Advanced search×

Kinetic spectrophotometric determination of nizatidine and ranitidine in pharmaceutical preparations.

E M EM Hassan and F F Belal

J Pharm Biomed Anal 27(1-2):31-8 (2002) PMID 11682208

A new simple and sensitive kinetic spectrophotometric method is described for analysis of nizatidine (I) and ranitidine (II). The method involves the reaction of the drugs with alkaline potassium permanganate, whereby a green color peaking at 610 nm is produced. The reaction is monitored spectrophotometrically by measuring the rate of change of absorbance of the resulting manganate species at 610 nm. Calibration graphs are linear over the concentration range 0.8-4.0 microg/ml and the precision (% RSD 1.80, 1.53 for I and II, respectively) is quite acceptable. The method is satisfactorily applied for direct analysis of pharmaceutical preparations containing I and II. A proposal of the reaction pathway is postulated.

Version: za2963e q8zae q8zb5 q8zc7 q8zd1 q8ze7 q8zf8 q8zg2

Similar articles you may find interesting…

  1. A kinetic model for glycerol chlorination in the presence of acetic acid catalyst
    Zheng-Hong Luo, Xiao-Zi You, and Hua-Rong Li

    Kor J Chem Eng 27(1):66-72 (2010)

  2. Editorial board
    Author(s) unavailable

    Bioorg Med Chem Lett 19(13):0 (2009)

  3. Separation and structural elucidation of a novel analogue of vardenafil included as an adulterant in a dietary supplement by liquid chromato...
    Lee

    J Pharm Biomed Anal 54(3):6 (2011) PMID 20952140

    MEGATON, a dietary supplement, was analyzed in order to detect PDE-5 inhibitors and their analogues. A new analogue of vardenafil could be detected by high-performance liquid chromatography (HPLC) analysis with a photodiode array detector (PDA). This compound was compared with silden...