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Ulinastatin attenuates reperfusion injury in the isolated blood-perfused rabbit heart.

Z L ZL Cao, Y Y Okazaki, K K Naito, T T Ueno, M M Natsuaki, and T T Itoh

Ann Thorac Surg 69(4):1121-6 (2000) PMID 10800804

Ventricular dysfunction after long cardioplegic arrest has been observed in cardiac operations. Urinary trypsin inhibitor, also called ulinastatin, may attenuate myocardial ischemia-reperfusion injury. The present study was designed to determine the protective efficacy of ulinastatin in blood-perfused parabiotic isolated rabbit hearts as a surgically relevant model with long (4-hour) cardioplegic arrest.

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