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Horizontal transmissible protection against myxomatosis and rabbit hemorrhagic disease by using a recombinant myxoma virus.

J J Bárcena, M M Morales, B B Vázquez, J A JA Boga, F F Parra, J J Lucientes, A A Pagès-Manté, J M JM Sánchez-Vizcaíno, R R Blasco, and J M JM Torres

J Virol 74(3):1114-23 (2000) PMID 10627521 PMCID 111445

We have developed a new strategy for immunization of wild rabbit populations against myxomatosis and rabbit hemorrhagic disease (RHD) that uses recombinant viruses based on a naturally attenuated field strain of myxoma virus (MV). The recombinant viruses expressed the RHDV major capsid protein (VP60) including a linear epitope tag from the transmissible gastroenteritis virus (TGEV) nucleoprotein. Following inoculation, the recombinant viruses induced specific antibody responses against MV, RHDV, and the TGEV tag. Immunization of wild rabbits by the subcutaneous and oral routes conferred protection against virulent RHDV and MV challenges. The recombinant viruses showed a limited horizontal transmission capacity, either by direct contact or in a flea-mediated process, promoting immunization of contact uninoculated animals.

DOI: 10.1128/JVI.74.3.1114-1123.2000
Version: za2963e q8za0 q8zb7 q8zc0 q8zd4 q8ze4 q8zf1 q8zg2

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