Between 1998 and 2001, tissues from four captive white-tailed deer were observed to have histologic lesions of systemic lymphocytic vasculitis. These lesions suggested malignant catarrhal fever, although epizootic hemorrhagic disease and bluetongue were included in the differential diagnosis. Initial diagnostic efforts, including virus isolation and reverse transcription-PCR for epizootic hemorrhagic disease virus and bluetongue virus, failed to identify an etiologic agent. However, consensus primer PCR targeted to the herpesvirus DNA polymerase gene detected viral genomic DNA in each of these four cases. Nucleotide sequence analysis of the amplified product demonstrated that the detected virus was identical over the compared region to the recently described malignant catarrhal fever virus of white-tailed deer (H. Li, N. Dyer, J. Keller, and T. B. Crawford, J. Clin. Microbiol. 38:1313-1318, 2000). Additional nucleotide sequencing of both the DNA polymerase gene and DNA packaging gene followed by phylogenetic analysis solidified this newly recognized herpesvirus as a member of the Gammaherpesvirinae and suggests that this virus, along with ovine herpesvirus 2, alcelaphine herpesvirus 1, alcelaphine herpesvirus 2 and caprine herpesvirus 2, may be part of a separate clade within this subfamily.
We performed here a highly detailed evaluation of
Community detection algorithms, which has two main novelties: 1) using complex
Closed benchmarks, which provide precise ways to assess whether the solutions
Generated by the algorithms are optimal; and, 2) A novel type of analysis,
Based on hierarchi...
We develop a simple theory to establish these conditions, and we successfully
Apply it to various classes of network models. Our main result is that
Heterogeneity in the degree distribution helps modularity to correctly recover
The community structure of a network and that, in the realistic case of...
Biomarkers which predict patient's survival can play an important role in
medical diagnosis and treatment. How to select the significant biomarkers from
hundreds of protein markers is a key step in survival analysis. In this paper a
novel method is proposed to detect the prognostic biomarkers of su...
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