Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy.
The IgA1 molecule, which is predominantly deposited in glomeruli in IgA nephropathy (IgAN), is a unique serum glycoprotein because it has O-glycan side chains in its hinge region. Our study was conducted to investigate the O-glycan structure in the glomerular IgA1 in IgAN.
DOI: 10.1046/j.1523-1755.2001.0590031077.x
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