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Trimethylsilylethynyl ketones as surrogates for ethynyl ketones in the double Michael reaction.

Derrick S DS Holeman, Ravindra M RM Rasne, and Robert B RB Grossman

J Org Chem 67(9):3149-51 (2002) PMID 11975585

Trimethylsilylethynyl ketones can be desilylated in the presence of a tethered carbon diacid and induced to undergo a double Michael reaction in situ. The trimethylsilylethynyl ketones can serve as surrogates of ethynyl ketones that are difficult to prepare or isolate.

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