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Antimycobacterial activity of lipodepsipeptides produced by Pseudomonas syringae pv syringae B359.

E E Buber, A A Stindl, N L NL Acan, T T Kocagoz, and R R Zocher

Nat Prod Lett 16(6):419-23 (2002) PMID 12462348

Some lipodepsipeptides produced by Pseudomonas syringae pv. syringae showed strong antimycobacterial activity towards Mycobacterium smegmatis. MIC values found were between 1.5-3.2 microg/ml, which is comparable to some primary drugs for tuberculosis. Among the lipodepsipeptides, Syringomycin E (SRE) appears to be the most potent antimycobacterial agent.

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