Abstract
The tight junction (TJ) is a critical cellular component for maintenance of tissue integrity, cellular interactions and cell-cell communications, and physiologically functions as the "great wall" against external agents and the surrounding hostile environment. During the host-pathogen evolution, vir...
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PMID: 20082472
PDF is available here.
Abstract
At first blush, an outbreak of mouse hepatitis virus or epizootic diarrhea of infant mice virus in a research colony of laboratory mice may not seem like a disaster. However, irrespective of magnitude, such an outbreak at an academic institution is disruptive for researchers at all levels. It can be...
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PMID: 20375435
PDF is available here.
Abstract
The epidemiology of acute viral hepatitis (AVH) is dynamic and affected by many factors including hygiene, socioeconomic status and vaccination coverage. A total of 4,302 cases of AVH were sequentially enrolled in this nationwide study between 1980 and 2008. Of the cases of AVH, acute hepatitis A (A...
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PMID: 20068345
PDF is available here.
Abstract
We describe some of these advances, focusing on the progress made in the development of lentiviral shRNA delivery strategies to combat viral infections....
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PMID: 19341774
PDF is available here.
Abstract
Fulminant hepatic failure (FHF) associated with parvovirus B19 (B19) infection has a favorable prognosis in children. However, there is no data available to predict outcome in cases of FHF associated with hepatotropic virus coinfection. Clinical characteristics of 3 pediatric groups with FHF were co...
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PMID: 19483661
PDF is available here.
M M Sugitani,
A A Sheikh,
K K Suzuki,
N N Kinukawa,
M M Moriyama,
Y Y Arakawa,
K K Komiyama,
T-C TC Li,
N N Takeda,
S M SM Ishaque,
P K PK Roy,
A S M A AS Raihan and
M M Hasan
Abstract
In a recent investigation of hepatitis in Bangladesh, the sera from 74 adult patients (aged 15-67 years) who had been clinically diagnosed as cases of sporadic acute hepatitis were collected at various hospitals in and around Dhaka. Five cases were positive for IgM antibody against the hepatitis A v...
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PMID: 19508752
PDF is available here.
Abstract
The transmission of hepatitis viruses as a result of sexual activity is a common problem in medical practice. A system of stages is proposed to diagnose viral hepatitis. Testing for anti-HBc, HBsAg, anti-HAV and anti-HCV is sufficient for initial screening. Depending on the circumstances, this may b...
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PMID: 19436974
PDF is available here.
Abstract
The incidence of acute hepatitis A and B infection has declined significantly, especially among children less than 15 years of age. Five oral antiviral agents have been approved for the treatment of chronic hepatitis B. Telbivudine is more potent than lamivudine but is associated with a high rate of...
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PMID: 19387254
PDF is available here.
Abstract
We tested the hypothesis of a viral aetiology of this disease by screening liver samples of a large number of BA patients for the common human hepatotropic viruses. Moreover, we correlated our findings to the expression of Mx protein, which has been shown to be significantly up-regulated during vira...
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PMID: 18560888
PDF is available here.
Abstract
We screened a phage display library for peptides recognized by one such antibody (8H5). We analysed the specificity of 8H5 for reactive peptides presented as fusion proteins of HBc (hepatitis B core protein) and HEV (hepatitis E virus) structural protein, p239. This was then related to the specifici...
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PMID: 18973474
PDF is available here.
Abstract
We evaluated the incidence of HCC by aminotransferase level in 19 812 middle-aged and older individuals with and without hepatitis virus infection from a large-scale population-based cohort study (JPHC Study cohort II) in Japan. Hepatitis virus infection was identified at baseline in 1236 participan...
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PMID: 19077561
PDF is available here.
Abstract
The straight line nucleic acids detection method of viruses and wide spectrum of virus antigens immunodiagnostics in acute hepatitis of unknown etiology patients has allowed verifying the diagnosis at 19% cases (a viral hepatitis A, C or E). Results of research do not allow to consider hepatotropic...
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PMID: 20469673
PDF is available here.
Abstract
NV-F is a novel hepatotropic viruslike agent. To investigate the impact of the NV-F agent during chronic hepatitis C virus (HCV) infection, 101 consecutive patients with chronic HCV infection were evaluated. NV-F DNA in serum samples and NV-F antigen expression in liver tissues were assessed. All pa...
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PMID: 18954259
PDF is available here.
Abstract
Sixteen pregnant women presented at the three main hospitals in Khartoum province, Sudan during the period of March-September 2007 with features of acute viral hepatitis. Their mean (SD) gestational age was 28.0(6.7) weeks. The etiology of acute viral hepatitis was hepatitis B virus in five women (3...
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PMID: 18712815
PDF is available here.
Abstract
We showed previously an unexpected very high positive correlation between breast cancer (BC) and young-adult Hodgkin disease incidence rates. In a population-based case-control study of BC, older ages at the first Epstein-Barr virus exposure, indicated by older ages at onset of infectious mononucleo...
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PMID: 18537160
PDF is available here.
D D FitzSimons,
G G François,
G G De Carli,
D D Shouval,
A A Prüss-Ustün,
V V Puro,
I I Williams,
D D Lavanchy,
A A De Schryver,
A A Kopka,
F F Ncube,
G G Ippolito and
P P Van Damme
Abstract
The Viral Hepatitis Prevention Board (VHPB) convened a meeting of international experts from the public and private sectors in order to review and evaluate the epidemiology of blood-borne infections in healthcare workers, to evaluate the transmission of hepatitis B and C viruses as an occupational r...
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PMID: 18562683
PDF is available here.
Abstract
Viral hepatitides are satisfactorily diagnosed in the laboratory by immunoassays for either antigen or antibody detection in serum samples. However, the early detection of acute infections during the window period, investigation of occult infections, and issues related to the establishment and follo...
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PMID: 19195449
PDF is available here.
Abstract
The prevalence of woodchuck hepatitis virus (WHV) in wild populations of woodchucks is understudied and therefore unclear. Although infection is common in the southeastern region of Pennsylvania and surrounding states, it is virtually absent in New York and New England. Sera were collected from wild...
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PMID: 18634221
PDF is available here.
Abstract
BACKGROUND: Hepatitis can be caused by a number of viruses, which have similar clinical manifestations and render infected individuals at high risk of death from cirrhosis and liver cancer. Current therapies for hepatitis have limited effects and unsatisfactory patient outcomes. Nuclear factor kappa...
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PMID: 18269337
PDF is available here.
Abstract
We have previously reported that immortalized human hepatocytes (IHH) support the generation of infectious hepatitis C virus (HCV) genotype 1a (clone H77). In the present study, we have investigated the growth of HCV genotype 1a (clone H77) through serial passages and accompanying changes in IHH in...
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PMID: 18077704
PDF is available here.
Abstract
Chemical or radiant energy injuries to the eyes are considered ocular burns. The majority of these injuries are occupation-related. Chemical burns are by far more common and represent a true emergency. Thermal and UV injuries are associated with severe pain, but often result in less long-term sequel...
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PMID: 18249260
PDF is available here.
Abstract
Functional analysis of hepatitis B virus (HBV) core particles has associated a number of biological roles with the C terminus of the capsid protein. One set of functions require the C terminus to be on the exterior of the capsid, while others place this domain on the interior. According to the cryst...
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PMID: 18022640
PDF is available here.
Abstract
Mongolia is known for its high endemicity for viral hepatitis infections, accounted for 25% of infectious disease cases in 2000. Studies revealed these infections are prevalent among young adults in Mongolia. The infections are first and foremost nosocomial infections. The incidence of primary liver...
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PMID: 18807490
PDF is available here.
Abstract
The most common etiology of acute viral hepatitis in Korea is hepatitis A virus, and hepatitis C and B virus were the next most common causes. The sporadic cases of acute hepatitis E were not rare, and coinfection of HAV and HEV was observed. A multicenter, prospective study is warranted in the futu...
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PMID: 18159147
PDF is available here.
Abstract
This is prospective cross-sectional study on 37 patients presenting to different hospitals in Khartoum state, Sudan, sought to determine the etiology, clinical course, and predictors of mortality in patients presenting with fulminant hepatic failure (FHF). Patients were subclassified...
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PMID: 17436091
PDF is available here.
Abstract
We postulate that the five constituent iminosugars present in the silkworm extract contribute, in a synergistic manner, toward the antiviral effects observed for the inhibition of intact maturation of hepatitis viral particles and may complement conventional therapies. These results indicate that pr...
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PMID: 17978803
PDF is available here.
Abstract
Glutathione status in the HCC suggested that the antioxidant system is severely impaired, supporting a consistent role of the free radical cytotoxicity in the pathophysiology of the disease....
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PMID: 17706189
PDF is available here.
Abstract
The transplant community has been slow to recognize the efficacy of highly active antiretroviral therapy in changing the course of human immunodeficiency virus (HIV) infection to a chronic condition. People infected with HIV are dying less often from progression of HIV to acquired immune deficiency...
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PMID: 17876267
PDF is available here.
Abstract
Most survival studies of chronic liver disease avoid including more than one condition, often present in patients with liver disease; survival analysis of patients with liver disease in general was undertaken. Over a 9-year period, the survival experience of 365 patients who underwen...
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PMID: 17406827
PDF is available here.
Abstract
We discuss replicative and non-replicative molecular mechanisms of genome variation, modulating effects of mutant spectra, and several modes of viral evolution that can affect viral pathogenesis. Relevant evolutionary events include the generation of minority virus variants with altered functional p...
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PMID: 17349710
PDF is available here.
Abstract
Blood-borne infections are transmitted by way of direct blood contact from one individual to another from injured skin or a mucous membrane. Blood-borne infections can also be transmitted through blood doping and drug abuse and through sexual contact. Risk factors for hepatitis B virus (HBV) HBV inf...
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PMID: 17826193
PDF is available here.
Abstract
Infants born from mothers with multiple blood-borne viral infections are at risk of multiple transmissions. Whether the risk of transmission of multiple infections increases with the number of viruses infecting the mother is still unknown. The aim of this study was to describe the risk of mother-to-...
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PMID: 17457925
PDF is available here.
Abstract
A number of previous literature reviews and research studies have found a correlation between viral hepatitis infections and tattoos. The 1897 subjects of the current study were young adult male military recruits in southern Taiwan (476 with tattoos and 1421 without tattoos) who underwent induction...
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PMID: 17521106
PDF is available here.
Abstract
Elevated hepatitis B virus DNA levels in patients in their 40s with perinatally acquired hepatitis B virus infection increases the risk for cirrhosis and hepatocellular carcinoma. Six approved therapies are available for chronic hepatitis B. Entecavir is a potent antiviral for nucleoside-naïve pati...
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PMID: 17414841
PDF is available here.
Abstract
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and the major risk factors include chronic infections with the hepatitis B (HBV) or C (HCV) virus, and exposure to dietary aflatoxin B(1) (AFB(1)) or alcohol consumption. Multiple genetic and epigenetic changes are invol...
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PMID: 17401425
PDF is available here.
Abstract
We describe a simple, rapid and sensitive integrated protein microarray with three different reaction models. The integrated protein microarray could simultaneously determine in human sera two viral antigens (HBsAg, HBeAg) and seven viral antibodies (HBsAb, HBcAb, HBeAb, HCVAb, HDVAb, HEVAb, HGVAb)...
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PMID: 17239337
PDF is available here.
Abstract
A fragment of DNA sequence derived from a hepatotropic virus, named NV-F was isolated recently. The aim of this study was to examine whether this virus was associated with hepatocellular carcinoma (HCC). Total cellular DNA was extracted from hepatocellular carcinoma tissues. NV-F virus DNA was detec...
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PMID: 17133558
PDF is available here.
Abstract
The negativity to HCV-related viruses and the negativity of the Cercopithecidae species tested against HBV/HDV do not allow us to definitively rule out the presence of an animal counterpart of human hepatitis viruses in non-human primates....
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PMID: 17214667
PDF is available here.
Abstract
Co-infection with multiple viruses is observed in one-quarter of patients with sporadic AVH in childhood. Such infection does not produce a more severe disease. HEV positivity is a strong marker for multiple infections....
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PMID: 16928213
PDF is available here.
Abstract
A novel hepatotropic virus, named NV-F virus, was recently identified. The clinical information for this virus is still scarce. Using PCR assay, NV-F viral DNA (NV-F-DNA) was detected in 12 of 50 (24%) hepatitis C virus (HCV)-infected patients (HCV-coinfected [HCVCI] group), 34 of 250 (13.6%) hepati...
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PMID: 16954237
PDF is available here.
N N Aslan,
C C Yurdaydin,
J J Wiegand,
T T Greten,
A A Ciner,
M F MF Meyer,
H H Heiken,
B B Kuhlmann,
T T Kaiser,
H H Bozkaya,
H L HL Tillmann,
A M AM Bozdayi,
M P MP Manns and
H H Wedemeyer
Abstract
We investigated 76 patients with viral hepatitis [15 hepatitis B virus (HBV), 22 HBV/hepatitis D virus and 17 hepatitis C virus (HCV)] for cytotoxic CD4+ T cells. The frequency of perforin-positive CD4+ T cells in viral hepatitis was highly variable ranging from < 1% to more than 25%. Perforin-posit...
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PMID: 16901280
PDF is available here.
Abstract
None of the patients had hepatitis A virus (HAV) and hepatitis D virus (HDV) infections. Overall prevalence of TTV-DNA was detected in 27.1% cases with AVH, 18.9% cases with CVH, 48.4% cases with cirrhosis and 9.4% cases with FHF. TTV-DNA simultaneously tested in 100 healthy blood donors showed 27%...
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PMID: 16688839
PDF is available here.
Abstract
We have identified a novel single-stranded DNA fragment derived from a virus-like agent associated with human hepatitis....
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PMID: 16544249
PDF is available here.
Abstract
Viral hepatitis is an infectious disease affecting the liver. At this time, five different human hepatitis viruses are recognized and characterized in detail: Hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and hepatitis E virus (HEV). The hepatiti...
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PMID: 16725087
PDF is available here.
Abstract
The recombinant baculovirus transduced BHK cells with efficiencies higher than 90% as determined by flow cytometry. The expression level was significantly higher than that obtained by plasmid transfection and was further enhanced 3-fold to around 19 pg/cell by the addition of 10 mmol/L sodium butyra...
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PMID: 16570347
PDF is available here.
Yuichi Y Tanaka,
Hiroyuki H Marusawa,
Hiroshi H Seno,
Yuko Y Matsumoto,
Yoshihide Y Ueda,
Yuzo Y Kodama,
Yoko Y Endo,
Junichi J Yamauchi,
Tomonori T Matsumoto,
Akifumi A Takaori-Kondo,
Iwao I Ikai and
Tsutomu T Chiba
Abstract
Our findings provided the first evidence showing that APOBEC3G is induced by IFN stimulation in human hepatocytes and thus could be involved in host defense mechanisms directed against hepatitis viruses....
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PMID: 16426578
PDF is available here.
Abstract
Hepatitis of viral aetiology caused by hepatotropic virus (A, E, B, D and C) represents an important work load for the clinical virology laboratory. Most of the diagnostic is based upon detection in serum and plasma samples of different serological and virological markers, which correlates with diff...
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PMID: 16606561
PDF is available here.
Abstract
A method is developed of kryopreservation of a liquid virus vaccine against duck hepatitis virus in liquid nitrogen at -196 degrees C or in its pairs (-168 to - 175 degrees C) with the subsequent fast defreezing on water bath at 40 degrees C within 2 minutes allowing to keep to initial property of a...
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PMID: 17100332
PDF is available here.
Abstract
The paper summarizes the updates available in the literature and the authors' own data on the etiology of hepatitis, its models, and experimental studies on susceptible simian types. A comparative analysis of the etiological agents--the causative agents of simian and human hepatitis will give a bett...
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PMID: 16929591
PDF is available here.