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Hormonal effects of Depo-Provera in cervical smears: a comparison with Triphasil and postmenopausal effects.

Stamatina Kaptain, Leonard I Bloom, and Michele M Weir

Cancer 96(2):74-82 (2002) PMID 11954024

Long-acting injectable contraceptive agents may cause changes in cervical smears that could impair the detection of epithelial abnormalities. The objectives of the current study were to 1) compare the hormonal effects of depot-medroxyprogesterone acetate (Depo-Provera) (DP) in cervical smears with those of levonorgestrel and ethinyl estradiol (Triphasil) (TP) and postmenopausal (PM) changes; and 2) determine whether the duration of DP use affects squamous maturation.

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