The past, present and future of genome-wide re-annotation.

Genome Biology 3(2):COMMENT2001 (2002) PMID 11864365 PMCID PMC139008

Annotation, the process by which structural or functional information is inferred for genes or proteins, is crucial for obtaining value from genome sequences. We define the process of annotating a previously annotated genome sequence as 're-annotation', and examine the strengths and weaknesses of current manual and automatic genome-wide re-annotation approaches.