Unusual features of thyroid carcinomas in Japanese patients with Werner syndrome and possible genotype-phenotype relations to cell type and race.

doi:10.1002/(SICI)1097-0142(19990315)85:6<1345::AID-CNCR18>3.0.CO;2-#

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Unusual features of thyroid carcinomas in Japanese patients with Werner syndrome and possible genotype-phenotype relations to cell type and race.

Y Y Ishikawa, H H Sugano, T T Matsumoto, Y Y Furuichi, R W RW Miller and M M Goto Cancer 85(6):1345-52 (1999) PMID 10189141

Werner syndrome (WS), an autosomal recessive disease characterized by premature aging, has a high frequency of association with six rare neoplasms in Japanese patients, and only four of these neoplasms also occur excessively in whites. Several differ from what is usual in their epidemiology and/or histology. Described in this article are peculiarities in the occurrences of follicular and papillary thyroid carcinomas among Japanese patients and the possible genotype-phenotype relations pertaining to cell types and the absence of excess thyroid carcinoma occurrence in whites with WS.

DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1345::AID-CNCR18>3.0.CO;2-#
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Unusual features of thyroid carcinomas in Japanese patients with Werner syndrome and possible genotype-phenotype relations to cell type and race.

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