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Generation of fiber-modified adenovirus vectors containing heterologous peptides in both the HI loop and C terminus of the fiber knob.

Naoya N Koizumi, Hiroyuki H Mizuguchi, Naoki N Utoguchi, Yoshiteru Y Watanabe, and Takao T Hayakawa

J Gene Med 5(4):267-76 (2003) PMID 12692861

Fiber-modified adenovirus (Ad) vectors can be effective in overcoming the limitations of conventional Ad vectors, specifically their inefficient gene transfer into cells lacking the primary receptor, the coxsackievirus and adenovirus receptor (CAR). Several types of fiber-modified Ad vectors have been developed. In this study, we evaluated the functionality of several fiber-modified Ad vectors.

DOI: 10.1002/jgm.348
Version: za2963e q8za5 q8zb1 q8zc4 q8zde q8zeb q8zfd q8zg5

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