Advanced search×

Intra- and extracellular enzymes of collagen biosynthesis as biological and chemical targets in the control of fibrosis.

H M HM Kagan

Acta Trop 77(1):147-52 (2000) PMID 10996130

The several steps in the pathway for the biosynthesis of fibrillar collagen are reviewed to illustrate potential sites for the chemotherapeutic control of fibrosis. Particular emphasis is placed upon the properties and inhibition of lysyl oxidase, the enzyme which initiates the covalent crosslinking of extracellular collagen molecules converting these to insoluble fibers, and upon the properties and inhibition of prolyl hydroxylase, the intracellular enzyme which hyroxylates proline residues within collagen.

Version: za2963e q8za1 q8zb5 q8zc0 q8zd4 q8ze8 q8zfa q8zg1
Buy PDF

Similar articles you may find interesting…

  1. Plausible Novel Ribose Metabolism Catalyzed by Enzymes of the Methionine Salvage Pathway in Bacillus subtilis.
    Toshihiro Nakano, Yohtaro Saito, and Hiroki Ashida

    Biosci Biotechnol Biochem (2013) PMID 23649237

    We propose a novel ribose metabolic pathway performed by MSP enzymes of Bacilli. MtnK, an initial catalyst of MSP, had significant ribose kinase activity, with Vmax and Km values of 2.9 µmol min(-1) mg of protein(-1) and 4.8 mM. Downstream enzymes catalyzed the isomerization of ribose-1-phosphate a...
    Buy PDF
  2. Optimizing conditions of polysaccharide extraction from Shiitake mushroom using response surface methodology and its regulating lipid metabo...
    Min Zhu, Ping Nie, and Bing Wang

    Carbohydr Polym 95(2):644-8 (2013) PMID 23648024

    Process conditions (extraction time, extraction temperature, water/solid ratio and incubation time) of Shiitake mushroom polysaccharides (SMP) were optimized by conducting experiments at three different levels using the response surface method (RSM). A second-order polynomial respons...
    Buy PDF
  3. The role of enzyme compartmentalization on the regulation of steroid synthesis.
    Phuong T T Nguyen, Alan J Conley, and Paul R Shorten

    J Theor Biol (2013) PMID 23639404

    Steroidogenic enzymes can be compartmentalized at different levels, some by virtue of being membrane bound in specific intra-cellular compartments. Although both 3β-hydroxysteroid dehydrogenase/Δ(5)-Δ(4) isomerase (3β-HSD) and 17α-hydroxylase/17,20-lyase cytochrome P450 (P450c17...
    Buy PDF