNA viruses requires that they gain control of key cellular signalling pathways that affect broad aspects of cellular macromolecular synthesis, metabolism, growth and survival. The phosphatidylinositol 3'-kinase-Akt-mammalian target of rapamycin (PI3K-Akt-mTOR...
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PMID: 18311165
PDF is available here.
PDF is available here.
Abstract
We review our current knowledge of the rates of mutation and substitution, as well as their determinants, in RNA viruses, DNA viruses and retroviruses. We show that the high rate of nucleotide substitution in RNA viruses is matched by some DNA viruses, suggesting that evolutionary rates in viruses a...
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PMID: 18319742
PDF is available here.
PDF is available here.
Abstract
The RNA triphosphatase (RTPase) components of the mRNA capping apparatus are a bellwether of eukaryal taxonomy. Fungal and protozoal RTPases belong to the triphosphate tunnel metalloenzyme (TTM) family, exemplified by yeast Cet1. Several large DNA viruses encode metal-dependent RTPases unrelated to...
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PMID: 18400173
PDF is available here.
PDF is available here.
Abstract
We describe the new multiparameter RespiFinder assay, which is based on the multiplex ligation-dependent probe amplification (MLPA) technology. This assay detects 15 respiratory viruses in one reaction. The MLPA reaction is preceded by a preamplification step which ensures the detection of both RNA...
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PMID: 18256230
PDF is available here.
PDF is available here.
Nucleic Acids Research (36)7 2008
Abstract
We report for the first time that deleting either one or the two NC zinc fingers leads to an unexpected premature viral DNA synthesis in virus producer cells and the production of noninfectious particles with a high level of viral DNA. In addition to providing the first example of reverse transcript...
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PMID: 18296486
PDF is available here.
PDF is available here.
Abstract
We argue that the most plausible explanation for this is a trade-off with replication speed. We suggest that research into further increasing this mutation rate artificially as an antiviral treatment requires a theoretical reevaluation, especially relating to the so-called error threshold. The main...
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PMID: 18295930
PDF is available here.
PDF is available here.
Abstract
We screened 496 respiratory specimens from 9 pneumonia-patient populations for APM. This virus was not detected in any specimen, which suggests it is not a common respiratory pathogen....
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PMID: 18325263
PDF is available here.
PDF is available here.
EMBO Reports (9)3 2008
Abstract
Abstract
We report the 4.5-A resolution structure of a 22-MDa macromolecular assembly, the capsid of the infectious epsilon15 (epsilon15) particle, by single-particle electron cryomicroscopy. From this density map we constructed a complete backbone trace of its major capsid protein, gene product 7 (gp7). The...
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PMID: 18305544
PDF is available here.
PDF is available here.